Amino acid dipepetide frequency for Carnobacterium iners

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.216AlaAla: 5.216 ± 0.138
0.412AlaCys: 0.412 ± 0.027
3.331AlaAsp: 3.331 ± 0.074
4.335AlaGlu: 4.335 ± 0.112
3.15AlaPhe: 3.15 ± 0.085
4.669AlaGly: 4.669 ± 0.106
1.041AlaHis: 1.041 ± 0.037
6.41AlaIle: 6.41 ± 0.111
4.778AlaLys: 4.778 ± 0.091
7.122AlaLeu: 7.122 ± 0.118
2.0AlaMet: 2.0 ± 0.062
2.92AlaAsn: 2.92 ± 0.074
1.794AlaPro: 1.794 ± 0.059
2.165AlaGln: 2.165 ± 0.074
2.39AlaArg: 2.39 ± 0.078
4.033AlaSer: 4.033 ± 0.08
3.972AlaThr: 3.972 ± 0.085
4.667AlaVal: 4.667 ± 0.093
0.402AlaTrp: 0.402 ± 0.025
2.363AlaTyr: 2.363 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.334CysAla: 0.334 ± 0.024
0.064CysCys: 0.064 ± 0.01
0.262CysAsp: 0.262 ± 0.021
0.368CysGlu: 0.368 ± 0.024
0.304CysPhe: 0.304 ± 0.021
0.488CysGly: 0.488 ± 0.029
0.157CysHis: 0.157 ± 0.017
0.432CysIle: 0.432 ± 0.025
0.228CysLys: 0.228 ± 0.019
0.518CysLeu: 0.518 ± 0.027
0.134CysMet: 0.134 ± 0.015
0.196CysAsn: 0.196 ± 0.02
0.221CysPro: 0.221 ± 0.019
0.196CysGln: 0.196 ± 0.019
0.182CysArg: 0.182 ± 0.017
0.385CysSer: 0.385 ± 0.025
0.296CysThr: 0.296 ± 0.024
0.324CysVal: 0.324 ± 0.021
0.036CysTrp: 0.036 ± 0.008
0.187CysTyr: 0.187 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
3.252AspAla: 3.252 ± 0.081
0.335AspCys: 0.335 ± 0.024
2.355AspAsp: 2.355 ± 0.066
4.22AspGlu: 4.22 ± 0.087
2.594AspPhe: 2.594 ± 0.061
3.153AspGly: 3.153 ± 0.083
0.927AspHis: 0.927 ± 0.04
4.245AspIle: 4.245 ± 0.084
3.92AspLys: 3.92 ± 0.084
5.208AspLeu: 5.208 ± 0.091
1.316AspMet: 1.316 ± 0.047
2.242AspAsn: 2.242 ± 0.067
1.701AspPro: 1.701 ± 0.055
1.966AspGln: 1.966 ± 0.058
1.91AspArg: 1.91 ± 0.056
3.358AspSer: 3.358 ± 0.072
2.932AspThr: 2.932 ± 0.07
3.526AspVal: 3.526 ± 0.082
0.555AspTrp: 0.555 ± 0.032
2.491AspTyr: 2.491 ± 0.07
0.0AspXaa: 0.0 ± 0.0
Glu
5.188GluAla: 5.188 ± 0.111
0.32GluCys: 0.32 ± 0.022
3.849GluAsp: 3.849 ± 0.086
6.625GluGlu: 6.625 ± 0.124
2.46GluPhe: 2.46 ± 0.067
3.835GluGly: 3.835 ± 0.081
1.009GluHis: 1.009 ± 0.043
6.198GluIle: 6.198 ± 0.109
7.317GluLys: 7.317 ± 0.123
7.462GluLeu: 7.462 ± 0.126
2.393GluMet: 2.393 ± 0.063
4.337GluAsn: 4.337 ± 0.082
1.822GluPro: 1.822 ± 0.052
3.157GluGln: 3.157 ± 0.089
3.015GluArg: 3.015 ± 0.078
4.029GluSer: 4.029 ± 0.082
4.377GluThr: 4.377 ± 0.087
4.957GluVal: 4.957 ± 0.099
0.725GluTrp: 0.725 ± 0.039
2.076GluTyr: 2.076 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
2.432PheAla: 2.432 ± 0.074
0.259PheCys: 0.259 ± 0.02
2.605PheAsp: 2.605 ± 0.068
2.97PheGlu: 2.97 ± 0.067
2.393PhePhe: 2.393 ± 0.067
3.119PheGly: 3.119 ± 0.082
0.748PheHis: 0.748 ± 0.036
4.123PheIle: 4.123 ± 0.099
2.857PheLys: 2.857 ± 0.065
4.302PheLeu: 4.302 ± 0.105
1.105PheMet: 1.105 ± 0.036
2.199PheAsn: 2.199 ± 0.052
1.422PhePro: 1.422 ± 0.048
1.447PheGln: 1.447 ± 0.054
1.37PheArg: 1.37 ± 0.053
3.671PheSer: 3.671 ± 0.077
2.552PheThr: 2.552 ± 0.067
2.941PheVal: 2.941 ± 0.064
0.422PheTrp: 0.422 ± 0.03
1.814PheTyr: 1.814 ± 0.058
0.0PheXaa: 0.0 ± 0.0
Gly
4.302GlyAla: 4.302 ± 0.102
0.421GlyCys: 0.421 ± 0.022
3.06GlyAsp: 3.06 ± 0.078
4.279GlyGlu: 4.279 ± 0.081
3.157GlyPhe: 3.157 ± 0.09
4.471GlyGly: 4.471 ± 0.136
1.18GlyHis: 1.18 ± 0.043
6.104GlyIle: 6.104 ± 0.106
4.873GlyLys: 4.873 ± 0.09
6.45GlyLeu: 6.45 ± 0.112
1.972GlyMet: 1.972 ± 0.061
2.834GlyAsn: 2.834 ± 0.068
1.425GlyPro: 1.425 ± 0.047
2.034GlyGln: 2.034 ± 0.069
2.295GlyArg: 2.295 ± 0.065
3.858GlySer: 3.858 ± 0.087
4.078GlyThr: 4.078 ± 0.082
4.531GlyVal: 4.531 ± 0.092
0.62GlyTrp: 0.62 ± 0.038
2.67GlyTyr: 2.67 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
1.055HisAla: 1.055 ± 0.04
0.125HisCys: 0.125 ± 0.014
0.82HisAsp: 0.82 ± 0.036
1.044HisGlu: 1.044 ± 0.042
0.913HisPhe: 0.913 ± 0.038
1.043HisGly: 1.043 ± 0.041
0.475HisHis: 0.475 ± 0.026
1.306HisIle: 1.306 ± 0.047
0.912HisLys: 0.912 ± 0.038
1.899HisLeu: 1.899 ± 0.057
0.418HisMet: 0.418 ± 0.027
0.642HisAsn: 0.642 ± 0.031
0.89HisPro: 0.89 ± 0.041
0.698HisGln: 0.698 ± 0.035
0.658HisArg: 0.658 ± 0.033
1.149HisSer: 1.149 ± 0.055
0.903HisThr: 0.903 ± 0.037
1.068HisVal: 1.068 ± 0.049
0.189HisTrp: 0.189 ± 0.018
0.956HisTyr: 0.956 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
6.146IleAla: 6.146 ± 0.103
0.553IleCys: 0.553 ± 0.032
4.823IleAsp: 4.823 ± 0.085
6.566IleGlu: 6.566 ± 0.101
3.648IlePhe: 3.648 ± 0.094
6.067IleGly: 6.067 ± 0.122
1.443IleHis: 1.443 ± 0.054
6.983IleIle: 6.983 ± 0.146
5.827IleLys: 5.827 ± 0.1
8.054IleLeu: 8.054 ± 0.138
1.919IleMet: 1.919 ± 0.057
3.769IleAsn: 3.769 ± 0.087
3.289IlePro: 3.289 ± 0.077
3.238IleGln: 3.238 ± 0.081
3.082IleArg: 3.082 ± 0.081
5.613IleSer: 5.613 ± 0.102
4.517IleThr: 4.517 ± 0.1
5.693IleVal: 5.693 ± 0.103
0.572IleTrp: 0.572 ± 0.029
2.731IleTyr: 2.731 ± 0.06
0.0IleXaa: 0.0 ± 0.0
Lys
4.648LysAla: 4.648 ± 0.086
0.217LysCys: 0.217 ± 0.018
4.198LysAsp: 4.198 ± 0.085
8.064LysGlu: 8.064 ± 0.126
2.04LysPhe: 2.04 ± 0.052
4.252LysGly: 4.252 ± 0.086
1.048LysHis: 1.048 ± 0.045
5.883LysIle: 5.883 ± 0.115
7.838LysLys: 7.838 ± 0.133
6.059LysLeu: 6.059 ± 0.099
2.419LysMet: 2.419 ± 0.061
4.619LysAsn: 4.619 ± 0.092
2.026LysPro: 2.026 ± 0.055
3.224LysGln: 3.224 ± 0.068
3.23LysArg: 3.23 ± 0.086
4.033LysSer: 4.033 ± 0.084
4.296LysThr: 4.296 ± 0.08
4.732LysVal: 4.732 ± 0.101
0.655LysTrp: 0.655 ± 0.034
2.22LysTyr: 2.22 ± 0.061
0.0LysXaa: 0.0 ± 0.0
Leu
7.513LeuAla: 7.513 ± 0.121
0.503LeuCys: 0.503 ± 0.027
5.287LeuAsp: 5.287 ± 0.094
6.628LeuGlu: 6.628 ± 0.117
5.001LeuPhe: 5.001 ± 0.116
6.121LeuGly: 6.121 ± 0.118
1.462LeuHis: 1.462 ± 0.046
8.181LeuIle: 8.181 ± 0.147
7.16LeuLys: 7.16 ± 0.123
9.931LeuLeu: 9.931 ± 0.165
2.549LeuMet: 2.549 ± 0.063
5.019LeuAsn: 5.019 ± 0.101
3.542LeuPro: 3.542 ± 0.072
3.026LeuGln: 3.026 ± 0.076
3.22LeuArg: 3.22 ± 0.078
7.401LeuSer: 7.401 ± 0.117
6.427LeuThr: 6.427 ± 0.091
6.556LeuVal: 6.556 ± 0.113
0.616LeuTrp: 0.616 ± 0.04
3.071LeuTyr: 3.071 ± 0.081
0.0LeuXaa: 0.0 ± 0.0
Met
1.925MetAla: 1.925 ± 0.062
0.109MetCys: 0.109 ± 0.014
1.587MetAsp: 1.587 ± 0.05
1.789MetGlu: 1.789 ± 0.057
0.82MetPhe: 0.82 ± 0.036
1.849MetGly: 1.849 ± 0.054
0.426MetHis: 0.426 ± 0.027
2.411MetIle: 2.411 ± 0.067
2.36MetLys: 2.36 ± 0.058
2.22MetLeu: 2.22 ± 0.06
0.809MetMet: 0.809 ± 0.037
1.649MetAsn: 1.649 ± 0.05
0.881MetPro: 0.881 ± 0.038
0.935MetGln: 0.935 ± 0.038
1.013MetArg: 1.013 ± 0.037
1.693MetSer: 1.693 ± 0.054
1.849MetThr: 1.849 ± 0.049
1.794MetVal: 1.794 ± 0.054
0.142MetTrp: 0.142 ± 0.016
0.731MetTyr: 0.731 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
2.666AsnAla: 2.666 ± 0.081
0.253AsnCys: 0.253 ± 0.017
2.424AsnAsp: 2.424 ± 0.065
4.003AsnGlu: 4.003 ± 0.093
1.967AsnPhe: 1.967 ± 0.052
3.369AsnGly: 3.369 ± 0.079
1.136AsnHis: 1.136 ± 0.047
3.549AsnIle: 3.549 ± 0.075
4.017AsnLys: 4.017 ± 0.087
4.569AsnLeu: 4.569 ± 0.089
1.3AsnMet: 1.3 ± 0.044
2.388AsnAsn: 2.388 ± 0.063
2.072AsnPro: 2.072 ± 0.051
2.676AsnGln: 2.676 ± 0.077
2.081AsnArg: 2.081 ± 0.062
2.652AsnSer: 2.652 ± 0.064
2.371AsnThr: 2.371 ± 0.068
2.739AsnVal: 2.739 ± 0.076
0.553AsnTrp: 0.553 ± 0.028
1.952AsnTyr: 1.952 ± 0.065
0.0AsnXaa: 0.0 ± 0.0
Pro
2.022ProAla: 2.022 ± 0.063
0.159ProCys: 0.159 ± 0.016
1.802ProAsp: 1.802 ± 0.058
2.775ProGlu: 2.775 ± 0.068
1.749ProPhe: 1.749 ± 0.054
1.956ProGly: 1.956 ± 0.054
0.613ProHis: 0.613 ± 0.03
2.87ProIle: 2.87 ± 0.078
2.106ProLys: 2.106 ± 0.059
3.234ProLeu: 3.234 ± 0.068
0.695ProMet: 0.695 ± 0.037
1.599ProAsn: 1.599 ± 0.05
0.6ProPro: 0.6 ± 0.032
0.97ProGln: 0.97 ± 0.036
0.881ProArg: 0.881 ± 0.037
1.871ProSer: 1.871 ± 0.053
2.087ProThr: 2.087 ± 0.063
2.408ProVal: 2.408 ± 0.064
0.285ProTrp: 0.285 ± 0.021
1.256ProTyr: 1.256 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
2.806GlnAla: 2.806 ± 0.072
0.125GlnCys: 0.125 ± 0.014
1.528GlnAsp: 1.528 ± 0.055
2.966GlnGlu: 2.966 ± 0.082
1.59GlnPhe: 1.59 ± 0.046
1.978GlnGly: 1.978 ± 0.06
0.585GlnHis: 0.585 ± 0.04
2.655GlnIle: 2.655 ± 0.072
2.97GlnLys: 2.97 ± 0.071
4.449GlnLeu: 4.449 ± 0.109
1.108GlnMet: 1.108 ± 0.045
1.669GlnAsn: 1.669 ± 0.056
1.068GlnPro: 1.068 ± 0.043
1.637GlnGln: 1.637 ± 0.061
1.317GlnArg: 1.317 ± 0.054
2.128GlnSer: 2.128 ± 0.057
2.449GlnThr: 2.449 ± 0.071
2.55GlnVal: 2.55 ± 0.066
0.298GlnTrp: 0.298 ± 0.023
1.261GlnTyr: 1.261 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
2.069ArgAla: 2.069 ± 0.068
0.176ArgCys: 0.176 ± 0.018
1.761ArgAsp: 1.761 ± 0.054
2.75ArgGlu: 2.75 ± 0.069
1.721ArgPhe: 1.721 ± 0.053
2.143ArgGly: 2.143 ± 0.065
0.686ArgHis: 0.686 ± 0.037
3.124ArgIle: 3.124 ± 0.064
2.973ArgLys: 2.973 ± 0.068
3.817ArgLeu: 3.817 ± 0.083
1.168ArgMet: 1.168 ± 0.045
1.863ArgAsn: 1.863 ± 0.056
1.113ArgPro: 1.113 ± 0.041
1.38ArgGln: 1.38 ± 0.052
1.61ArgArg: 1.61 ± 0.06
2.001ArgSer: 2.001 ± 0.054
1.998ArgThr: 1.998 ± 0.056
2.503ArgVal: 2.503 ± 0.07
0.293ArgTrp: 0.293 ± 0.024
1.503ArgTyr: 1.503 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
3.772SerAla: 3.772 ± 0.09
0.316SerCys: 0.316 ± 0.026
3.32SerAsp: 3.32 ± 0.069
4.33SerGlu: 4.33 ± 0.082
3.242SerPhe: 3.242 ± 0.081
4.527SerGly: 4.527 ± 0.096
1.166SerHis: 1.166 ± 0.047
5.601SerIle: 5.601 ± 0.098
4.475SerLys: 4.475 ± 0.075
6.542SerLeu: 6.542 ± 0.099
1.529SerMet: 1.529 ± 0.048
2.907SerAsn: 2.907 ± 0.073
1.861SerPro: 1.861 ± 0.05
2.287SerGln: 2.287 ± 0.065
2.273SerArg: 2.273 ± 0.064
4.31SerSer: 4.31 ± 0.11
3.532SerThr: 3.532 ± 0.084
4.176SerVal: 4.176 ± 0.076
0.555SerTrp: 0.555 ± 0.029
2.549SerTyr: 2.549 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
4.16ThrAla: 4.16 ± 0.085
0.265ThrCys: 0.265 ± 0.021
3.102ThrAsp: 3.102 ± 0.073
3.618ThrGlu: 3.618 ± 0.076
2.609ThrPhe: 2.609 ± 0.073
4.198ThrGly: 4.198 ± 0.084
1.058ThrHis: 1.058 ± 0.036
5.729ThrIle: 5.729 ± 0.088
4.073ThrLys: 4.073 ± 0.075
5.835ThrLeu: 5.835 ± 0.098
1.325ThrMet: 1.325 ± 0.05
2.91ThrAsn: 2.91 ± 0.074
2.217ThrPro: 2.217 ± 0.059
1.863ThrGln: 1.863 ± 0.054
1.92ThrArg: 1.92 ± 0.062
3.52ThrSer: 3.52 ± 0.082
3.582ThrThr: 3.582 ± 0.085
4.335ThrVal: 4.335 ± 0.095
0.415ThrTrp: 0.415 ± 0.033
1.992ThrTyr: 1.992 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
4.985ValAla: 4.985 ± 0.098
0.422ValCys: 0.422 ± 0.025
3.651ValAsp: 3.651 ± 0.083
4.874ValGlu: 4.874 ± 0.086
2.977ValPhe: 2.977 ± 0.07
4.533ValGly: 4.533 ± 0.109
1.074ValHis: 1.074 ± 0.04
5.532ValIle: 5.532 ± 0.103
4.386ValLys: 4.386 ± 0.099
6.639ValLeu: 6.639 ± 0.105
1.799ValMet: 1.799 ± 0.06
2.937ValAsn: 2.937 ± 0.086
2.355ValPro: 2.355 ± 0.057
2.026ValGln: 2.026 ± 0.054
2.352ValArg: 2.352 ± 0.07
4.74ValSer: 4.74 ± 0.08
4.129ValThr: 4.129 ± 0.086
4.823ValVal: 4.823 ± 0.105
0.479ValTrp: 0.479 ± 0.029
2.131ValTyr: 2.131 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
0.465TrpAla: 0.465 ± 0.025
0.048TrpCys: 0.048 ± 0.008
0.45TrpAsp: 0.45 ± 0.027
0.563TrpGlu: 0.563 ± 0.028
0.471TrpPhe: 0.471 ± 0.03
0.528TrpGly: 0.528 ± 0.032
0.161TrpHis: 0.161 ± 0.015
0.72TrpIle: 0.72 ± 0.036
0.528TrpLys: 0.528 ± 0.03
0.913TrpLeu: 0.913 ± 0.038
0.243TrpMet: 0.243 ± 0.017
0.432TrpAsn: 0.432 ± 0.028
0.193TrpPro: 0.193 ± 0.02
0.359TrpGln: 0.359 ± 0.022
0.315TrpArg: 0.315 ± 0.02
0.558TrpSer: 0.558 ± 0.031
0.432TrpThr: 0.432 ± 0.028
0.468TrpVal: 0.468 ± 0.028
0.062TrpTrp: 0.062 ± 0.009
0.281TrpTyr: 0.281 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.213TyrAla: 2.213 ± 0.055
0.231TyrCys: 0.231 ± 0.018
1.989TyrAsp: 1.989 ± 0.05
2.382TyrGlu: 2.382 ± 0.064
1.945TyrPhe: 1.945 ± 0.055
2.315TyrGly: 2.315 ± 0.063
0.767TyrHis: 0.767 ± 0.037
2.478TyrIle: 2.478 ± 0.064
2.103TyrLys: 2.103 ± 0.059
3.991TyrLeu: 3.991 ± 0.089
0.79TyrMet: 0.79 ± 0.039
1.604TyrAsn: 1.604 ± 0.057
1.447TyrPro: 1.447 ± 0.043
1.853TyrGln: 1.853 ± 0.063
1.539TyrArg: 1.539 ± 0.052
2.27TyrSer: 2.27 ± 0.06
1.947TyrThr: 1.947 ± 0.06
2.054TyrVal: 2.054 ± 0.05
0.316TyrTrp: 0.316 ± 0.023
1.473TyrTyr: 1.473 ± 0.055
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2071 proteins (641523 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski