Amino acid dipepetide frequency for Altererythrobacter luteolus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.101AlaAla: 16.101 ± 0.194	0.995AlaCys: 0.995 ± 0.036	7.208AlaAsp: 7.208 ± 0.1	8.213AlaGlu: 8.213 ± 0.109	4.016AlaPhe: 4.016 ± 0.07	10.712AlaGly: 10.712 ± 0.151	1.913AlaHis: 1.913 ± 0.042	6.777AlaIle: 6.777 ± 0.094	4.754AlaLys: 4.754 ± 0.091	11.985AlaLeu: 11.985 ± 0.141	3.651AlaMet: 3.651 ± 0.07	3.479AlaAsn: 3.479 ± 0.073	5.231AlaPro: 5.231 ± 0.102	4.436AlaGln: 4.436 ± 0.077	7.564AlaArg: 7.564 ± 0.114	6.762AlaSer: 6.762 ± 0.095	5.12AlaThr: 5.12 ± 0.076	7.802AlaVal: 7.802 ± 0.11	1.378AlaTrp: 1.378 ± 0.047	2.479AlaTyr: 2.479 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	0.978CysAla: 0.978 ± 0.035	0.067CysCys: 0.067 ± 0.008	0.645CysAsp: 0.645 ± 0.029	0.524CysGlu: 0.524 ± 0.025	0.276CysPhe: 0.276 ± 0.019	0.886CysGly: 0.886 ± 0.034	0.218CysHis: 0.218 ± 0.023	0.403CysIle: 0.403 ± 0.021	0.205CysLys: 0.205 ± 0.015	0.67CysLeu: 0.67 ± 0.027	0.146CysMet: 0.146 ± 0.013	0.257CysAsn: 0.257 ± 0.018	0.442CysPro: 0.442 ± 0.023	0.22CysGln: 0.22 ± 0.015	0.482CysArg: 0.482 ± 0.023	0.519CysSer: 0.519 ± 0.024	0.392CysThr: 0.392 ± 0.018	0.555CysVal: 0.555 ± 0.028	0.11CysTrp: 0.11 ± 0.012	0.179CysTyr: 0.179 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.375AspAla: 7.375 ± 0.113	0.547AspCys: 0.547 ± 0.026	3.788AspAsp: 3.788 ± 0.081	4.207AspGlu: 4.207 ± 0.079	2.392AspPhe: 2.392 ± 0.055	5.862AspGly: 5.862 ± 0.097	1.316AspHis: 1.316 ± 0.038	3.263AspIle: 3.263 ± 0.071	2.091AspLys: 2.091 ± 0.06	5.93AspLeu: 5.93 ± 0.081	1.575AspMet: 1.575 ± 0.041	1.694AspAsn: 1.694 ± 0.053	3.6AspPro: 3.6 ± 0.064	2.121AspGln: 2.121 ± 0.052	4.609AspArg: 4.609 ± 0.088	2.663AspSer: 2.663 ± 0.054	2.981AspThr: 2.981 ± 0.063	3.958AspVal: 3.958 ± 0.077	1.227AspTrp: 1.227 ± 0.035	1.611AspTyr: 1.611 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	7.611GluAla: 7.611 ± 0.106	0.418GluCys: 0.418 ± 0.022	3.619GluAsp: 3.619 ± 0.064	4.076GluGlu: 4.076 ± 0.091	2.22GluPhe: 2.22 ± 0.053	4.969GluGly: 4.969 ± 0.076	1.168GluHis: 1.168 ± 0.038	3.735GluIle: 3.735 ± 0.072	2.672GluLys: 2.672 ± 0.063	6.048GluLeu: 6.048 ± 0.092	1.93GluMet: 1.93 ± 0.056	2.099GluAsn: 2.099 ± 0.049	2.858GluPro: 2.858 ± 0.068	2.653GluGln: 2.653 ± 0.064	4.63GluArg: 4.63 ± 0.085	2.848GluSer: 2.848 ± 0.062	3.651GluThr: 3.651 ± 0.077	3.864GluVal: 3.864 ± 0.068	0.962GluTrp: 0.962 ± 0.038	1.362GluTyr: 1.362 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	4.789PheAla: 4.789 ± 0.089	0.377PheCys: 0.377 ± 0.021	2.833PheAsp: 2.833 ± 0.063	2.364PheGlu: 2.364 ± 0.052	1.423PhePhe: 1.423 ± 0.05	3.911PheGly: 3.911 ± 0.078	0.696PheHis: 0.696 ± 0.03	1.745PheIle: 1.745 ± 0.05	1.022PheLys: 1.022 ± 0.038	3.193PheLeu: 3.193 ± 0.072	0.831PheMet: 0.831 ± 0.035	1.109PheAsn: 1.109 ± 0.04	1.468PhePro: 1.468 ± 0.038	0.999PheGln: 0.999 ± 0.034	2.169PheArg: 2.169 ± 0.049	2.4PheSer: 2.4 ± 0.063	2.084PheThr: 2.084 ± 0.056	2.584PheVal: 2.584 ± 0.049	0.562PheTrp: 0.562 ± 0.026	0.952PheTyr: 0.952 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.22GlyAla: 9.22 ± 0.117	0.847GlyCys: 0.847 ± 0.031	5.375GlyAsp: 5.375 ± 0.106	5.568GlyGlu: 5.568 ± 0.101	3.73GlyPhe: 3.73 ± 0.074	8.186GlyGly: 8.186 ± 0.194	1.726GlyHis: 1.726 ± 0.048	4.756GlyIle: 4.756 ± 0.082	3.857GlyLys: 3.857 ± 0.072	8.363GlyLeu: 8.363 ± 0.099	2.443GlyMet: 2.443 ± 0.056	2.677GlyAsn: 2.677 ± 0.073	3.52GlyPro: 3.52 ± 0.062	3.172GlyGln: 3.172 ± 0.064	5.431GlyArg: 5.431 ± 0.084	5.384GlySer: 5.384 ± 0.114	4.96GlyThr: 4.96 ± 0.1	5.712GlyVal: 5.712 ± 0.089	1.498GlyTrp: 1.498 ± 0.049	2.284GlyTyr: 2.284 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.974HisAla: 1.974 ± 0.058	0.252HisCys: 0.252 ± 0.018	1.175HisAsp: 1.175 ± 0.038	1.104HisGlu: 1.104 ± 0.033	0.84HisPhe: 0.84 ± 0.031	1.816HisGly: 1.816 ± 0.051	0.517HisHis: 0.517 ± 0.027	1.017HisIle: 1.017 ± 0.036	0.566HisLys: 0.566 ± 0.027	1.711HisLeu: 1.711 ± 0.045	0.438HisMet: 0.438 ± 0.023	0.509HisAsn: 0.509 ± 0.024	1.209HisPro: 1.209 ± 0.039	0.531HisGln: 0.531 ± 0.025	1.284HisArg: 1.284 ± 0.045	1.033HisSer: 1.033 ± 0.036	0.786HisThr: 0.786 ± 0.031	1.204HisVal: 1.204 ± 0.036	0.313HisTrp: 0.313 ± 0.018	0.549HisTyr: 0.549 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.65IleAla: 7.65 ± 0.107	0.492IleCys: 0.492 ± 0.022	4.093IleAsp: 4.093 ± 0.08	4.11IleGlu: 4.11 ± 0.075	1.833IlePhe: 1.833 ± 0.052	5.433IleGly: 5.433 ± 0.098	0.931IleHis: 0.931 ± 0.036	2.521IleIle: 2.521 ± 0.058	1.526IleLys: 1.526 ± 0.048	4.311IleLeu: 4.311 ± 0.078	1.111IleMet: 1.111 ± 0.039	1.493IleAsn: 1.493 ± 0.047	2.535IlePro: 2.535 ± 0.057	1.266IleGln: 1.266 ± 0.04	3.186IleArg: 3.186 ± 0.061	3.205IleSer: 3.205 ± 0.057	2.832IleThr: 2.832 ± 0.062	3.984IleVal: 3.984 ± 0.078	0.67IleTrp: 0.67 ± 0.027	1.1IleTyr: 1.1 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.274LysAla: 4.274 ± 0.085	0.202LysCys: 0.202 ± 0.017	1.903LysAsp: 1.903 ± 0.052	1.822LysGlu: 1.822 ± 0.049	1.177LysPhe: 1.177 ± 0.038	2.775LysGly: 2.775 ± 0.065	0.669LysHis: 0.669 ± 0.028	1.873LysIle: 1.873 ± 0.048	1.545LysLys: 1.545 ± 0.052	3.724LysLeu: 3.724 ± 0.076	0.985LysMet: 0.985 ± 0.036	0.979LysAsn: 0.979 ± 0.033	2.144LysPro: 2.144 ± 0.051	1.185LysGln: 1.185 ± 0.034	2.636LysArg: 2.636 ± 0.06	1.992LysSer: 1.992 ± 0.047	1.97LysThr: 1.97 ± 0.047	2.407LysVal: 2.407 ± 0.058	0.493LysTrp: 0.493 ± 0.022	0.723LysTyr: 0.723 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	12.72LeuAla: 12.72 ± 0.141	0.754LeuCys: 0.754 ± 0.029	6.012LeuAsp: 6.012 ± 0.097	5.704LeuGlu: 5.704 ± 0.089	3.551LeuPhe: 3.551 ± 0.063	8.105LeuGly: 8.105 ± 0.104	1.652LeuHis: 1.652 ± 0.047	4.979LeuIle: 4.979 ± 0.083	3.268LeuLys: 3.268 ± 0.061	8.764LeuLeu: 8.764 ± 0.138	2.202LeuMet: 2.202 ± 0.054	2.43LeuAsn: 2.43 ± 0.052	5.207LeuPro: 5.207 ± 0.075	2.709LeuGln: 2.709 ± 0.056	6.045LeuArg: 6.045 ± 0.085	6.29LeuSer: 6.29 ± 0.088	5.321LeuThr: 5.321 ± 0.083	6.742LeuVal: 6.742 ± 0.093	1.13LeuTrp: 1.13 ± 0.037	1.847LeuTyr: 1.847 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	3.203MetAla: 3.203 ± 0.067	0.187MetCys: 0.187 ± 0.015	1.297MetAsp: 1.297 ± 0.044	1.316MetGlu: 1.316 ± 0.044	0.723MetPhe: 0.723 ± 0.029	2.035MetGly: 2.035 ± 0.058	0.485MetHis: 0.485 ± 0.026	1.482MetIle: 1.482 ± 0.034	1.083MetLys: 1.083 ± 0.039	2.731MetLeu: 2.731 ± 0.059	0.695MetMet: 0.695 ± 0.03	0.808MetAsn: 0.808 ± 0.032	1.507MetPro: 1.507 ± 0.041	0.886MetGln: 0.886 ± 0.032	1.79MetArg: 1.79 ± 0.041	1.56MetSer: 1.56 ± 0.038	1.685MetThr: 1.685 ± 0.048	1.639MetVal: 1.639 ± 0.047	0.257MetTrp: 0.257 ± 0.017	0.318MetTyr: 0.318 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.478AsnAla: 3.478 ± 0.075	0.284AsnCys: 0.284 ± 0.017	1.663AsnAsp: 1.663 ± 0.046	1.478AsnGlu: 1.478 ± 0.044	1.222AsnPhe: 1.222 ± 0.035	2.656AsnGly: 2.656 ± 0.075	0.54AsnHis: 0.54 ± 0.028	1.547AsnIle: 1.547 ± 0.045	0.764AsnLys: 0.764 ± 0.031	2.669AsnLeu: 2.669 ± 0.063	0.668AsnMet: 0.668 ± 0.031	0.77AsnAsn: 0.77 ± 0.038	1.946AsnPro: 1.946 ± 0.054	0.863AsnGln: 0.863 ± 0.033	1.966AsnArg: 1.966 ± 0.045	1.581AsnSer: 1.581 ± 0.045	1.399AsnThr: 1.399 ± 0.046	2.034AsnVal: 2.034 ± 0.058	0.501AsnTrp: 0.501 ± 0.025	0.731AsnTyr: 0.731 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	5.969ProAla: 5.969 ± 0.101	0.297ProCys: 0.297 ± 0.018	3.803ProAsp: 3.803 ± 0.067	3.955ProGlu: 3.955 ± 0.076	1.922ProPhe: 1.922 ± 0.05	4.35ProGly: 4.35 ± 0.065	0.982ProHis: 0.982 ± 0.037	2.48ProIle: 2.48 ± 0.061	1.693ProLys: 1.693 ± 0.045	4.519ProLeu: 4.519 ± 0.084	1.189ProMet: 1.189 ± 0.041	1.261ProAsn: 1.261 ± 0.039	2.249ProPro: 2.249 ± 0.077	1.745ProGln: 1.745 ± 0.05	2.58ProArg: 2.58 ± 0.062	2.682ProSer: 2.682 ± 0.056	2.236ProThr: 2.236 ± 0.057	4.012ProVal: 4.012 ± 0.065	0.627ProTrp: 0.627 ± 0.025	1.093ProTyr: 1.093 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.911GlnAla: 3.911 ± 0.076	0.242GlnCys: 0.242 ± 0.017	1.741GlnAsp: 1.741 ± 0.048	1.719GlnGlu: 1.719 ± 0.044	1.275GlnPhe: 1.275 ± 0.039	2.532GlnGly: 2.532 ± 0.054	0.669GlnHis: 0.669 ± 0.028	2.076GlnIle: 2.076 ± 0.052	1.079GlnLys: 1.079 ± 0.037	3.282GlnLeu: 3.282 ± 0.063	0.941GlnMet: 0.941 ± 0.033	0.988GlnAsn: 0.988 ± 0.039	1.797GlnPro: 1.797 ± 0.046	1.362GlnGln: 1.362 ± 0.044	2.395GlnArg: 2.395 ± 0.057	2.008GlnSer: 2.008 ± 0.05	1.733GlnThr: 1.733 ± 0.041	2.267GlnVal: 2.267 ± 0.058	0.476GlnTrp: 0.476 ± 0.024	0.664GlnTyr: 0.664 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	6.918ArgAla: 6.918 ± 0.109	0.438ArgCys: 0.438 ± 0.027	4.107ArgAsp: 4.107 ± 0.078	4.388ArgGlu: 4.388 ± 0.077	2.854ArgPhe: 2.854 ± 0.065	4.681ArgGly: 4.681 ± 0.09	1.358ArgHis: 1.358 ± 0.039	3.861ArgIle: 3.861 ± 0.061	2.649ArgLys: 2.649 ± 0.06	6.852ArgLeu: 6.852 ± 0.111	1.803ArgMet: 1.803 ± 0.05	1.962ArgAsn: 1.962 ± 0.047	2.932ArgPro: 2.932 ± 0.063	2.294ArgGln: 2.294 ± 0.057	4.408ArgArg: 4.408 ± 0.095	3.711ArgSer: 3.711 ± 0.069	3.088ArgThr: 3.088 ± 0.066	4.111ArgVal: 4.111 ± 0.07	1.074ArgTrp: 1.074 ± 0.034	1.612ArgTyr: 1.612 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.862SerAla: 6.862 ± 0.111	0.458SerCys: 0.458 ± 0.022	3.801SerAsp: 3.801 ± 0.071	3.559SerGlu: 3.559 ± 0.067	2.261SerPhe: 2.261 ± 0.058	6.091SerGly: 6.091 ± 0.094	0.974SerHis: 0.974 ± 0.034	3.064SerIle: 3.064 ± 0.073	1.886SerLys: 1.886 ± 0.053	5.374SerLeu: 5.374 ± 0.082	1.365SerMet: 1.365 ± 0.043	1.669SerAsn: 1.669 ± 0.043	2.789SerPro: 2.789 ± 0.056	1.862SerGln: 1.862 ± 0.045	3.616SerArg: 3.616 ± 0.072	3.301SerSer: 3.301 ± 0.076	2.689SerThr: 2.689 ± 0.054	3.77SerVal: 3.77 ± 0.078	0.799SerTrp: 0.799 ± 0.033	1.312SerTyr: 1.312 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	6.062ThrAla: 6.062 ± 0.088	0.397ThrCys: 0.397 ± 0.024	3.164ThrAsp: 3.164 ± 0.064	2.8ThrGlu: 2.8 ± 0.061	1.855ThrPhe: 1.855 ± 0.045	5.308ThrGly: 5.308 ± 0.096	0.927ThrHis: 0.927 ± 0.035	3.022ThrIle: 3.022 ± 0.057	1.508ThrLys: 1.508 ± 0.04	5.198ThrLeu: 5.198 ± 0.082	1.187ThrMet: 1.187 ± 0.037	1.409ThrAsn: 1.409 ± 0.043	2.883ThrPro: 2.883 ± 0.06	1.472ThrGln: 1.472 ± 0.043	3.118ThrArg: 3.118 ± 0.058	2.871ThrSer: 2.871 ± 0.068	2.45ThrThr: 2.45 ± 0.058	3.885ThrVal: 3.885 ± 0.068	0.548ThrTrp: 0.548 ± 0.025	1.184ThrTyr: 1.184 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	7.797ValAla: 7.797 ± 0.113	0.533ValCys: 0.533 ± 0.025	4.303ValAsp: 4.303 ± 0.076	4.538ValGlu: 4.538 ± 0.077	2.397ValPhe: 2.397 ± 0.056	5.332ValGly: 5.332 ± 0.1	1.238ValHis: 1.238 ± 0.041	3.957ValIle: 3.957 ± 0.075	2.213ValLys: 2.213 ± 0.06	6.225ValLeu: 6.225 ± 0.098	1.719ValMet: 1.719 ± 0.05	2.031ValAsn: 2.031 ± 0.046	3.631ValPro: 3.631 ± 0.066	1.985ValGln: 1.985 ± 0.048	4.285ValArg: 4.285 ± 0.069	4.315ValSer: 4.315 ± 0.074	4.086ValThr: 4.086 ± 0.081	4.672ValVal: 4.672 ± 0.081	0.842ValTrp: 0.842 ± 0.033	1.305ValTyr: 1.305 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.297TrpAla: 1.297 ± 0.041	0.131TrpCys: 0.131 ± 0.013	0.727TrpAsp: 0.727 ± 0.029	0.675TrpGlu: 0.675 ± 0.033	0.621TrpPhe: 0.621 ± 0.028	0.984TrpGly: 0.984 ± 0.034	0.363TrpHis: 0.363 ± 0.021	0.74TrpIle: 0.74 ± 0.031	0.492TrpLys: 0.492 ± 0.023	1.741TrpLeu: 1.741 ± 0.053	0.398TrpMet: 0.398 ± 0.026	0.506TrpAsn: 0.506 ± 0.021	0.668TrpPro: 0.668 ± 0.025	0.645TrpGln: 0.645 ± 0.03	1.128TrpArg: 1.128 ± 0.037	0.906TrpSer: 0.906 ± 0.033	0.719TrpThr: 0.719 ± 0.03	0.77TrpVal: 0.77 ± 0.035	0.258TrpTrp: 0.258 ± 0.02	0.3TrpTyr: 0.3 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.388TyrAla: 2.388 ± 0.054	0.255TyrCys: 0.255 ± 0.016	1.555TyrAsp: 1.555 ± 0.047	1.274TyrGlu: 1.274 ± 0.046	0.922TyrPhe: 0.922 ± 0.036	2.085TyrGly: 2.085 ± 0.052	0.486TyrHis: 0.486 ± 0.024	0.984TyrIle: 0.984 ± 0.03	0.604TyrLys: 0.604 ± 0.026	2.142TyrLeu: 2.142 ± 0.049	0.407TyrMet: 0.407 ± 0.02	0.629TyrAsn: 0.629 ± 0.027	1.03TyrPro: 1.03 ± 0.035	0.75TyrGln: 0.75 ± 0.034	1.783TyrArg: 1.783 ± 0.045	1.469TyrSer: 1.469 ± 0.04	1.065TyrThr: 1.065 ± 0.039	1.431TyrVal: 1.431 ± 0.037	0.345TyrTrp: 0.345 ± 0.023	0.637TyrTyr: 0.637 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2684 proteins (876097 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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