Amino acid dipepetide frequency for Muricauda sp.

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.29AlaAla: 5.29 ± 0.103	0.599AlaCys: 0.599 ± 0.028	3.74AlaAsp: 3.74 ± 0.069	4.545AlaGlu: 4.545 ± 0.074	3.668AlaPhe: 3.668 ± 0.063	4.638AlaGly: 4.638 ± 0.091	1.419AlaHis: 1.419 ± 0.042	5.593AlaIle: 5.593 ± 0.08	4.807AlaLys: 4.807 ± 0.091	7.496AlaLeu: 7.496 ± 0.116	1.865AlaMet: 1.865 ± 0.052	3.533AlaAsn: 3.533 ± 0.069	2.3AlaPro: 2.3 ± 0.063	2.887AlaGln: 2.887 ± 0.054	2.343AlaArg: 2.343 ± 0.051	4.498AlaSer: 4.498 ± 0.078	3.962AlaThr: 3.962 ± 0.088	4.629AlaVal: 4.629 ± 0.087	0.678AlaTrp: 0.678 ± 0.029	2.765AlaTyr: 2.765 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.484CysAla: 0.484 ± 0.024	0.1CysCys: 0.1 ± 0.009	0.426CysAsp: 0.426 ± 0.021	0.455CysGlu: 0.455 ± 0.024	0.419CysPhe: 0.419 ± 0.025	0.599CysGly: 0.599 ± 0.03	0.197CysHis: 0.197 ± 0.014	0.503CysIle: 0.503 ± 0.023	0.35CysLys: 0.35 ± 0.021	0.656CysLeu: 0.656 ± 0.025	0.159CysMet: 0.159 ± 0.014	0.356CysAsn: 0.356 ± 0.021	0.285CysPro: 0.285 ± 0.02	0.263CysGln: 0.263 ± 0.015	0.219CysArg: 0.219 ± 0.013	0.535CysSer: 0.535 ± 0.026	0.46CysThr: 0.46 ± 0.031	0.409CysVal: 0.409 ± 0.021	0.056CysTrp: 0.056 ± 0.008	0.267CysTyr: 0.267 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.27AspAla: 4.27 ± 0.076	0.413AspCys: 0.413 ± 0.025	3.279AspAsp: 3.279 ± 0.084	3.911AspGlu: 3.911 ± 0.075	3.835AspPhe: 3.835 ± 0.076	4.489AspGly: 4.489 ± 0.098	1.05AspHis: 1.05 ± 0.034	4.014AspIle: 4.014 ± 0.072	3.498AspLys: 3.498 ± 0.074	5.404AspLeu: 5.404 ± 0.094	1.238AspMet: 1.238 ± 0.034	2.898AspAsn: 2.898 ± 0.069	2.051AspPro: 2.051 ± 0.063	1.842AspGln: 1.842 ± 0.059	2.079AspArg: 2.079 ± 0.046	3.382AspSer: 3.382 ± 0.068	2.89AspThr: 2.89 ± 0.062	3.595AspVal: 3.595 ± 0.072	0.813AspTrp: 0.813 ± 0.033	2.677AspTyr: 2.677 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	4.853GluAla: 4.853 ± 0.078	0.299GluCys: 0.299 ± 0.019	3.556GluAsp: 3.556 ± 0.059	4.921GluGlu: 4.921 ± 0.1	2.93GluPhe: 2.93 ± 0.059	4.237GluGly: 4.237 ± 0.072	1.263GluHis: 1.263 ± 0.035	4.914GluIle: 4.914 ± 0.085	5.319GluLys: 5.319 ± 0.101	6.49GluLeu: 6.49 ± 0.088	1.61GluMet: 1.61 ± 0.043	4.219GluAsn: 4.219 ± 0.077	1.802GluPro: 1.802 ± 0.051	2.548GluGln: 2.548 ± 0.058	2.945GluArg: 2.945 ± 0.061	3.268GluSer: 3.268 ± 0.06	3.5GluThr: 3.5 ± 0.064	4.765GluVal: 4.765 ± 0.071	0.676GluTrp: 0.676 ± 0.023	2.147GluTyr: 2.147 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	3.32PheAla: 3.32 ± 0.054	0.43PheCys: 0.43 ± 0.024	3.564PheAsp: 3.564 ± 0.069	3.822PheGlu: 3.822 ± 0.06	2.939PhePhe: 2.939 ± 0.07	4.021PheGly: 4.021 ± 0.082	0.862PheHis: 0.862 ± 0.031	3.24PheIle: 3.24 ± 0.079	3.205PheLys: 3.205 ± 0.066	5.006PheLeu: 5.006 ± 0.084	1.168PheMet: 1.168 ± 0.033	2.845PheAsn: 2.845 ± 0.071	1.779PhePro: 1.779 ± 0.042	1.645PheGln: 1.645 ± 0.049	1.888PheArg: 1.888 ± 0.048	3.752PheSer: 3.752 ± 0.061	2.948PheThr: 2.948 ± 0.067	3.327PheVal: 3.327 ± 0.061	0.624PheTrp: 0.624 ± 0.027	2.096PheTyr: 2.096 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	4.824GlyAla: 4.824 ± 0.084	0.661GlyCys: 0.661 ± 0.043	3.938GlyAsp: 3.938 ± 0.083	4.071GlyGlu: 4.071 ± 0.063	3.933GlyPhe: 3.933 ± 0.073	5.159GlyGly: 5.159 ± 0.125	1.337GlyHis: 1.337 ± 0.038	5.525GlyIle: 5.525 ± 0.083	4.768GlyLys: 4.768 ± 0.083	6.63GlyLeu: 6.63 ± 0.093	1.773GlyMet: 1.773 ± 0.043	3.802GlyAsn: 3.802 ± 0.079	1.718GlyPro: 1.718 ± 0.05	2.407GlyGln: 2.407 ± 0.048	2.574GlyArg: 2.574 ± 0.054	4.344GlySer: 4.344 ± 0.079	4.267GlyThr: 4.267 ± 0.113	4.751GlyVal: 4.751 ± 0.073	0.916GlyTrp: 0.916 ± 0.04	2.863GlyTyr: 2.863 ± 0.066	0.0GlyXaa: 0.0 ± 0.0
His	1.186HisAla: 1.186 ± 0.038	0.195HisCys: 0.195 ± 0.015	0.916HisAsp: 0.916 ± 0.034	1.17HisGlu: 1.17 ± 0.038	1.154HisPhe: 1.154 ± 0.039	1.213HisGly: 1.213 ± 0.034	0.553HisHis: 0.553 ± 0.027	1.428HisIle: 1.428 ± 0.038	1.118HisLys: 1.118 ± 0.04	1.926HisLeu: 1.926 ± 0.043	0.387HisMet: 0.387 ± 0.018	0.884HisAsn: 0.884 ± 0.029	0.957HisPro: 0.957 ± 0.037	0.815HisGln: 0.815 ± 0.03	0.775HisArg: 0.775 ± 0.026	0.958HisSer: 0.958 ± 0.034	1.041HisThr: 1.041 ± 0.032	1.064HisVal: 1.064 ± 0.043	0.256HisTrp: 0.256 ± 0.017	0.872HisTyr: 0.872 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.79IleAla: 5.79 ± 0.09	0.535IleCys: 0.535 ± 0.022	4.6IleAsp: 4.6 ± 0.08	4.774IleGlu: 4.774 ± 0.085	3.324IlePhe: 3.324 ± 0.066	5.021IleGly: 5.021 ± 0.081	1.238IleHis: 1.238 ± 0.038	4.438IleIle: 4.438 ± 0.075	4.527IleLys: 4.527 ± 0.084	6.292IleLeu: 6.292 ± 0.094	1.25IleMet: 1.25 ± 0.036	3.671IleAsn: 3.671 ± 0.075	3.054IlePro: 3.054 ± 0.063	2.458IleGln: 2.458 ± 0.052	2.793IleArg: 2.793 ± 0.053	4.722IleSer: 4.722 ± 0.071	4.082IleThr: 4.082 ± 0.088	4.508IleVal: 4.508 ± 0.076	0.71IleTrp: 0.71 ± 0.028	2.403IleTyr: 2.403 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.938LysAla: 4.938 ± 0.089	0.248LysCys: 0.248 ± 0.016	3.747LysAsp: 3.747 ± 0.077	5.401LysGlu: 5.401 ± 0.096	2.448LysPhe: 2.448 ± 0.061	4.395LysGly: 4.395 ± 0.081	1.199LysHis: 1.199 ± 0.039	4.885LysIle: 4.885 ± 0.083	6.378LysLys: 6.378 ± 0.119	5.881LysLeu: 5.881 ± 0.095	1.745LysMet: 1.745 ± 0.049	4.142LysAsn: 4.142 ± 0.07	2.228LysPro: 2.228 ± 0.049	2.415LysGln: 2.415 ± 0.058	3.04LysArg: 3.04 ± 0.071	3.992LysSer: 3.992 ± 0.069	3.914LysThr: 3.914 ± 0.075	4.493LysVal: 4.493 ± 0.072	0.763LysTrp: 0.763 ± 0.031	2.359LysTyr: 2.359 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	6.962LeuAla: 6.962 ± 0.115	0.725LeuCys: 0.725 ± 0.027	5.567LeuAsp: 5.567 ± 0.086	6.375LeuGlu: 6.375 ± 0.096	5.029LeuPhe: 5.029 ± 0.095	6.819LeuGly: 6.819 ± 0.09	1.7LeuHis: 1.7 ± 0.048	6.21LeuIle: 6.21 ± 0.101	6.925LeuLys: 6.925 ± 0.111	9.716LeuLeu: 9.716 ± 0.159	2.151LeuMet: 2.151 ± 0.051	5.273LeuAsn: 5.273 ± 0.08	3.733LeuPro: 3.733 ± 0.065	3.56LeuGln: 3.56 ± 0.069	3.672LeuArg: 3.672 ± 0.069	6.213LeuSer: 6.213 ± 0.092	5.134LeuThr: 5.134 ± 0.086	6.533LeuVal: 6.533 ± 0.102	0.963LeuTrp: 0.963 ± 0.038	3.116LeuTyr: 3.116 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	2.045MetAla: 2.045 ± 0.05	0.136MetCys: 0.136 ± 0.011	1.313MetAsp: 1.313 ± 0.039	1.488MetGlu: 1.488 ± 0.04	0.852MetPhe: 0.852 ± 0.033	1.843MetGly: 1.843 ± 0.045	0.453MetHis: 0.453 ± 0.023	1.286MetIle: 1.286 ± 0.041	1.909MetLys: 1.909 ± 0.049	2.008MetLeu: 2.008 ± 0.05	0.549MetMet: 0.549 ± 0.026	1.241MetAsn: 1.241 ± 0.035	0.911MetPro: 0.911 ± 0.03	0.889MetGln: 0.889 ± 0.036	1.031MetArg: 1.031 ± 0.033	1.204MetSer: 1.204 ± 0.036	1.215MetThr: 1.215 ± 0.035	1.632MetVal: 1.632 ± 0.041	0.168MetTrp: 0.168 ± 0.013	0.612MetTyr: 0.612 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.94AsnAla: 3.94 ± 0.062	0.404AsnCys: 0.404 ± 0.026	3.093AsnAsp: 3.093 ± 0.07	3.365AsnGlu: 3.365 ± 0.063	2.864AsnPhe: 2.864 ± 0.067	4.097AsnGly: 4.097 ± 0.097	1.024AsnHis: 1.024 ± 0.034	3.728AsnIle: 3.728 ± 0.077	3.146AsnLys: 3.146 ± 0.079	4.994AsnLeu: 4.994 ± 0.081	1.208AsnMet: 1.208 ± 0.031	2.9AsnAsn: 2.9 ± 0.057	2.778AsnPro: 2.778 ± 0.063	2.164AsnGln: 2.164 ± 0.047	2.403AsnArg: 2.403 ± 0.055	3.349AsnSer: 3.349 ± 0.056	3.228AsnThr: 3.228 ± 0.063	3.146AsnVal: 3.146 ± 0.065	0.759AsnTrp: 0.759 ± 0.03	2.409AsnTyr: 2.409 ± 0.056	0.0AsnXaa: 0.0 ± 0.0
Pro	2.143ProAla: 2.143 ± 0.059	0.201ProCys: 0.201 ± 0.014	2.337ProAsp: 2.337 ± 0.063	2.971ProGlu: 2.971 ± 0.065	1.989ProPhe: 1.989 ± 0.051	2.201ProGly: 2.201 ± 0.055	0.724ProHis: 0.724 ± 0.027	2.745ProIle: 2.745 ± 0.058	2.627ProLys: 2.627 ± 0.062	3.261ProLeu: 3.261 ± 0.066	0.816ProMet: 0.816 ± 0.028	2.329ProAsn: 2.329 ± 0.053	1.081ProPro: 1.081 ± 0.052	1.222ProGln: 1.222 ± 0.038	1.107ProArg: 1.107 ± 0.04	2.186ProSer: 2.186 ± 0.047	2.087ProThr: 2.087 ± 0.057	2.266ProVal: 2.266 ± 0.057	0.442ProTrp: 0.442 ± 0.025	1.397ProTyr: 1.397 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	2.358GlnAla: 2.358 ± 0.05	0.194GlnCys: 0.194 ± 0.015	1.902GlnAsp: 1.902 ± 0.044	2.552GlnGlu: 2.552 ± 0.064	1.89GlnPhe: 1.89 ± 0.045	2.265GlnGly: 2.265 ± 0.039	0.745GlnHis: 0.745 ± 0.029	2.522GlnIle: 2.522 ± 0.052	2.756GlnLys: 2.756 ± 0.058	3.957GlnLeu: 3.957 ± 0.07	0.913GlnMet: 0.913 ± 0.034	2.229GlnAsn: 2.229 ± 0.053	1.203GlnPro: 1.203 ± 0.039	1.702GlnGln: 1.702 ± 0.047	1.587GlnArg: 1.587 ± 0.05	1.956GlnSer: 1.956 ± 0.05	1.893GlnThr: 1.893 ± 0.057	2.212GlnVal: 2.212 ± 0.049	0.426GlnTrp: 0.426 ± 0.021	1.239GlnTyr: 1.239 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.48ArgAla: 2.48 ± 0.057	0.207ArgCys: 0.207 ± 0.015	2.076ArgAsp: 2.076 ± 0.054	2.413ArgGlu: 2.413 ± 0.054	2.256ArgPhe: 2.256 ± 0.052	2.386ArgGly: 2.386 ± 0.058	0.724ArgHis: 0.724 ± 0.03	3.037ArgIle: 3.037 ± 0.064	2.854ArgLys: 2.854 ± 0.062	3.853ArgLeu: 3.853 ± 0.077	1.028ArgMet: 1.028 ± 0.033	2.215ArgAsn: 2.215 ± 0.054	1.36ArgPro: 1.36 ± 0.039	1.475ArgGln: 1.475 ± 0.041	1.664ArgArg: 1.664 ± 0.045	2.267ArgSer: 2.267 ± 0.063	2.097ArgThr: 2.097 ± 0.049	2.319ArgVal: 2.319 ± 0.05	0.457ArgTrp: 0.457 ± 0.023	1.771ArgTyr: 1.771 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	3.965SerAla: 3.965 ± 0.07	0.549SerCys: 0.549 ± 0.029	3.354SerAsp: 3.354 ± 0.066	3.826SerGlu: 3.826 ± 0.065	3.546SerPhe: 3.546 ± 0.059	4.86SerGly: 4.86 ± 0.1	1.037SerHis: 1.037 ± 0.039	4.467SerIle: 4.467 ± 0.064	4.204SerLys: 4.204 ± 0.071	5.934SerLeu: 5.934 ± 0.084	1.295SerMet: 1.295 ± 0.042	3.332SerAsn: 3.332 ± 0.073	2.105SerPro: 2.105 ± 0.054	2.124SerGln: 2.124 ± 0.05	2.256SerArg: 2.256 ± 0.046	3.778SerSer: 3.778 ± 0.071	3.36SerThr: 3.36 ± 0.071	3.852SerVal: 3.852 ± 0.073	0.791SerTrp: 0.791 ± 0.033	2.406SerTyr: 2.406 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	4.007ThrAla: 4.007 ± 0.093	0.344ThrCys: 0.344 ± 0.027	3.272ThrAsp: 3.272 ± 0.115	3.1ThrGlu: 3.1 ± 0.052	2.971ThrPhe: 2.971 ± 0.074	4.055ThrGly: 4.055 ± 0.096	1.055ThrHis: 1.055 ± 0.035	4.337ThrIle: 4.337 ± 0.091	3.289ThrLys: 3.289 ± 0.061	5.511ThrLeu: 5.511 ± 0.075	1.084ThrMet: 1.084 ± 0.036	2.983ThrAsn: 2.983 ± 0.076	2.47ThrPro: 2.47 ± 0.064	1.916ThrGln: 1.916 ± 0.053	1.804ThrArg: 1.804 ± 0.042	3.493ThrSer: 3.493 ± 0.071	3.29ThrThr: 3.29 ± 0.077	3.888ThrVal: 3.888 ± 0.095	0.607ThrTrp: 0.607 ± 0.029	2.282ThrTyr: 2.282 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	5.024ValAla: 5.024 ± 0.082	0.54ValCys: 0.54 ± 0.025	3.966ValAsp: 3.966 ± 0.064	3.995ValGlu: 3.995 ± 0.076	3.563ValPhe: 3.563 ± 0.065	4.414ValGly: 4.414 ± 0.077	1.193ValHis: 1.193 ± 0.042	4.41ValIle: 4.41 ± 0.075	3.922ValLys: 3.922 ± 0.068	6.582ValLeu: 6.582 ± 0.094	1.481ValMet: 1.481 ± 0.041	3.382ValAsn: 3.382 ± 0.071	2.517ValPro: 2.517 ± 0.052	2.113ValGln: 2.113 ± 0.047	2.472ValArg: 2.472 ± 0.045	4.323ValSer: 4.323 ± 0.082	3.714ValThr: 3.714 ± 0.101	4.819ValVal: 4.819 ± 0.082	0.669ValTrp: 0.669 ± 0.028	2.254ValTyr: 2.254 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.71TrpAla: 0.71 ± 0.028	0.104TrpCys: 0.104 ± 0.012	0.682TrpAsp: 0.682 ± 0.032	0.745TrpGlu: 0.745 ± 0.031	0.596TrpPhe: 0.596 ± 0.028	0.789TrpGly: 0.789 ± 0.033	0.263TrpHis: 0.263 ± 0.017	0.726TrpIle: 0.726 ± 0.035	0.736TrpLys: 0.736 ± 0.03	1.072TrpLeu: 1.072 ± 0.034	0.371TrpMet: 0.371 ± 0.022	0.705TrpAsn: 0.705 ± 0.029	0.334TrpPro: 0.334 ± 0.023	0.464TrpGln: 0.464 ± 0.019	0.48TrpArg: 0.48 ± 0.023	0.681TrpSer: 0.681 ± 0.033	0.575TrpThr: 0.575 ± 0.03	0.794TrpVal: 0.794 ± 0.032	0.188TrpTrp: 0.188 ± 0.016	0.42TrpTyr: 0.42 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.666TyrAla: 2.666 ± 0.057	0.314TyrCys: 0.314 ± 0.016	2.299TyrAsp: 2.299 ± 0.047	2.363TyrGlu: 2.363 ± 0.064	2.273TyrPhe: 2.273 ± 0.05	2.76TyrGly: 2.76 ± 0.059	0.835TyrHis: 0.835 ± 0.033	2.183TyrIle: 2.183 ± 0.054	2.274TyrLys: 2.274 ± 0.055	3.706TyrLeu: 3.706 ± 0.078	0.695TyrMet: 0.695 ± 0.027	2.061TyrAsn: 2.061 ± 0.046	1.463TyrPro: 1.463 ± 0.043	1.592TyrGln: 1.592 ± 0.045	1.809TyrArg: 1.809 ± 0.052	2.14TyrSer: 2.14 ± 0.059	2.099TyrThr: 2.099 ± 0.061	2.351TyrVal: 2.351 ± 0.049	0.473TyrTrp: 0.473 ± 0.024	1.577TyrTyr: 1.577 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2810 proteins (964233 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---