Amino acid dipepetide frequency for Algibacter pectinivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.943AlaAla: 3.943 ± 0.081	0.56AlaCys: 0.56 ± 0.026	3.223AlaAsp: 3.223 ± 0.054	3.882AlaGlu: 3.882 ± 0.077	3.485AlaPhe: 3.485 ± 0.055	3.926AlaGly: 3.926 ± 0.077	1.205AlaHis: 1.205 ± 0.036	5.587AlaIle: 5.587 ± 0.076	5.029AlaLys: 5.029 ± 0.095	6.505AlaLeu: 6.505 ± 0.105	1.426AlaMet: 1.426 ± 0.038	3.789AlaAsn: 3.789 ± 0.064	1.899AlaPro: 1.899 ± 0.045	2.353AlaGln: 2.353 ± 0.05	1.83AlaArg: 1.83 ± 0.048	4.309AlaSer: 4.309 ± 0.069	3.595AlaThr: 3.595 ± 0.078	4.042AlaVal: 4.042 ± 0.068	0.627AlaTrp: 0.627 ± 0.023	2.594AlaTyr: 2.594 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.467CysAla: 0.467 ± 0.023	0.092CysCys: 0.092 ± 0.011	0.454CysAsp: 0.454 ± 0.024	0.483CysGlu: 0.483 ± 0.026	0.483CysPhe: 0.483 ± 0.022	0.605CysGly: 0.605 ± 0.03	0.177CysHis: 0.177 ± 0.014	0.613CysIle: 0.613 ± 0.025	0.536CysLys: 0.536 ± 0.025	0.648CysLeu: 0.648 ± 0.027	0.144CysMet: 0.144 ± 0.011	0.461CysAsn: 0.461 ± 0.021	0.309CysPro: 0.309 ± 0.015	0.201CysGln: 0.201 ± 0.013	0.185CysArg: 0.185 ± 0.013	0.593CysSer: 0.593 ± 0.024	0.409CysThr: 0.409 ± 0.023	0.445CysVal: 0.445 ± 0.021	0.067CysTrp: 0.067 ± 0.009	0.337CysTyr: 0.337 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.059AspAla: 4.059 ± 0.071	0.437AspCys: 0.437 ± 0.025	3.118AspAsp: 3.118 ± 0.067	3.509AspGlu: 3.509 ± 0.062	3.626AspPhe: 3.626 ± 0.063	3.671AspGly: 3.671 ± 0.079	0.834AspHis: 0.834 ± 0.03	4.761AspIle: 4.761 ± 0.065	4.149AspLys: 4.149 ± 0.076	5.213AspLeu: 5.213 ± 0.065	1.127AspMet: 1.127 ± 0.035	3.56AspAsn: 3.56 ± 0.069	1.532AspPro: 1.532 ± 0.044	1.269AspGln: 1.269 ± 0.029	1.688AspArg: 1.688 ± 0.038	3.242AspSer: 3.242 ± 0.059	2.978AspThr: 2.978 ± 0.062	3.86AspVal: 3.86 ± 0.068	0.696AspTrp: 0.696 ± 0.025	2.941AspTyr: 2.941 ± 0.062	0.0AspXaa: 0.0 ± 0.0
Glu	4.657GluAla: 4.657 ± 0.084	0.342GluCys: 0.342 ± 0.023	3.762GluAsp: 3.762 ± 0.067	4.124GluGlu: 4.124 ± 0.079	3.029GluPhe: 3.029 ± 0.061	3.5GluGly: 3.5 ± 0.061	1.211GluHis: 1.211 ± 0.033	5.05GluIle: 5.05 ± 0.067	5.127GluLys: 5.127 ± 0.079	5.927GluLeu: 5.927 ± 0.08	1.272GluMet: 1.272 ± 0.034	4.581GluAsn: 4.581 ± 0.074	1.599GluPro: 1.599 ± 0.041	2.231GluGln: 2.231 ± 0.053	2.337GluArg: 2.337 ± 0.051	3.475GluSer: 3.475 ± 0.058	4.009GluThr: 4.009 ± 0.065	4.064GluVal: 4.064 ± 0.066	0.572GluTrp: 0.572 ± 0.022	2.247GluTyr: 2.247 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	2.847PheAla: 2.847 ± 0.053	0.452PheCys: 0.452 ± 0.02	3.237PheAsp: 3.237 ± 0.062	3.375PheGlu: 3.375 ± 0.067	2.583PhePhe: 2.583 ± 0.061	3.646PheGly: 3.646 ± 0.068	0.789PheHis: 0.789 ± 0.028	3.967PheIle: 3.967 ± 0.074	4.475PheLys: 4.475 ± 0.075	4.568PheLeu: 4.568 ± 0.081	1.08PheMet: 1.08 ± 0.034	3.99PheAsn: 3.99 ± 0.07	1.614PhePro: 1.614 ± 0.04	1.475PheGln: 1.475 ± 0.037	1.493PheArg: 1.493 ± 0.032	4.157PheSer: 4.157 ± 0.067	3.177PheThr: 3.177 ± 0.064	3.102PheVal: 3.102 ± 0.059	0.599PheTrp: 0.599 ± 0.025	2.191PheTyr: 2.191 ± 0.058	0.0PheXaa: 0.0 ± 0.0
Gly	4.196GlyAla: 4.196 ± 0.07	0.586GlyCys: 0.586 ± 0.034	3.446GlyAsp: 3.446 ± 0.062	3.508GlyGlu: 3.508 ± 0.068	3.713GlyPhe: 3.713 ± 0.064	4.321GlyGly: 4.321 ± 0.087	1.125GlyHis: 1.125 ± 0.032	5.094GlyIle: 5.094 ± 0.083	4.816GlyLys: 4.816 ± 0.07	5.789GlyLeu: 5.789 ± 0.086	1.407GlyMet: 1.407 ± 0.038	3.686GlyAsn: 3.686 ± 0.073	1.295GlyPro: 1.295 ± 0.04	1.818GlyGln: 1.818 ± 0.044	1.985GlyArg: 1.985 ± 0.049	3.856GlySer: 3.856 ± 0.065	3.906GlyThr: 3.906 ± 0.091	4.581GlyVal: 4.581 ± 0.073	0.76GlyTrp: 0.76 ± 0.03	2.719GlyTyr: 2.719 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.036HisAla: 1.036 ± 0.033	0.167HisCys: 0.167 ± 0.014	0.894HisAsp: 0.894 ± 0.03	0.941HisGlu: 0.941 ± 0.026	1.14HisPhe: 1.14 ± 0.038	1.055HisGly: 1.055 ± 0.031	0.447HisHis: 0.447 ± 0.021	1.515HisIle: 1.515 ± 0.037	1.278HisLys: 1.278 ± 0.039	1.791HisLeu: 1.791 ± 0.046	0.293HisMet: 0.293 ± 0.016	1.113HisAsn: 1.113 ± 0.032	0.8HisPro: 0.8 ± 0.029	0.627HisGln: 0.627 ± 0.021	0.588HisArg: 0.588 ± 0.024	1.0HisSer: 1.0 ± 0.033	0.905HisThr: 0.905 ± 0.03	1.01HisVal: 1.01 ± 0.034	0.219HisTrp: 0.219 ± 0.017	0.862HisTyr: 0.862 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.429IleAla: 5.429 ± 0.08	0.637IleCys: 0.637 ± 0.027	5.143IleAsp: 5.143 ± 0.079	5.585IleGlu: 5.585 ± 0.076	3.427IlePhe: 3.427 ± 0.066	5.095IleGly: 5.095 ± 0.079	1.255IleHis: 1.255 ± 0.039	6.188IleIle: 6.188 ± 0.105	6.469IleLys: 6.469 ± 0.088	6.895IleLeu: 6.895 ± 0.095	1.389IleMet: 1.389 ± 0.039	5.317IleAsn: 5.317 ± 0.075	3.115IlePro: 3.115 ± 0.051	2.407IleGln: 2.407 ± 0.051	2.346IleArg: 2.346 ± 0.053	5.588IleSer: 5.588 ± 0.073	5.105IleThr: 5.105 ± 0.079	4.765IleVal: 4.765 ± 0.071	0.676IleTrp: 0.676 ± 0.022	2.882IleTyr: 2.882 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	5.592LysAla: 5.592 ± 0.095	0.356LysCys: 0.356 ± 0.018	4.665LysAsp: 4.665 ± 0.07	5.617LysGlu: 5.617 ± 0.089	3.11LysPhe: 3.11 ± 0.063	4.63LysGly: 4.63 ± 0.063	1.634LysHis: 1.634 ± 0.039	6.069LysIle: 6.069 ± 0.08	6.603LysLys: 6.603 ± 0.115	7.095LysLeu: 7.095 ± 0.085	1.914LysMet: 1.914 ± 0.045	5.437LysAsn: 5.437 ± 0.089	2.669LysPro: 2.669 ± 0.052	3.095LysGln: 3.095 ± 0.068	3.015LysArg: 3.015 ± 0.051	4.664LysSer: 4.664 ± 0.068	5.355LysThr: 5.355 ± 0.078	4.724LysVal: 4.724 ± 0.064	0.801LysTrp: 0.801 ± 0.028	3.12LysTyr: 3.12 ± 0.06	0.0LysXaa: 0.0 ± 0.0
Leu	5.61LeuAla: 5.61 ± 0.077	0.737LeuCys: 0.737 ± 0.026	5.077LeuAsp: 5.077 ± 0.073	6.152LeuGlu: 6.152 ± 0.08	4.896LeuPhe: 4.896 ± 0.089	5.798LeuGly: 5.798 ± 0.084	1.471LeuHis: 1.471 ± 0.038	6.999LeuIle: 6.999 ± 0.097	8.41LeuLys: 8.41 ± 0.107	8.405LeuLeu: 8.405 ± 0.116	1.924LeuMet: 1.924 ± 0.047	6.492LeuAsn: 6.492 ± 0.091	3.365LeuPro: 3.365 ± 0.054	3.003LeuGln: 3.003 ± 0.058	2.989LeuArg: 2.989 ± 0.053	6.53LeuSer: 6.53 ± 0.082	5.16LeuThr: 5.16 ± 0.07	5.481LeuVal: 5.481 ± 0.075	0.814LeuTrp: 0.814 ± 0.028	3.141LeuTyr: 3.141 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	1.536MetAla: 1.536 ± 0.041	0.171MetCys: 0.171 ± 0.012	1.05MetAsp: 1.05 ± 0.036	1.194MetGlu: 1.194 ± 0.036	0.91MetPhe: 0.91 ± 0.04	1.21MetGly: 1.21 ± 0.035	0.403MetHis: 0.403 ± 0.019	1.371MetIle: 1.371 ± 0.04	1.877MetLys: 1.877 ± 0.041	1.915MetLeu: 1.915 ± 0.048	0.491MetMet: 0.491 ± 0.022	1.165MetAsn: 1.165 ± 0.031	0.842MetPro: 0.842 ± 0.025	0.837MetGln: 0.837 ± 0.028	0.78MetArg: 0.78 ± 0.026	1.37MetSer: 1.37 ± 0.034	1.018MetThr: 1.018 ± 0.032	1.317MetVal: 1.317 ± 0.033	0.153MetTrp: 0.153 ± 0.01	0.697MetTyr: 0.697 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	4.139AsnAla: 4.139 ± 0.066	0.497AsnCys: 0.497 ± 0.024	3.507AsnAsp: 3.507 ± 0.064	3.909AsnGlu: 3.909 ± 0.058	3.302AsnPhe: 3.302 ± 0.065	4.267AsnGly: 4.267 ± 0.077	1.124AsnHis: 1.124 ± 0.035	5.418AsnIle: 5.418 ± 0.076	5.146AsnLys: 5.146 ± 0.083	5.974AsnLeu: 5.974 ± 0.08	1.289AsnMet: 1.289 ± 0.042	4.681AsnAsn: 4.681 ± 0.085	2.835AsnPro: 2.835 ± 0.059	2.349AsnGln: 2.349 ± 0.044	2.193AsnArg: 2.193 ± 0.047	4.091AsnSer: 4.091 ± 0.074	4.471AsnThr: 4.471 ± 0.071	3.809AsnVal: 3.809 ± 0.064	0.815AsnTrp: 0.815 ± 0.028	3.086AsnTyr: 3.086 ± 0.065	0.0AsnXaa: 0.0 ± 0.0
Pro	1.703ProAla: 1.703 ± 0.046	0.215ProCys: 0.215 ± 0.017	1.972ProAsp: 1.972 ± 0.042	2.919ProGlu: 2.919 ± 0.065	1.921ProPhe: 1.921 ± 0.05	1.771ProGly: 1.771 ± 0.039	0.602ProHis: 0.602 ± 0.023	2.712ProIle: 2.712 ± 0.057	2.654ProLys: 2.654 ± 0.056	2.92ProLeu: 2.92 ± 0.052	0.622ProMet: 0.622 ± 0.023	2.452ProAsn: 2.452 ± 0.051	0.766ProPro: 0.766 ± 0.029	1.047ProGln: 1.047 ± 0.029	0.877ProArg: 0.877 ± 0.027	2.06ProSer: 2.06 ± 0.047	1.972ProThr: 1.972 ± 0.046	2.216ProVal: 2.216 ± 0.046	0.328ProTrp: 0.328 ± 0.021	1.398ProTyr: 1.398 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.002GlnAla: 2.002 ± 0.052	0.18GlnCys: 0.18 ± 0.012	1.801GlnAsp: 1.801 ± 0.046	2.105GlnGlu: 2.105 ± 0.046	1.659GlnPhe: 1.659 ± 0.04	1.821GlnGly: 1.821 ± 0.045	0.631GlnHis: 0.631 ± 0.025	2.624GlnIle: 2.624 ± 0.045	2.551GlnLys: 2.551 ± 0.057	3.261GlnLeu: 3.261 ± 0.058	0.73GlnMet: 0.73 ± 0.027	2.224GlnAsn: 2.224 ± 0.045	1.086GlnPro: 1.086 ± 0.035	1.252GlnGln: 1.252 ± 0.04	1.122GlnArg: 1.122 ± 0.032	1.83GlnSer: 1.83 ± 0.039	1.888GlnThr: 1.888 ± 0.045	2.115GlnVal: 2.115 ± 0.043	0.345GlnTrp: 0.345 ± 0.018	1.279GlnTyr: 1.279 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.098ArgAla: 2.098 ± 0.051	0.197ArgCys: 0.197 ± 0.013	1.661ArgAsp: 1.661 ± 0.038	1.899ArgGlu: 1.899 ± 0.047	1.833ArgPhe: 1.833 ± 0.041	1.913ArgGly: 1.913 ± 0.045	0.634ArgHis: 0.634 ± 0.029	2.708ArgIle: 2.708 ± 0.051	2.499ArgLys: 2.499 ± 0.058	3.062ArgLeu: 3.062 ± 0.065	0.777ArgMet: 0.777 ± 0.025	1.996ArgAsn: 1.996 ± 0.04	1.102ArgPro: 1.102 ± 0.032	1.038ArgGln: 1.038 ± 0.027	1.179ArgArg: 1.179 ± 0.036	1.744ArgSer: 1.744 ± 0.046	1.809ArgThr: 1.809 ± 0.042	2.037ArgVal: 2.037 ± 0.041	0.381ArgTrp: 0.381 ± 0.018	1.467ArgTyr: 1.467 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	3.761SerAla: 3.761 ± 0.067	0.696SerCys: 0.696 ± 0.03	3.43SerAsp: 3.43 ± 0.058	3.91SerGlu: 3.91 ± 0.057	3.806SerPhe: 3.806 ± 0.057	4.519SerGly: 4.519 ± 0.075	1.107SerHis: 1.107 ± 0.03	5.416SerIle: 5.416 ± 0.077	5.309SerLys: 5.309 ± 0.082	5.734SerLeu: 5.734 ± 0.082	1.22SerMet: 1.22 ± 0.038	4.413SerAsn: 4.413 ± 0.065	1.981SerPro: 1.981 ± 0.048	2.013SerGln: 2.013 ± 0.045	2.051SerArg: 2.051 ± 0.04	4.313SerSer: 4.313 ± 0.083	3.695SerThr: 3.695 ± 0.062	4.021SerVal: 4.021 ± 0.071	0.725SerTrp: 0.725 ± 0.03	2.703SerTyr: 2.703 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	3.654ThrAla: 3.654 ± 0.065	0.407ThrCys: 0.407 ± 0.02	3.322ThrAsp: 3.322 ± 0.066	3.52ThrGlu: 3.52 ± 0.058	3.327ThrPhe: 3.327 ± 0.065	3.927ThrGly: 3.927 ± 0.079	1.048ThrHis: 1.048 ± 0.035	5.133ThrIle: 5.133 ± 0.079	4.287ThrLys: 4.287 ± 0.062	5.611ThrLeu: 5.611 ± 0.073	0.959ThrMet: 0.959 ± 0.032	3.757ThrAsn: 3.757 ± 0.065	2.58ThrPro: 2.58 ± 0.057	1.925ThrGln: 1.925 ± 0.042	1.654ThrArg: 1.654 ± 0.043	4.031ThrSer: 4.031 ± 0.083	3.718ThrThr: 3.718 ± 0.071	3.885ThrVal: 3.885 ± 0.076	0.607ThrTrp: 0.607 ± 0.023	2.606ThrTyr: 2.606 ± 0.061	0.0ThrXaa: 0.0 ± 0.0
Val	4.032ValAla: 4.032 ± 0.06	0.527ValCys: 0.527 ± 0.024	3.677ValAsp: 3.677 ± 0.067	3.796ValGlu: 3.796 ± 0.066	3.527ValPhe: 3.527 ± 0.055	3.739ValGly: 3.739 ± 0.06	0.95ValHis: 0.95 ± 0.03	4.939ValIle: 4.939 ± 0.066	4.759ValLys: 4.759 ± 0.081	6.313ValLeu: 6.313 ± 0.084	1.246ValMet: 1.246 ± 0.037	3.939ValAsn: 3.939 ± 0.072	2.093ValPro: 2.093 ± 0.043	1.626ValGln: 1.626 ± 0.044	1.821ValArg: 1.821 ± 0.04	4.671ValSer: 4.671 ± 0.074	3.631ValThr: 3.631 ± 0.08	4.286ValVal: 4.286 ± 0.074	0.579ValTrp: 0.579 ± 0.024	2.448ValTyr: 2.448 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.571TrpAla: 0.571 ± 0.022	0.123TrpCys: 0.123 ± 0.011	0.641TrpAsp: 0.641 ± 0.031	0.67TrpGlu: 0.67 ± 0.028	0.594TrpPhe: 0.594 ± 0.026	0.633TrpGly: 0.633 ± 0.026	0.248TrpHis: 0.248 ± 0.017	0.681TrpIle: 0.681 ± 0.029	0.773TrpLys: 0.773 ± 0.028	1.005TrpLeu: 1.005 ± 0.03	0.271TrpMet: 0.271 ± 0.018	0.716TrpAsn: 0.716 ± 0.034	0.227TrpPro: 0.227 ± 0.015	0.431TrpGln: 0.431 ± 0.021	0.391TrpArg: 0.391 ± 0.017	0.661TrpSer: 0.661 ± 0.027	0.581TrpThr: 0.581 ± 0.025	0.624TrpVal: 0.624 ± 0.028	0.145TrpTrp: 0.145 ± 0.011	0.434TrpTyr: 0.434 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.475TyrAla: 2.475 ± 0.05	0.328TyrCys: 0.328 ± 0.019	2.191TyrAsp: 2.191 ± 0.047	2.016TyrGlu: 2.016 ± 0.05	2.45TyrPhe: 2.45 ± 0.052	2.558TyrGly: 2.558 ± 0.053	0.784TyrHis: 0.784 ± 0.027	2.865TyrIle: 2.865 ± 0.058	3.419TyrLys: 3.419 ± 0.063	3.826TyrLeu: 3.826 ± 0.061	0.727TyrMet: 0.727 ± 0.025	3.134TyrAsn: 3.134 ± 0.067	1.419TyrPro: 1.419 ± 0.038	1.511TyrGln: 1.511 ± 0.042	1.508TyrArg: 1.508 ± 0.041	2.64TyrSer: 2.64 ± 0.051	2.574TyrThr: 2.574 ± 0.061	2.219TyrVal: 2.219 ± 0.042	0.509TyrTrp: 0.509 ± 0.024	1.829TyrTyr: 1.829 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3126 proteins (1081701 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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