Amino acid dipepetide frequency for Vibrio virus CTXphi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.647AlaAla: 5.647 ± 1.304
0.0AlaCys: 0.0 ± 0.0
2.053AlaAsp: 2.053 ± 1.207
3.08AlaGlu: 3.08 ± 1.095
3.593AlaPhe: 3.593 ± 0.75
3.593AlaGly: 3.593 ± 1.138
1.54AlaHis: 1.54 ± 0.798
5.133AlaIle: 5.133 ± 2.482
4.62AlaLys: 4.62 ± 1.16
9.754AlaLeu: 9.754 ± 2.153
1.54AlaMet: 1.54 ± 0.678
2.567AlaAsn: 2.567 ± 1.071
5.133AlaPro: 5.133 ± 1.95
1.54AlaGln: 1.54 ± 0.483
3.593AlaArg: 3.593 ± 1.037
5.133AlaSer: 5.133 ± 1.355
3.08AlaThr: 3.08 ± 1.616
3.593AlaVal: 3.593 ± 1.586
1.027AlaTrp: 1.027 ± 0.58
3.593AlaTyr: 3.593 ± 1.278
0.0AlaXaa: 0.0 ± 0.0
Cys
1.027CysAla: 1.027 ± 0.772
0.0CysCys: 0.0 ± 0.0
1.54CysAsp: 1.54 ± 1.001
0.0CysGlu: 0.0 ± 0.0
0.513CysPhe: 0.513 ± 0.476
1.027CysGly: 1.027 ± 0.592
0.513CysHis: 0.513 ± 0.499
1.027CysIle: 1.027 ± 0.503
0.513CysLys: 0.513 ± 0.476
2.053CysLeu: 2.053 ± 0.59
0.513CysMet: 0.513 ± 0.476
0.0CysAsn: 0.0 ± 0.0
0.513CysPro: 0.513 ± 0.476
0.513CysGln: 0.513 ± 0.476
0.513CysArg: 0.513 ± 0.499
2.053CysSer: 2.053 ± 0.914
0.0CysThr: 0.0 ± 0.0
1.54CysVal: 1.54 ± 0.668
0.0CysTrp: 0.0 ± 0.0
0.513CysTyr: 0.513 ± 0.499
0.0CysXaa: 0.0 ± 0.0
Asp
3.08AspAla: 3.08 ± 1.184
0.0AspCys: 0.0 ± 0.0
3.08AspAsp: 3.08 ± 1.336
7.187AspGlu: 7.187 ± 2.479
1.54AspPhe: 1.54 ± 0.483
3.593AspGly: 3.593 ± 1.197
1.027AspHis: 1.027 ± 0.592
4.107AspIle: 4.107 ± 1.112
3.08AspLys: 3.08 ± 1.187
4.62AspLeu: 4.62 ± 1.779
3.593AspMet: 3.593 ± 1.474
2.053AspAsn: 2.053 ± 1.285
1.54AspPro: 1.54 ± 1.095
1.027AspGln: 1.027 ± 0.71
2.567AspArg: 2.567 ± 1.096
4.62AspSer: 4.62 ± 0.93
6.16AspThr: 6.16 ± 1.373
2.567AspVal: 2.567 ± 0.679
0.513AspTrp: 0.513 ± 0.582
2.567AspTyr: 2.567 ± 1.095
0.0AspXaa: 0.0 ± 0.0
Glu
2.567GluAla: 2.567 ± 1.017
1.027GluCys: 1.027 ± 0.503
1.027GluAsp: 1.027 ± 0.642
2.053GluGlu: 2.053 ± 1.05
1.027GluPhe: 1.027 ± 0.695
2.053GluGly: 2.053 ± 1.003
1.027GluHis: 1.027 ± 0.58
3.08GluIle: 3.08 ± 0.634
4.62GluLys: 4.62 ± 2.001
5.133GluLeu: 5.133 ± 1.391
1.54GluMet: 1.54 ± 0.841
2.053GluAsn: 2.053 ± 0.767
2.567GluPro: 2.567 ± 0.848
2.567GluGln: 2.567 ± 1.001
4.107GluArg: 4.107 ± 1.302
5.133GluSer: 5.133 ± 1.404
3.08GluThr: 3.08 ± 1.601
5.647GluVal: 5.647 ± 1.058
0.0GluTrp: 0.0 ± 0.0
2.053GluTyr: 2.053 ± 1.084
0.0GluXaa: 0.0 ± 0.0
Phe
2.567PheAla: 2.567 ± 0.903
1.54PheCys: 1.54 ± 0.483
4.107PheAsp: 4.107 ± 0.955
1.54PheGlu: 1.54 ± 0.86
2.567PhePhe: 2.567 ± 1.243
6.16PheGly: 6.16 ± 1.12
1.027PheHis: 1.027 ± 0.539
2.567PheIle: 2.567 ± 1.366
2.567PheLys: 2.567 ± 1.054
6.16PheLeu: 6.16 ± 1.938
0.513PheMet: 0.513 ± 0.402
2.053PheAsn: 2.053 ± 0.81
1.54PhePro: 1.54 ± 0.727
1.027PheGln: 1.027 ± 0.772
3.08PheArg: 3.08 ± 1.759
5.133PheSer: 5.133 ± 1.857
3.08PheThr: 3.08 ± 1.288
5.647PheVal: 5.647 ± 2.137
1.027PheTrp: 1.027 ± 0.649
1.027PheTyr: 1.027 ± 0.695
0.0PheXaa: 0.0 ± 0.0
Gly
5.647GlyAla: 5.647 ± 0.922
2.053GlyCys: 2.053 ± 0.837
2.053GlyAsp: 2.053 ± 0.843
1.027GlyGlu: 1.027 ± 0.539
4.62GlyPhe: 4.62 ± 1.149
4.107GlyGly: 4.107 ± 1.188
1.027GlyHis: 1.027 ± 0.592
1.54GlyIle: 1.54 ± 0.954
3.593GlyLys: 3.593 ± 1.506
9.754GlyLeu: 9.754 ± 1.887
0.513GlyMet: 0.513 ± 0.406
2.053GlyAsn: 2.053 ± 0.837
0.513GlyPro: 0.513 ± 0.503
3.08GlyGln: 3.08 ± 1.123
3.593GlyArg: 3.593 ± 1.503
3.593GlySer: 3.593 ± 1.076
3.593GlyThr: 3.593 ± 1.264
5.133GlyVal: 5.133 ± 1.742
1.027GlyTrp: 1.027 ± 0.592
4.107GlyTyr: 4.107 ± 1.687
0.0GlyXaa: 0.0 ± 0.0
His
3.08HisAla: 3.08 ± 0.857
0.0HisCys: 0.0 ± 0.0
2.053HisAsp: 2.053 ± 0.837
0.0HisGlu: 0.0 ± 0.0
2.053HisPhe: 2.053 ± 0.837
2.053HisGly: 2.053 ± 0.964
2.053HisHis: 2.053 ± 1.242
2.053HisIle: 2.053 ± 0.85
0.513HisLys: 0.513 ± 0.499
1.027HisLeu: 1.027 ± 0.58
0.0HisMet: 0.0 ± 0.0
1.54HisAsn: 1.54 ± 0.753
1.027HisPro: 1.027 ± 0.592
1.54HisGln: 1.54 ± 0.985
1.54HisArg: 1.54 ± 1.018
2.053HisSer: 2.053 ± 0.646
1.027HisThr: 1.027 ± 0.772
1.54HisVal: 1.54 ± 0.923
1.54HisTrp: 1.54 ± 0.996
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
3.593IleAla: 3.593 ± 1.632
0.513IleCys: 0.513 ± 0.406
7.187IleAsp: 7.187 ± 1.657
4.62IleGlu: 4.62 ± 1.271
5.133IlePhe: 5.133 ± 1.787
2.053IleGly: 2.053 ± 1.062
2.567IleHis: 2.567 ± 1.04
3.08IleIle: 3.08 ± 0.81
4.107IleLys: 4.107 ± 1.189
2.567IleLeu: 2.567 ± 0.976
1.54IleMet: 1.54 ± 0.839
3.593IleAsn: 3.593 ± 1.219
2.053IlePro: 2.053 ± 0.96
1.54IleGln: 1.54 ± 1.367
4.107IleArg: 4.107 ± 1.678
3.593IleSer: 3.593 ± 0.826
2.053IleThr: 2.053 ± 1.15
2.567IleVal: 2.567 ± 1.461
1.027IleTrp: 1.027 ± 0.574
3.593IleTyr: 3.593 ± 0.865
0.0IleXaa: 0.0 ± 0.0
Lys
5.133LysAla: 5.133 ± 1.622
0.0LysCys: 0.0 ± 0.0
5.133LysAsp: 5.133 ± 1.105
2.053LysGlu: 2.053 ± 1.256
3.08LysPhe: 3.08 ± 0.852
3.08LysGly: 3.08 ± 0.817
1.027LysHis: 1.027 ± 0.997
4.62LysIle: 4.62 ± 1.119
3.593LysLys: 3.593 ± 1.386
6.674LysLeu: 6.674 ± 2.226
1.54LysMet: 1.54 ± 0.808
2.567LysAsn: 2.567 ± 1.082
2.567LysPro: 2.567 ± 1.617
2.053LysGln: 2.053 ± 0.837
2.053LysArg: 2.053 ± 0.759
4.107LysSer: 4.107 ± 1.485
3.593LysThr: 3.593 ± 0.967
3.08LysVal: 3.08 ± 0.913
1.027LysTrp: 1.027 ± 0.997
1.027LysTyr: 1.027 ± 0.574
0.0LysXaa: 0.0 ± 0.0
Leu
5.133LeuAla: 5.133 ± 1.339
2.567LeuCys: 2.567 ± 1.147
7.7LeuAsp: 7.7 ± 1.578
5.133LeuGlu: 5.133 ± 1.54
9.24LeuPhe: 9.24 ± 1.935
7.187LeuGly: 7.187 ± 2.253
3.08LeuHis: 3.08 ± 0.77
5.647LeuIle: 5.647 ± 2.432
4.107LeuLys: 4.107 ± 0.935
4.62LeuLeu: 4.62 ± 1.209
4.62LeuMet: 4.62 ± 2.056
7.187LeuAsn: 7.187 ± 2.156
4.62LeuPro: 4.62 ± 1.643
1.54LeuGln: 1.54 ± 0.997
3.593LeuArg: 3.593 ± 0.676
5.647LeuSer: 5.647 ± 2.145
4.62LeuThr: 4.62 ± 2.216
4.62LeuVal: 4.62 ± 1.549
3.08LeuTrp: 3.08 ± 1.507
4.107LeuTyr: 4.107 ± 1.321
0.0LeuXaa: 0.0 ± 0.0
Met
3.593MetAla: 3.593 ± 1.368
0.513MetCys: 0.513 ± 0.476
1.54MetAsp: 1.54 ± 0.912
1.027MetGlu: 1.027 ± 0.628
2.567MetPhe: 2.567 ± 1.126
1.027MetGly: 1.027 ± 0.659
1.027MetHis: 1.027 ± 0.574
2.567MetIle: 2.567 ± 1.017
2.567MetLys: 2.567 ± 1.539
2.053MetLeu: 2.053 ± 1.421
1.027MetMet: 1.027 ± 0.713
1.027MetAsn: 1.027 ± 0.632
1.027MetPro: 1.027 ± 0.58
0.0MetGln: 0.0 ± 0.0
1.027MetArg: 1.027 ± 0.667
2.567MetSer: 2.567 ± 0.958
1.027MetThr: 1.027 ± 0.916
1.54MetVal: 1.54 ± 0.602
0.513MetTrp: 0.513 ± 0.582
0.513MetTyr: 0.513 ± 0.406
0.0MetXaa: 0.0 ± 0.0
Asn
1.54AsnAla: 1.54 ± 0.595
0.513AsnCys: 0.513 ± 0.476
3.08AsnAsp: 3.08 ± 1.231
3.08AsnGlu: 3.08 ± 0.958
0.0AsnPhe: 0.0 ± 0.0
3.08AsnGly: 3.08 ± 1.083
1.027AsnHis: 1.027 ± 0.503
2.567AsnIle: 2.567 ± 0.806
2.053AsnLys: 2.053 ± 1.233
5.647AsnLeu: 5.647 ± 1.084
1.54AsnMet: 1.54 ± 0.785
1.027AsnAsn: 1.027 ± 0.706
2.053AsnPro: 2.053 ± 1.337
2.053AsnGln: 2.053 ± 1.175
2.567AsnArg: 2.567 ± 0.793
2.053AsnSer: 2.053 ± 1.148
5.133AsnThr: 5.133 ± 2.167
2.567AsnVal: 2.567 ± 0.492
0.513AsnTrp: 0.513 ± 0.476
1.027AsnTyr: 1.027 ± 0.951
0.0AsnXaa: 0.0 ± 0.0
Pro
2.053ProAla: 2.053 ± 0.81
0.0ProCys: 0.0 ± 0.0
5.133ProAsp: 5.133 ± 0.862
3.08ProGlu: 3.08 ± 0.595
0.513ProPhe: 0.513 ± 0.499
2.053ProGly: 2.053 ± 0.834
1.027ProHis: 1.027 ± 0.737
5.133ProIle: 5.133 ± 1.57
1.027ProLys: 1.027 ± 0.628
3.08ProLeu: 3.08 ± 0.826
0.513ProMet: 0.513 ± 0.476
4.62ProAsn: 4.62 ± 1.896
5.133ProPro: 5.133 ± 1.987
2.053ProGln: 2.053 ± 0.998
2.053ProArg: 2.053 ± 0.986
2.567ProSer: 2.567 ± 1.296
1.54ProThr: 1.54 ± 0.891
2.053ProVal: 2.053 ± 1.111
1.027ProTrp: 1.027 ± 0.58
2.567ProTyr: 2.567 ± 0.492
0.0ProXaa: 0.0 ± 0.0
Gln
2.567GlnAla: 2.567 ± 1.772
0.513GlnCys: 0.513 ± 0.55
1.027GlnAsp: 1.027 ± 0.503
1.54GlnGlu: 1.54 ± 0.897
1.54GlnPhe: 1.54 ± 1.06
0.513GlnGly: 0.513 ± 0.476
1.027GlnHis: 1.027 ± 0.761
3.08GlnIle: 3.08 ± 1.113
2.567GlnLys: 2.567 ± 1.232
3.08GlnLeu: 3.08 ± 1.273
1.54GlnMet: 1.54 ± 0.602
1.54GlnAsn: 1.54 ± 0.791
1.027GlnPro: 1.027 ± 0.641
1.54GlnGln: 1.54 ± 1.06
0.513GlnArg: 0.513 ± 0.476
5.133GlnSer: 5.133 ± 2.093
1.54GlnThr: 1.54 ± 1.091
3.593GlnVal: 3.593 ± 0.967
0.513GlnTrp: 0.513 ± 0.55
0.513GlnTyr: 0.513 ± 0.582
0.0GlnXaa: 0.0 ± 0.0
Arg
3.08ArgAla: 3.08 ± 0.82
1.54ArgCys: 1.54 ± 1.427
2.567ArgAsp: 2.567 ± 1.093
4.107ArgGlu: 4.107 ± 0.678
2.053ArgPhe: 2.053 ± 0.881
3.593ArgGly: 3.593 ± 2.171
2.567ArgHis: 2.567 ± 1.173
4.107ArgIle: 4.107 ± 1.67
2.567ArgLys: 2.567 ± 0.808
5.133ArgLeu: 5.133 ± 2.283
4.107ArgMet: 4.107 ± 1.094
2.053ArgAsn: 2.053 ± 1.067
1.027ArgPro: 1.027 ± 0.592
2.567ArgGln: 2.567 ± 1.009
0.513ArgArg: 0.513 ± 0.499
1.54ArgSer: 1.54 ± 1.096
1.54ArgThr: 1.54 ± 1.496
2.567ArgVal: 2.567 ± 0.82
0.0ArgTrp: 0.0 ± 0.0
2.053ArgTyr: 2.053 ± 0.81
0.0ArgXaa: 0.0 ± 0.0
Ser
5.133SerAla: 5.133 ± 2.272
1.027SerCys: 1.027 ± 0.539
3.593SerAsp: 3.593 ± 0.712
4.107SerGlu: 4.107 ± 1.117
4.107SerPhe: 4.107 ± 0.946
5.647SerGly: 5.647 ± 1.88
2.053SerHis: 2.053 ± 0.897
2.567SerIle: 2.567 ± 1.173
6.674SerLys: 6.674 ± 1.76
7.187SerLeu: 7.187 ± 1.835
1.54SerMet: 1.54 ± 0.855
2.567SerAsn: 2.567 ± 1.074
5.133SerPro: 5.133 ± 1.789
3.593SerGln: 3.593 ± 1.702
5.133SerArg: 5.133 ± 2.271
6.16SerSer: 6.16 ± 1.467
2.567SerThr: 2.567 ± 1.118
2.567SerVal: 2.567 ± 1.182
0.0SerTrp: 0.0 ± 0.0
4.107SerTyr: 4.107 ± 0.927
0.0SerXaa: 0.0 ± 0.0
Thr
5.133ThrAla: 5.133 ± 1.376
1.027ThrCys: 1.027 ± 0.58
1.027ThrAsp: 1.027 ± 0.654
3.593ThrGlu: 3.593 ± 1.444
3.08ThrPhe: 3.08 ± 1.53
3.08ThrGly: 3.08 ± 1.115
1.027ThrHis: 1.027 ± 0.592
2.053ThrIle: 2.053 ± 1.088
1.54ThrLys: 1.54 ± 0.687
6.16ThrLeu: 6.16 ± 1.518
1.54ThrMet: 1.54 ± 0.78
2.053ThrAsn: 2.053 ± 0.967
3.593ThrPro: 3.593 ± 1.228
3.593ThrGln: 3.593 ± 1.647
1.54ThrArg: 1.54 ± 0.931
2.567ThrSer: 2.567 ± 0.569
3.08ThrThr: 3.08 ± 1.559
4.62ThrVal: 4.62 ± 1.324
0.513ThrTrp: 0.513 ± 0.582
1.027ThrTyr: 1.027 ± 0.706
0.0ThrXaa: 0.0 ± 0.0
Val
4.62ValAla: 4.62 ± 1.307
0.513ValCys: 0.513 ± 0.55
2.053ValAsp: 2.053 ± 0.843
3.593ValGlu: 3.593 ± 1.373
5.133ValPhe: 5.133 ± 1.543
5.647ValGly: 5.647 ± 1.855
1.027ValHis: 1.027 ± 0.592
4.107ValIle: 4.107 ± 2.534
3.593ValLys: 3.593 ± 1.461
8.214ValLeu: 8.214 ± 1.668
0.0ValMet: 0.0 ± 0.0
1.027ValAsn: 1.027 ± 0.632
4.107ValPro: 4.107 ± 1.107
1.54ValGln: 1.54 ± 0.891
1.54ValArg: 1.54 ± 0.602
5.647ValSer: 5.647 ± 1.551
4.107ValThr: 4.107 ± 1.455
3.08ValVal: 3.08 ± 1.007
1.027ValTrp: 1.027 ± 0.706
0.513ValTyr: 0.513 ± 0.476
0.0ValXaa: 0.0 ± 0.0
Trp
2.053TrpAla: 2.053 ± 1.148
0.0TrpCys: 0.0 ± 0.0
1.027TrpAsp: 1.027 ± 0.503
0.513TrpGlu: 0.513 ± 0.582
0.513TrpPhe: 0.513 ± 0.499
0.0TrpGly: 0.0 ± 0.0
0.513TrpHis: 0.513 ± 0.406
1.027TrpIle: 1.027 ± 0.742
1.027TrpLys: 1.027 ± 0.642
2.053TrpLeu: 2.053 ± 1.167
0.0TrpMet: 0.0 ± 0.0
1.027TrpAsn: 1.027 ± 0.772
1.027TrpPro: 1.027 ± 0.503
0.0TrpGln: 0.0 ± 0.0
1.54TrpArg: 1.54 ± 0.959
1.027TrpSer: 1.027 ± 0.539
0.0TrpThr: 0.0 ± 0.0
1.027TrpVal: 1.027 ± 0.642
0.513TrpTrp: 0.513 ± 0.499
0.513TrpTyr: 0.513 ± 0.499
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.567TyrAla: 2.567 ± 1.04
1.027TyrCys: 1.027 ± 0.951
1.54TyrAsp: 1.54 ± 0.8
1.027TyrGlu: 1.027 ± 0.628
2.053TyrPhe: 2.053 ± 0.837
3.08TyrGly: 3.08 ± 0.797
0.513TyrHis: 0.513 ± 0.584
1.027TyrIle: 1.027 ± 0.632
3.08TyrLys: 3.08 ± 1.088
3.08TyrLeu: 3.08 ± 0.765
0.513TyrMet: 0.513 ± 0.499
1.027TyrAsn: 1.027 ± 0.539
1.027TyrPro: 1.027 ± 0.71
1.54TyrGln: 1.54 ± 1.091
4.107TyrArg: 4.107 ± 1.884
5.133TyrSer: 5.133 ± 1.267
1.027TyrThr: 1.027 ± 0.706
1.54TyrVal: 1.54 ± 1.035
0.513TyrTrp: 0.513 ± 0.499
1.027TyrTyr: 1.027 ± 0.998
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (1949 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski