Amino acid dipepetide frequency for Banna-like virus strain Balaton/2010/HUN

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.488AlaAla: 6.488 ± 1.768
0.877AlaCys: 0.877 ± 0.441
5.611AlaAsp: 5.611 ± 0.858
3.507AlaGlu: 3.507 ± 1.143
2.806AlaPhe: 2.806 ± 0.546
4.208AlaGly: 4.208 ± 0.899
1.929AlaHis: 1.929 ± 0.524
4.384AlaIle: 4.384 ± 0.962
2.981AlaLys: 2.981 ± 0.723
7.014AlaLeu: 7.014 ± 0.945
3.332AlaMet: 3.332 ± 0.85
4.384AlaAsn: 4.384 ± 0.629
4.208AlaPro: 4.208 ± 0.719
3.156AlaGln: 3.156 ± 1.151
4.559AlaArg: 4.559 ± 0.682
5.085AlaSer: 5.085 ± 0.559
6.312AlaThr: 6.312 ± 0.923
3.507AlaVal: 3.507 ± 0.481
0.175AlaTrp: 0.175 ± 0.172
2.28AlaTyr: 2.28 ± 0.756
0.0AlaXaa: 0.0 ± 0.0
Cys
1.227CysAla: 1.227 ± 0.429
0.351CysCys: 0.351 ± 0.297
0.175CysAsp: 0.175 ± 0.149
1.578CysGlu: 1.578 ± 0.497
0.526CysPhe: 0.526 ± 0.307
0.526CysGly: 0.526 ± 0.269
0.0CysHis: 0.0 ± 0.0
0.701CysIle: 0.701 ± 0.368
0.526CysLys: 0.526 ± 0.31
1.052CysLeu: 1.052 ± 0.278
0.701CysMet: 0.701 ± 0.289
1.052CysAsn: 1.052 ± 0.445
0.351CysPro: 0.351 ± 0.21
0.175CysGln: 0.175 ± 0.165
0.701CysArg: 0.701 ± 0.43
0.701CysSer: 0.701 ± 0.27
0.526CysThr: 0.526 ± 0.343
0.701CysVal: 0.701 ± 0.342
0.175CysTrp: 0.175 ± 0.149
0.175CysTyr: 0.175 ± 0.189
0.0CysXaa: 0.0 ± 0.0
Asp
3.682AspAla: 3.682 ± 0.866
0.701AspCys: 0.701 ± 0.446
5.26AspAsp: 5.26 ± 0.991
5.26AspGlu: 5.26 ± 0.55
2.63AspPhe: 2.63 ± 0.471
4.033AspGly: 4.033 ± 0.763
1.403AspHis: 1.403 ± 0.427
5.436AspIle: 5.436 ± 0.525
2.981AspLys: 2.981 ± 0.877
3.507AspLeu: 3.507 ± 0.389
1.578AspMet: 1.578 ± 0.32
2.63AspAsn: 2.63 ± 0.788
2.455AspPro: 2.455 ± 0.62
1.403AspGln: 1.403 ± 0.61
3.332AspArg: 3.332 ± 0.752
4.384AspSer: 4.384 ± 0.757
1.929AspThr: 1.929 ± 0.533
5.26AspVal: 5.26 ± 0.822
0.351AspTrp: 0.351 ± 0.218
3.682AspTyr: 3.682 ± 0.903
0.0AspXaa: 0.0 ± 0.0
Glu
3.332GluAla: 3.332 ± 0.968
1.052GluCys: 1.052 ± 0.469
1.753GluAsp: 1.753 ± 0.655
1.403GluGlu: 1.403 ± 0.344
1.227GluPhe: 1.227 ± 0.362
2.28GluGly: 2.28 ± 0.839
1.929GluHis: 1.929 ± 0.598
3.332GluIle: 3.332 ± 0.667
1.753GluLys: 1.753 ± 0.675
6.312GluLeu: 6.312 ± 0.86
1.052GluMet: 1.052 ± 0.456
1.753GluAsn: 1.753 ± 0.521
2.28GluPro: 2.28 ± 0.553
1.929GluGln: 1.929 ± 0.419
3.682GluArg: 3.682 ± 1.102
4.033GluSer: 4.033 ± 0.394
2.28GluThr: 2.28 ± 0.565
3.682GluVal: 3.682 ± 0.917
0.175GluTrp: 0.175 ± 0.175
2.63GluTyr: 2.63 ± 0.598
0.0GluXaa: 0.0 ± 0.0
Phe
2.455PheAla: 2.455 ± 0.661
0.526PheCys: 0.526 ± 0.218
2.455PheAsp: 2.455 ± 0.497
2.104PheGlu: 2.104 ± 0.536
1.578PhePhe: 1.578 ± 0.504
2.981PheGly: 2.981 ± 0.394
0.701PheHis: 0.701 ± 0.459
1.929PheIle: 1.929 ± 0.505
2.104PheLys: 2.104 ± 0.433
3.507PheLeu: 3.507 ± 0.438
0.526PheMet: 0.526 ± 0.372
2.981PheAsn: 2.981 ± 0.547
1.052PhePro: 1.052 ± 0.303
1.403PheGln: 1.403 ± 0.645
1.929PheArg: 1.929 ± 0.417
2.455PheSer: 2.455 ± 0.719
2.455PheThr: 2.455 ± 0.521
2.63PheVal: 2.63 ± 0.692
0.175PheTrp: 0.175 ± 0.175
0.351PheTyr: 0.351 ± 0.182
0.0PheXaa: 0.0 ± 0.0
Gly
4.033GlyAla: 4.033 ± 0.932
0.526GlyCys: 0.526 ± 0.296
2.28GlyAsp: 2.28 ± 0.627
2.28GlyGlu: 2.28 ± 0.414
1.403GlyPhe: 1.403 ± 0.465
2.806GlyGly: 2.806 ± 0.468
0.701GlyHis: 0.701 ± 0.253
3.507GlyIle: 3.507 ± 0.48
1.929GlyLys: 1.929 ± 0.67
6.312GlyLeu: 6.312 ± 0.801
0.526GlyMet: 0.526 ± 0.29
2.63GlyAsn: 2.63 ± 0.574
2.104GlyPro: 2.104 ± 0.724
1.929GlyGln: 1.929 ± 0.591
2.806GlyArg: 2.806 ± 0.661
6.488GlySer: 6.488 ± 0.661
4.384GlyThr: 4.384 ± 1.448
5.436GlyVal: 5.436 ± 0.94
0.701GlyTrp: 0.701 ± 0.299
2.981GlyTyr: 2.981 ± 0.638
0.0GlyXaa: 0.0 ± 0.0
His
2.455HisAla: 2.455 ± 0.604
0.701HisCys: 0.701 ± 0.221
1.578HisAsp: 1.578 ± 0.505
1.403HisGlu: 1.403 ± 0.452
1.753HisPhe: 1.753 ± 0.439
1.227HisGly: 1.227 ± 0.322
0.351HisHis: 0.351 ± 0.298
1.753HisIle: 1.753 ± 0.904
1.227HisLys: 1.227 ± 0.631
1.578HisLeu: 1.578 ± 0.51
0.351HisMet: 0.351 ± 0.252
1.052HisAsn: 1.052 ± 0.589
0.877HisPro: 0.877 ± 0.53
0.526HisGln: 0.526 ± 0.39
0.877HisArg: 0.877 ± 0.408
3.156HisSer: 3.156 ± 0.742
0.701HisThr: 0.701 ± 0.352
1.403HisVal: 1.403 ± 0.553
0.0HisTrp: 0.0 ± 0.0
1.578HisTyr: 1.578 ± 0.343
0.0HisXaa: 0.0 ± 0.0
Ile
4.384IleAla: 4.384 ± 1.237
0.526IleCys: 0.526 ± 0.211
5.085IleAsp: 5.085 ± 1.307
2.455IleGlu: 2.455 ± 0.617
2.104IlePhe: 2.104 ± 0.348
4.559IleGly: 4.559 ± 1.107
1.403IleHis: 1.403 ± 0.455
6.312IleIle: 6.312 ± 0.719
3.507IleLys: 3.507 ± 0.815
3.682IleLeu: 3.682 ± 0.81
1.052IleMet: 1.052 ± 0.515
4.559IleAsn: 4.559 ± 0.405
4.384IlePro: 4.384 ± 0.911
1.929IleGln: 1.929 ± 0.54
3.507IleArg: 3.507 ± 0.709
6.137IleSer: 6.137 ± 0.718
5.436IleThr: 5.436 ± 0.887
3.682IleVal: 3.682 ± 0.739
0.351IleTrp: 0.351 ± 0.19
1.929IleTyr: 1.929 ± 0.568
0.0IleXaa: 0.0 ± 0.0
Lys
1.753LysAla: 1.753 ± 0.73
0.526LysCys: 0.526 ± 0.415
2.104LysAsp: 2.104 ± 0.671
1.929LysGlu: 1.929 ± 0.377
0.526LysPhe: 0.526 ± 0.203
2.28LysGly: 2.28 ± 0.63
2.455LysHis: 2.455 ± 0.748
2.63LysIle: 2.63 ± 0.684
2.455LysLys: 2.455 ± 0.573
5.085LysLeu: 5.085 ± 0.565
1.227LysMet: 1.227 ± 0.277
3.156LysAsn: 3.156 ± 0.873
2.455LysPro: 2.455 ± 0.567
1.578LysGln: 1.578 ± 0.506
2.981LysArg: 2.981 ± 0.375
3.332LysSer: 3.332 ± 0.722
3.858LysThr: 3.858 ± 0.909
2.63LysVal: 2.63 ± 0.534
0.0LysTrp: 0.0 ± 0.0
1.929LysTyr: 1.929 ± 0.393
0.0LysXaa: 0.0 ± 0.0
Leu
7.365LeuAla: 7.365 ± 1.089
0.0LeuCys: 0.0 ± 0.0
5.26LeuAsp: 5.26 ± 0.773
3.156LeuGlu: 3.156 ± 0.662
3.156LeuPhe: 3.156 ± 0.549
4.559LeuGly: 4.559 ± 1.004
1.578LeuHis: 1.578 ± 0.552
6.137LeuIle: 6.137 ± 1.291
5.611LeuLys: 5.611 ± 1.335
9.118LeuLeu: 9.118 ± 1.267
2.455LeuMet: 2.455 ± 0.453
5.085LeuAsn: 5.085 ± 1.009
4.559LeuPro: 4.559 ± 1.076
3.156LeuGln: 3.156 ± 0.523
5.611LeuArg: 5.611 ± 0.945
6.488LeuSer: 6.488 ± 0.995
8.241LeuThr: 8.241 ± 1.301
7.715LeuVal: 7.715 ± 0.758
0.526LeuTrp: 0.526 ± 0.243
3.332LeuTyr: 3.332 ± 0.869
0.0LeuXaa: 0.0 ± 0.0
Met
2.455MetAla: 2.455 ± 0.498
0.0MetCys: 0.0 ± 0.0
2.455MetAsp: 2.455 ± 0.524
0.877MetGlu: 0.877 ± 0.425
1.227MetPhe: 1.227 ± 0.267
0.526MetGly: 0.526 ± 0.325
1.403MetHis: 1.403 ± 0.66
1.403MetIle: 1.403 ± 0.55
1.052MetLys: 1.052 ± 0.226
2.806MetLeu: 2.806 ± 0.414
0.526MetMet: 0.526 ± 0.315
1.578MetAsn: 1.578 ± 0.477
1.753MetPro: 1.753 ± 0.366
0.877MetGln: 0.877 ± 0.468
1.227MetArg: 1.227 ± 0.492
1.052MetSer: 1.052 ± 0.46
3.682MetThr: 3.682 ± 0.845
1.929MetVal: 1.929 ± 0.46
0.175MetTrp: 0.175 ± 0.149
0.701MetTyr: 0.701 ± 0.425
0.0MetXaa: 0.0 ± 0.0
Asn
2.806AsnAla: 2.806 ± 0.95
0.526AsnCys: 0.526 ± 0.316
3.156AsnAsp: 3.156 ± 0.656
2.455AsnGlu: 2.455 ± 0.554
2.28AsnPhe: 2.28 ± 0.646
4.208AsnGly: 4.208 ± 0.492
1.403AsnHis: 1.403 ± 0.256
4.734AsnIle: 4.734 ± 1.032
2.63AsnLys: 2.63 ± 0.797
5.26AsnLeu: 5.26 ± 0.708
1.929AsnMet: 1.929 ± 0.567
2.63AsnAsn: 2.63 ± 0.715
3.682AsnPro: 3.682 ± 1.062
1.052AsnGln: 1.052 ± 0.367
2.806AsnArg: 2.806 ± 0.358
3.507AsnSer: 3.507 ± 0.667
2.63AsnThr: 2.63 ± 0.891
4.91AsnVal: 4.91 ± 0.772
0.877AsnTrp: 0.877 ± 0.392
1.929AsnTyr: 1.929 ± 0.393
0.0AsnXaa: 0.0 ± 0.0
Pro
4.734ProAla: 4.734 ± 0.593
0.701ProCys: 0.701 ± 0.473
2.63ProAsp: 2.63 ± 0.607
1.753ProGlu: 1.753 ± 0.618
1.929ProPhe: 1.929 ± 0.457
2.63ProGly: 2.63 ± 0.647
1.227ProHis: 1.227 ± 0.549
2.104ProIle: 2.104 ± 0.714
1.227ProLys: 1.227 ± 0.579
4.208ProLeu: 4.208 ± 0.638
1.929ProMet: 1.929 ± 0.738
1.929ProAsn: 1.929 ± 0.675
1.403ProPro: 1.403 ± 0.474
1.052ProGln: 1.052 ± 0.47
3.156ProArg: 3.156 ± 0.776
2.63ProSer: 2.63 ± 0.531
3.507ProThr: 3.507 ± 0.779
3.858ProVal: 3.858 ± 1.247
0.351ProTrp: 0.351 ± 0.345
1.227ProTyr: 1.227 ± 0.828
0.0ProXaa: 0.0 ± 0.0
Gln
3.332GlnAla: 3.332 ± 1.08
0.351GlnCys: 0.351 ± 0.233
0.701GlnAsp: 0.701 ± 0.367
1.227GlnGlu: 1.227 ± 0.641
2.104GlnPhe: 2.104 ± 0.449
2.63GlnGly: 2.63 ± 0.678
0.351GlnHis: 0.351 ± 0.19
1.753GlnIle: 1.753 ± 0.784
0.877GlnLys: 0.877 ± 0.377
3.507GlnLeu: 3.507 ± 0.894
1.227GlnMet: 1.227 ± 0.518
1.578GlnAsn: 1.578 ± 0.493
1.227GlnPro: 1.227 ± 0.447
1.403GlnGln: 1.403 ± 0.558
1.403GlnArg: 1.403 ± 0.41
4.033GlnSer: 4.033 ± 1.091
1.578GlnThr: 1.578 ± 0.607
2.63GlnVal: 2.63 ± 0.823
0.701GlnTrp: 0.701 ± 0.29
1.227GlnTyr: 1.227 ± 0.344
0.0GlnXaa: 0.0 ± 0.0
Arg
7.365ArgAla: 7.365 ± 0.937
0.526ArgCys: 0.526 ± 0.296
3.156ArgAsp: 3.156 ± 0.692
2.806ArgGlu: 2.806 ± 0.834
2.28ArgPhe: 2.28 ± 0.486
2.104ArgGly: 2.104 ± 0.477
1.578ArgHis: 1.578 ± 0.622
3.858ArgIle: 3.858 ± 0.599
2.28ArgLys: 2.28 ± 0.952
6.488ArgLeu: 6.488 ± 0.86
1.403ArgMet: 1.403 ± 0.491
4.033ArgAsn: 4.033 ± 0.838
1.403ArgPro: 1.403 ± 0.452
1.753ArgGln: 1.753 ± 0.503
2.28ArgArg: 2.28 ± 0.613
4.91ArgSer: 4.91 ± 0.733
3.156ArgThr: 3.156 ± 0.453
2.981ArgVal: 2.981 ± 0.753
0.351ArgTrp: 0.351 ± 0.232
2.806ArgTyr: 2.806 ± 0.685
0.0ArgXaa: 0.0 ± 0.0
Ser
5.436SerAla: 5.436 ± 1.053
0.877SerCys: 0.877 ± 0.48
4.384SerAsp: 4.384 ± 0.676
4.208SerGlu: 4.208 ± 0.728
3.156SerPhe: 3.156 ± 0.92
4.559SerGly: 4.559 ± 0.703
1.929SerHis: 1.929 ± 0.554
5.085SerIle: 5.085 ± 0.922
2.104SerLys: 2.104 ± 0.677
7.014SerLeu: 7.014 ± 1.335
2.104SerMet: 2.104 ± 0.523
3.682SerAsn: 3.682 ± 0.692
3.682SerPro: 3.682 ± 0.471
4.033SerGln: 4.033 ± 0.749
5.085SerArg: 5.085 ± 0.742
5.436SerSer: 5.436 ± 0.886
4.384SerThr: 4.384 ± 0.779
4.91SerVal: 4.91 ± 1.019
1.052SerTrp: 1.052 ± 0.29
2.981SerTyr: 2.981 ± 0.567
0.0SerXaa: 0.0 ± 0.0
Thr
5.786ThrAla: 5.786 ± 1.212
0.351ThrCys: 0.351 ± 0.221
5.085ThrAsp: 5.085 ± 1.114
2.806ThrGlu: 2.806 ± 0.728
1.929ThrPhe: 1.929 ± 0.496
4.033ThrGly: 4.033 ± 0.625
1.403ThrHis: 1.403 ± 0.624
4.033ThrIle: 4.033 ± 0.96
4.033ThrLys: 4.033 ± 0.972
7.014ThrLeu: 7.014 ± 0.823
1.753ThrMet: 1.753 ± 0.392
3.332ThrAsn: 3.332 ± 0.971
2.104ThrPro: 2.104 ± 0.778
3.156ThrGln: 3.156 ± 0.648
3.858ThrArg: 3.858 ± 0.637
5.436ThrSer: 5.436 ± 1.096
6.663ThrThr: 6.663 ± 1.397
5.085ThrVal: 5.085 ± 0.616
0.0ThrTrp: 0.0 ± 0.0
2.63ThrTyr: 2.63 ± 0.606
0.0ThrXaa: 0.0 ± 0.0
Val
4.033ValAla: 4.033 ± 1.243
1.929ValCys: 1.929 ± 0.803
6.312ValAsp: 6.312 ± 0.613
4.559ValGlu: 4.559 ± 0.527
2.28ValPhe: 2.28 ± 0.56
3.507ValGly: 3.507 ± 0.937
1.227ValHis: 1.227 ± 0.549
5.085ValIle: 5.085 ± 0.776
3.156ValLys: 3.156 ± 0.754
3.682ValLeu: 3.682 ± 0.588
2.455ValMet: 2.455 ± 0.72
5.962ValAsn: 5.962 ± 1.193
2.455ValPro: 2.455 ± 0.623
1.929ValGln: 1.929 ± 0.537
4.384ValArg: 4.384 ± 0.707
3.682ValSer: 3.682 ± 0.97
5.962ValThr: 5.962 ± 1.059
4.384ValVal: 4.384 ± 0.936
0.351ValTrp: 0.351 ± 0.224
2.28ValTyr: 2.28 ± 1.015
0.0ValXaa: 0.0 ± 0.0
Trp
0.526TrpAla: 0.526 ± 0.244
0.0TrpCys: 0.0 ± 0.0
0.526TrpAsp: 0.526 ± 0.286
0.526TrpGlu: 0.526 ± 0.216
0.175TrpPhe: 0.175 ± 0.172
0.175TrpGly: 0.175 ± 0.149
0.175TrpHis: 0.175 ± 0.175
0.175TrpIle: 0.175 ± 0.149
0.351TrpLys: 0.351 ± 0.233
1.052TrpLeu: 1.052 ± 0.372
0.175TrpMet: 0.175 ± 0.188
0.175TrpAsn: 0.175 ± 0.172
0.0TrpPro: 0.0 ± 0.0
0.351TrpGln: 0.351 ± 0.201
0.175TrpArg: 0.175 ± 0.165
1.052TrpSer: 1.052 ± 0.492
0.526TrpThr: 0.526 ± 0.351
0.351TrpVal: 0.351 ± 0.213
0.0TrpTrp: 0.0 ± 0.0
0.175TrpTyr: 0.175 ± 0.189
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.156TyrAla: 3.156 ± 0.549
0.877TyrCys: 0.877 ± 0.305
1.929TyrAsp: 1.929 ± 0.454
1.578TyrGlu: 1.578 ± 0.482
1.227TyrPhe: 1.227 ± 0.403
1.929TyrGly: 1.929 ± 0.459
1.403TyrHis: 1.403 ± 0.56
2.63TyrIle: 2.63 ± 0.85
2.104TyrLys: 2.104 ± 0.7
4.91TyrLeu: 4.91 ± 1.148
1.227TyrMet: 1.227 ± 0.378
1.227TyrAsn: 1.227 ± 0.464
1.753TyrPro: 1.753 ± 0.465
1.052TyrGln: 1.052 ± 0.447
3.156TyrArg: 3.156 ± 0.49
2.28TyrSer: 2.28 ± 0.497
2.28TyrThr: 2.28 ± 0.575
1.929TyrVal: 1.929 ± 0.539
0.175TyrTrp: 0.175 ± 0.165
1.578TyrTyr: 1.578 ± 0.513
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (5704 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski