Amino acid dipepetide frequency for Pseudomonas caspiana

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.073AlaAla: 12.073 ± 0.128	1.101AlaCys: 1.101 ± 0.025	5.786AlaAsp: 5.786 ± 0.059	6.441AlaGlu: 6.441 ± 0.064	3.723AlaPhe: 3.723 ± 0.051	8.309AlaGly: 8.309 ± 0.08	2.075AlaHis: 2.075 ± 0.035	5.356AlaIle: 5.356 ± 0.051	4.011AlaLys: 4.011 ± 0.07	12.92AlaLeu: 12.92 ± 0.1	2.879AlaMet: 2.879 ± 0.049	3.101AlaAsn: 3.101 ± 0.045	4.441AlaPro: 4.441 ± 0.071	5.121AlaGln: 5.121 ± 0.068	6.305AlaArg: 6.305 ± 0.06	6.371AlaSer: 6.371 ± 0.061	4.964AlaThr: 4.964 ± 0.059	7.438AlaVal: 7.438 ± 0.077	1.45AlaTrp: 1.45 ± 0.032	2.449AlaTyr: 2.449 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.006CysAla: 1.006 ± 0.026	0.115CysCys: 0.115 ± 0.008	0.508CysAsp: 0.508 ± 0.016	0.513CysGlu: 0.513 ± 0.016	0.326CysPhe: 0.326 ± 0.015	0.883CysGly: 0.883 ± 0.028	0.246CysHis: 0.246 ± 0.011	0.456CysIle: 0.456 ± 0.016	0.299CysLys: 0.299 ± 0.016	1.047CysLeu: 1.047 ± 0.025	0.207CysMet: 0.207 ± 0.012	0.273CysAsn: 0.273 ± 0.013	0.445CysPro: 0.445 ± 0.015	0.336CysGln: 0.336 ± 0.014	0.577CysArg: 0.577 ± 0.019	0.604CysSer: 0.604 ± 0.018	0.457CysThr: 0.457 ± 0.015	0.694CysVal: 0.694 ± 0.018	0.15CysTrp: 0.15 ± 0.01	0.229CysTyr: 0.229 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	5.674AspAla: 5.674 ± 0.066	0.519AspCys: 0.519 ± 0.018	2.848AspAsp: 2.848 ± 0.048	3.479AspGlu: 3.479 ± 0.053	2.177AspPhe: 2.177 ± 0.041	4.248AspGly: 4.248 ± 0.058	1.108AspHis: 1.108 ± 0.026	2.819AspIle: 2.819 ± 0.037	2.112AspLys: 2.112 ± 0.044	5.983AspLeu: 5.983 ± 0.065	1.298AspMet: 1.298 ± 0.026	1.67AspAsn: 1.67 ± 0.031	2.784AspPro: 2.784 ± 0.042	2.236AspGln: 2.236 ± 0.041	3.029AspArg: 3.029 ± 0.052	3.097AspSer: 3.097 ± 0.05	2.49AspThr: 2.49 ± 0.046	3.835AspVal: 3.835 ± 0.05	0.945AspTrp: 0.945 ± 0.023	1.755AspTyr: 1.755 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	5.911GluAla: 5.911 ± 0.067	0.418GluCys: 0.418 ± 0.017	2.534GluAsp: 2.534 ± 0.049	3.147GluGlu: 3.147 ± 0.057	1.917GluPhe: 1.917 ± 0.034	3.858GluGly: 3.858 ± 0.052	1.654GluHis: 1.654 ± 0.035	2.898GluIle: 2.898 ± 0.049	2.356GluLys: 2.356 ± 0.045	6.896GluLeu: 6.896 ± 0.079	1.39GluMet: 1.39 ± 0.03	1.747GluAsn: 1.747 ± 0.031	2.532GluPro: 2.532 ± 0.045	3.587GluGln: 3.587 ± 0.057	4.362GluArg: 4.362 ± 0.064	2.992GluSer: 2.992 ± 0.044	2.676GluThr: 2.676 ± 0.042	4.12GluVal: 4.12 ± 0.056	0.74GluTrp: 0.74 ± 0.022	1.282GluTyr: 1.282 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.007PheAla: 4.007 ± 0.046	0.433PheCys: 0.433 ± 0.016	2.454PheAsp: 2.454 ± 0.038	2.148PheGlu: 2.148 ± 0.037	1.489PhePhe: 1.489 ± 0.036	3.246PheGly: 3.246 ± 0.05	0.718PheHis: 0.718 ± 0.02	1.975PheIle: 1.975 ± 0.036	1.425PheLys: 1.425 ± 0.029	3.289PheLeu: 3.289 ± 0.046	0.915PheMet: 0.915 ± 0.028	1.469PheAsn: 1.469 ± 0.034	1.523PhePro: 1.523 ± 0.03	1.241PheGln: 1.241 ± 0.026	1.762PheArg: 1.762 ± 0.035	2.75PheSer: 2.75 ± 0.037	2.014PheThr: 2.014 ± 0.033	2.566PheVal: 2.566 ± 0.04	0.572PheTrp: 0.572 ± 0.02	1.069PheTyr: 1.069 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	6.91GlyAla: 6.91 ± 0.071	0.883GlyCys: 0.883 ± 0.025	3.868GlyAsp: 3.868 ± 0.048	4.511GlyGlu: 4.511 ± 0.052	3.418GlyPhe: 3.418 ± 0.052	5.759GlyGly: 5.759 ± 0.068	1.726GlyHis: 1.726 ± 0.035	4.216GlyIle: 4.216 ± 0.055	3.62GlyLys: 3.62 ± 0.043	8.952GlyLeu: 8.952 ± 0.084	2.263GlyMet: 2.263 ± 0.044	2.423GlyAsn: 2.423 ± 0.046	2.569GlyPro: 2.569 ± 0.036	3.4GlyGln: 3.4 ± 0.045	4.57GlyArg: 4.57 ± 0.049	4.728GlySer: 4.728 ± 0.07	3.84GlyThr: 3.84 ± 0.058	5.956GlyVal: 5.956 ± 0.065	1.328GlyTrp: 1.328 ± 0.029	2.465GlyTyr: 2.465 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.112HisAla: 2.112 ± 0.033	0.295HisCys: 0.295 ± 0.015	1.216HisAsp: 1.216 ± 0.026	1.222HisGlu: 1.222 ± 0.028	0.949HisPhe: 0.949 ± 0.023	1.811HisGly: 1.811 ± 0.035	0.593HisHis: 0.593 ± 0.022	1.008HisIle: 1.008 ± 0.027	0.7HisLys: 0.7 ± 0.023	2.465HisLeu: 2.465 ± 0.042	0.535HisMet: 0.535 ± 0.018	0.616HisAsn: 0.616 ± 0.018	1.352HisPro: 1.352 ± 0.03	0.91HisGln: 0.91 ± 0.023	1.278HisArg: 1.278 ± 0.028	1.284HisSer: 1.284 ± 0.024	0.989HisThr: 0.989 ± 0.021	1.375HisVal: 1.375 ± 0.031	0.426HisTrp: 0.426 ± 0.017	0.694HisTyr: 0.694 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.209IleAla: 6.209 ± 0.068	0.555IleCys: 0.555 ± 0.019	3.452IleAsp: 3.452 ± 0.043	3.487IleGlu: 3.487 ± 0.047	1.591IlePhe: 1.591 ± 0.031	4.653IleGly: 4.653 ± 0.062	0.989IleHis: 0.989 ± 0.023	2.349IleIle: 2.349 ± 0.044	2.014IleLys: 2.014 ± 0.039	4.391IleLeu: 4.391 ± 0.05	0.896IleMet: 0.896 ± 0.023	2.037IleAsn: 2.037 ± 0.043	2.389IlePro: 2.389 ± 0.035	1.768IleGln: 1.768 ± 0.037	2.881IleArg: 2.881 ± 0.04	3.434IleSer: 3.434 ± 0.045	2.789IleThr: 2.789 ± 0.043	3.483IleVal: 3.483 ± 0.046	0.565IleTrp: 0.565 ± 0.018	1.21IleTyr: 1.21 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	4.282LysAla: 4.282 ± 0.067	0.198LysCys: 0.198 ± 0.011	1.966LysAsp: 1.966 ± 0.039	1.901LysGlu: 1.901 ± 0.04	1.004LysPhe: 1.004 ± 0.025	2.812LysGly: 2.812 ± 0.047	0.828LysHis: 0.828 ± 0.022	1.905LysIle: 1.905 ± 0.038	1.534LysLys: 1.534 ± 0.041	4.049LysLeu: 4.049 ± 0.057	0.883LysMet: 0.883 ± 0.021	1.213LysAsn: 1.213 ± 0.027	2.267LysPro: 2.267 ± 0.041	1.648LysGln: 1.648 ± 0.032	2.481LysArg: 2.481 ± 0.038	2.19LysSer: 2.19 ± 0.037	2.164LysThr: 2.164 ± 0.039	3.031LysVal: 3.031 ± 0.058	0.424LysTrp: 0.424 ± 0.016	0.791LysTyr: 0.791 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.991LeuAla: 12.991 ± 0.111	1.136LeuCys: 1.136 ± 0.029	6.495LeuAsp: 6.495 ± 0.066	6.282LeuGlu: 6.282 ± 0.069	4.095LeuPhe: 4.095 ± 0.059	8.729LeuGly: 8.729 ± 0.082	2.36LeuHis: 2.36 ± 0.04	6.134LeuIle: 6.134 ± 0.072	4.576LeuLys: 4.576 ± 0.06	12.79LeuLeu: 12.79 ± 0.125	2.7LeuMet: 2.7 ± 0.043	3.959LeuAsn: 3.959 ± 0.055	6.049LeuPro: 6.049 ± 0.071	4.521LeuGln: 4.521 ± 0.062	6.923LeuArg: 6.923 ± 0.074	7.664LeuSer: 7.664 ± 0.06	5.956LeuThr: 5.956 ± 0.057	7.566LeuVal: 7.566 ± 0.069	1.306LeuTrp: 1.306 ± 0.029	2.477LeuTyr: 2.477 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	2.554MetAla: 2.554 ± 0.044	0.182MetCys: 0.182 ± 0.011	1.14MetAsp: 1.14 ± 0.027	1.028MetGlu: 1.028 ± 0.025	0.778MetPhe: 0.778 ± 0.021	1.772MetGly: 1.772 ± 0.032	0.487MetHis: 0.487 ± 0.016	1.33MetIle: 1.33 ± 0.035	0.969MetLys: 0.969 ± 0.026	2.775MetLeu: 2.775 ± 0.039	0.534MetMet: 0.534 ± 0.021	0.938MetAsn: 0.938 ± 0.023	1.35MetPro: 1.35 ± 0.03	1.066MetGln: 1.066 ± 0.024	1.553MetArg: 1.553 ± 0.03	1.902MetSer: 1.902 ± 0.033	1.627MetThr: 1.627 ± 0.031	1.634MetVal: 1.634 ± 0.032	0.184MetTrp: 0.184 ± 0.01	0.398MetTyr: 0.398 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.411AsnAla: 3.411 ± 0.051	0.29AsnCys: 0.29 ± 0.015	1.751AsnAsp: 1.751 ± 0.036	1.623AsnGlu: 1.623 ± 0.033	1.162AsnPhe: 1.162 ± 0.027	2.714AsnGly: 2.714 ± 0.042	0.653AsnHis: 0.653 ± 0.02	1.608AsnIle: 1.608 ± 0.033	1.087AsnLys: 1.087 ± 0.027	3.615AsnLeu: 3.615 ± 0.048	0.664AsnMet: 0.664 ± 0.021	1.106AsnAsn: 1.106 ± 0.029	2.083AsnPro: 2.083 ± 0.035	1.351AsnGln: 1.351 ± 0.033	1.916AsnArg: 1.916 ± 0.034	1.904AsnSer: 1.904 ± 0.038	1.664AsnThr: 1.664 ± 0.036	2.206AsnVal: 2.206 ± 0.047	0.52AsnTrp: 0.52 ± 0.019	0.861AsnTyr: 0.861 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.272ProAla: 5.272 ± 0.072	0.327ProCys: 0.327 ± 0.016	2.976ProAsp: 2.976 ± 0.047	3.358ProGlu: 3.358 ± 0.045	1.838ProPhe: 1.838 ± 0.031	3.81ProGly: 3.81 ± 0.049	1.051ProHis: 1.051 ± 0.023	2.15ProIle: 2.15 ± 0.039	1.763ProLys: 1.763 ± 0.031	5.415ProLeu: 5.415 ± 0.064	1.146ProMet: 1.146 ± 0.029	1.418ProAsn: 1.418 ± 0.027	1.822ProPro: 1.822 ± 0.037	2.144ProGln: 2.144 ± 0.042	2.336ProArg: 2.336 ± 0.045	2.687ProSer: 2.687 ± 0.045	2.314ProThr: 2.314 ± 0.034	3.908ProVal: 3.908 ± 0.05	0.691ProTrp: 0.691 ± 0.02	1.211ProTyr: 1.211 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	5.413GlnAla: 5.413 ± 0.065	0.311GlnCys: 0.311 ± 0.016	1.799GlnAsp: 1.799 ± 0.035	1.952GlnGlu: 1.952 ± 0.04	1.364GlnPhe: 1.364 ± 0.029	3.172GlnGly: 3.172 ± 0.043	1.091GlnHis: 1.091 ± 0.027	2.291GlnIle: 2.291 ± 0.038	1.42GlnLys: 1.42 ± 0.03	5.419GlnLeu: 5.419 ± 0.076	1.113GlnMet: 1.113 ± 0.028	1.24GlnAsn: 1.24 ± 0.03	2.291GlnPro: 2.291 ± 0.039	2.623GlnGln: 2.623 ± 0.057	3.39GlnArg: 3.39 ± 0.055	2.559GlnSer: 2.559 ± 0.043	2.224GlnThr: 2.224 ± 0.043	3.307GlnVal: 3.307 ± 0.046	0.679GlnTrp: 0.679 ± 0.02	1.002GlnTyr: 1.002 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	5.511ArgAla: 5.511 ± 0.058	0.541ArgCys: 0.541 ± 0.018	3.408ArgAsp: 3.408 ± 0.052	3.818ArgGlu: 3.818 ± 0.051	2.64ArgPhe: 2.64 ± 0.046	3.775ArgGly: 3.775 ± 0.048	1.504ArgHis: 1.504 ± 0.031	3.386ArgIle: 3.386 ± 0.043	2.152ArgLys: 2.152 ± 0.041	7.663ArgLeu: 7.663 ± 0.087	1.622ArgMet: 1.622 ± 0.034	2.048ArgAsn: 2.048 ± 0.033	2.621ArgPro: 2.621 ± 0.044	3.095ArgGln: 3.095 ± 0.055	3.844ArgArg: 3.844 ± 0.058	3.479ArgSer: 3.479 ± 0.042	2.771ArgThr: 2.771 ± 0.038	4.243ArgVal: 4.243 ± 0.052	0.999ArgTrp: 0.999 ± 0.023	1.978ArgTyr: 1.978 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.438SerAla: 6.438 ± 0.069	0.481SerCys: 0.481 ± 0.018	3.159SerAsp: 3.159 ± 0.042	3.279SerGlu: 3.279 ± 0.045	2.368SerPhe: 2.368 ± 0.035	5.468SerGly: 5.468 ± 0.055	1.383SerHis: 1.383 ± 0.027	3.215SerIle: 3.215 ± 0.041	2.182SerLys: 2.182 ± 0.041	7.19SerLeu: 7.19 ± 0.07	1.499SerMet: 1.499 ± 0.032	1.968SerAsn: 1.968 ± 0.042	2.781SerPro: 2.781 ± 0.041	2.597SerGln: 2.597 ± 0.04	3.738SerArg: 3.738 ± 0.043	3.947SerSer: 3.947 ± 0.06	3.203SerThr: 3.203 ± 0.05	4.489SerVal: 4.489 ± 0.047	0.869SerTrp: 0.869 ± 0.025	1.596SerTyr: 1.596 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.259ThrAla: 5.259 ± 0.057	0.427ThrCys: 0.427 ± 0.015	2.673ThrAsp: 2.673 ± 0.045	2.578ThrGlu: 2.578 ± 0.04	1.907ThrPhe: 1.907 ± 0.034	4.26ThrGly: 4.26 ± 0.047	1.129ThrHis: 1.129 ± 0.025	2.168ThrIle: 2.168 ± 0.035	1.375ThrLys: 1.375 ± 0.032	6.696ThrLeu: 6.696 ± 0.069	0.896ThrMet: 0.896 ± 0.025	1.376ThrAsn: 1.376 ± 0.034	3.169ThrPro: 3.169 ± 0.052	2.167ThrGln: 2.167 ± 0.039	3.116ThrArg: 3.116 ± 0.045	2.989ThrSer: 2.989 ± 0.051	2.611ThrThr: 2.611 ± 0.046	3.741ThrVal: 3.741 ± 0.049	0.721ThrTrp: 0.721 ± 0.021	1.32ThrTyr: 1.32 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	7.677ValAla: 7.677 ± 0.082	0.724ValCys: 0.724 ± 0.024	4.063ValAsp: 4.063 ± 0.049	4.402ValGlu: 4.402 ± 0.049	2.692ValPhe: 2.692 ± 0.04	5.204ValGly: 5.204 ± 0.06	1.361ValHis: 1.361 ± 0.027	4.116ValIle: 4.116 ± 0.056	2.591ValLys: 2.591 ± 0.042	8.015ValLeu: 8.015 ± 0.085	1.879ValMet: 1.879 ± 0.036	2.327ValAsn: 2.327 ± 0.038	3.228ValPro: 3.228 ± 0.045	2.742ValGln: 2.742 ± 0.04	4.121ValArg: 4.121 ± 0.052	4.739ValSer: 4.739 ± 0.051	3.905ValThr: 3.905 ± 0.058	5.504ValVal: 5.504 ± 0.06	0.898ValTrp: 0.898 ± 0.024	1.592ValTyr: 1.592 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.118TrpAla: 1.118 ± 0.028	0.152TrpCys: 0.152 ± 0.008	0.63TrpAsp: 0.63 ± 0.017	0.559TrpGlu: 0.559 ± 0.018	0.582TrpPhe: 0.582 ± 0.021	0.883TrpGly: 0.883 ± 0.026	0.367TrpHis: 0.367 ± 0.014	0.702TrpIle: 0.702 ± 0.02	0.508TrpLys: 0.508 ± 0.017	2.137TrpLeu: 2.137 ± 0.044	0.394TrpMet: 0.394 ± 0.015	0.482TrpAsn: 0.482 ± 0.017	0.636TrpPro: 0.636 ± 0.023	0.886TrpGln: 0.886 ± 0.024	1.019TrpArg: 1.019 ± 0.025	0.848TrpSer: 0.848 ± 0.022	0.656TrpThr: 0.656 ± 0.021	0.964TrpVal: 0.964 ± 0.026	0.223TrpTrp: 0.223 ± 0.013	0.33TrpTyr: 0.33 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.487TyrAla: 2.487 ± 0.038	0.284TyrCys: 0.284 ± 0.013	1.38TyrAsp: 1.38 ± 0.031	1.287TyrGlu: 1.287 ± 0.029	1.047TyrPhe: 1.047 ± 0.025	2.036TyrGly: 2.036 ± 0.041	0.508TyrHis: 0.508 ± 0.017	1.059TyrIle: 1.059 ± 0.025	0.876TyrLys: 0.876 ± 0.027	3.002TyrLeu: 3.002 ± 0.044	0.486TyrMet: 0.486 ± 0.019	0.777TyrAsn: 0.777 ± 0.023	1.306TyrPro: 1.306 ± 0.033	1.224TyrGln: 1.224 ± 0.031	1.898TyrArg: 1.898 ± 0.035	1.684TyrSer: 1.684 ± 0.032	1.266TyrThr: 1.266 ± 0.028	1.718TyrVal: 1.718 ± 0.033	0.383TyrTrp: 0.383 ± 0.015	0.691TyrTyr: 0.691 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5280 proteins (1716129 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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