Amino acid dipepetide frequency for Flavobacteriaceae bacterium MAR_2010_188

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.236AlaAla: 4.236 ± 0.102	0.589AlaCys: 0.589 ± 0.06	3.682AlaAsp: 3.682 ± 0.095	4.14AlaGlu: 4.14 ± 0.061	3.04AlaPhe: 3.04 ± 0.06	4.167AlaGly: 4.167 ± 0.073	1.016AlaHis: 1.016 ± 0.031	5.21AlaIle: 5.21 ± 0.085	4.325AlaLys: 4.325 ± 0.076	5.771AlaLeu: 5.771 ± 0.078	1.56AlaMet: 1.56 ± 0.044	3.392AlaAsn: 3.392 ± 0.064	1.822AlaPro: 1.822 ± 0.08	2.212AlaGln: 2.212 ± 0.049	2.017AlaArg: 2.017 ± 0.043	4.13AlaSer: 4.13 ± 0.127	3.706AlaThr: 3.706 ± 0.155	3.924AlaVal: 3.924 ± 0.081	0.574AlaTrp: 0.574 ± 0.035	2.282AlaTyr: 2.282 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.457CysAla: 0.457 ± 0.023	0.1CysCys: 0.1 ± 0.011	0.535CysAsp: 0.535 ± 0.069	0.493CysGlu: 0.493 ± 0.024	0.391CysPhe: 0.391 ± 0.019	0.686CysGly: 0.686 ± 0.06	0.148CysHis: 0.148 ± 0.013	0.605CysIle: 0.605 ± 0.024	0.458CysLys: 0.458 ± 0.022	0.637CysLeu: 0.637 ± 0.024	0.141CysMet: 0.141 ± 0.012	0.405CysAsn: 0.405 ± 0.024	0.325CysPro: 0.325 ± 0.024	0.2CysGln: 0.2 ± 0.013	0.21CysArg: 0.21 ± 0.013	0.622CysSer: 0.622 ± 0.043	0.4CysThr: 0.4 ± 0.03	0.397CysVal: 0.397 ± 0.019	0.062CysTrp: 0.062 ± 0.007	0.279CysTyr: 0.279 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.824AspAla: 3.824 ± 0.092	0.519AspCys: 0.519 ± 0.067	3.472AspAsp: 3.472 ± 0.083	4.286AspGlu: 4.286 ± 0.069	3.856AspPhe: 3.856 ± 0.068	4.269AspGly: 4.269 ± 0.127	0.909AspHis: 0.909 ± 0.031	4.712AspIle: 4.712 ± 0.065	4.334AspLys: 4.334 ± 0.072	5.457AspLeu: 5.457 ± 0.079	1.307AspMet: 1.307 ± 0.037	3.446AspAsn: 3.446 ± 0.07	1.851AspPro: 1.851 ± 0.059	1.752AspGln: 1.752 ± 0.043	2.039AspArg: 2.039 ± 0.046	4.078AspSer: 4.078 ± 0.082	2.716AspThr: 2.716 ± 0.063	3.755AspVal: 3.755 ± 0.069	0.743AspTrp: 0.743 ± 0.031	3.214AspTyr: 3.214 ± 0.067	0.0AspXaa: 0.0 ± 0.0
Glu	4.27GluAla: 4.27 ± 0.078	0.407GluCys: 0.407 ± 0.056	4.099GluAsp: 4.099 ± 0.069	5.08GluGlu: 5.08 ± 0.09	3.222GluPhe: 3.222 ± 0.056	3.716GluGly: 3.716 ± 0.067	1.121GluHis: 1.121 ± 0.033	5.891GluIle: 5.891 ± 0.092	5.642GluLys: 5.642 ± 0.093	6.078GluLeu: 6.078 ± 0.095	1.672GluMet: 1.672 ± 0.042	4.85GluAsn: 4.85 ± 0.079	1.682GluPro: 1.682 ± 0.042	2.202GluGln: 2.202 ± 0.049	2.698GluArg: 2.698 ± 0.062	3.815GluSer: 3.815 ± 0.066	3.706GluThr: 3.706 ± 0.068	4.237GluVal: 4.237 ± 0.073	0.631GluTrp: 0.631 ± 0.027	2.489GluTyr: 2.489 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	2.968PheAla: 2.968 ± 0.054	0.409PheCys: 0.409 ± 0.018	3.268PheAsp: 3.268 ± 0.06	3.432PheGlu: 3.432 ± 0.064	2.633PhePhe: 2.633 ± 0.062	3.572PheGly: 3.572 ± 0.065	0.771PheHis: 0.771 ± 0.027	3.941PheIle: 3.941 ± 0.082	3.882PheLys: 3.882 ± 0.072	4.68PheLeu: 4.68 ± 0.085	1.108PheMet: 1.108 ± 0.037	3.347PheAsn: 3.347 ± 0.06	1.729PhePro: 1.729 ± 0.039	1.644PheGln: 1.644 ± 0.047	1.729PheArg: 1.729 ± 0.041	3.905PheSer: 3.905 ± 0.062	2.944PheThr: 2.944 ± 0.1	2.882PheVal: 2.882 ± 0.055	0.558PheTrp: 0.558 ± 0.025	2.082PheTyr: 2.082 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.01GlyAla: 4.01 ± 0.102	0.662GlyCys: 0.662 ± 0.045	3.536GlyAsp: 3.536 ± 0.078	3.784GlyGlu: 3.784 ± 0.061	3.528GlyPhe: 3.528 ± 0.059	4.67GlyGly: 4.67 ± 0.101	1.11GlyHis: 1.11 ± 0.033	5.526GlyIle: 5.526 ± 0.085	4.733GlyLys: 4.733 ± 0.088	5.966GlyLeu: 5.966 ± 0.087	1.635GlyMet: 1.635 ± 0.049	3.895GlyAsn: 3.895 ± 0.102	1.481GlyPro: 1.481 ± 0.045	1.88GlyGln: 1.88 ± 0.047	2.192GlyArg: 2.192 ± 0.047	4.218GlySer: 4.218 ± 0.075	3.994GlyThr: 3.994 ± 0.18	4.208GlyVal: 4.208 ± 0.086	0.728GlyTrp: 0.728 ± 0.027	2.726GlyTyr: 2.726 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	0.88HisAla: 0.88 ± 0.028	0.163HisCys: 0.163 ± 0.011	0.873HisAsp: 0.873 ± 0.029	0.953HisGlu: 0.953 ± 0.03	1.06HisPhe: 1.06 ± 0.031	1.103HisGly: 1.103 ± 0.032	0.44HisHis: 0.44 ± 0.019	1.342HisIle: 1.342 ± 0.033	1.1HisLys: 1.1 ± 0.039	1.65HisLeu: 1.65 ± 0.042	0.326HisMet: 0.326 ± 0.017	0.902HisAsn: 0.902 ± 0.029	0.873HisPro: 0.873 ± 0.032	0.614HisGln: 0.614 ± 0.023	0.663HisArg: 0.663 ± 0.022	1.084HisSer: 1.084 ± 0.035	0.828HisThr: 0.828 ± 0.027	0.859HisVal: 0.859 ± 0.028	0.2HisTrp: 0.2 ± 0.014	0.809HisTyr: 0.809 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.313IleAla: 5.313 ± 0.079	0.674IleCys: 0.674 ± 0.026	5.024IleAsp: 5.024 ± 0.078	5.612IleGlu: 5.612 ± 0.077	3.941IlePhe: 3.941 ± 0.073	5.235IleGly: 5.235 ± 0.078	1.255IleHis: 1.255 ± 0.035	6.298IleIle: 6.298 ± 0.115	5.737IleLys: 5.737 ± 0.077	7.472IleLeu: 7.472 ± 0.122	1.545IleMet: 1.545 ± 0.038	4.793IleAsn: 4.793 ± 0.071	3.216IlePro: 3.216 ± 0.062	2.384IleGln: 2.384 ± 0.051	2.721IleArg: 2.721 ± 0.057	6.187IleSer: 6.187 ± 0.07	4.732IleThr: 4.732 ± 0.111	4.701IleVal: 4.701 ± 0.075	0.721IleTrp: 0.721 ± 0.03	2.97IleTyr: 2.97 ± 0.064	0.0IleXaa: 0.0 ± 0.0
Lys	4.262LysAla: 4.262 ± 0.06	0.35LysCys: 0.35 ± 0.018	4.797LysAsp: 4.797 ± 0.07	5.726LysGlu: 5.726 ± 0.087	3.105LysPhe: 3.105 ± 0.061	4.095LysGly: 4.095 ± 0.066	1.254LysHis: 1.254 ± 0.032	6.237LysIle: 6.237 ± 0.091	5.95LysLys: 5.95 ± 0.11	6.402LysLeu: 6.402 ± 0.084	2.022LysMet: 2.022 ± 0.044	5.076LysAsn: 5.076 ± 0.077	2.33LysPro: 2.33 ± 0.05	2.428LysGln: 2.428 ± 0.053	2.837LysArg: 2.837 ± 0.056	5.054LysSer: 5.054 ± 0.083	4.256LysThr: 4.256 ± 0.08	4.602LysVal: 4.602 ± 0.071	0.719LysTrp: 0.719 ± 0.025	2.925LysTyr: 2.925 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	5.764LeuAla: 5.764 ± 0.089	0.667LeuCys: 0.667 ± 0.028	5.347LeuAsp: 5.347 ± 0.085	6.029LeuGlu: 6.029 ± 0.087	4.484LeuPhe: 4.484 ± 0.069	5.751LeuGly: 5.751 ± 0.091	1.517LeuHis: 1.517 ± 0.045	7.111LeuIle: 7.111 ± 0.117	7.829LeuLys: 7.829 ± 0.112	8.448LeuLeu: 8.448 ± 0.121	2.074LeuMet: 2.074 ± 0.05	5.82LeuAsn: 5.82 ± 0.072	3.484LeuPro: 3.484 ± 0.062	3.149LeuGln: 3.149 ± 0.055	3.362LeuArg: 3.362 ± 0.063	6.819LeuSer: 6.819 ± 0.08	4.861LeuThr: 4.861 ± 0.084	5.265LeuVal: 5.265 ± 0.08	0.796LeuTrp: 0.796 ± 0.033	3.161LeuTyr: 3.161 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	1.671MetAla: 1.671 ± 0.047	0.135MetCys: 0.135 ± 0.011	1.359MetAsp: 1.359 ± 0.037	1.451MetGlu: 1.451 ± 0.044	0.893MetPhe: 0.893 ± 0.03	1.424MetGly: 1.424 ± 0.038	0.406MetHis: 0.406 ± 0.019	1.666MetIle: 1.666 ± 0.046	2.184MetLys: 2.184 ± 0.048	2.016MetLeu: 2.016 ± 0.048	0.679MetMet: 0.679 ± 0.029	1.258MetAsn: 1.258 ± 0.034	0.901MetPro: 0.901 ± 0.028	0.766MetGln: 0.766 ± 0.025	0.871MetArg: 0.871 ± 0.03	1.567MetSer: 1.567 ± 0.043	1.201MetThr: 1.201 ± 0.036	1.544MetVal: 1.544 ± 0.044	0.162MetTrp: 0.162 ± 0.013	0.694MetTyr: 0.694 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.582AsnAla: 3.582 ± 0.084	0.493AsnCys: 0.493 ± 0.037	3.624AsnAsp: 3.624 ± 0.066	3.728AsnGlu: 3.728 ± 0.077	3.137AsnPhe: 3.137 ± 0.054	4.09AsnGly: 4.09 ± 0.084	1.13AsnHis: 1.13 ± 0.037	4.749AsnIle: 4.749 ± 0.072	4.0AsnLys: 4.0 ± 0.066	5.852AsnLeu: 5.852 ± 0.076	1.361AsnMet: 1.361 ± 0.034	3.635AsnAsn: 3.635 ± 0.077	2.845AsnPro: 2.845 ± 0.056	2.187AsnGln: 2.187 ± 0.053	2.316AsnArg: 2.316 ± 0.048	4.409AsnSer: 4.409 ± 0.076	3.284AsnThr: 3.284 ± 0.082	3.542AsnVal: 3.542 ± 0.064	0.739AsnTrp: 0.739 ± 0.027	2.72AsnTyr: 2.72 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	1.963ProAla: 1.963 ± 0.063	0.2ProCys: 0.2 ± 0.015	2.168ProAsp: 2.168 ± 0.051	2.811ProGlu: 2.811 ± 0.052	1.794ProPhe: 1.794 ± 0.041	1.968ProGly: 1.968 ± 0.049	0.579ProHis: 0.579 ± 0.025	2.791ProIle: 2.791 ± 0.052	2.507ProLys: 2.507 ± 0.061	2.875ProLeu: 2.875 ± 0.057	0.771ProMet: 0.771 ± 0.027	2.34ProAsn: 2.34 ± 0.058	0.875ProPro: 0.875 ± 0.03	1.114ProGln: 1.114 ± 0.034	0.99ProArg: 0.99 ± 0.029	2.169ProSer: 2.169 ± 0.055	2.085ProThr: 2.085 ± 0.069	2.23ProVal: 2.23 ± 0.081	0.358ProTrp: 0.358 ± 0.02	1.421ProTyr: 1.421 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	1.816GlnAla: 1.816 ± 0.049	0.162GlnCys: 0.162 ± 0.014	1.827GlnAsp: 1.827 ± 0.042	2.176GlnGlu: 2.176 ± 0.052	1.765GlnPhe: 1.765 ± 0.045	1.834GlnGly: 1.834 ± 0.042	0.589GlnHis: 0.589 ± 0.023	2.672GlnIle: 2.672 ± 0.043	2.596GlnLys: 2.596 ± 0.048	3.354GlnLeu: 3.354 ± 0.061	0.82GlnMet: 0.82 ± 0.028	2.096GlnAsn: 2.096 ± 0.051	1.071GlnPro: 1.071 ± 0.028	1.279GlnGln: 1.279 ± 0.037	1.242GlnArg: 1.242 ± 0.035	2.03GlnSer: 2.03 ± 0.047	1.821GlnThr: 1.821 ± 0.049	1.693GlnVal: 1.693 ± 0.04	0.312GlnTrp: 0.312 ± 0.016	1.273GlnTyr: 1.273 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.022ArgAla: 2.022 ± 0.052	0.206ArgCys: 0.206 ± 0.013	2.02ArgAsp: 2.02 ± 0.043	2.354ArgGlu: 2.354 ± 0.053	2.017ArgPhe: 2.017 ± 0.049	1.965ArgGly: 1.965 ± 0.05	0.602ArgHis: 0.602 ± 0.023	3.043ArgIle: 3.043 ± 0.048	2.683ArgLys: 2.683 ± 0.057	3.443ArgLeu: 3.443 ± 0.066	0.927ArgMet: 0.927 ± 0.03	2.291ArgAsn: 2.291 ± 0.05	1.208ArgPro: 1.208 ± 0.039	1.144ArgGln: 1.144 ± 0.032	1.41ArgArg: 1.41 ± 0.037	2.122ArgSer: 2.122 ± 0.05	1.955ArgThr: 1.955 ± 0.048	2.068ArgVal: 2.068 ± 0.051	0.378ArgTrp: 0.378 ± 0.02	1.579ArgTyr: 1.579 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	4.044SerAla: 4.044 ± 0.067	0.637SerCys: 0.637 ± 0.026	4.225SerAsp: 4.225 ± 0.078	4.595SerGlu: 4.595 ± 0.076	3.757SerPhe: 3.757 ± 0.058	4.817SerGly: 4.817 ± 0.101	1.1SerHis: 1.1 ± 0.029	5.534SerIle: 5.534 ± 0.078	5.007SerLys: 5.007 ± 0.078	6.256SerLeu: 6.256 ± 0.093	1.425SerMet: 1.425 ± 0.036	3.968SerAsn: 3.968 ± 0.108	2.258SerPro: 2.258 ± 0.051	2.312SerGln: 2.312 ± 0.05	2.398SerArg: 2.398 ± 0.051	4.763SerSer: 4.763 ± 0.081	3.93SerThr: 3.93 ± 0.097	4.163SerVal: 4.163 ± 0.076	0.751SerTrp: 0.751 ± 0.028	2.757SerTyr: 2.757 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	3.841ThrAla: 3.841 ± 0.133	0.323ThrCys: 0.323 ± 0.018	3.72ThrAsp: 3.72 ± 0.105	3.47ThrGlu: 3.47 ± 0.068	2.939ThrPhe: 2.939 ± 0.073	3.905ThrGly: 3.905 ± 0.119	0.859ThrHis: 0.859 ± 0.024	4.818ThrIle: 4.818 ± 0.083	3.579ThrLys: 3.579 ± 0.066	5.086ThrLeu: 5.086 ± 0.071	1.012ThrMet: 1.012 ± 0.035	3.162ThrAsn: 3.162 ± 0.093	2.239ThrPro: 2.239 ± 0.097	1.644ThrGln: 1.644 ± 0.042	1.644ThrArg: 1.644 ± 0.041	3.84ThrSer: 3.84 ± 0.097	3.883ThrThr: 3.883 ± 0.32	3.978ThrVal: 3.978 ± 0.211	0.589ThrTrp: 0.589 ± 0.039	2.374ThrTyr: 2.374 ± 0.064	0.0ThrXaa: 0.0 ± 0.0
Val	4.063ValAla: 4.063 ± 0.071	0.47ValCys: 0.47 ± 0.023	3.868ValAsp: 3.868 ± 0.086	4.315ValGlu: 4.315 ± 0.08	3.038ValPhe: 3.038 ± 0.066	3.962ValGly: 3.962 ± 0.068	0.92ValHis: 0.92 ± 0.028	4.799ValIle: 4.799 ± 0.066	4.144ValLys: 4.144 ± 0.067	5.599ValLeu: 5.599 ± 0.088	1.412ValMet: 1.412 ± 0.039	3.489ValAsn: 3.489 ± 0.064	2.096ValPro: 2.096 ± 0.055	1.614ValGln: 1.614 ± 0.034	2.015ValArg: 2.015 ± 0.048	4.403ValSer: 4.403 ± 0.072	3.784ValThr: 3.784 ± 0.192	4.154ValVal: 4.154 ± 0.08	0.554ValTrp: 0.554 ± 0.022	2.333ValTyr: 2.333 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.565TrpAla: 0.565 ± 0.025	0.077TrpCys: 0.077 ± 0.007	0.612TrpAsp: 0.612 ± 0.026	0.699TrpGlu: 0.699 ± 0.024	0.532TrpPhe: 0.532 ± 0.023	0.589TrpGly: 0.589 ± 0.026	0.22TrpHis: 0.22 ± 0.013	0.752TrpIle: 0.752 ± 0.024	0.782TrpLys: 0.782 ± 0.032	0.928TrpLeu: 0.928 ± 0.039	0.316TrpMet: 0.316 ± 0.02	0.655TrpAsn: 0.655 ± 0.025	0.26TrpPro: 0.26 ± 0.019	0.371TrpGln: 0.371 ± 0.021	0.388TrpArg: 0.388 ± 0.021	0.674TrpSer: 0.674 ± 0.041	0.535TrpThr: 0.535 ± 0.028	0.628TrpVal: 0.628 ± 0.028	0.131TrpTrp: 0.131 ± 0.011	0.434TrpTyr: 0.434 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.242TyrAla: 2.242 ± 0.044	0.307TyrCys: 0.307 ± 0.016	2.484TyrAsp: 2.484 ± 0.05	2.371TyrGlu: 2.371 ± 0.06	2.35TyrPhe: 2.35 ± 0.051	2.663TyrGly: 2.663 ± 0.055	0.774TyrHis: 0.774 ± 0.029	2.835TyrIle: 2.835 ± 0.058	2.955TyrLys: 2.955 ± 0.053	3.768TyrLeu: 3.768 ± 0.071	0.735TyrMet: 0.735 ± 0.028	2.602TyrAsn: 2.602 ± 0.052	1.464TyrPro: 1.464 ± 0.029	1.531TyrGln: 1.531 ± 0.042	1.694TyrArg: 1.694 ± 0.046	2.81TyrSer: 2.81 ± 0.055	2.284TyrThr: 2.284 ± 0.088	2.205TyrVal: 2.205 ± 0.042	0.445TyrTrp: 0.445 ± 0.02	1.787TyrTyr: 1.787 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3255 proteins (1129829 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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