Amino acid dipepetide frequency for Aquisalibacillus elongatus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.1AlaAla: 4.1 ± 0.085	0.495AlaCys: 0.495 ± 0.023	3.091AlaAsp: 3.091 ± 0.056	4.221AlaGlu: 4.221 ± 0.082	3.001AlaPhe: 3.001 ± 0.069	4.304AlaGly: 4.304 ± 0.078	1.21AlaHis: 1.21 ± 0.042	5.387AlaIle: 5.387 ± 0.094	4.006AlaLys: 4.006 ± 0.07	6.389AlaLeu: 6.389 ± 0.115	1.803AlaMet: 1.803 ± 0.052	2.64AlaAsn: 2.64 ± 0.063	1.766AlaPro: 1.766 ± 0.052	2.169AlaGln: 2.169 ± 0.056	2.236AlaArg: 2.236 ± 0.056	3.707AlaSer: 3.707 ± 0.076	3.192AlaThr: 3.192 ± 0.068	4.584AlaVal: 4.584 ± 0.097	0.529AlaTrp: 0.529 ± 0.026	2.156AlaTyr: 2.156 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.306CysAla: 0.306 ± 0.023	0.051CysCys: 0.051 ± 0.009	0.388CysAsp: 0.388 ± 0.021	0.422CysGlu: 0.422 ± 0.024	0.253CysPhe: 0.253 ± 0.018	0.56CysGly: 0.56 ± 0.027	0.173CysHis: 0.173 ± 0.015	0.39CysIle: 0.39 ± 0.024	0.279CysLys: 0.279 ± 0.018	0.538CysLeu: 0.538 ± 0.026	0.14CysMet: 0.14 ± 0.012	0.222CysAsn: 0.222 ± 0.016	0.301CysPro: 0.301 ± 0.019	0.235CysGln: 0.235 ± 0.018	0.246CysArg: 0.246 ± 0.018	0.33CysSer: 0.33 ± 0.021	0.304CysThr: 0.304 ± 0.018	0.378CysVal: 0.378 ± 0.022	0.051CysTrp: 0.051 ± 0.008	0.231CysTyr: 0.231 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.246AspAla: 3.246 ± 0.079	0.349AspCys: 0.349 ± 0.024	3.728AspAsp: 3.728 ± 0.084	6.241AspGlu: 6.241 ± 0.115	2.691AspPhe: 2.691 ± 0.062	3.687AspGly: 3.687 ± 0.074	1.608AspHis: 1.608 ± 0.047	4.462AspIle: 4.462 ± 0.079	2.548AspLys: 2.548 ± 0.057	5.992AspLeu: 5.992 ± 0.106	1.541AspMet: 1.541 ± 0.042	1.879AspAsn: 1.879 ± 0.063	2.195AspPro: 2.195 ± 0.055	3.429AspGln: 3.429 ± 0.07	2.543AspArg: 2.543 ± 0.059	2.979AspSer: 2.979 ± 0.076	2.633AspThr: 2.633 ± 0.055	4.671AspVal: 4.671 ± 0.076	0.703AspTrp: 0.703 ± 0.028	2.695AspTyr: 2.695 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	5.167GluAla: 5.167 ± 0.087	0.307GluCys: 0.307 ± 0.018	5.12GluAsp: 5.12 ± 0.101	8.269GluGlu: 8.269 ± 0.159	2.85GluPhe: 2.85 ± 0.062	4.693GluGly: 4.693 ± 0.083	1.921GluHis: 1.921 ± 0.047	5.497GluIle: 5.497 ± 0.092	5.855GluLys: 5.855 ± 0.103	7.49GluLeu: 7.49 ± 0.107	2.265GluMet: 2.265 ± 0.056	3.919GluAsn: 3.919 ± 0.08	2.328GluPro: 2.328 ± 0.052	4.279GluGln: 4.279 ± 0.099	3.656GluArg: 3.656 ± 0.082	4.318GluSer: 4.318 ± 0.077	4.079GluThr: 4.079 ± 0.086	5.745GluVal: 5.745 ± 0.087	0.916GluTrp: 0.916 ± 0.043	2.548GluTyr: 2.548 ± 0.076	0.0GluXaa: 0.0 ± 0.0
Phe	2.593PheAla: 2.593 ± 0.074	0.287PheCys: 0.287 ± 0.019	2.695PheAsp: 2.695 ± 0.049	3.237PheGlu: 3.237 ± 0.063	2.238PhePhe: 2.238 ± 0.07	3.174PheGly: 3.174 ± 0.073	0.951PheHis: 0.951 ± 0.032	4.017PheIle: 4.017 ± 0.081	2.609PheLys: 2.609 ± 0.055	4.317PheLeu: 4.317 ± 0.096	1.224PheMet: 1.224 ± 0.04	2.256PheAsn: 2.256 ± 0.056	1.582PhePro: 1.582 ± 0.048	1.643PheGln: 1.643 ± 0.048	1.499PheArg: 1.499 ± 0.043	2.982PheSer: 2.982 ± 0.063	2.427PheThr: 2.427 ± 0.061	3.156PheVal: 3.156 ± 0.074	0.495PheTrp: 0.495 ± 0.024	1.909PheTyr: 1.909 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	4.385GlyAla: 4.385 ± 0.096	0.505GlyCys: 0.505 ± 0.024	3.562GlyAsp: 3.562 ± 0.073	4.81GlyGlu: 4.81 ± 0.089	3.343GlyPhe: 3.343 ± 0.072	4.452GlyGly: 4.452 ± 0.101	1.523GlyHis: 1.523 ± 0.038	5.347GlyIle: 5.347 ± 0.093	4.142GlyLys: 4.142 ± 0.076	6.418GlyLeu: 6.418 ± 0.118	2.04GlyMet: 2.04 ± 0.06	2.55GlyAsn: 2.55 ± 0.076	1.758GlyPro: 1.758 ± 0.059	2.584GlyGln: 2.584 ± 0.055	2.448GlyArg: 2.448 ± 0.057	3.89GlySer: 3.89 ± 0.056	3.646GlyThr: 3.646 ± 0.077	5.02GlyVal: 5.02 ± 0.088	0.695GlyTrp: 0.695 ± 0.032	2.871GlyTyr: 2.871 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	1.293HisAla: 1.293 ± 0.036	0.16HisCys: 0.16 ± 0.014	1.341HisAsp: 1.341 ± 0.042	1.73HisGlu: 1.73 ± 0.048	1.108HisPhe: 1.108 ± 0.032	1.411HisGly: 1.411 ± 0.042	0.774HisHis: 0.774 ± 0.03	1.678HisIle: 1.678 ± 0.052	1.084HisLys: 1.084 ± 0.042	2.199HisLeu: 2.199 ± 0.057	0.574HisMet: 0.574 ± 0.023	0.912HisAsn: 0.912 ± 0.034	1.089HisPro: 1.089 ± 0.039	1.103HisGln: 1.103 ± 0.037	0.88HisArg: 0.88 ± 0.03	1.28HisSer: 1.28 ± 0.042	1.063HisThr: 1.063 ± 0.038	1.585HisVal: 1.585 ± 0.043	0.242HisTrp: 0.242 ± 0.016	0.967HisTyr: 0.967 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	5.195IleAla: 5.195 ± 0.099	0.522IleCys: 0.522 ± 0.024	4.848IleAsp: 4.848 ± 0.088	5.962IleGlu: 5.962 ± 0.096	3.425IlePhe: 3.425 ± 0.095	5.758IleGly: 5.758 ± 0.116	1.726IleHis: 1.726 ± 0.042	5.996IleIle: 5.996 ± 0.107	4.609IleLys: 4.609 ± 0.078	6.984IleLeu: 6.984 ± 0.119	1.85IleMet: 1.85 ± 0.044	3.645IleAsn: 3.645 ± 0.067	3.164IlePro: 3.164 ± 0.066	3.176IleGln: 3.176 ± 0.071	2.986IleArg: 2.986 ± 0.058	4.768IleSer: 4.768 ± 0.077	4.093IleThr: 4.093 ± 0.071	5.542IleVal: 5.542 ± 0.093	0.667IleTrp: 0.667 ± 0.029	2.702IleTyr: 2.702 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	3.805LysAla: 3.805 ± 0.08	0.264LysCys: 0.264 ± 0.018	3.948LysAsp: 3.948 ± 0.073	6.017LysGlu: 6.017 ± 0.116	1.858LysPhe: 1.858 ± 0.043	3.994LysGly: 3.994 ± 0.074	1.51LysHis: 1.51 ± 0.045	3.967LysIle: 3.967 ± 0.074	4.727LysLys: 4.727 ± 0.112	5.292LysLeu: 5.292 ± 0.085	1.83LysMet: 1.83 ± 0.055	2.856LysAsn: 2.856 ± 0.068	2.148LysPro: 2.148 ± 0.047	3.372LysGln: 3.372 ± 0.079	3.228LysArg: 3.228 ± 0.067	3.406LysSer: 3.406 ± 0.069	3.253LysThr: 3.253 ± 0.064	4.393LysVal: 4.393 ± 0.065	0.741LysTrp: 0.741 ± 0.031	2.029LysTyr: 2.029 ± 0.058	0.0LysXaa: 0.0 ± 0.0
Leu	6.222LeuAla: 6.222 ± 0.106	0.466LeuCys: 0.466 ± 0.026	5.657LeuAsp: 5.657 ± 0.088	7.072LeuGlu: 7.072 ± 0.121	4.551LeuPhe: 4.551 ± 0.101	6.07LeuGly: 6.07 ± 0.098	1.739LeuHis: 1.739 ± 0.043	7.857LeuIle: 7.857 ± 0.138	6.358LeuLys: 6.358 ± 0.098	9.359LeuLeu: 9.359 ± 0.17	2.628LeuMet: 2.628 ± 0.056	5.28LeuAsn: 5.28 ± 0.085	3.578LeuPro: 3.578 ± 0.065	3.27LeuGln: 3.27 ± 0.076	3.296LeuArg: 3.296 ± 0.074	6.543LeuSer: 6.543 ± 0.099	5.566LeuThr: 5.566 ± 0.083	6.323LeuVal: 6.323 ± 0.098	0.772LeuTrp: 0.772 ± 0.035	3.245LeuTyr: 3.245 ± 0.074	0.0LeuXaa: 0.0 ± 0.0
Met	1.912MetAla: 1.912 ± 0.055	0.123MetCys: 0.123 ± 0.012	1.671MetAsp: 1.671 ± 0.047	1.844MetGlu: 1.844 ± 0.05	1.192MetPhe: 1.192 ± 0.044	1.729MetGly: 1.729 ± 0.054	0.413MetHis: 0.413 ± 0.021	2.006MetIle: 2.006 ± 0.051	2.268MetLys: 2.268 ± 0.057	2.518MetLeu: 2.518 ± 0.057	0.919MetMet: 0.919 ± 0.04	1.619MetAsn: 1.619 ± 0.048	0.929MetPro: 0.929 ± 0.032	0.933MetGln: 0.933 ± 0.038	1.046MetArg: 1.046 ± 0.041	1.842MetSer: 1.842 ± 0.049	1.743MetThr: 1.743 ± 0.048	1.952MetVal: 1.952 ± 0.051	0.206MetTrp: 0.206 ± 0.016	0.811MetTyr: 0.811 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	2.468AsnAla: 2.468 ± 0.057	0.272AsnCys: 0.272 ± 0.018	2.825AsnAsp: 2.825 ± 0.072	4.228AsnGlu: 4.228 ± 0.084	1.79AsnPhe: 1.79 ± 0.046	3.149AsnGly: 3.149 ± 0.067	1.303AsnHis: 1.303 ± 0.042	3.445AsnIle: 3.445 ± 0.071	2.691AsnLys: 2.691 ± 0.068	4.076AsnLeu: 4.076 ± 0.078	1.26AsnMet: 1.26 ± 0.032	2.143AsnAsn: 2.143 ± 0.059	2.085AsnPro: 2.085 ± 0.05	2.922AsnGln: 2.922 ± 0.077	2.236AsnArg: 2.236 ± 0.057	2.346AsnSer: 2.346 ± 0.059	2.089AsnThr: 2.089 ± 0.054	3.237AsnVal: 3.237 ± 0.067	0.55AsnTrp: 0.55 ± 0.025	1.732AsnTyr: 1.732 ± 0.056	0.0AsnXaa: 0.0 ± 0.0
Pro	1.759ProAla: 1.759 ± 0.045	0.187ProCys: 0.187 ± 0.015	2.219ProAsp: 2.219 ± 0.06	3.109ProGlu: 3.109 ± 0.07	1.887ProPhe: 1.887 ± 0.047	2.206ProGly: 2.206 ± 0.062	0.771ProHis: 0.771 ± 0.034	2.827ProIle: 2.827 ± 0.057	2.263ProLys: 2.263 ± 0.052	3.163ProLeu: 3.163 ± 0.065	0.78ProMet: 0.78 ± 0.03	1.953ProAsn: 1.953 ± 0.047	0.925ProPro: 0.925 ± 0.04	1.095ProGln: 1.095 ± 0.036	1.075ProArg: 1.075 ± 0.033	2.136ProSer: 2.136 ± 0.053	1.959ProThr: 1.959 ± 0.053	2.684ProVal: 2.684 ± 0.061	0.337ProTrp: 0.337 ± 0.021	1.475ProTyr: 1.475 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.889GlnAla: 2.889 ± 0.063	0.158GlnCys: 0.158 ± 0.012	2.582GlnAsp: 2.582 ± 0.065	3.558GlnGlu: 3.558 ± 0.076	1.775GlnPhe: 1.775 ± 0.048	2.438GlnGly: 2.438 ± 0.057	1.003GlnHis: 1.003 ± 0.04	2.921GlnIle: 2.921 ± 0.071	2.793GlnLys: 2.793 ± 0.066	4.569GlnLeu: 4.569 ± 0.087	1.314GlnMet: 1.314 ± 0.046	2.159GlnAsn: 2.159 ± 0.062	1.344GlnPro: 1.344 ± 0.045	2.192GlnGln: 2.192 ± 0.078	1.519GlnArg: 1.519 ± 0.048	2.705GlnSer: 2.705 ± 0.071	2.296GlnThr: 2.296 ± 0.05	2.87GlnVal: 2.87 ± 0.066	0.417GlnTrp: 0.417 ± 0.022	1.656GlnTyr: 1.656 ± 0.055	0.0GlnXaa: 0.0 ± 0.0
Arg	2.089ArgAla: 2.089 ± 0.058	0.216ArgCys: 0.216 ± 0.017	2.342ArgAsp: 2.342 ± 0.051	3.252ArgGlu: 3.252 ± 0.063	1.834ArgPhe: 1.834 ± 0.048	2.312ArgGly: 2.312 ± 0.051	0.863ArgHis: 0.863 ± 0.031	2.913ArgIle: 2.913 ± 0.059	2.876ArgLys: 2.876 ± 0.063	3.93ArgLeu: 3.93 ± 0.077	1.226ArgMet: 1.226 ± 0.036	1.826ArgAsn: 1.826 ± 0.05	1.302ArgPro: 1.302 ± 0.037	1.73ArgGln: 1.73 ± 0.047	1.791ArgArg: 1.791 ± 0.052	2.064ArgSer: 2.064 ± 0.053	1.886ArgThr: 1.886 ± 0.044	2.706ArgVal: 2.706 ± 0.057	0.353ArgTrp: 0.353 ± 0.022	1.52ArgTyr: 1.52 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	3.23SerAla: 3.23 ± 0.066	0.338SerCys: 0.338 ± 0.018	3.418SerAsp: 3.418 ± 0.058	4.474SerGlu: 4.474 ± 0.075	3.074SerPhe: 3.074 ± 0.072	4.239SerGly: 4.239 ± 0.079	1.254SerHis: 1.254 ± 0.035	5.165SerIle: 5.165 ± 0.085	3.566SerLys: 3.566 ± 0.071	5.755SerLeu: 5.755 ± 0.092	1.742SerMet: 1.742 ± 0.048	2.867SerAsn: 2.867 ± 0.067	1.988SerPro: 1.988 ± 0.052	2.351SerGln: 2.351 ± 0.056	2.163SerArg: 2.163 ± 0.051	3.722SerSer: 3.722 ± 0.075	3.039SerThr: 3.039 ± 0.063	4.204SerVal: 4.204 ± 0.071	0.575SerTrp: 0.575 ± 0.03	2.233SerTyr: 2.233 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	3.152ThrAla: 3.152 ± 0.068	0.3ThrCys: 0.3 ± 0.019	2.882ThrAsp: 2.882 ± 0.069	3.667ThrGlu: 3.667 ± 0.072	2.677ThrPhe: 2.677 ± 0.067	3.843ThrGly: 3.843 ± 0.071	1.141ThrHis: 1.141 ± 0.037	4.496ThrIle: 4.496 ± 0.081	2.945ThrLys: 2.945 ± 0.064	5.196ThrLeu: 5.196 ± 0.083	1.286ThrMet: 1.286 ± 0.04	2.563ThrAsn: 2.563 ± 0.063	2.119ThrPro: 2.119 ± 0.046	1.659ThrGln: 1.659 ± 0.045	1.663ThrArg: 1.663 ± 0.043	3.211ThrSer: 3.211 ± 0.071	2.945ThrThr: 2.945 ± 0.084	4.004ThrVal: 4.004 ± 0.075	0.506ThrTrp: 0.506 ± 0.025	2.176ThrTyr: 2.176 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	4.616ValAla: 4.616 ± 0.09	0.491ValCys: 0.491 ± 0.029	4.424ValAsp: 4.424 ± 0.081	5.399ValGlu: 5.399 ± 0.095	3.222ValPhe: 3.222 ± 0.074	4.956ValGly: 4.956 ± 0.093	1.388ValHis: 1.388 ± 0.043	5.788ValIle: 5.788 ± 0.095	4.372ValLys: 4.372 ± 0.078	6.84ValLeu: 6.84 ± 0.111	2.028ValMet: 2.028 ± 0.051	3.369ValAsn: 3.369 ± 0.063	2.527ValPro: 2.527 ± 0.055	2.658ValGln: 2.658 ± 0.058	2.546ValArg: 2.546 ± 0.051	4.458ValSer: 4.458 ± 0.076	3.984ValThr: 3.984 ± 0.066	5.438ValVal: 5.438 ± 0.104	0.649ValTrp: 0.649 ± 0.029	2.474ValTyr: 2.474 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	0.53TrpAla: 0.53 ± 0.027	0.049TrpCys: 0.049 ± 0.008	0.567TrpAsp: 0.567 ± 0.027	0.672TrpGlu: 0.672 ± 0.026	0.595TrpPhe: 0.595 ± 0.031	0.575TrpGly: 0.575 ± 0.028	0.206TrpHis: 0.206 ± 0.015	0.875TrpIle: 0.875 ± 0.033	0.617TrpLys: 0.617 ± 0.029	1.182TrpLeu: 1.182 ± 0.042	0.324TrpMet: 0.324 ± 0.02	0.508TrpAsn: 0.508 ± 0.028	0.247TrpPro: 0.247 ± 0.017	0.366TrpGln: 0.366 ± 0.023	0.385TrpArg: 0.385 ± 0.021	0.599TrpSer: 0.599 ± 0.026	0.491TrpThr: 0.491 ± 0.025	0.645TrpVal: 0.645 ± 0.027	0.136TrpTrp: 0.136 ± 0.013	0.397TrpTyr: 0.397 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.029TyrAla: 2.029 ± 0.05	0.257TyrCys: 0.257 ± 0.019	2.51TyrAsp: 2.51 ± 0.092	3.039TyrGlu: 3.039 ± 0.068	1.925TyrPhe: 1.925 ± 0.049	2.438TyrGly: 2.438 ± 0.06	0.995TyrHis: 0.995 ± 0.035	2.583TyrIle: 2.583 ± 0.055	2.033TyrLys: 2.033 ± 0.055	3.646TyrLeu: 3.646 ± 0.074	0.901TyrMet: 0.901 ± 0.034	1.682TyrAsn: 1.682 ± 0.05	1.435TyrPro: 1.435 ± 0.045	1.992TyrGln: 1.992 ± 0.053	1.59TyrArg: 1.59 ± 0.046	2.11TyrSer: 2.11 ± 0.059	1.746TyrThr: 1.746 ± 0.047	2.489TyrVal: 2.489 ± 0.045	0.427TyrTrp: 0.427 ± 0.023	1.541TyrTyr: 1.541 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2958 proteins (843163 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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