Amino acid dipepetide frequency for Streptomyces scabiei (strain 87.22)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.736AlaAla: 20.736 ± 0.154	1.078AlaCys: 1.078 ± 0.021	8.415AlaAsp: 8.415 ± 0.067	8.746AlaGlu: 8.746 ± 0.085	3.401AlaPhe: 3.401 ± 0.038	13.051AlaGly: 13.051 ± 0.091	3.019AlaHis: 3.019 ± 0.039	3.253AlaIle: 3.253 ± 0.042	2.754AlaLys: 2.754 ± 0.043	14.306AlaLeu: 14.306 ± 0.103	2.401AlaMet: 2.401 ± 0.033	1.949AlaAsn: 1.949 ± 0.028	7.306AlaPro: 7.306 ± 0.074	3.563AlaGln: 3.563 ± 0.041	10.555AlaArg: 10.555 ± 0.085	5.98AlaSer: 5.98 ± 0.053	7.056AlaThr: 7.056 ± 0.055	12.164AlaVal: 12.164 ± 0.08	1.894AlaTrp: 1.894 ± 0.026	2.788AlaTyr: 2.788 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.093CysAla: 1.093 ± 0.021	0.095CysCys: 0.095 ± 0.006	0.487CysAsp: 0.487 ± 0.013	0.428CysGlu: 0.428 ± 0.012	0.215CysPhe: 0.215 ± 0.008	0.971CysGly: 0.971 ± 0.021	0.2CysHis: 0.2 ± 0.008	0.158CysIle: 0.158 ± 0.007	0.11CysLys: 0.11 ± 0.007	0.771CysLeu: 0.771 ± 0.017	0.118CysMet: 0.118 ± 0.007	0.133CysAsn: 0.133 ± 0.008	0.494CysPro: 0.494 ± 0.014	0.158CysGln: 0.158 ± 0.007	0.615CysArg: 0.615 ± 0.015	0.421CysSer: 0.421 ± 0.012	0.499CysThr: 0.499 ± 0.013	0.663CysVal: 0.663 ± 0.018	0.129CysTrp: 0.129 ± 0.007	0.145CysTyr: 0.145 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.633AspAla: 7.633 ± 0.059	0.425AspCys: 0.425 ± 0.012	3.759AspAsp: 3.759 ± 0.041	3.945AspGlu: 3.945 ± 0.043	1.692AspPhe: 1.692 ± 0.027	6.706AspGly: 6.706 ± 0.056	1.508AspHis: 1.508 ± 0.023	1.911AspIle: 1.911 ± 0.028	1.181AspLys: 1.181 ± 0.025	6.286AspLeu: 6.286 ± 0.053	0.829AspMet: 0.829 ± 0.015	0.993AspAsn: 0.993 ± 0.021	4.532AspPro: 4.532 ± 0.043	1.499AspGln: 1.499 ± 0.023	5.167AspArg: 5.167 ± 0.047	2.621AspSer: 2.621 ± 0.033	3.535AspThr: 3.535 ± 0.037	4.696AspVal: 4.696 ± 0.043	1.05AspTrp: 1.05 ± 0.022	1.102AspTyr: 1.102 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	7.448GluAla: 7.448 ± 0.072	0.365GluCys: 0.365 ± 0.01	2.903GluAsp: 2.903 ± 0.037	3.573GluGlu: 3.573 ± 0.048	1.48GluPhe: 1.48 ± 0.025	4.408GluGly: 4.408 ± 0.046	1.506GluHis: 1.506 ± 0.023	2.233GluIle: 2.233 ± 0.031	1.431GluLys: 1.431 ± 0.024	6.512GluLeu: 6.512 ± 0.06	0.876GluMet: 0.876 ± 0.019	1.087GluAsn: 1.087 ± 0.018	3.456GluPro: 3.456 ± 0.042	2.146GluGln: 2.146 ± 0.031	5.541GluArg: 5.541 ± 0.057	2.595GluSer: 2.595 ± 0.029	2.984GluThr: 2.984 ± 0.03	4.449GluVal: 4.449 ± 0.041	0.781GluTrp: 0.781 ± 0.018	1.128GluTyr: 1.128 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.592PheAla: 3.592 ± 0.037	0.244PheCys: 0.244 ± 0.009	1.981PheAsp: 1.981 ± 0.028	1.426PheGlu: 1.426 ± 0.025	0.829PhePhe: 0.829 ± 0.021	2.98PheGly: 2.98 ± 0.035	0.624PheHis: 0.624 ± 0.015	0.65PheIle: 0.65 ± 0.016	0.502PheLys: 0.502 ± 0.016	2.558PheLeu: 2.558 ± 0.029	0.409PheMet: 0.409 ± 0.012	0.544PheAsn: 0.544 ± 0.015	1.353PhePro: 1.353 ± 0.023	0.658PheGln: 0.658 ± 0.015	1.883PheArg: 1.883 ± 0.028	1.45PheSer: 1.45 ± 0.023	1.999PheThr: 1.999 ± 0.027	2.254PheVal: 2.254 ± 0.031	0.408PheTrp: 0.408 ± 0.011	0.592PheTyr: 0.592 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	11.054GlyAla: 11.054 ± 0.084	0.819GlyCys: 0.819 ± 0.018	5.426GlyAsp: 5.426 ± 0.049	5.187GlyGlu: 5.187 ± 0.046	2.848GlyPhe: 2.848 ± 0.033	9.067GlyGly: 9.067 ± 0.088	2.381GlyHis: 2.381 ± 0.031	3.303GlyIle: 3.303 ± 0.036	2.369GlyLys: 2.369 ± 0.035	9.245GlyLeu: 9.245 ± 0.074	1.941GlyMet: 1.941 ± 0.029	1.79GlyAsn: 1.79 ± 0.03	5.389GlyPro: 5.389 ± 0.051	2.625GlyGln: 2.625 ± 0.033	8.145GlyArg: 8.145 ± 0.067	5.434GlySer: 5.434 ± 0.055	6.729GlyThr: 6.729 ± 0.059	7.483GlyVal: 7.483 ± 0.056	1.72GlyTrp: 1.72 ± 0.027	2.211GlyTyr: 2.211 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	2.773HisAla: 2.773 ± 0.034	0.214HisCys: 0.214 ± 0.009	1.418HisAsp: 1.418 ± 0.024	1.285HisGlu: 1.285 ± 0.021	0.631HisPhe: 0.631 ± 0.016	2.476HisGly: 2.476 ± 0.034	0.758HisHis: 0.758 ± 0.018	0.699HisIle: 0.699 ± 0.017	0.354HisLys: 0.354 ± 0.012	2.489HisLeu: 2.489 ± 0.034	0.334HisMet: 0.334 ± 0.011	0.39HisAsn: 0.39 ± 0.011	1.863HisPro: 1.863 ± 0.032	0.655HisGln: 0.655 ± 0.017	2.224HisArg: 2.224 ± 0.033	0.994HisSer: 0.994 ± 0.021	1.423HisThr: 1.423 ± 0.022	1.692HisVal: 1.692 ± 0.024	0.383HisTrp: 0.383 ± 0.012	0.48HisTyr: 0.48 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.521IleAla: 4.521 ± 0.046	0.289IleCys: 0.289 ± 0.009	2.188IleAsp: 2.188 ± 0.031	1.888IleGlu: 1.888 ± 0.024	0.656IlePhe: 0.656 ± 0.017	3.36IleGly: 3.36 ± 0.038	0.603IleHis: 0.603 ± 0.015	0.832IleIle: 0.832 ± 0.021	0.705IleLys: 0.705 ± 0.019	2.346IleLeu: 2.346 ± 0.034	0.445IleMet: 0.445 ± 0.012	0.665IleAsn: 0.665 ± 0.018	1.728IlePro: 1.728 ± 0.023	0.686IleGln: 0.686 ± 0.016	2.24IleArg: 2.24 ± 0.033	1.598IleSer: 1.598 ± 0.027	2.231IleThr: 2.231 ± 0.031	2.664IleVal: 2.664 ± 0.037	0.368IleTrp: 0.368 ± 0.013	0.493IleTyr: 0.493 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.83LysAla: 2.83 ± 0.039	0.112LysCys: 0.112 ± 0.006	1.359LysAsp: 1.359 ± 0.027	1.213LysGlu: 1.213 ± 0.023	0.443LysPhe: 0.443 ± 0.015	1.888LysGly: 1.888 ± 0.03	0.413LysHis: 0.413 ± 0.012	0.824LysIle: 0.824 ± 0.02	0.868LysLys: 0.868 ± 0.025	1.944LysLeu: 1.944 ± 0.029	0.361LysMet: 0.361 ± 0.012	0.525LysAsn: 0.525 ± 0.016	1.324LysPro: 1.324 ± 0.023	0.671LysGln: 0.671 ± 0.017	1.411LysArg: 1.411 ± 0.023	1.15LysSer: 1.15 ± 0.021	1.253LysThr: 1.253 ± 0.026	1.878LysVal: 1.878 ± 0.03	0.29LysTrp: 0.29 ± 0.011	0.453LysTyr: 0.453 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	14.731LeuAla: 14.731 ± 0.107	0.85LeuCys: 0.85 ± 0.017	6.774LeuAsp: 6.774 ± 0.06	4.508LeuGlu: 4.508 ± 0.047	2.539LeuPhe: 2.539 ± 0.032	9.178LeuGly: 9.178 ± 0.067	2.359LeuHis: 2.359 ± 0.032	3.104LeuIle: 3.104 ± 0.035	2.066LeuLys: 2.066 ± 0.03	11.195LeuLeu: 11.195 ± 0.095	1.567LeuMet: 1.567 ± 0.022	1.653LeuAsn: 1.653 ± 0.024	6.47LeuPro: 6.47 ± 0.049	2.144LeuGln: 2.144 ± 0.027	8.803LeuArg: 8.803 ± 0.071	5.283LeuSer: 5.283 ± 0.048	7.051LeuThr: 7.051 ± 0.054	8.742LeuVal: 8.742 ± 0.072	1.321LeuTrp: 1.321 ± 0.022	1.869LeuTyr: 1.869 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.176MetAla: 2.176 ± 0.029	0.144MetCys: 0.144 ± 0.007	0.861MetAsp: 0.861 ± 0.018	0.739MetGlu: 0.739 ± 0.017	0.451MetPhe: 0.451 ± 0.013	1.286MetGly: 1.286 ± 0.023	0.355MetHis: 0.355 ± 0.011	0.641MetIle: 0.641 ± 0.015	0.433MetLys: 0.433 ± 0.012	1.606MetLeu: 1.606 ± 0.024	0.304MetMet: 0.304 ± 0.012	0.424MetAsn: 0.424 ± 0.012	1.136MetPro: 1.136 ± 0.019	0.422MetGln: 0.422 ± 0.014	1.436MetArg: 1.436 ± 0.021	1.274MetSer: 1.274 ± 0.022	1.555MetThr: 1.555 ± 0.024	1.282MetVal: 1.282 ± 0.019	0.216MetTrp: 0.216 ± 0.009	0.319MetTyr: 0.319 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.189AsnAla: 2.189 ± 0.03	0.162AsnCys: 0.162 ± 0.007	1.004AsnAsp: 1.004 ± 0.02	0.801AsnGlu: 0.801 ± 0.016	0.48AsnPhe: 0.48 ± 0.014	1.928AsnGly: 1.928 ± 0.032	0.398AsnHis: 0.398 ± 0.011	0.658AsnIle: 0.658 ± 0.017	0.404AsnLys: 0.404 ± 0.014	1.629AsnLeu: 1.629 ± 0.028	0.298AsnMet: 0.298 ± 0.01	0.446AsnAsn: 0.446 ± 0.014	1.338AsnPro: 1.338 ± 0.021	0.541AsnGln: 0.541 ± 0.015	1.317AsnArg: 1.317 ± 0.024	0.952AsnSer: 0.952 ± 0.021	1.16AsnThr: 1.16 ± 0.021	1.352AsnVal: 1.352 ± 0.023	0.288AsnTrp: 0.288 ± 0.012	0.431AsnTyr: 0.431 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.843ProAla: 8.843 ± 0.071	0.349ProCys: 0.349 ± 0.011	4.603ProAsp: 4.603 ± 0.046	4.362ProGlu: 4.362 ± 0.042	1.549ProPhe: 1.549 ± 0.024	6.867ProGly: 6.867 ± 0.065	1.482ProHis: 1.482 ± 0.024	1.214ProIle: 1.214 ± 0.022	1.144ProLys: 1.144 ± 0.019	5.38ProLeu: 5.38 ± 0.047	0.999ProMet: 0.999 ± 0.023	0.885ProAsn: 0.885 ± 0.021	3.77ProPro: 3.77 ± 0.051	1.652ProGln: 1.652 ± 0.027	4.121ProArg: 4.121 ± 0.047	3.355ProSer: 3.355 ± 0.042	3.285ProThr: 3.285 ± 0.041	5.538ProVal: 5.538 ± 0.048	0.939ProTrp: 0.939 ± 0.022	1.458ProTyr: 1.458 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.51GlnAla: 3.51 ± 0.038	0.183GlnCys: 0.183 ± 0.009	1.399GlnAsp: 1.399 ± 0.022	1.415GlnGlu: 1.415 ± 0.023	0.665GlnPhe: 0.665 ± 0.015	2.24GlnGly: 2.24 ± 0.035	0.622GlnHis: 0.622 ± 0.014	1.044GlnIle: 1.044 ± 0.02	0.597GlnLys: 0.597 ± 0.015	2.912GlnLeu: 2.912 ± 0.031	0.472GlnMet: 0.472 ± 0.015	0.532GlnAsn: 0.532 ± 0.014	1.651GlnPro: 1.651 ± 0.03	1.194GlnGln: 1.194 ± 0.029	2.31GlnArg: 2.31 ± 0.034	1.247GlnSer: 1.247 ± 0.021	1.299GlnThr: 1.299 ± 0.022	2.257GlnVal: 2.257 ± 0.029	0.49GlnTrp: 0.49 ± 0.013	0.604GlnTyr: 0.604 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.298ArgAla: 10.298 ± 0.073	0.6ArgCys: 0.6 ± 0.014	4.446ArgAsp: 4.446 ± 0.05	4.819ArgGlu: 4.819 ± 0.048	2.378ArgPhe: 2.378 ± 0.033	5.891ArgGly: 5.891 ± 0.056	2.247ArgHis: 2.247 ± 0.028	3.18ArgIle: 3.18 ± 0.032	1.621ArgLys: 1.621 ± 0.027	9.069ArgLeu: 9.069 ± 0.075	1.716ArgMet: 1.716 ± 0.024	1.383ArgAsn: 1.383 ± 0.021	5.24ArgPro: 5.24 ± 0.045	2.327ArgGln: 2.327 ± 0.03	8.048ArgArg: 8.048 ± 0.071	4.165ArgSer: 4.165 ± 0.04	5.798ArgThr: 5.798 ± 0.056	5.95ArgVal: 5.95 ± 0.055	1.388ArgTrp: 1.388 ± 0.025	1.796ArgTyr: 1.796 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	6.816SerAla: 6.816 ± 0.059	0.424SerCys: 0.424 ± 0.013	2.752SerAsp: 2.752 ± 0.036	2.393SerGlu: 2.393 ± 0.031	1.486SerPhe: 1.486 ± 0.025	6.047SerGly: 6.047 ± 0.058	1.033SerHis: 1.033 ± 0.02	1.375SerIle: 1.375 ± 0.03	1.033SerLys: 1.033 ± 0.025	4.868SerLeu: 4.868 ± 0.045	1.068SerMet: 1.068 ± 0.018	0.868SerAsn: 0.868 ± 0.021	3.275SerPro: 3.275 ± 0.042	1.229SerGln: 1.229 ± 0.023	3.758SerArg: 3.758 ± 0.036	2.878SerSer: 2.878 ± 0.046	3.133SerThr: 3.133 ± 0.037	4.262SerVal: 4.262 ± 0.044	0.9SerTrp: 0.9 ± 0.018	1.211SerTyr: 1.211 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	9.231ThrAla: 9.231 ± 0.068	0.444ThrCys: 0.444 ± 0.014	3.813ThrAsp: 3.813 ± 0.033	3.337ThrGlu: 3.337 ± 0.032	1.66ThrPhe: 1.66 ± 0.029	6.95ThrGly: 6.95 ± 0.06	1.263ThrHis: 1.263 ± 0.021	1.67ThrIle: 1.67 ± 0.026	1.154ThrLys: 1.154 ± 0.026	5.865ThrLeu: 5.865 ± 0.052	0.957ThrMet: 0.957 ± 0.017	1.033ThrAsn: 1.033 ± 0.022	4.312ThrPro: 4.312 ± 0.045	1.319ThrGln: 1.319 ± 0.024	4.14ThrArg: 4.14 ± 0.04	3.281ThrSer: 3.281 ± 0.041	4.121ThrThr: 4.121 ± 0.048	6.222ThrVal: 6.222 ± 0.052	0.958ThrTrp: 0.958 ± 0.019	1.421ThrTyr: 1.421 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	10.443ValAla: 10.443 ± 0.075	0.752ValCys: 0.752 ± 0.016	5.055ValAsp: 5.055 ± 0.04	4.787ValGlu: 4.787 ± 0.046	2.4ValPhe: 2.4 ± 0.03	6.5ValGly: 6.5 ± 0.063	1.99ValHis: 1.99 ± 0.029	2.71ValIle: 2.71 ± 0.032	1.691ValLys: 1.691 ± 0.029	9.351ValLeu: 9.351 ± 0.067	1.431ValMet: 1.431 ± 0.02	1.641ValAsn: 1.641 ± 0.026	5.314ValPro: 5.314 ± 0.05	1.988ValGln: 1.988 ± 0.031	7.422ValArg: 7.422 ± 0.056	4.228ValSer: 4.228 ± 0.04	5.722ValThr: 5.722 ± 0.055	7.942ValVal: 7.942 ± 0.065	1.217ValTrp: 1.217 ± 0.02	1.584ValTyr: 1.584 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.708TrpAla: 1.708 ± 0.023	0.163TrpCys: 0.163 ± 0.007	0.872TrpAsp: 0.872 ± 0.02	0.757TrpGlu: 0.757 ± 0.019	0.516TrpPhe: 0.516 ± 0.014	1.074TrpGly: 1.074 ± 0.019	0.385TrpHis: 0.385 ± 0.011	0.563TrpIle: 0.563 ± 0.015	0.387TrpLys: 0.387 ± 0.015	1.796TrpLeu: 1.796 ± 0.03	0.276TrpMet: 0.276 ± 0.009	0.44TrpAsn: 0.44 ± 0.013	0.791TrpPro: 0.791 ± 0.018	0.595TrpGln: 0.595 ± 0.013	1.36TrpArg: 1.36 ± 0.021	0.98TrpSer: 0.98 ± 0.022	1.094TrpThr: 1.094 ± 0.022	0.984TrpVal: 0.984 ± 0.019	0.339TrpTrp: 0.339 ± 0.015	0.379TrpTyr: 0.379 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.79TyrAla: 2.79 ± 0.035	0.191TyrCys: 0.191 ± 0.009	1.558TyrAsp: 1.558 ± 0.027	1.293TyrGlu: 1.293 ± 0.023	0.618TyrPhe: 0.618 ± 0.015	2.3TyrGly: 2.3 ± 0.029	0.387TyrHis: 0.387 ± 0.013	0.484TyrIle: 0.484 ± 0.014	0.405TyrLys: 0.405 ± 0.014	2.078TyrLeu: 2.078 ± 0.029	0.256TyrMet: 0.256 ± 0.011	0.395TyrAsn: 0.395 ± 0.013	1.052TyrPro: 1.052 ± 0.018	0.571TyrGln: 0.571 ± 0.015	1.868TyrArg: 1.868 ± 0.029	0.922TyrSer: 0.922 ± 0.018	1.227TyrThr: 1.227 ± 0.021	1.693TyrVal: 1.693 ± 0.027	0.378TyrTrp: 0.378 ± 0.012	0.461TyrTyr: 0.461 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8700 proteins (2906667 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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