Amino acid dipepetide frequency for Octadecabacter temperatus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.137AlaAla: 14.137 ± 0.178	1.099AlaCys: 1.099 ± 0.035	7.265AlaAsp: 7.265 ± 0.09	7.241AlaGlu: 7.241 ± 0.114	4.427AlaPhe: 4.427 ± 0.067	9.643AlaGly: 9.643 ± 0.113	2.075AlaHis: 2.075 ± 0.054	6.192AlaIle: 6.192 ± 0.08	4.439AlaLys: 4.439 ± 0.095	11.966AlaLeu: 11.966 ± 0.14	3.675AlaMet: 3.675 ± 0.065	3.249AlaAsn: 3.249 ± 0.046	5.116AlaPro: 5.116 ± 0.077	4.311AlaGln: 4.311 ± 0.084	6.592AlaArg: 6.592 ± 0.091	5.744AlaSer: 5.744 ± 0.08	6.318AlaThr: 6.318 ± 0.107	7.922AlaVal: 7.922 ± 0.102	1.307AlaTrp: 1.307 ± 0.037	2.475AlaTyr: 2.475 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.043CysAla: 1.043 ± 0.032	0.12CysCys: 0.12 ± 0.011	0.692CysAsp: 0.692 ± 0.032	0.536CysGlu: 0.536 ± 0.026	0.389CysPhe: 0.389 ± 0.021	0.985CysGly: 0.985 ± 0.036	0.266CysHis: 0.266 ± 0.018	0.497CysIle: 0.497 ± 0.023	0.267CysLys: 0.267 ± 0.017	0.85CysLeu: 0.85 ± 0.029	0.193CysMet: 0.193 ± 0.014	0.273CysAsn: 0.273 ± 0.018	0.467CysPro: 0.467 ± 0.024	0.239CysGln: 0.239 ± 0.017	0.442CysArg: 0.442 ± 0.021	0.51CysSer: 0.51 ± 0.023	0.516CysThr: 0.516 ± 0.032	0.685CysVal: 0.685 ± 0.026	0.114CysTrp: 0.114 ± 0.011	0.221CysTyr: 0.221 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.759AspAla: 7.759 ± 0.106	0.577AspCys: 0.577 ± 0.024	4.117AspAsp: 4.117 ± 0.116	4.027AspGlu: 4.027 ± 0.068	2.529AspPhe: 2.529 ± 0.055	6.122AspGly: 6.122 ± 0.113	1.397AspHis: 1.397 ± 0.042	3.572AspIle: 3.572 ± 0.061	1.871AspLys: 1.871 ± 0.049	6.264AspLeu: 6.264 ± 0.085	1.93AspMet: 1.93 ± 0.046	1.646AspAsn: 1.646 ± 0.049	3.421AspPro: 3.421 ± 0.068	1.979AspGln: 1.979 ± 0.049	3.682AspArg: 3.682 ± 0.068	2.242AspSer: 2.242 ± 0.054	3.496AspThr: 3.496 ± 0.094	5.257AspVal: 5.257 ± 0.082	1.138AspTrp: 1.138 ± 0.035	1.568AspTyr: 1.568 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	7.476GluAla: 7.476 ± 0.11	0.427GluCys: 0.427 ± 0.023	3.587GluAsp: 3.587 ± 0.064	3.276GluGlu: 3.276 ± 0.082	1.971GluPhe: 1.971 ± 0.044	4.723GluGly: 4.723 ± 0.091	1.226GluHis: 1.226 ± 0.037	3.74GluIle: 3.74 ± 0.061	2.252GluLys: 2.252 ± 0.062	5.158GluLeu: 5.158 ± 0.085	1.957GluMet: 1.957 ± 0.051	2.192GluAsn: 2.192 ± 0.051	2.331GluPro: 2.331 ± 0.05	2.079GluGln: 2.079 ± 0.043	3.746GluArg: 3.746 ± 0.071	2.267GluSer: 2.267 ± 0.046	4.102GluThr: 4.102 ± 0.065	4.469GluVal: 4.469 ± 0.081	0.752GluTrp: 0.752 ± 0.029	1.136GluTyr: 1.136 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.483PheAla: 4.483 ± 0.078	0.458PheCys: 0.458 ± 0.021	2.971PheAsp: 2.971 ± 0.062	2.512PheGlu: 2.512 ± 0.051	1.532PhePhe: 1.532 ± 0.05	3.973PheGly: 3.973 ± 0.068	0.696PheHis: 0.696 ± 0.026	1.939PheIle: 1.939 ± 0.048	1.147PheLys: 1.147 ± 0.034	3.469PheLeu: 3.469 ± 0.074	1.004PheMet: 1.004 ± 0.032	1.312PheAsn: 1.312 ± 0.036	1.548PhePro: 1.548 ± 0.038	1.108PheGln: 1.108 ± 0.035	1.908PheArg: 1.908 ± 0.046	2.254PheSer: 2.254 ± 0.052	2.351PheThr: 2.351 ± 0.054	2.95PheVal: 2.95 ± 0.052	0.58PheTrp: 0.58 ± 0.029	1.002PheTyr: 1.002 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	9.156GlyAla: 9.156 ± 0.109	0.902GlyCys: 0.902 ± 0.031	5.209GlyAsp: 5.209 ± 0.114	4.859GlyGlu: 4.859 ± 0.082	3.77GlyPhe: 3.77 ± 0.072	7.403GlyGly: 7.403 ± 0.146	1.81GlyHis: 1.81 ± 0.041	4.647GlyIle: 4.647 ± 0.085	3.271GlyLys: 3.271 ± 0.07	8.607GlyLeu: 8.607 ± 0.119	2.676GlyMet: 2.676 ± 0.052	2.493GlyAsn: 2.493 ± 0.074	3.347GlyPro: 3.347 ± 0.062	3.058GlyGln: 3.058 ± 0.062	4.679GlyArg: 4.679 ± 0.065	4.312GlySer: 4.312 ± 0.077	5.057GlyThr: 5.057 ± 0.087	6.561GlyVal: 6.561 ± 0.105	1.363GlyTrp: 1.363 ± 0.041	2.312GlyTyr: 2.312 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.05HisAla: 2.05 ± 0.053	0.212HisCys: 0.212 ± 0.016	1.305HisAsp: 1.305 ± 0.046	1.032HisGlu: 1.032 ± 0.031	0.887HisPhe: 0.887 ± 0.027	1.745HisGly: 1.745 ± 0.04	0.491HisHis: 0.491 ± 0.028	1.073HisIle: 1.073 ± 0.033	0.607HisLys: 0.607 ± 0.024	2.023HisLeu: 2.023 ± 0.051	0.553HisMet: 0.553 ± 0.024	0.526HisAsn: 0.526 ± 0.023	1.263HisPro: 1.263 ± 0.037	0.58HisGln: 0.58 ± 0.027	1.09HisArg: 1.09 ± 0.032	0.972HisSer: 0.972 ± 0.033	0.918HisThr: 0.918 ± 0.032	1.516HisVal: 1.516 ± 0.043	0.313HisTrp: 0.313 ± 0.019	0.562HisTyr: 0.562 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.29IleAla: 7.29 ± 0.101	0.656IleCys: 0.656 ± 0.025	3.794IleAsp: 3.794 ± 0.06	3.906IleGlu: 3.906 ± 0.069	1.938IlePhe: 1.938 ± 0.061	5.21IleGly: 5.21 ± 0.084	0.963IleHis: 0.963 ± 0.031	2.909IleIle: 2.909 ± 0.066	1.794IleLys: 1.794 ± 0.048	4.934IleLeu: 4.934 ± 0.085	1.313IleMet: 1.313 ± 0.04	1.707IleAsn: 1.707 ± 0.046	2.513IlePro: 2.513 ± 0.048	1.343IleGln: 1.343 ± 0.04	2.788IleArg: 2.788 ± 0.049	3.344IleSer: 3.344 ± 0.059	3.306IleThr: 3.306 ± 0.068	4.227IleVal: 4.227 ± 0.076	0.789IleTrp: 0.789 ± 0.034	1.302IleTyr: 1.302 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.133LysAla: 4.133 ± 0.081	0.214LysCys: 0.214 ± 0.015	2.198LysAsp: 2.198 ± 0.052	1.61LysGlu: 1.61 ± 0.039	1.131LysPhe: 1.131 ± 0.034	2.825LysGly: 2.825 ± 0.058	0.737LysHis: 0.737 ± 0.028	2.003LysIle: 2.003 ± 0.044	1.415LysLys: 1.415 ± 0.047	3.195LysLeu: 3.195 ± 0.066	1.054LysMet: 1.054 ± 0.034	0.974LysAsn: 0.974 ± 0.034	1.919LysPro: 1.919 ± 0.05	1.002LysGln: 1.002 ± 0.039	2.377LysArg: 2.377 ± 0.054	2.122LysSer: 2.122 ± 0.052	2.341LysThr: 2.341 ± 0.055	2.512LysVal: 2.512 ± 0.06	0.449LysTrp: 0.449 ± 0.023	0.718LysTyr: 0.718 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	11.298LeuAla: 11.298 ± 0.143	0.906LeuCys: 0.906 ± 0.029	5.881LeuAsp: 5.881 ± 0.083	5.281LeuGlu: 5.281 ± 0.076	3.562LeuPhe: 3.562 ± 0.079	8.094LeuGly: 8.094 ± 0.103	1.693LeuHis: 1.693 ± 0.048	5.468LeuIle: 5.468 ± 0.084	3.297LeuLys: 3.297 ± 0.069	8.119LeuLeu: 8.119 ± 0.139	2.728LeuMet: 2.728 ± 0.056	3.109LeuAsn: 3.109 ± 0.054	4.82LeuPro: 4.82 ± 0.073	2.759LeuGln: 2.759 ± 0.057	5.763LeuArg: 5.763 ± 0.102	6.551LeuSer: 6.551 ± 0.091	6.117LeuThr: 6.117 ± 0.096	6.623LeuVal: 6.623 ± 0.095	1.209LeuTrp: 1.209 ± 0.036	1.871LeuTyr: 1.871 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.401MetAla: 3.401 ± 0.06	0.217MetCys: 0.217 ± 0.016	1.682MetAsp: 1.682 ± 0.044	1.471MetGlu: 1.471 ± 0.045	1.018MetPhe: 1.018 ± 0.035	2.449MetGly: 2.449 ± 0.059	0.456MetHis: 0.456 ± 0.022	1.747MetIle: 1.747 ± 0.043	1.271MetLys: 1.271 ± 0.031	2.616MetLeu: 2.616 ± 0.057	0.88MetMet: 0.88 ± 0.034	0.989MetAsn: 0.989 ± 0.032	1.487MetPro: 1.487 ± 0.044	0.965MetGln: 0.965 ± 0.029	1.877MetArg: 1.877 ± 0.042	2.043MetSer: 2.043 ± 0.042	2.21MetThr: 2.21 ± 0.048	1.977MetVal: 1.977 ± 0.048	0.299MetTrp: 0.299 ± 0.019	0.422MetTyr: 0.422 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.684AsnAla: 3.684 ± 0.06	0.323AsnCys: 0.323 ± 0.02	2.017AsnAsp: 2.017 ± 0.07	1.572AsnGlu: 1.572 ± 0.043	1.142AsnPhe: 1.142 ± 0.034	2.997AsnGly: 2.997 ± 0.066	0.589AsnHis: 0.589 ± 0.022	1.678AsnIle: 1.678 ± 0.046	0.861AsnLys: 0.861 ± 0.029	2.884AsnLeu: 2.884 ± 0.061	0.845AsnMet: 0.845 ± 0.028	0.884AsnAsn: 0.884 ± 0.028	1.998AsnPro: 1.998 ± 0.043	0.881AsnGln: 0.881 ± 0.027	1.8AsnArg: 1.8 ± 0.041	1.475AsnSer: 1.475 ± 0.037	1.656AsnThr: 1.656 ± 0.056	2.364AsnVal: 2.364 ± 0.044	0.489AsnTrp: 0.489 ± 0.025	0.752AsnTyr: 0.752 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	4.829ProAla: 4.829 ± 0.071	0.378ProCys: 0.378 ± 0.018	3.7ProAsp: 3.7 ± 0.067	3.681ProGlu: 3.681 ± 0.068	2.025ProPhe: 2.025 ± 0.047	2.947ProGly: 2.947 ± 0.052	1.001ProHis: 1.001 ± 0.033	2.587ProIle: 2.587 ± 0.053	1.922ProLys: 1.922 ± 0.051	4.197ProLeu: 4.197 ± 0.068	1.321ProMet: 1.321 ± 0.036	1.746ProAsn: 1.746 ± 0.037	1.744ProPro: 1.744 ± 0.048	1.573ProGln: 1.573 ± 0.042	2.193ProArg: 2.193 ± 0.051	2.855ProSer: 2.855 ± 0.057	2.721ProThr: 2.721 ± 0.057	3.863ProVal: 3.863 ± 0.068	0.605ProTrp: 0.605 ± 0.027	1.124ProTyr: 1.124 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.714GlnAla: 3.714 ± 0.069	0.227GlnCys: 0.227 ± 0.014	1.859GlnAsp: 1.859 ± 0.041	1.539GlnGlu: 1.539 ± 0.039	1.184GlnPhe: 1.184 ± 0.038	2.515GlnGly: 2.515 ± 0.056	0.623GlnHis: 0.623 ± 0.026	2.127GlnIle: 2.127 ± 0.048	1.073GlnLys: 1.073 ± 0.038	2.896GlnLeu: 2.896 ± 0.056	1.169GlnMet: 1.169 ± 0.036	1.056GlnAsn: 1.056 ± 0.038	1.389GlnPro: 1.389 ± 0.041	1.111GlnGln: 1.111 ± 0.038	1.957GlnArg: 1.957 ± 0.05	1.973GlnSer: 1.973 ± 0.047	2.209GlnThr: 2.209 ± 0.05	2.393GlnVal: 2.393 ± 0.049	0.422GlnTrp: 0.422 ± 0.021	0.634GlnTyr: 0.634 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	6.274ArgAla: 6.274 ± 0.077	0.469ArgCys: 0.469 ± 0.022	3.816ArgAsp: 3.816 ± 0.065	3.393ArgGlu: 3.393 ± 0.066	2.283ArgPhe: 2.283 ± 0.052	4.014ArgGly: 4.014 ± 0.069	1.242ArgHis: 1.242 ± 0.037	3.321ArgIle: 3.321 ± 0.056	2.211ArgLys: 2.211 ± 0.053	5.809ArgLeu: 5.809 ± 0.093	1.823ArgMet: 1.823 ± 0.043	1.792ArgAsn: 1.792 ± 0.045	2.496ArgPro: 2.496 ± 0.056	1.944ArgGln: 1.944 ± 0.048	3.577ArgArg: 3.577 ± 0.084	3.056ArgSer: 3.056 ± 0.051	3.002ArgThr: 3.002 ± 0.052	4.241ArgVal: 4.241 ± 0.064	0.769ArgTrp: 0.769 ± 0.027	1.349ArgTyr: 1.349 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.826SerAla: 5.826 ± 0.081	0.533SerCys: 0.533 ± 0.03	3.703SerAsp: 3.703 ± 0.065	3.127SerGlu: 3.127 ± 0.059	2.319SerPhe: 2.319 ± 0.049	5.407SerGly: 5.407 ± 0.08	1.081SerHis: 1.081 ± 0.031	2.993SerIle: 2.993 ± 0.054	1.826SerLys: 1.826 ± 0.043	4.977SerLeu: 4.977 ± 0.08	1.614SerMet: 1.614 ± 0.041	1.809SerAsn: 1.809 ± 0.047	2.464SerPro: 2.464 ± 0.046	1.736SerGln: 1.736 ± 0.042	2.951SerArg: 2.951 ± 0.061	2.866SerSer: 2.866 ± 0.06	2.984SerThr: 2.984 ± 0.058	4.174SerVal: 4.174 ± 0.066	0.655SerTrp: 0.655 ± 0.03	1.362SerTyr: 1.362 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	6.351ThrAla: 6.351 ± 0.104	0.568ThrCys: 0.568 ± 0.031	3.703ThrAsp: 3.703 ± 0.079	3.034ThrGlu: 3.034 ± 0.063	2.503ThrPhe: 2.503 ± 0.057	5.487ThrGly: 5.487 ± 0.092	1.265ThrHis: 1.265 ± 0.036	3.278ThrIle: 3.278 ± 0.075	1.877ThrLys: 1.877 ± 0.044	6.284ThrLeu: 6.284 ± 0.095	1.515ThrMet: 1.515 ± 0.042	1.735ThrAsn: 1.735 ± 0.055	3.557ThrPro: 3.557 ± 0.065	1.907ThrGln: 1.907 ± 0.043	3.248ThrArg: 3.248 ± 0.059	3.257ThrSer: 3.257 ± 0.066	3.321ThrThr: 3.321 ± 0.067	4.635ThrVal: 4.635 ± 0.102	0.734ThrTrp: 0.734 ± 0.027	1.508ThrTyr: 1.508 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	8.412ValAla: 8.412 ± 0.104	0.658ValCys: 0.658 ± 0.026	4.599ValAsp: 4.599 ± 0.083	4.774ValGlu: 4.774 ± 0.08	3.042ValPhe: 3.042 ± 0.058	5.762ValGly: 5.762 ± 0.081	1.293ValHis: 1.293 ± 0.036	4.432ValIle: 4.432 ± 0.073	2.455ValLys: 2.455 ± 0.057	7.298ValLeu: 7.298 ± 0.1	2.263ValMet: 2.263 ± 0.054	2.289ValAsn: 2.289 ± 0.052	3.379ValPro: 3.379 ± 0.06	2.239ValGln: 2.239 ± 0.05	3.958ValArg: 3.958 ± 0.065	4.51ValSer: 4.51 ± 0.069	5.092ValThr: 5.092 ± 0.112	5.856ValVal: 5.856 ± 0.092	0.962ValTrp: 0.962 ± 0.034	1.534ValTyr: 1.534 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.371TrpAla: 1.371 ± 0.043	0.124TrpCys: 0.124 ± 0.012	0.835TrpAsp: 0.835 ± 0.028	0.656TrpGlu: 0.656 ± 0.027	0.579TrpPhe: 0.579 ± 0.027	0.999TrpGly: 0.999 ± 0.036	0.278TrpHis: 0.278 ± 0.015	0.777TrpIle: 0.777 ± 0.029	0.442TrpLys: 0.442 ± 0.021	1.472TrpLeu: 1.472 ± 0.043	0.444TrpMet: 0.444 ± 0.02	0.449TrpAsn: 0.449 ± 0.023	0.665TrpPro: 0.665 ± 0.031	0.498TrpGln: 0.498 ± 0.024	0.885TrpArg: 0.885 ± 0.031	0.757TrpSer: 0.757 ± 0.027	0.815TrpThr: 0.815 ± 0.027	0.976TrpVal: 0.976 ± 0.034	0.221TrpTrp: 0.221 ± 0.014	0.265TrpTyr: 0.265 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.506TyrAla: 2.506 ± 0.061	0.237TyrCys: 0.237 ± 0.015	1.659TyrAsp: 1.659 ± 0.047	1.339TyrGlu: 1.339 ± 0.04	0.966TyrPhe: 0.966 ± 0.032	2.193TyrGly: 2.193 ± 0.056	0.536TyrHis: 0.536 ± 0.023	1.045TyrIle: 1.045 ± 0.032	0.632TyrLys: 0.632 ± 0.03	2.128TyrLeu: 2.128 ± 0.044	0.518TyrMet: 0.518 ± 0.022	0.661TyrAsn: 0.661 ± 0.025	1.089TyrPro: 1.089 ± 0.034	0.758TyrGln: 0.758 ± 0.029	1.369TyrArg: 1.369 ± 0.036	1.297TyrSer: 1.297 ± 0.038	1.237TyrThr: 1.237 ± 0.046	1.605TyrVal: 1.605 ± 0.04	0.34TyrTrp: 0.34 ± 0.021	0.592TyrTyr: 0.592 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3276 proteins (992371 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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