Amino acid dipepetide frequency for Cryptococcus gattii serotype B (strain R265) (Filobasidiella gattii) (Cryptococcus bacillisporus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.673AlaAla: 8.673 ± 0.13	0.886AlaCys: 0.886 ± 0.026	3.782AlaAsp: 3.782 ± 0.058	5.399AlaGlu: 5.399 ± 0.069	2.966AlaPhe: 2.966 ± 0.055	6.057AlaGly: 6.057 ± 0.072	1.779AlaHis: 1.779 ± 0.036	4.129AlaIle: 4.129 ± 0.062	4.739AlaLys: 4.739 ± 0.078	7.926AlaLeu: 7.926 ± 0.095	1.992AlaMet: 1.992 ± 0.04	2.794AlaAsn: 2.794 ± 0.045	5.054AlaPro: 5.054 ± 0.086	3.457AlaGln: 3.457 ± 0.072	4.766AlaArg: 4.766 ± 0.07	7.586AlaSer: 7.586 ± 0.112	4.869AlaThr: 4.869 ± 0.067	5.207AlaVal: 5.207 ± 0.065	1.045AlaTrp: 1.045 ± 0.03	2.045AlaTyr: 2.045 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.754CysAla: 0.754 ± 0.023	0.183CysCys: 0.183 ± 0.013	0.505CysAsp: 0.505 ± 0.019	0.51CysGlu: 0.51 ± 0.022	0.424CysPhe: 0.424 ± 0.018	0.815CysGly: 0.815 ± 0.031	0.242CysHis: 0.242 ± 0.014	0.533CysIle: 0.533 ± 0.022	0.475CysLys: 0.475 ± 0.022	1.068CysLeu: 1.068 ± 0.031	0.249CysMet: 0.249 ± 0.015	0.308CysAsn: 0.308 ± 0.014	0.62CysPro: 0.62 ± 0.027	0.342CysGln: 0.342 ± 0.016	0.541CysArg: 0.541 ± 0.021	0.713CysSer: 0.713 ± 0.026	0.608CysThr: 0.608 ± 0.023	0.671CysVal: 0.671 ± 0.026	0.149CysTrp: 0.149 ± 0.011	0.292CysTyr: 0.292 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.063AspAla: 4.063 ± 0.05	0.499AspCys: 0.499 ± 0.023	3.906AspAsp: 3.906 ± 0.076	5.041AspGlu: 5.041 ± 0.088	1.865AspPhe: 1.865 ± 0.045	3.939AspGly: 3.939 ± 0.067	1.081AspHis: 1.081 ± 0.031	2.799AspIle: 2.799 ± 0.049	2.666AspLys: 2.666 ± 0.058	4.82AspLeu: 4.82 ± 0.063	1.256AspMet: 1.256 ± 0.033	1.689AspAsn: 1.689 ± 0.043	3.175AspPro: 3.175 ± 0.057	1.659AspGln: 1.659 ± 0.035	2.79AspArg: 2.79 ± 0.053	3.52AspSer: 3.52 ± 0.062	2.403AspThr: 2.403 ± 0.047	3.78AspVal: 3.78 ± 0.063	0.839AspTrp: 0.839 ± 0.021	1.434AspTyr: 1.434 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	5.525GluAla: 5.525 ± 0.08	0.566GluCys: 0.566 ± 0.019	4.608GluAsp: 4.608 ± 0.08	7.689GluGlu: 7.689 ± 0.152	1.754GluPhe: 1.754 ± 0.039	5.178GluGly: 5.178 ± 0.067	1.309GluHis: 1.309 ± 0.032	3.203GluIle: 3.203 ± 0.056	4.649GluLys: 4.649 ± 0.076	5.237GluLeu: 5.237 ± 0.074	1.725GluMet: 1.725 ± 0.037	2.278GluAsn: 2.278 ± 0.047	2.643GluPro: 2.643 ± 0.053	2.564GluGln: 2.564 ± 0.05	4.506GluArg: 4.506 ± 0.068	4.304GluSer: 4.304 ± 0.06	3.233GluThr: 3.233 ± 0.05	4.021GluVal: 4.021 ± 0.053	0.997GluTrp: 0.997 ± 0.029	1.555GluTyr: 1.555 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	2.839PheAla: 2.839 ± 0.051	0.434PheCys: 0.434 ± 0.019	2.019PheAsp: 2.019 ± 0.042	2.094PheGlu: 2.094 ± 0.041	1.417PhePhe: 1.417 ± 0.038	2.792PheGly: 2.792 ± 0.057	0.825PheHis: 0.825 ± 0.027	1.772PheIle: 1.772 ± 0.041	1.585PheLys: 1.585 ± 0.039	3.117PheLeu: 3.117 ± 0.058	0.711PheMet: 0.711 ± 0.022	1.327PheAsn: 1.327 ± 0.031	1.989PhePro: 1.989 ± 0.038	1.143PheGln: 1.143 ± 0.028	1.687PheArg: 1.687 ± 0.043	2.866PheSer: 2.866 ± 0.052	2.058PheThr: 2.058 ± 0.04	2.204PheVal: 2.204 ± 0.051	0.498PheTrp: 0.498 ± 0.021	0.925PheTyr: 0.925 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	5.45GlyAla: 5.45 ± 0.085	0.779GlyCys: 0.779 ± 0.029	3.646GlyAsp: 3.646 ± 0.055	4.738GlyGlu: 4.738 ± 0.064	2.558GlyPhe: 2.558 ± 0.048	6.523GlyGly: 6.523 ± 0.108	1.631GlyHis: 1.631 ± 0.039	3.494GlyIle: 3.494 ± 0.056	4.657GlyLys: 4.657 ± 0.067	6.138GlyLeu: 6.138 ± 0.079	1.85GlyMet: 1.85 ± 0.046	2.38GlyAsn: 2.38 ± 0.049	3.233GlyPro: 3.233 ± 0.056	2.705GlyGln: 2.705 ± 0.051	4.256GlyArg: 4.256 ± 0.057	5.705GlySer: 5.705 ± 0.081	3.791GlyThr: 3.791 ± 0.053	4.852GlyVal: 4.852 ± 0.064	1.407GlyTrp: 1.407 ± 0.035	2.066GlyTyr: 2.066 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	1.778HisAla: 1.778 ± 0.04	0.251HisCys: 0.251 ± 0.013	1.085HisAsp: 1.085 ± 0.032	1.193HisGlu: 1.193 ± 0.032	0.834HisPhe: 0.834 ± 0.027	1.485HisGly: 1.485 ± 0.038	0.846HisHis: 0.846 ± 0.036	1.234HisIle: 1.234 ± 0.032	0.9HisLys: 0.9 ± 0.031	2.51HisLeu: 2.51 ± 0.047	0.441HisMet: 0.441 ± 0.018	0.733HisAsn: 0.733 ± 0.023	1.983HisPro: 1.983 ± 0.038	0.866HisGln: 0.866 ± 0.028	1.341HisArg: 1.341 ± 0.032	1.981HisSer: 1.981 ± 0.046	1.292HisThr: 1.292 ± 0.032	1.343HisVal: 1.343 ± 0.033	0.278HisTrp: 0.278 ± 0.015	0.651HisTyr: 0.651 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	4.057IleAla: 4.057 ± 0.067	0.659IleCys: 0.659 ± 0.024	2.761IleAsp: 2.761 ± 0.043	2.932IleGlu: 2.932 ± 0.046	1.822IlePhe: 1.822 ± 0.042	3.309IleGly: 3.309 ± 0.054	1.18IleHis: 1.18 ± 0.033	2.602IleIle: 2.602 ± 0.058	2.461IleLys: 2.461 ± 0.042	4.423IleLeu: 4.423 ± 0.067	1.006IleMet: 1.006 ± 0.027	1.77IleAsn: 1.77 ± 0.042	3.502IlePro: 3.502 ± 0.048	1.698IleGln: 1.698 ± 0.036	2.697IleArg: 2.697 ± 0.044	4.157IleSer: 4.157 ± 0.062	2.769IleThr: 2.769 ± 0.046	3.137IleVal: 3.137 ± 0.052	0.688IleTrp: 0.688 ± 0.023	1.247IleTyr: 1.247 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	4.824LysAla: 4.824 ± 0.08	0.435LysCys: 0.435 ± 0.019	2.954LysAsp: 2.954 ± 0.059	4.544LysGlu: 4.544 ± 0.077	1.437LysPhe: 1.437 ± 0.036	4.102LysGly: 4.102 ± 0.057	1.095LysHis: 1.095 ± 0.03	2.447LysIle: 2.447 ± 0.042	4.419LysLys: 4.419 ± 0.09	4.277LysLeu: 4.277 ± 0.065	1.208LysMet: 1.208 ± 0.029	1.687LysAsn: 1.687 ± 0.041	2.82LysPro: 2.82 ± 0.049	1.937LysGln: 1.937 ± 0.041	3.874LysArg: 3.874 ± 0.068	3.812LysSer: 3.812 ± 0.065	2.883LysThr: 2.883 ± 0.05	3.35LysVal: 3.35 ± 0.053	0.762LysTrp: 0.762 ± 0.023	1.349LysTyr: 1.349 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	8.04LeuAla: 8.04 ± 0.083	0.987LeuCys: 0.987 ± 0.028	4.728LeuAsp: 4.728 ± 0.062	5.588LeuGlu: 5.588 ± 0.074	3.181LeuPhe: 3.181 ± 0.054	6.062LeuGly: 6.062 ± 0.077	2.287LeuHis: 2.287 ± 0.045	4.226LeuIle: 4.226 ± 0.064	4.379LeuLys: 4.379 ± 0.076	8.579LeuLeu: 8.579 ± 0.115	1.696LeuMet: 1.696 ± 0.037	2.941LeuAsn: 2.941 ± 0.045	6.508LeuPro: 6.508 ± 0.082	3.324LeuGln: 3.324 ± 0.052	5.23LeuArg: 5.23 ± 0.068	8.304LeuSer: 8.304 ± 0.084	5.011LeuThr: 5.011 ± 0.07	5.335LeuVal: 5.335 ± 0.076	1.039LeuTrp: 1.039 ± 0.03	2.199LeuTyr: 2.199 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.002MetAla: 2.002 ± 0.045	0.194MetCys: 0.194 ± 0.013	1.238MetAsp: 1.238 ± 0.038	1.429MetGlu: 1.429 ± 0.038	0.74MetPhe: 0.74 ± 0.028	1.656MetGly: 1.656 ± 0.045	0.351MetHis: 0.351 ± 0.016	0.957MetIle: 0.957 ± 0.026	1.064MetLys: 1.064 ± 0.031	1.746MetLeu: 1.746 ± 0.036	0.593MetMet: 0.593 ± 0.025	0.718MetAsn: 0.718 ± 0.023	1.358MetPro: 1.358 ± 0.034	0.692MetGln: 0.692 ± 0.026	1.28MetArg: 1.28 ± 0.034	2.202MetSer: 2.202 ± 0.041	1.294MetThr: 1.294 ± 0.026	1.286MetVal: 1.286 ± 0.033	0.248MetTrp: 0.248 ± 0.013	0.436MetTyr: 0.436 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.003AsnAla: 3.003 ± 0.047	0.321AsnCys: 0.321 ± 0.015	1.771AsnAsp: 1.771 ± 0.036	2.081AsnGlu: 2.081 ± 0.04	1.171AsnPhe: 1.171 ± 0.035	2.694AsnGly: 2.694 ± 0.055	0.748AsnHis: 0.748 ± 0.026	1.761AsnIle: 1.761 ± 0.037	1.665AsnLys: 1.665 ± 0.037	3.083AsnLeu: 3.083 ± 0.048	0.71AsnMet: 0.71 ± 0.024	1.228AsnAsn: 1.228 ± 0.033	2.461AsnPro: 2.461 ± 0.046	1.229AsnGln: 1.229 ± 0.032	1.714AsnArg: 1.714 ± 0.031	2.545AsnSer: 2.545 ± 0.056	1.915AsnThr: 1.915 ± 0.044	2.314AsnVal: 2.314 ± 0.039	0.463AsnTrp: 0.463 ± 0.023	0.897AsnTyr: 0.897 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.306ProAla: 5.306 ± 0.089	0.446ProCys: 0.446 ± 0.022	2.909ProAsp: 2.909 ± 0.047	3.733ProGlu: 3.733 ± 0.061	2.193ProPhe: 2.193 ± 0.043	3.666ProGly: 3.666 ± 0.059	1.53ProHis: 1.53 ± 0.034	3.032ProIle: 3.032 ± 0.048	2.903ProLys: 2.903 ± 0.055	5.631ProLeu: 5.631 ± 0.069	1.014ProMet: 1.014 ± 0.03	2.235ProAsn: 2.235 ± 0.045	6.104ProPro: 6.104 ± 0.124	2.492ProGln: 2.492 ± 0.058	3.206ProArg: 3.206 ± 0.06	7.851ProSer: 7.851 ± 0.118	4.427ProThr: 4.427 ± 0.07	3.721ProVal: 3.721 ± 0.055	0.605ProTrp: 0.605 ± 0.021	1.581ProTyr: 1.581 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.478GlnAla: 3.478 ± 0.068	0.344GlnCys: 0.344 ± 0.018	1.708GlnAsp: 1.708 ± 0.039	2.344GlnGlu: 2.344 ± 0.052	1.118GlnPhe: 1.118 ± 0.03	2.528GlnGly: 2.528 ± 0.038	0.874GlnHis: 0.874 ± 0.024	1.751GlnIle: 1.751 ± 0.036	1.86GlnLys: 1.86 ± 0.044	3.285GlnLeu: 3.285 ± 0.052	0.881GlnMet: 0.881 ± 0.028	1.316GlnAsn: 1.316 ± 0.037	2.657GlnPro: 2.657 ± 0.068	2.198GlnGln: 2.198 ± 0.089	2.314GlnArg: 2.314 ± 0.043	3.161GlnSer: 3.161 ± 0.056	2.2GlnThr: 2.2 ± 0.045	2.156GlnVal: 2.156 ± 0.045	0.498GlnTrp: 0.498 ± 0.02	0.987GlnTyr: 0.987 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	4.755ArgAla: 4.755 ± 0.06	0.511ArgCys: 0.511 ± 0.02	2.942ArgAsp: 2.942 ± 0.064	4.164ArgGlu: 4.164 ± 0.066	1.852ArgPhe: 1.852 ± 0.035	3.884ArgGly: 3.884 ± 0.068	1.403ArgHis: 1.403 ± 0.033	2.724ArgIle: 2.724 ± 0.047	3.689ArgLys: 3.689 ± 0.06	5.129ArgLeu: 5.129 ± 0.072	1.369ArgMet: 1.369 ± 0.029	1.903ArgAsn: 1.903 ± 0.038	3.603ArgPro: 3.603 ± 0.068	2.438ArgGln: 2.438 ± 0.04	4.859ArgArg: 4.859 ± 0.084	4.62ArgSer: 4.62 ± 0.08	3.019ArgThr: 3.019 ± 0.047	3.264ArgVal: 3.264 ± 0.047	0.87ArgTrp: 0.87 ± 0.027	1.484ArgTyr: 1.484 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	7.37SerAla: 7.37 ± 0.101	0.677SerCys: 0.677 ± 0.026	4.08SerAsp: 4.08 ± 0.066	4.382SerGlu: 4.382 ± 0.071	3.074SerPhe: 3.074 ± 0.049	5.825SerGly: 5.825 ± 0.076	2.213SerHis: 2.213 ± 0.056	4.085SerIle: 4.085 ± 0.062	4.073SerLys: 4.073 ± 0.064	7.974SerLeu: 7.974 ± 0.091	1.515SerMet: 1.515 ± 0.035	2.951SerAsn: 2.951 ± 0.052	6.366SerPro: 6.366 ± 0.112	3.334SerGln: 3.334 ± 0.063	4.768SerArg: 4.768 ± 0.09	11.114SerSer: 11.114 ± 0.194	6.253SerThr: 6.253 ± 0.096	4.838SerVal: 4.838 ± 0.061	0.951SerTrp: 0.951 ± 0.029	2.106SerTyr: 2.106 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.928ThrAla: 4.928 ± 0.057	0.644ThrCys: 0.644 ± 0.026	2.468ThrAsp: 2.468 ± 0.051	2.883ThrGlu: 2.883 ± 0.047	2.159ThrPhe: 2.159 ± 0.036	3.976ThrGly: 3.976 ± 0.06	1.362ThrHis: 1.362 ± 0.031	3.02ThrIle: 3.02 ± 0.049	2.608ThrLys: 2.608 ± 0.046	5.389ThrLeu: 5.389 ± 0.065	1.039ThrMet: 1.039 ± 0.029	1.862ThrAsn: 1.862 ± 0.046	4.718ThrPro: 4.718 ± 0.073	1.891ThrGln: 1.891 ± 0.041	2.965ThrArg: 2.965 ± 0.048	5.964ThrSer: 5.964 ± 0.087	3.819ThrThr: 3.819 ± 0.078	3.497ThrVal: 3.497 ± 0.053	0.72ThrTrp: 0.72 ± 0.025	1.536ThrTyr: 1.536 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	5.109ValAla: 5.109 ± 0.073	0.686ValCys: 0.686 ± 0.024	3.639ValAsp: 3.639 ± 0.058	4.328ValGlu: 4.328 ± 0.066	2.229ValPhe: 2.229 ± 0.04	4.406ValGly: 4.406 ± 0.067	1.344ValHis: 1.344 ± 0.031	3.1ValIle: 3.1 ± 0.053	3.523ValLys: 3.523 ± 0.052	5.61ValLeu: 5.61 ± 0.076	1.321ValMet: 1.321 ± 0.027	2.142ValAsn: 2.142 ± 0.039	3.737ValPro: 3.737 ± 0.054	2.304ValGln: 2.304 ± 0.044	3.388ValArg: 3.388 ± 0.051	4.615ValSer: 4.615 ± 0.059	3.305ValThr: 3.305 ± 0.045	4.198ValVal: 4.198 ± 0.065	0.942ValTrp: 0.942 ± 0.03	1.646ValTyr: 1.646 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.078TrpAla: 1.078 ± 0.032	0.177TrpCys: 0.177 ± 0.012	0.909TrpAsp: 0.909 ± 0.03	0.984TrpGlu: 0.984 ± 0.03	0.456TrpPhe: 0.456 ± 0.02	1.036TrpGly: 1.036 ± 0.033	0.245TrpHis: 0.245 ± 0.015	0.675TrpIle: 0.675 ± 0.022	0.812TrpLys: 0.812 ± 0.028	1.168TrpLeu: 1.168 ± 0.03	0.357TrpMet: 0.357 ± 0.016	0.507TrpAsn: 0.507 ± 0.023	0.531TrpPro: 0.531 ± 0.022	0.487TrpGln: 0.487 ± 0.02	0.897TrpArg: 0.897 ± 0.03	0.989TrpSer: 0.989 ± 0.026	0.787TrpThr: 0.787 ± 0.024	0.882TrpVal: 0.882 ± 0.03	0.285TrpTrp: 0.285 ± 0.015	0.357TrpTyr: 0.357 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.121TyrAla: 2.121 ± 0.037	0.324TyrCys: 0.324 ± 0.016	1.562TyrAsp: 1.562 ± 0.039	1.488TyrGlu: 1.488 ± 0.035	1.052TyrPhe: 1.052 ± 0.029	1.925TyrGly: 1.925 ± 0.044	0.681TyrHis: 0.681 ± 0.024	1.331TyrIle: 1.331 ± 0.035	1.089TyrLys: 1.089 ± 0.039	2.534TyrLeu: 2.534 ± 0.047	0.548TyrMet: 0.548 ± 0.02	1.006TyrAsn: 1.006 ± 0.026	1.524TyrPro: 1.524 ± 0.037	0.9TyrGln: 0.9 ± 0.027	1.402TyrArg: 1.402 ± 0.034	1.943TyrSer: 1.943 ± 0.039	1.512TyrThr: 1.512 ± 0.04	1.518TyrVal: 1.518 ± 0.031	0.335TyrTrp: 0.335 ± 0.018	0.805TyrTyr: 0.805 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2942 proteins (1331672 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---