Amino acid dipepetide frequency for Olsenella sp. oral taxon 809 str. F0356

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.172AlaAla: 13.172 ± 0.225
1.907AlaCys: 1.907 ± 0.061
6.639AlaAsp: 6.639 ± 0.101
6.826AlaGlu: 6.826 ± 0.12
3.606AlaPhe: 3.606 ± 0.079
9.866AlaGly: 9.866 ± 0.165
2.051AlaHis: 2.051 ± 0.056
5.046AlaIle: 5.046 ± 0.116
3.632AlaLys: 3.632 ± 0.096
11.947AlaLeu: 11.947 ± 0.191
2.924AlaMet: 2.924 ± 0.076
2.605AlaAsn: 2.605 ± 0.068
4.202AlaPro: 4.202 ± 0.097
3.795AlaGln: 3.795 ± 0.081
8.7AlaArg: 8.7 ± 0.145
7.43AlaSer: 7.43 ± 0.115
5.537AlaThr: 5.537 ± 0.096
7.97AlaVal: 7.97 ± 0.118
1.231AlaTrp: 1.231 ± 0.044
2.764AlaTyr: 2.764 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
1.693CysAla: 1.693 ± 0.053
0.323CysCys: 0.323 ± 0.023
1.079CysAsp: 1.079 ± 0.042
0.943CysGlu: 0.943 ± 0.045
0.468CysPhe: 0.468 ± 0.03
1.669CysGly: 1.669 ± 0.051
0.323CysHis: 0.323 ± 0.023
0.559CysIle: 0.559 ± 0.033
0.371CysLys: 0.371 ± 0.025
1.273CysLeu: 1.273 ± 0.046
0.307CysMet: 0.307 ± 0.025
0.309CysAsn: 0.309 ± 0.022
0.791CysPro: 0.791 ± 0.038
0.404CysGln: 0.404 ± 0.026
0.927CysArg: 0.927 ± 0.037
0.82CysSer: 0.82 ± 0.04
0.661CysThr: 0.661 ± 0.035
1.34CysVal: 1.34 ± 0.043
0.149CysTrp: 0.149 ± 0.018
0.391CysTyr: 0.391 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
7.745AspAla: 7.745 ± 0.118
0.789AspCys: 0.789 ± 0.036
4.08AspAsp: 4.08 ± 0.102
5.922AspGlu: 5.922 ± 0.094
2.519AspPhe: 2.519 ± 0.064
6.176AspGly: 6.176 ± 0.144
1.183AspHis: 1.183 ± 0.045
2.372AspIle: 2.372 ± 0.074
1.721AspLys: 1.721 ± 0.056
5.848AspLeu: 5.848 ± 0.097
1.412AspMet: 1.412 ± 0.048
1.204AspAsn: 1.204 ± 0.04
3.171AspPro: 3.171 ± 0.079
1.747AspGln: 1.747 ± 0.059
3.488AspArg: 3.488 ± 0.082
3.169AspSer: 3.169 ± 0.07
2.346AspThr: 2.346 ± 0.061
5.75AspVal: 5.75 ± 0.101
0.82AspTrp: 0.82 ± 0.039
1.91AspTyr: 1.91 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
7.545GluAla: 7.545 ± 0.123
0.769GluCys: 0.769 ± 0.037
3.885GluAsp: 3.885 ± 0.077
4.857GluGlu: 4.857 ± 0.11
2.018GluPhe: 2.018 ± 0.063
6.767GluGly: 6.767 ± 0.123
1.356GluHis: 1.356 ± 0.047
1.962GluIle: 1.962 ± 0.066
2.138GluLys: 2.138 ± 0.076
8.383GluLeu: 8.383 ± 0.146
1.467GluMet: 1.467 ± 0.055
1.337GluAsn: 1.337 ± 0.051
2.777GluPro: 2.777 ± 0.086
2.115GluGln: 2.115 ± 0.071
5.99GluArg: 5.99 ± 0.111
3.148GluSer: 3.148 ± 0.078
2.482GluThr: 2.482 ± 0.065
5.319GluVal: 5.319 ± 0.093
0.641GluTrp: 0.641 ± 0.031
1.451GluTyr: 1.451 ± 0.061
0.0GluXaa: 0.0 ± 0.0
Phe
3.709PheAla: 3.709 ± 0.083
0.557PheCys: 0.557 ± 0.031
2.815PheAsp: 2.815 ± 0.07
2.243PheGlu: 2.243 ± 0.062
1.235PhePhe: 1.235 ± 0.056
3.225PheGly: 3.225 ± 0.078
0.634PheHis: 0.634 ± 0.033
1.105PheIle: 1.105 ± 0.055
0.964PheLys: 0.964 ± 0.041
3.026PheLeu: 3.026 ± 0.076
0.793PheMet: 0.793 ± 0.036
0.861PheAsn: 0.861 ± 0.044
1.347PhePro: 1.347 ± 0.049
0.874PheGln: 0.874 ± 0.037
1.782PheArg: 1.782 ± 0.058
2.392PheSer: 2.392 ± 0.069
1.51PheThr: 1.51 ± 0.056
3.239PheVal: 3.239 ± 0.083
0.399PheTrp: 0.399 ± 0.025
0.951PheTyr: 0.951 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
8.219GlyAla: 8.219 ± 0.119
1.491GlyCys: 1.491 ± 0.057
4.919GlyAsp: 4.919 ± 0.101
6.231GlyGlu: 6.231 ± 0.106
3.34GlyPhe: 3.34 ± 0.075
7.667GlyGly: 7.667 ± 0.155
1.886GlyHis: 1.886 ± 0.063
4.785GlyIle: 4.785 ± 0.099
3.337GlyLys: 3.337 ± 0.083
8.666GlyLeu: 8.666 ± 0.158
2.77GlyMet: 2.77 ± 0.073
2.162GlyAsn: 2.162 ± 0.066
2.847GlyPro: 2.847 ± 0.071
2.661GlyGln: 2.661 ± 0.066
6.849GlyArg: 6.849 ± 0.121
6.315GlySer: 6.315 ± 0.122
4.809GlyThr: 4.809 ± 0.084
7.299GlyVal: 7.299 ± 0.121
1.217GlyTrp: 1.217 ± 0.052
2.668GlyTyr: 2.668 ± 0.072
0.0GlyXaa: 0.0 ± 0.0
His
2.083HisAla: 2.083 ± 0.058
0.298HisCys: 0.298 ± 0.021
1.396HisAsp: 1.396 ± 0.053
1.38HisGlu: 1.38 ± 0.051
0.693HisPhe: 0.693 ± 0.035
1.914HisGly: 1.914 ± 0.052
0.444HisHis: 0.444 ± 0.031
0.673HisIle: 0.673 ± 0.033
0.551HisLys: 0.551 ± 0.026
1.64HisLeu: 1.64 ± 0.056
0.452HisMet: 0.452 ± 0.029
0.461HisAsn: 0.461 ± 0.026
1.131HisPro: 1.131 ± 0.04
0.447HisGln: 0.447 ± 0.026
1.159HisArg: 1.159 ± 0.048
0.934HisSer: 0.934 ± 0.044
0.78HisThr: 0.78 ± 0.032
1.829HisVal: 1.829 ± 0.06
0.2HisTrp: 0.2 ± 0.017
0.54HisTyr: 0.54 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.131IleAla: 5.131 ± 0.106
0.719IleCys: 0.719 ± 0.033
3.14IleAsp: 3.14 ± 0.073
2.934IleGlu: 2.934 ± 0.067
1.137IlePhe: 1.137 ± 0.047
3.323IleGly: 3.323 ± 0.082
0.7IleHis: 0.7 ± 0.036
1.619IleIle: 1.619 ± 0.075
1.387IleLys: 1.387 ± 0.055
3.369IleLeu: 3.369 ± 0.086
1.022IleMet: 1.022 ± 0.046
1.158IleAsn: 1.158 ± 0.049
2.139IlePro: 2.139 ± 0.066
1.09IleGln: 1.09 ± 0.052
2.418IleArg: 2.418 ± 0.06
2.665IleSer: 2.665 ± 0.07
2.07IleThr: 2.07 ± 0.063
3.717IleVal: 3.717 ± 0.1
0.339IleTrp: 0.339 ± 0.023
1.004IleTyr: 1.004 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
3.653LysAla: 3.653 ± 0.104
0.311LysCys: 0.311 ± 0.022
1.821LysAsp: 1.821 ± 0.051
1.89LysGlu: 1.89 ± 0.07
0.786LysPhe: 0.786 ± 0.04
2.772LysGly: 2.772 ± 0.07
0.503LysHis: 0.503 ± 0.028
1.395LysIle: 1.395 ± 0.055
1.374LysLys: 1.374 ± 0.066
2.791LysLeu: 2.791 ± 0.064
0.759LysMet: 0.759 ± 0.036
0.972LysAsn: 0.972 ± 0.044
1.355LysPro: 1.355 ± 0.049
0.821LysGln: 0.821 ± 0.041
2.184LysArg: 2.184 ± 0.066
2.021LysSer: 2.021 ± 0.064
1.896LysThr: 1.896 ± 0.063
2.858LysVal: 2.858 ± 0.078
0.295LysTrp: 0.295 ± 0.019
0.825LysTyr: 0.825 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
13.041LeuAla: 13.041 ± 0.212
1.526LeuCys: 1.526 ± 0.055
6.665LeuAsp: 6.665 ± 0.122
6.143LeuGlu: 6.143 ± 0.118
3.118LeuPhe: 3.118 ± 0.08
9.416LeuGly: 9.416 ± 0.157
1.603LeuHis: 1.603 ± 0.051
3.044LeuIle: 3.044 ± 0.088
2.649LeuLys: 2.649 ± 0.083
9.88LeuLeu: 9.88 ± 0.199
2.5LeuMet: 2.5 ± 0.064
2.038LeuAsn: 2.038 ± 0.058
4.897LeuPro: 4.897 ± 0.083
2.373LeuGln: 2.373 ± 0.066
7.297LeuArg: 7.297 ± 0.153
7.071LeuSer: 7.071 ± 0.13
4.508LeuThr: 4.508 ± 0.081
9.203LeuVal: 9.203 ± 0.133
0.935LeuTrp: 0.935 ± 0.039
2.104LeuTyr: 2.104 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
3.05MetAla: 3.05 ± 0.066
0.29MetCys: 0.29 ± 0.022
1.596MetAsp: 1.596 ± 0.058
1.414MetGlu: 1.414 ± 0.052
0.661MetPhe: 0.661 ± 0.034
2.689MetGly: 2.689 ± 0.07
0.445MetHis: 0.445 ± 0.029
0.873MetIle: 0.873 ± 0.043
0.7MetLys: 0.7 ± 0.032
2.437MetLeu: 2.437 ± 0.074
0.548MetMet: 0.548 ± 0.028
0.673MetAsn: 0.673 ± 0.03
1.342MetPro: 1.342 ± 0.043
0.717MetGln: 0.717 ± 0.036
1.998MetArg: 1.998 ± 0.055
1.808MetSer: 1.808 ± 0.055
1.166MetThr: 1.166 ± 0.042
2.002MetVal: 2.002 ± 0.061
0.171MetTrp: 0.171 ± 0.016
0.506MetTyr: 0.506 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
2.815AsnAla: 2.815 ± 0.067
0.322AsnCys: 0.322 ± 0.025
1.556AsnAsp: 1.556 ± 0.06
1.39AsnGlu: 1.39 ± 0.05
0.812AsnPhe: 0.812 ± 0.035
2.117AsnGly: 2.117 ± 0.068
0.485AsnHis: 0.485 ± 0.032
1.047AsnIle: 1.047 ± 0.049
0.743AsnLys: 0.743 ± 0.036
2.312AsnLeu: 2.312 ± 0.067
0.634AsnMet: 0.634 ± 0.033
0.6AsnAsn: 0.6 ± 0.04
1.633AsnPro: 1.633 ± 0.055
0.709AsnGln: 0.709 ± 0.036
1.246AsnArg: 1.246 ± 0.045
1.3AsnSer: 1.3 ± 0.052
1.078AsnThr: 1.078 ± 0.047
2.341AsnVal: 2.341 ± 0.075
0.267AsnTrp: 0.267 ± 0.022
0.788AsnTyr: 0.788 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
4.687ProAla: 4.687 ± 0.113
0.589ProCys: 0.589 ± 0.034
3.057ProAsp: 3.057 ± 0.071
3.523ProGlu: 3.523 ± 0.079
1.556ProPhe: 1.556 ± 0.055
3.776ProGly: 3.776 ± 0.092
0.834ProHis: 0.834 ± 0.037
1.685ProIle: 1.685 ± 0.052
1.54ProLys: 1.54 ± 0.056
4.143ProLeu: 4.143 ± 0.077
0.825ProMet: 0.825 ± 0.038
1.167ProAsn: 1.167 ± 0.053
1.188ProPro: 1.188 ± 0.049
1.638ProGln: 1.638 ± 0.051
2.818ProArg: 2.818 ± 0.071
3.151ProSer: 3.151 ± 0.074
2.346ProThr: 2.346 ± 0.057
3.54ProVal: 3.54 ± 0.084
0.546ProTrp: 0.546 ± 0.027
1.276ProTyr: 1.276 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
3.404GlnAla: 3.404 ± 0.079
0.226GlnCys: 0.226 ± 0.017
1.715GlnAsp: 1.715 ± 0.055
1.898GlnGlu: 1.898 ± 0.063
0.842GlnPhe: 0.842 ± 0.041
2.625GlnGly: 2.625 ± 0.069
0.442GlnHis: 0.442 ± 0.028
1.545GlnIle: 1.545 ± 0.051
1.007GlnLys: 1.007 ± 0.042
3.014GlnLeu: 3.014 ± 0.073
0.951GlnMet: 0.951 ± 0.039
0.914GlnAsn: 0.914 ± 0.04
1.119GlnPro: 1.119 ± 0.041
0.924GlnGln: 0.924 ± 0.052
2.232GlnArg: 2.232 ± 0.081
1.705GlnSer: 1.705 ± 0.05
1.64GlnThr: 1.64 ± 0.054
2.554GlnVal: 2.554 ± 0.058
0.269GlnTrp: 0.269 ± 0.024
0.652GlnTyr: 0.652 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
7.143ArgAla: 7.143 ± 0.143
0.895ArgCys: 0.895 ± 0.042
4.301ArgAsp: 4.301 ± 0.101
5.342ArgGlu: 5.342 ± 0.103
2.259ArgPhe: 2.259 ± 0.062
5.653ArgGly: 5.653 ± 0.116
1.566ArgHis: 1.566 ± 0.047
3.183ArgIle: 3.183 ± 0.077
2.154ArgLys: 2.154 ± 0.064
7.427ArgLeu: 7.427 ± 0.162
2.064ArgMet: 2.064 ± 0.056
1.657ArgAsn: 1.657 ± 0.06
3.139ArgPro: 3.139 ± 0.093
2.37ArgGln: 2.37 ± 0.065
6.211ArgArg: 6.211 ± 0.151
4.229ArgSer: 4.229 ± 0.093
2.988ArgThr: 2.988 ± 0.077
5.6ArgVal: 5.6 ± 0.116
0.821ArgTrp: 0.821 ± 0.035
1.949ArgTyr: 1.949 ± 0.071
0.0ArgXaa: 0.0 ± 0.0
Ser
6.527SerAla: 6.527 ± 0.113
1.079SerCys: 1.079 ± 0.046
3.798SerAsp: 3.798 ± 0.08
3.406SerGlu: 3.406 ± 0.078
2.687SerPhe: 2.687 ± 0.071
5.821SerGly: 5.821 ± 0.107
1.308SerHis: 1.308 ± 0.044
2.879SerIle: 2.879 ± 0.076
2.054SerLys: 2.054 ± 0.059
6.528SerLeu: 6.528 ± 0.115
1.552SerMet: 1.552 ± 0.049
1.587SerAsn: 1.587 ± 0.054
2.725SerPro: 2.725 ± 0.066
2.099SerGln: 2.099 ± 0.063
4.069SerArg: 4.069 ± 0.09
4.493SerSer: 4.493 ± 0.112
3.166SerThr: 3.166 ± 0.083
5.135SerVal: 5.135 ± 0.091
0.916SerTrp: 0.916 ± 0.042
2.175SerTyr: 2.175 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
4.541ThrAla: 4.541 ± 0.087
0.724ThrCys: 0.724 ± 0.029
2.746ThrAsp: 2.746 ± 0.063
2.327ThrGlu: 2.327 ± 0.067
1.742ThrPhe: 1.742 ± 0.062
4.418ThrGly: 4.418 ± 0.101
1.065ThrHis: 1.065 ± 0.043
2.508ThrIle: 2.508 ± 0.076
1.609ThrLys: 1.609 ± 0.056
5.153ThrLeu: 5.153 ± 0.093
1.142ThrMet: 1.142 ± 0.036
1.424ThrAsn: 1.424 ± 0.047
2.671ThrPro: 2.671 ± 0.071
1.424ThrGln: 1.424 ± 0.049
2.961ThrArg: 2.961 ± 0.082
3.281ThrSer: 3.281 ± 0.085
2.804ThrThr: 2.804 ± 0.071
3.982ThrVal: 3.982 ± 0.093
0.472ThrTrp: 0.472 ± 0.028
1.359ThrTyr: 1.359 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
9.861ValAla: 9.861 ± 0.172
1.449ValCys: 1.449 ± 0.05
5.529ValAsp: 5.529 ± 0.105
5.307ValGlu: 5.307 ± 0.108
2.765ValPhe: 2.765 ± 0.072
6.98ValGly: 6.98 ± 0.115
1.355ValHis: 1.355 ± 0.051
3.596ValIle: 3.596 ± 0.084
2.239ValLys: 2.239 ± 0.07
8.067ValLeu: 8.067 ± 0.142
2.138ValMet: 2.138 ± 0.058
2.051ValAsn: 2.051 ± 0.064
3.926ValPro: 3.926 ± 0.084
2.122ValGln: 2.122 ± 0.061
5.954ValArg: 5.954 ± 0.13
5.928ValSer: 5.928 ± 0.093
4.89ValThr: 4.89 ± 0.107
8.139ValVal: 8.139 ± 0.139
0.86ValTrp: 0.86 ± 0.032
1.854ValTyr: 1.854 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
1.055TrpAla: 1.055 ± 0.042
0.213TrpCys: 0.213 ± 0.017
0.73TrpAsp: 0.73 ± 0.034
0.735TrpGlu: 0.735 ± 0.031
0.394TrpPhe: 0.394 ± 0.022
0.95TrpGly: 0.95 ± 0.041
0.266TrpHis: 0.266 ± 0.023
0.357TrpIle: 0.357 ± 0.022
0.384TrpLys: 0.384 ± 0.024
1.139TrpLeu: 1.139 ± 0.042
0.304TrpMet: 0.304 ± 0.02
0.317TrpAsn: 0.317 ± 0.021
0.418TrpPro: 0.418 ± 0.026
0.408TrpGln: 0.408 ± 0.026
0.895TrpArg: 0.895 ± 0.048
0.629TrpSer: 0.629 ± 0.032
0.452TrpThr: 0.452 ± 0.033
0.837TrpVal: 0.837 ± 0.036
0.146TrpTrp: 0.146 ± 0.016
0.331TrpTyr: 0.331 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.775TyrAla: 2.775 ± 0.062
0.323TyrCys: 0.323 ± 0.024
1.904TyrAsp: 1.904 ± 0.052
1.699TyrGlu: 1.699 ± 0.05
1.023TyrPhe: 1.023 ± 0.045
2.319TyrGly: 2.319 ± 0.066
0.552TyrHis: 0.552 ± 0.033
0.849TyrIle: 0.849 ± 0.044
0.725TyrLys: 0.725 ± 0.038
2.966TyrLeu: 2.966 ± 0.083
0.522TyrMet: 0.522 ± 0.033
0.698TyrAsn: 0.698 ± 0.033
1.07TyrPro: 1.07 ± 0.044
0.938TyrGln: 0.938 ± 0.044
1.773TyrArg: 1.773 ± 0.053
1.515TyrSer: 1.515 ± 0.062
1.225TyrThr: 1.225 ± 0.053
2.355TyrVal: 2.355 ± 0.061
0.266TyrTrp: 0.266 ± 0.022
0.775TyrTyr: 0.775 ± 0.047
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1898 proteins (624498 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski