Amino acid dipepetide frequency for Rubricoccus marinus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.438AlaAla: 16.438 ± 0.159
0.867AlaCys: 0.867 ± 0.028
8.035AlaAsp: 8.035 ± 0.094
8.517AlaGlu: 8.517 ± 0.1
4.921AlaPhe: 4.921 ± 0.07
10.248AlaGly: 10.248 ± 0.097
2.305AlaHis: 2.305 ± 0.054
4.584AlaIle: 4.584 ± 0.066
2.253AlaLys: 2.253 ± 0.057
15.384AlaLeu: 15.384 ± 0.167
2.781AlaMet: 2.781 ± 0.065
2.37AlaAsn: 2.37 ± 0.047
8.022AlaPro: 8.022 ± 0.102
4.103AlaGln: 4.103 ± 0.063
10.365AlaArg: 10.365 ± 0.119
10.008AlaSer: 10.008 ± 0.095
6.804AlaThr: 6.804 ± 0.076
9.884AlaVal: 9.884 ± 0.112
1.794AlaTrp: 1.794 ± 0.044
3.167AlaTyr: 3.167 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
0.72CysAla: 0.72 ± 0.026
0.063CysCys: 0.063 ± 0.007
0.387CysAsp: 0.387 ± 0.018
0.328CysGlu: 0.328 ± 0.017
0.184CysPhe: 0.184 ± 0.011
0.621CysGly: 0.621 ± 0.023
0.164CysHis: 0.164 ± 0.015
0.191CysIle: 0.191 ± 0.013
0.076CysLys: 0.076 ± 0.009
0.522CysLeu: 0.522 ± 0.019
0.078CysMet: 0.078 ± 0.009
0.139CysAsn: 0.139 ± 0.009
0.345CysPro: 0.345 ± 0.019
0.14CysGln: 0.14 ± 0.011
0.363CysArg: 0.363 ± 0.019
0.395CysSer: 0.395 ± 0.017
0.331CysThr: 0.331 ± 0.018
0.447CysVal: 0.447 ± 0.02
0.057CysTrp: 0.057 ± 0.008
0.121CysTyr: 0.121 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
9.706AspAla: 9.706 ± 0.099
0.304AspCys: 0.304 ± 0.015
3.801AspAsp: 3.801 ± 0.062
3.868AspGlu: 3.868 ± 0.065
2.037AspPhe: 2.037 ± 0.045
6.56AspGly: 6.56 ± 0.083
1.14AspHis: 1.14 ± 0.034
2.016AspIle: 2.016 ± 0.04
0.945AspLys: 0.945 ± 0.031
6.967AspLeu: 6.967 ± 0.082
0.855AspMet: 0.855 ± 0.027
1.049AspAsn: 1.049 ± 0.037
3.943AspPro: 3.943 ± 0.064
1.44AspGln: 1.44 ± 0.037
4.688AspArg: 4.688 ± 0.059
2.795AspSer: 2.795 ± 0.053
2.868AspThr: 2.868 ± 0.051
5.385AspVal: 5.385 ± 0.064
0.933AspTrp: 0.933 ± 0.03
1.498AspTyr: 1.498 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
11.397GluAla: 11.397 ± 0.128
0.218GluCys: 0.218 ± 0.012
3.522GluAsp: 3.522 ± 0.058
3.333GluGlu: 3.333 ± 0.069
1.463GluPhe: 1.463 ± 0.037
5.144GluGly: 5.144 ± 0.069
1.369GluHis: 1.369 ± 0.037
3.007GluIle: 3.007 ± 0.048
1.39GluLys: 1.39 ± 0.038
4.451GluLeu: 4.451 ± 0.065
1.41GluMet: 1.41 ± 0.038
1.444GluAsn: 1.444 ± 0.034
3.344GluPro: 3.344 ± 0.062
1.853GluGln: 1.853 ± 0.042
5.739GluArg: 5.739 ± 0.08
3.095GluSer: 3.095 ± 0.064
4.294GluThr: 4.294 ± 0.062
4.936GluVal: 4.936 ± 0.058
0.826GluTrp: 0.826 ± 0.026
1.17GluTyr: 1.17 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.357PheAla: 4.357 ± 0.061
0.226PheCys: 0.226 ± 0.013
2.509PheAsp: 2.509 ± 0.049
2.472PheGlu: 2.472 ± 0.043
1.268PhePhe: 1.268 ± 0.044
3.49PheGly: 3.49 ± 0.06
0.573PheHis: 0.573 ± 0.022
1.01PheIle: 1.01 ± 0.031
0.585PheLys: 0.585 ± 0.026
3.091PheLeu: 3.091 ± 0.054
0.568PheMet: 0.568 ± 0.021
0.869PheAsn: 0.869 ± 0.034
1.528PhePro: 1.528 ± 0.035
0.933PheGln: 0.933 ± 0.03
2.244PheArg: 2.244 ± 0.046
2.256PheSer: 2.256 ± 0.049
2.014PheThr: 2.014 ± 0.042
3.056PheVal: 3.056 ± 0.055
0.488PheTrp: 0.488 ± 0.019
0.904PheTyr: 0.904 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
11.86GlyAla: 11.86 ± 0.115
0.664GlyCys: 0.664 ± 0.023
5.803GlyAsp: 5.803 ± 0.086
5.973GlyGlu: 5.973 ± 0.07
3.223GlyPhe: 3.223 ± 0.057
8.428GlyGly: 8.428 ± 0.122
1.672GlyHis: 1.672 ± 0.043
3.608GlyIle: 3.608 ± 0.058
1.86GlyLys: 1.86 ± 0.048
9.149GlyLeu: 9.149 ± 0.099
1.826GlyMet: 1.826 ± 0.042
1.85GlyAsn: 1.85 ± 0.046
3.994GlyPro: 3.994 ± 0.054
2.538GlyGln: 2.538 ± 0.045
6.411GlyArg: 6.411 ± 0.079
4.959GlySer: 4.959 ± 0.074
5.831GlyThr: 5.831 ± 0.098
7.542GlyVal: 7.542 ± 0.082
1.404GlyTrp: 1.404 ± 0.032
2.37GlyTyr: 2.37 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
2.469HisAla: 2.469 ± 0.052
0.116HisCys: 0.116 ± 0.011
1.095HisAsp: 1.095 ± 0.032
1.168HisGlu: 1.168 ± 0.032
0.678HisPhe: 0.678 ± 0.026
1.566HisGly: 1.566 ± 0.046
0.464HisHis: 0.464 ± 0.02
0.641HisIle: 0.641 ± 0.027
0.345HisLys: 0.345 ± 0.016
2.031HisLeu: 2.031 ± 0.049
0.245HisMet: 0.245 ± 0.014
0.375HisAsn: 0.375 ± 0.02
1.284HisPro: 1.284 ± 0.04
0.441HisGln: 0.441 ± 0.019
1.419HisArg: 1.419 ± 0.037
0.78HisSer: 0.78 ± 0.025
1.035HisThr: 1.035 ± 0.032
1.757HisVal: 1.757 ± 0.041
0.188HisTrp: 0.188 ± 0.013
0.48HisTyr: 0.48 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
4.948IleAla: 4.948 ± 0.059
0.214IleCys: 0.214 ± 0.014
2.474IleAsp: 2.474 ± 0.044
2.794IleGlu: 2.794 ± 0.053
0.855IlePhe: 0.855 ± 0.026
3.745IleGly: 3.745 ± 0.057
0.65IleHis: 0.65 ± 0.023
1.102IleIle: 1.102 ± 0.037
0.709IleLys: 0.709 ± 0.03
3.189IleLeu: 3.189 ± 0.052
0.446IleMet: 0.446 ± 0.016
0.81IleAsn: 0.81 ± 0.025
2.088IlePro: 2.088 ± 0.043
1.15IleGln: 1.15 ± 0.031
2.803IleArg: 2.803 ± 0.051
1.878IleSer: 1.878 ± 0.039
2.145IleThr: 2.145 ± 0.043
3.144IleVal: 3.144 ± 0.051
0.359IleTrp: 0.359 ± 0.017
0.815IleTyr: 0.815 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
2.403LysAla: 2.403 ± 0.057
0.069LysCys: 0.069 ± 0.008
1.007LysAsp: 1.007 ± 0.032
1.111LysGlu: 1.111 ± 0.037
0.372LysPhe: 0.372 ± 0.018
1.585LysGly: 1.585 ± 0.041
0.392LysHis: 0.392 ± 0.02
0.708LysIle: 0.708 ± 0.031
0.784LysLys: 0.784 ± 0.038
1.754LysLeu: 1.754 ± 0.043
0.441LysMet: 0.441 ± 0.02
0.475LysAsn: 0.475 ± 0.019
1.11LysPro: 1.11 ± 0.03
0.576LysGln: 0.576 ± 0.02
1.625LysArg: 1.625 ± 0.037
0.992LysSer: 0.992 ± 0.032
1.385LysThr: 1.385 ± 0.039
1.351LysVal: 1.351 ± 0.044
0.247LysTrp: 0.247 ± 0.015
0.421LysTyr: 0.421 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
16.135LeuAla: 16.135 ± 0.154
0.576LeuCys: 0.576 ± 0.024
7.33LeuAsp: 7.33 ± 0.091
4.828LeuGlu: 4.828 ± 0.071
3.554LeuPhe: 3.554 ± 0.055
8.984LeuGly: 8.984 ± 0.104
1.893LeuHis: 1.893 ± 0.039
3.169LeuIle: 3.169 ± 0.06
1.92LeuLys: 1.92 ± 0.044
10.015LeuLeu: 10.015 ± 0.123
1.567LeuMet: 1.567 ± 0.043
2.059LeuAsn: 2.059 ± 0.044
5.275LeuPro: 5.275 ± 0.077
2.6LeuGln: 2.6 ± 0.048
7.962LeuArg: 7.962 ± 0.077
5.801LeuSer: 5.801 ± 0.069
5.799LeuThr: 5.799 ± 0.072
8.227LeuVal: 8.227 ± 0.103
1.392LeuTrp: 1.392 ± 0.034
2.352LeuTyr: 2.352 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
2.114MetAla: 2.114 ± 0.044
0.097MetCys: 0.097 ± 0.009
1.175MetAsp: 1.175 ± 0.031
1.212MetGlu: 1.212 ± 0.033
0.441MetPhe: 0.441 ± 0.019
1.552MetGly: 1.552 ± 0.041
0.322MetHis: 0.322 ± 0.018
0.691MetIle: 0.691 ± 0.025
0.458MetLys: 0.458 ± 0.019
1.654MetLeu: 1.654 ± 0.041
0.398MetMet: 0.398 ± 0.018
0.46MetAsn: 0.46 ± 0.02
1.274MetPro: 1.274 ± 0.032
0.579MetGln: 0.579 ± 0.02
1.58MetArg: 1.58 ± 0.036
1.052MetSer: 1.052 ± 0.027
1.326MetThr: 1.326 ± 0.031
1.12MetVal: 1.12 ± 0.036
0.18MetTrp: 0.18 ± 0.014
0.29MetTyr: 0.29 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.827AsnAla: 2.827 ± 0.053
0.128AsnCys: 0.128 ± 0.01
1.225AsnAsp: 1.225 ± 0.041
1.18AsnGlu: 1.18 ± 0.03
0.574AsnPhe: 0.574 ± 0.026
2.193AsnGly: 2.193 ± 0.055
0.352AsnHis: 0.352 ± 0.02
0.678AsnIle: 0.678 ± 0.026
0.381AsnLys: 0.381 ± 0.019
1.903AsnLeu: 1.903 ± 0.039
0.339AsnMet: 0.339 ± 0.016
0.554AsnAsn: 0.554 ± 0.03
1.679AsnPro: 1.679 ± 0.042
0.586AsnGln: 0.586 ± 0.024
1.512AsnArg: 1.512 ± 0.042
0.925AsnSer: 0.925 ± 0.03
1.207AsnThr: 1.207 ± 0.038
1.913AsnVal: 1.913 ± 0.046
0.282AsnTrp: 0.282 ± 0.016
0.51AsnTyr: 0.51 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
6.385ProAla: 6.385 ± 0.083
0.247ProCys: 0.247 ± 0.013
4.189ProAsp: 4.189 ± 0.061
6.135ProGlu: 6.135 ± 0.074
2.157ProPhe: 2.157 ± 0.04
4.852ProGly: 4.852 ± 0.069
1.028ProHis: 1.028 ± 0.031
1.957ProIle: 1.957 ± 0.038
0.909ProLys: 0.909 ± 0.033
6.03ProLeu: 6.03 ± 0.076
0.899ProMet: 0.899 ± 0.028
1.266ProAsn: 1.266 ± 0.04
3.248ProPro: 3.248 ± 0.08
1.422ProGln: 1.422 ± 0.034
3.089ProArg: 3.089 ± 0.062
3.431ProSer: 3.431 ± 0.054
3.183ProThr: 3.183 ± 0.058
4.382ProVal: 4.382 ± 0.06
0.587ProTrp: 0.587 ± 0.022
1.301ProTyr: 1.301 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
3.711GlnAla: 3.711 ± 0.069
0.107GlnCys: 0.107 ± 0.009
1.471GlnAsp: 1.471 ± 0.04
1.642GlnGlu: 1.642 ± 0.041
0.986GlnPhe: 0.986 ± 0.032
2.058GlnGly: 2.058 ± 0.037
0.528GlnHis: 0.528 ± 0.021
1.417GlnIle: 1.417 ± 0.036
0.784GlnLys: 0.784 ± 0.027
2.34GlnLeu: 2.34 ± 0.047
0.639GlnMet: 0.639 ± 0.026
0.79GlnAsn: 0.79 ± 0.027
1.642GlnPro: 1.642 ± 0.037
0.983GlnGln: 0.983 ± 0.036
2.903GlnArg: 2.903 ± 0.061
1.621GlnSer: 1.621 ± 0.038
2.102GlnThr: 2.102 ± 0.046
1.915GlnVal: 1.915 ± 0.04
0.334GlnTrp: 0.334 ± 0.017
0.654GlnTyr: 0.654 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
9.349ArgAla: 9.349 ± 0.112
0.333ArgCys: 0.333 ± 0.017
4.444ArgAsp: 4.444 ± 0.066
5.501ArgGlu: 5.501 ± 0.071
3.213ArgPhe: 3.213 ± 0.05
5.99ArgGly: 5.99 ± 0.07
1.461ArgHis: 1.461 ± 0.042
3.127ArgIle: 3.127 ± 0.056
1.411ArgLys: 1.411 ± 0.047
8.549ArgLeu: 8.549 ± 0.096
1.65ArgMet: 1.65 ± 0.038
1.382ArgAsn: 1.382 ± 0.037
3.914ArgPro: 3.914 ± 0.057
2.857ArgGln: 2.857 ± 0.055
6.001ArgArg: 6.001 ± 0.094
3.899ArgSer: 3.899 ± 0.066
4.143ArgThr: 4.143 ± 0.062
6.265ArgVal: 6.265 ± 0.074
1.135ArgTrp: 1.135 ± 0.03
2.146ArgTyr: 2.146 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
6.582SerAla: 6.582 ± 0.081
0.307SerCys: 0.307 ± 0.017
3.255SerAsp: 3.255 ± 0.053
2.905SerGlu: 2.905 ± 0.05
2.054SerPhe: 2.054 ± 0.045
8.472SerGly: 8.472 ± 0.109
0.914SerHis: 0.914 ± 0.031
1.974SerIle: 1.974 ± 0.043
0.974SerLys: 0.974 ± 0.03
5.672SerLeu: 5.672 ± 0.074
0.927SerMet: 0.927 ± 0.028
1.22SerAsn: 1.22 ± 0.034
3.46SerPro: 3.46 ± 0.053
1.39SerGln: 1.39 ± 0.037
3.978SerArg: 3.978 ± 0.06
2.842SerSer: 2.842 ± 0.047
3.162SerThr: 3.162 ± 0.051
4.504SerVal: 4.504 ± 0.068
0.656SerTrp: 0.656 ± 0.024
1.297SerTyr: 1.297 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
6.803ThrAla: 6.803 ± 0.086
0.369ThrCys: 0.369 ± 0.016
3.637ThrAsp: 3.637 ± 0.056
3.044ThrGlu: 3.044 ± 0.045
2.377ThrPhe: 2.377 ± 0.045
5.288ThrGly: 5.288 ± 0.08
1.062ThrHis: 1.062 ± 0.033
2.295ThrIle: 2.295 ± 0.045
0.892ThrLys: 0.892 ± 0.029
6.681ThrLeu: 6.681 ± 0.09
0.918ThrMet: 0.918 ± 0.032
1.259ThrAsn: 1.259 ± 0.038
4.398ThrPro: 4.398 ± 0.066
1.47ThrGln: 1.47 ± 0.037
3.754ThrArg: 3.754 ± 0.054
3.096ThrSer: 3.096 ± 0.056
3.338ThrThr: 3.338 ± 0.06
5.373ThrVal: 5.373 ± 0.079
0.82ThrTrp: 0.82 ± 0.033
1.598ThrTyr: 1.598 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
9.915ValAla: 9.915 ± 0.103
0.522ValCys: 0.522 ± 0.022
4.774ValAsp: 4.774 ± 0.065
5.272ValGlu: 5.272 ± 0.064
2.881ValPhe: 2.881 ± 0.056
6.84ValGly: 6.84 ± 0.081
1.52ValHis: 1.52 ± 0.042
2.824ValIle: 2.824 ± 0.052
1.399ValLys: 1.399 ± 0.041
8.486ValLeu: 8.486 ± 0.099
1.347ValMet: 1.347 ± 0.034
1.635ValAsn: 1.635 ± 0.042
4.405ValPro: 4.405 ± 0.061
2.52ValGln: 2.52 ± 0.039
6.926ValArg: 6.926 ± 0.087
4.669ValSer: 4.669 ± 0.066
5.028ValThr: 5.028 ± 0.072
7.105ValVal: 7.105 ± 0.091
1.093ValTrp: 1.093 ± 0.03
2.097ValTyr: 2.097 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
1.577TrpAla: 1.577 ± 0.037
0.087TrpCys: 0.087 ± 0.008
0.802TrpAsp: 0.802 ± 0.029
0.682TrpGlu: 0.682 ± 0.025
0.395TrpPhe: 0.395 ± 0.019
1.071TrpGly: 1.071 ± 0.034
0.278TrpHis: 0.278 ± 0.017
0.593TrpIle: 0.593 ± 0.024
0.296TrpLys: 0.296 ± 0.015
1.343TrpLeu: 1.343 ± 0.034
0.337TrpMet: 0.337 ± 0.015
0.355TrpAsn: 0.355 ± 0.017
0.589TrpPro: 0.589 ± 0.022
0.406TrpGln: 0.406 ± 0.02
1.337TrpArg: 1.337 ± 0.035
0.764TrpSer: 0.764 ± 0.028
0.95TrpThr: 0.95 ± 0.029
0.955TrpVal: 0.955 ± 0.027
0.241TrpTrp: 0.241 ± 0.016
0.278TrpTyr: 0.278 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.154TyrAla: 3.154 ± 0.056
0.157TyrCys: 0.157 ± 0.011
1.863TyrAsp: 1.863 ± 0.042
1.439TyrGlu: 1.439 ± 0.038
0.808TyrPhe: 0.808 ± 0.027
2.278TyrGly: 2.278 ± 0.049
0.491TyrHis: 0.491 ± 0.019
0.724TyrIle: 0.724 ± 0.029
0.438TyrLys: 0.438 ± 0.02
2.228TyrLeu: 2.228 ± 0.044
0.301TyrMet: 0.301 ± 0.015
0.586TyrAsn: 0.586 ± 0.03
1.156TyrPro: 1.156 ± 0.031
0.639TyrGln: 0.639 ± 0.023
2.07TyrArg: 2.07 ± 0.04
1.29TyrSer: 1.29 ± 0.039
1.528TyrThr: 1.528 ± 0.036
1.999TyrVal: 1.999 ± 0.044
0.318TyrTrp: 0.318 ± 0.015
0.615TyrTyr: 0.615 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3669 proteins (1282544 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski