Amino acid dipepetide frequency for Devosia enhydra

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.773AlaAla: 17.773 ± 0.157	0.891AlaCys: 0.891 ± 0.031	7.319AlaAsp: 7.319 ± 0.078	8.604AlaGlu: 8.604 ± 0.094	4.519AlaPhe: 4.519 ± 0.06	11.433AlaGly: 11.433 ± 0.128	2.26AlaHis: 2.26 ± 0.046	7.373AlaIle: 7.373 ± 0.084	2.939AlaLys: 2.939 ± 0.047	15.202AlaLeu: 15.202 ± 0.12	3.909AlaMet: 3.909 ± 0.066	2.931AlaAsn: 2.931 ± 0.062	6.304AlaPro: 6.304 ± 0.095	4.209AlaGln: 4.209 ± 0.071	9.645AlaArg: 9.645 ± 0.103	6.487AlaSer: 6.487 ± 0.073	6.36AlaThr: 6.36 ± 0.077	8.865AlaVal: 8.865 ± 0.091	1.44AlaTrp: 1.44 ± 0.036	2.594AlaTyr: 2.594 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.862CysAla: 0.862 ± 0.028	0.083CysCys: 0.083 ± 0.009	0.483CysAsp: 0.483 ± 0.023	0.369CysGlu: 0.369 ± 0.018	0.271CysPhe: 0.271 ± 0.016	0.781CysGly: 0.781 ± 0.026	0.21CysHis: 0.21 ± 0.013	0.333CysIle: 0.333 ± 0.018	0.134CysLys: 0.134 ± 0.009	0.671CysLeu: 0.671 ± 0.025	0.121CysMet: 0.121 ± 0.011	0.169CysAsn: 0.169 ± 0.012	0.369CysPro: 0.369 ± 0.019	0.185CysGln: 0.185 ± 0.012	0.547CysArg: 0.547 ± 0.023	0.336CysSer: 0.336 ± 0.017	0.35CysThr: 0.35 ± 0.018	0.461CysVal: 0.461 ± 0.018	0.103CysTrp: 0.103 ± 0.009	0.175CysTyr: 0.175 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.278AspAla: 7.278 ± 0.083	0.412AspCys: 0.412 ± 0.021	2.787AspAsp: 2.787 ± 0.06	3.308AspGlu: 3.308 ± 0.061	2.213AspPhe: 2.213 ± 0.043	5.268AspGly: 5.268 ± 0.078	1.204AspHis: 1.204 ± 0.035	3.22AspIle: 3.22 ± 0.046	1.418AspLys: 1.418 ± 0.033	5.986AspLeu: 5.986 ± 0.074	1.265AspMet: 1.265 ± 0.03	1.189AspAsn: 1.189 ± 0.032	3.7AspPro: 3.7 ± 0.05	1.614AspGln: 1.614 ± 0.037	4.482AspArg: 4.482 ± 0.074	1.884AspSer: 1.884 ± 0.043	2.487AspThr: 2.487 ± 0.046	3.903AspVal: 3.903 ± 0.061	1.008AspTrp: 1.008 ± 0.03	1.424AspTyr: 1.424 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	8.844GluAla: 8.844 ± 0.104	0.254GluCys: 0.254 ± 0.015	2.853GluAsp: 2.853 ± 0.054	2.79GluGlu: 2.79 ± 0.055	1.609GluPhe: 1.609 ± 0.037	4.839GluGly: 4.839 ± 0.065	1.075GluHis: 1.075 ± 0.026	3.4GluIle: 3.4 ± 0.055	1.89GluLys: 1.89 ± 0.046	5.044GluLeu: 5.044 ± 0.075	1.497GluMet: 1.497 ± 0.034	1.287GluAsn: 1.287 ± 0.032	2.882GluPro: 2.882 ± 0.058	1.84GluGln: 1.84 ± 0.04	4.738GluArg: 4.738 ± 0.074	2.256GluSer: 2.256 ± 0.045	3.786GluThr: 3.786 ± 0.052	3.562GluVal: 3.562 ± 0.059	0.617GluTrp: 0.617 ± 0.022	0.812GluTyr: 0.812 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.916PheAla: 4.916 ± 0.067	0.376PheCys: 0.376 ± 0.018	2.554PheAsp: 2.554 ± 0.045	2.095PheGlu: 2.095 ± 0.044	1.305PhePhe: 1.305 ± 0.036	3.749PheGly: 3.749 ± 0.06	0.737PheHis: 0.737 ± 0.022	1.764PheIle: 1.764 ± 0.044	0.804PheLys: 0.804 ± 0.026	3.199PheLeu: 3.199 ± 0.058	0.756PheMet: 0.756 ± 0.028	1.021PheAsn: 1.021 ± 0.025	1.655PhePro: 1.655 ± 0.038	0.925PheGln: 0.925 ± 0.026	2.148PheArg: 2.148 ± 0.039	2.4PheSer: 2.4 ± 0.041	1.961PheThr: 1.961 ± 0.043	2.854PheVal: 2.854 ± 0.048	0.577PheTrp: 0.577 ± 0.024	0.87PheTyr: 0.87 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.904GlyAla: 9.904 ± 0.108	0.707GlyCys: 0.707 ± 0.026	4.365GlyAsp: 4.365 ± 0.066	4.934GlyGlu: 4.934 ± 0.063	3.661GlyPhe: 3.661 ± 0.063	7.546GlyGly: 7.546 ± 0.115	1.894GlyHis: 1.894 ± 0.037	4.721GlyIle: 4.721 ± 0.064	2.722GlyLys: 2.722 ± 0.057	10.211GlyLeu: 10.211 ± 0.093	2.393GlyMet: 2.393 ± 0.052	2.114GlyAsn: 2.114 ± 0.053	4.023GlyPro: 4.023 ± 0.061	3.099GlyGln: 3.099 ± 0.054	6.667GlyArg: 6.667 ± 0.075	4.713GlySer: 4.713 ± 0.081	4.958GlyThr: 4.958 ± 0.082	6.348GlyVal: 6.348 ± 0.086	1.488GlyTrp: 1.488 ± 0.039	2.285GlyTyr: 2.285 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.281HisAla: 2.281 ± 0.05	0.194HisCys: 0.194 ± 0.012	1.167HisAsp: 1.167 ± 0.029	1.041HisGlu: 1.041 ± 0.029	0.84HisPhe: 0.84 ± 0.024	1.82HisGly: 1.82 ± 0.039	0.552HisHis: 0.552 ± 0.026	0.939HisIle: 0.939 ± 0.03	0.432HisLys: 0.432 ± 0.022	2.022HisLeu: 2.022 ± 0.039	0.444HisMet: 0.444 ± 0.021	0.425HisAsn: 0.425 ± 0.019	1.348HisPro: 1.348 ± 0.034	0.576HisGln: 0.576 ± 0.021	1.443HisArg: 1.443 ± 0.034	0.848HisSer: 0.848 ± 0.027	0.78HisThr: 0.78 ± 0.025	1.498HisVal: 1.498 ± 0.032	0.323HisTrp: 0.323 ± 0.015	0.536HisTyr: 0.536 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	8.279IleAla: 8.279 ± 0.093	0.437IleCys: 0.437 ± 0.016	3.659IleAsp: 3.659 ± 0.056	3.372IleGlu: 3.372 ± 0.058	1.783IlePhe: 1.783 ± 0.046	5.315IleGly: 5.315 ± 0.057	0.865IleHis: 0.865 ± 0.026	2.458IleIle: 2.458 ± 0.042	1.209IleLys: 1.209 ± 0.032	4.63IleLeu: 4.63 ± 0.064	1.024IleMet: 1.024 ± 0.028	1.375IleAsn: 1.375 ± 0.032	2.321IlePro: 2.321 ± 0.039	1.063IleGln: 1.063 ± 0.028	3.292IleArg: 3.292 ± 0.048	2.819IleSer: 2.819 ± 0.046	2.907IleThr: 2.907 ± 0.049	4.577IleVal: 4.577 ± 0.064	0.632IleTrp: 0.632 ± 0.021	1.128IleTyr: 1.128 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.893LysAla: 3.893 ± 0.058	0.095LysCys: 0.095 ± 0.009	1.279LysAsp: 1.279 ± 0.036	0.998LysGlu: 0.998 ± 0.03	0.725LysPhe: 0.725 ± 0.028	2.283LysGly: 2.283 ± 0.045	0.453LysHis: 0.453 ± 0.017	1.206LysIle: 1.206 ± 0.039	0.854LysLys: 0.854 ± 0.032	2.574LysLeu: 2.574 ± 0.052	0.561LysMet: 0.561 ± 0.024	0.551LysAsn: 0.551 ± 0.021	1.743LysPro: 1.743 ± 0.04	0.73LysGln: 0.73 ± 0.024	1.948LysArg: 1.948 ± 0.045	1.569LysSer: 1.569 ± 0.035	1.522LysThr: 1.522 ± 0.032	1.956LysVal: 1.956 ± 0.042	0.282LysTrp: 0.282 ± 0.016	0.454LysTyr: 0.454 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.893LeuAla: 14.893 ± 0.128	0.827LeuCys: 0.827 ± 0.029	6.308LeuAsp: 6.308 ± 0.082	5.48LeuGlu: 5.48 ± 0.078	3.676LeuPhe: 3.676 ± 0.069	9.212LeuGly: 9.212 ± 0.098	1.758LeuHis: 1.758 ± 0.04	5.203LeuIle: 5.203 ± 0.068	2.959LeuLys: 2.959 ± 0.05	9.979LeuLeu: 9.979 ± 0.115	2.538LeuMet: 2.538 ± 0.048	2.514LeuAsn: 2.514 ± 0.049	5.983LeuPro: 5.983 ± 0.069	2.417LeuGln: 2.417 ± 0.047	7.132LeuArg: 7.132 ± 0.078	6.817LeuSer: 6.817 ± 0.072	5.402LeuThr: 5.402 ± 0.073	8.534LeuVal: 8.534 ± 0.092	1.14LeuTrp: 1.14 ± 0.033	2.122LeuTyr: 2.122 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.486MetAla: 3.486 ± 0.049	0.129MetCys: 0.129 ± 0.01	1.134MetAsp: 1.134 ± 0.03	1.002MetGlu: 1.002 ± 0.031	0.674MetPhe: 0.674 ± 0.023	2.084MetGly: 2.084 ± 0.046	0.398MetHis: 0.398 ± 0.016	1.337MetIle: 1.337 ± 0.033	0.777MetLys: 0.777 ± 0.028	2.644MetLeu: 2.644 ± 0.052	0.626MetMet: 0.626 ± 0.022	0.648MetAsn: 0.648 ± 0.023	1.565MetPro: 1.565 ± 0.036	0.809MetGln: 0.809 ± 0.026	1.851MetArg: 1.851 ± 0.038	1.675MetSer: 1.675 ± 0.037	1.855MetThr: 1.855 ± 0.038	1.869MetVal: 1.869 ± 0.043	0.188MetTrp: 0.188 ± 0.012	0.287MetTyr: 0.287 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.072AsnAla: 3.072 ± 0.05	0.194AsnCys: 0.194 ± 0.013	1.19AsnAsp: 1.19 ± 0.03	1.065AsnGlu: 1.065 ± 0.029	0.897AsnPhe: 0.897 ± 0.029	2.258AsnGly: 2.258 ± 0.055	0.469AsnHis: 0.469 ± 0.018	1.255AsnIle: 1.255 ± 0.031	0.51AsnLys: 0.51 ± 0.02	2.429AsnLeu: 2.429 ± 0.047	0.537AsnMet: 0.537 ± 0.02	0.586AsnAsn: 0.586 ± 0.024	1.862AsnPro: 1.862 ± 0.037	0.669AsnGln: 0.669 ± 0.025	1.782AsnArg: 1.782 ± 0.037	1.144AsnSer: 1.144 ± 0.034	1.205AsnThr: 1.205 ± 0.033	1.719AsnVal: 1.719 ± 0.043	0.434AsnTrp: 0.434 ± 0.02	0.645AsnTyr: 0.645 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	7.123ProAla: 7.123 ± 0.09	0.267ProCys: 0.267 ± 0.018	3.861ProAsp: 3.861 ± 0.063	4.033ProGlu: 4.033 ± 0.058	2.054ProPhe: 2.054 ± 0.046	4.954ProGly: 4.954 ± 0.077	1.142ProHis: 1.142 ± 0.029	2.513ProIle: 2.513 ± 0.044	1.239ProLys: 1.239 ± 0.032	5.129ProLeu: 5.129 ± 0.07	1.343ProMet: 1.343 ± 0.035	1.336ProAsn: 1.336 ± 0.032	2.82ProPro: 2.82 ± 0.063	1.694ProGln: 1.694 ± 0.037	3.359ProArg: 3.359 ± 0.058	2.83ProSer: 2.83 ± 0.045	2.505ProThr: 2.505 ± 0.041	4.57ProVal: 4.57 ± 0.065	0.703ProTrp: 0.703 ± 0.023	1.215ProTyr: 1.215 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.893GlnAla: 3.893 ± 0.063	0.175GlnCys: 0.175 ± 0.012	1.294GlnAsp: 1.294 ± 0.034	1.213GlnGlu: 1.213 ± 0.03	1.079GlnPhe: 1.079 ± 0.03	2.409GlnGly: 2.409 ± 0.048	0.575GlnHis: 0.575 ± 0.022	1.694GlnIle: 1.694 ± 0.034	0.944GlnLys: 0.944 ± 0.031	2.875GlnLeu: 2.875 ± 0.056	1.009GlnMet: 1.009 ± 0.027	0.694GlnAsn: 0.694 ± 0.025	1.764GlnPro: 1.764 ± 0.038	1.132GlnGln: 1.132 ± 0.038	2.475GlnArg: 2.475 ± 0.052	1.785GlnSer: 1.785 ± 0.04	1.575GlnThr: 1.575 ± 0.034	2.271GlnVal: 2.271 ± 0.045	0.364GlnTrp: 0.364 ± 0.018	0.537GlnTyr: 0.537 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.396ArgAla: 8.396 ± 0.095	0.463ArgCys: 0.463 ± 0.021	4.086ArgAsp: 4.086 ± 0.058	4.006ArgGlu: 4.006 ± 0.064	3.078ArgPhe: 3.078 ± 0.051	4.915ArgGly: 4.915 ± 0.071	1.751ArgHis: 1.751 ± 0.037	4.274ArgIle: 4.274 ± 0.062	1.986ArgLys: 1.986 ± 0.042	8.539ArgLeu: 8.539 ± 0.103	1.959ArgMet: 1.959 ± 0.04	1.817ArgAsn: 1.817 ± 0.039	3.931ArgPro: 3.931 ± 0.072	2.769ArgGln: 2.769 ± 0.047	5.894ArgArg: 5.894 ± 0.084	3.797ArgSer: 3.797 ± 0.06	3.455ArgThr: 3.455 ± 0.053	4.873ArgVal: 4.873 ± 0.064	1.02ArgTrp: 1.02 ± 0.029	1.66ArgTyr: 1.66 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.558SerAla: 6.558 ± 0.082	0.342SerCys: 0.342 ± 0.018	2.828SerAsp: 2.828 ± 0.05	2.73SerGlu: 2.73 ± 0.041	2.249SerPhe: 2.249 ± 0.042	5.868SerGly: 5.868 ± 0.087	1.072SerHis: 1.072 ± 0.028	2.825SerIle: 2.825 ± 0.051	1.126SerLys: 1.126 ± 0.03	5.518SerLeu: 5.518 ± 0.062	1.268SerMet: 1.268 ± 0.033	1.271SerAsn: 1.271 ± 0.034	2.936SerPro: 2.936 ± 0.052	1.509SerGln: 1.509 ± 0.041	3.72SerArg: 3.72 ± 0.058	2.629SerSer: 2.629 ± 0.052	2.595SerThr: 2.595 ± 0.056	4.175SerVal: 4.175 ± 0.063	0.722SerTrp: 0.722 ± 0.023	1.185SerTyr: 1.185 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	6.37ThrAla: 6.37 ± 0.078	0.344ThrCys: 0.344 ± 0.016	2.754ThrAsp: 2.754 ± 0.048	2.644ThrGlu: 2.644 ± 0.05	1.855ThrPhe: 1.855 ± 0.036	5.234ThrGly: 5.234 ± 0.07	1.055ThrHis: 1.055 ± 0.029	3.156ThrIle: 3.156 ± 0.049	1.094ThrLys: 1.094 ± 0.031	6.361ThrLeu: 6.361 ± 0.067	1.125ThrMet: 1.125 ± 0.029	1.209ThrAsn: 1.209 ± 0.029	3.409ThrPro: 3.409 ± 0.058	1.367ThrGln: 1.367 ± 0.033	3.597ThrArg: 3.597 ± 0.053	2.727ThrSer: 2.727 ± 0.048	2.942ThrThr: 2.942 ± 0.053	4.168ThrVal: 4.168 ± 0.063	0.555ThrTrp: 0.555 ± 0.02	1.136ThrTyr: 1.136 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	9.517ValAla: 9.517 ± 0.071	0.492ValCys: 0.492 ± 0.023	4.155ValAsp: 4.155 ± 0.06	4.446ValGlu: 4.446 ± 0.06	2.737ValPhe: 2.737 ± 0.052	5.763ValGly: 5.763 ± 0.075	1.29ValHis: 1.29 ± 0.031	4.072ValIle: 4.072 ± 0.06	1.817ValLys: 1.817 ± 0.044	7.98ValLeu: 7.98 ± 0.079	1.963ValMet: 1.963 ± 0.043	1.831ValAsn: 1.831 ± 0.038	4.278ValPro: 4.278 ± 0.062	1.867ValGln: 1.867 ± 0.042	5.004ValArg: 5.004 ± 0.06	4.483ValSer: 4.483 ± 0.069	4.601ValThr: 4.601 ± 0.066	6.093ValVal: 6.093 ± 0.083	0.853ValTrp: 0.853 ± 0.022	1.466ValTyr: 1.466 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.244TrpAla: 1.244 ± 0.031	0.12TrpCys: 0.12 ± 0.009	0.667TrpAsp: 0.667 ± 0.023	0.525TrpGlu: 0.525 ± 0.02	0.516TrpPhe: 0.516 ± 0.019	0.934TrpGly: 0.934 ± 0.032	0.301TrpHis: 0.301 ± 0.016	0.57TrpIle: 0.57 ± 0.02	0.342TrpLys: 0.342 ± 0.017	1.701TrpLeu: 1.701 ± 0.043	0.292TrpMet: 0.292 ± 0.016	0.381TrpAsn: 0.381 ± 0.018	0.706TrpPro: 0.706 ± 0.024	0.638TrpGln: 0.638 ± 0.022	1.15TrpArg: 1.15 ± 0.034	0.823TrpSer: 0.823 ± 0.023	0.797TrpThr: 0.797 ± 0.027	0.813TrpVal: 0.813 ± 0.025	0.213TrpTrp: 0.213 ± 0.014	0.273TrpTyr: 0.273 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.476TyrAla: 2.476 ± 0.04	0.211TyrCys: 0.211 ± 0.012	1.304TyrAsp: 1.304 ± 0.034	1.217TyrGlu: 1.217 ± 0.027	0.927TyrPhe: 0.927 ± 0.023	2.089TyrGly: 2.089 ± 0.042	0.449TyrHis: 0.449 ± 0.02	0.83TyrIle: 0.83 ± 0.025	0.481TyrLys: 0.481 ± 0.02	2.198TyrLeu: 2.198 ± 0.045	0.409TyrMet: 0.409 ± 0.02	0.574TyrAsn: 0.574 ± 0.022	1.091TyrPro: 1.091 ± 0.03	0.647TyrGln: 0.647 ± 0.02	1.795TyrArg: 1.795 ± 0.04	1.104TyrSer: 1.104 ± 0.027	1.059TyrThr: 1.059 ± 0.03	1.601TyrVal: 1.601 ± 0.038	0.343TyrTrp: 0.343 ± 0.016	0.537TyrTyr: 0.537 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3974 proteins (1260071 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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