Amino acid dipepetide frequency for Clostridium grantii DSM 8605

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.873AlaAla: 3.873 ± 0.076	0.679AlaCys: 0.679 ± 0.026	2.494AlaAsp: 2.494 ± 0.049	3.624AlaGlu: 3.624 ± 0.063	2.587AlaPhe: 2.587 ± 0.053	3.53AlaGly: 3.53 ± 0.065	0.835AlaHis: 0.835 ± 0.025	5.65AlaIle: 5.65 ± 0.08	4.341AlaLys: 4.341 ± 0.06	5.464AlaLeu: 5.464 ± 0.078	1.637AlaMet: 1.637 ± 0.038	2.591AlaAsn: 2.591 ± 0.046	1.315AlaPro: 1.315 ± 0.036	1.336AlaGln: 1.336 ± 0.032	1.76AlaArg: 1.76 ± 0.039	3.286AlaSer: 3.286 ± 0.056	2.943AlaThr: 2.943 ± 0.061	3.862AlaVal: 3.862 ± 0.068	0.424AlaTrp: 0.424 ± 0.018	2.267AlaTyr: 2.267 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.558CysAla: 0.558 ± 0.021	0.194CysCys: 0.194 ± 0.014	0.653CysAsp: 0.653 ± 0.024	0.808CysGlu: 0.808 ± 0.026	0.516CysPhe: 0.516 ± 0.02	1.098CysGly: 1.098 ± 0.037	0.229CysHis: 0.229 ± 0.015	1.058CysIle: 1.058 ± 0.031	0.889CysLys: 0.889 ± 0.029	0.858CysLeu: 0.858 ± 0.023	0.256CysMet: 0.256 ± 0.016	0.634CysAsn: 0.634 ± 0.022	0.444CysPro: 0.444 ± 0.02	0.234CysGln: 0.234 ± 0.015	0.398CysArg: 0.398 ± 0.021	0.763CysSer: 0.763 ± 0.025	0.582CysThr: 0.582 ± 0.022	0.63CysVal: 0.63 ± 0.023	0.075CysTrp: 0.075 ± 0.007	0.479CysTyr: 0.479 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	2.623AspAla: 2.623 ± 0.053	0.547AspCys: 0.547 ± 0.022	2.625AspAsp: 2.625 ± 0.049	4.654AspGlu: 4.654 ± 0.077	2.939AspPhe: 2.939 ± 0.053	3.246AspGly: 3.246 ± 0.059	0.586AspHis: 0.586 ± 0.023	5.881AspIle: 5.881 ± 0.067	5.323AspLys: 5.323 ± 0.073	4.998AspLeu: 4.998 ± 0.063	1.535AspMet: 1.535 ± 0.036	3.248AspAsn: 3.248 ± 0.056	1.265AspPro: 1.265 ± 0.033	0.859AspGln: 0.859 ± 0.025	1.673AspArg: 1.673 ± 0.036	3.421AspSer: 3.421 ± 0.055	2.587AspThr: 2.587 ± 0.051	3.277AspVal: 3.277 ± 0.052	0.426AspTrp: 0.426 ± 0.02	2.75AspTyr: 2.75 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	4.106GluAla: 4.106 ± 0.069	0.702GluCys: 0.702 ± 0.025	4.369GluAsp: 4.369 ± 0.071	7.423GluGlu: 7.423 ± 0.101	3.313GluPhe: 3.313 ± 0.051	4.074GluGly: 4.074 ± 0.066	0.88GluHis: 0.88 ± 0.028	7.698GluIle: 7.698 ± 0.083	8.145GluLys: 8.145 ± 0.099	7.117GluLeu: 7.117 ± 0.09	2.122GluMet: 2.122 ± 0.046	5.743GluAsn: 5.743 ± 0.066	1.36GluPro: 1.36 ± 0.033	1.873GluGln: 1.873 ± 0.035	2.397GluArg: 2.397 ± 0.044	3.937GluSer: 3.937 ± 0.062	3.426GluThr: 3.426 ± 0.058	4.782GluVal: 4.782 ± 0.065	0.54GluTrp: 0.54 ± 0.021	3.291GluTyr: 3.291 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.284PheAla: 2.284 ± 0.054	0.533PheCys: 0.533 ± 0.021	2.724PheAsp: 2.724 ± 0.048	3.053PheGlu: 3.053 ± 0.053	2.218PhePhe: 2.218 ± 0.053	2.936PheGly: 2.936 ± 0.055	0.651PheHis: 0.651 ± 0.022	4.91PheIle: 4.91 ± 0.074	3.831PheLys: 3.831 ± 0.06	4.145PheLeu: 4.145 ± 0.071	1.279PheMet: 1.279 ± 0.031	3.05PheAsn: 3.05 ± 0.052	1.228PhePro: 1.228 ± 0.034	1.239PheGln: 1.239 ± 0.03	1.221PheArg: 1.221 ± 0.035	3.437PheSer: 3.437 ± 0.059	2.417PheThr: 2.417 ± 0.046	2.809PheVal: 2.809 ± 0.045	0.395PheTrp: 0.395 ± 0.019	1.961PheTyr: 1.961 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	3.785GlyAla: 3.785 ± 0.065	0.84GlyCys: 0.84 ± 0.029	3.118GlyAsp: 3.118 ± 0.058	4.288GlyGlu: 4.288 ± 0.064	3.182GlyPhe: 3.182 ± 0.057	3.986GlyGly: 3.986 ± 0.075	0.961GlyHis: 0.961 ± 0.03	6.514GlyIle: 6.514 ± 0.079	5.259GlyLys: 5.259 ± 0.073	5.231GlyLeu: 5.231 ± 0.073	1.752GlyMet: 1.752 ± 0.035	3.282GlyAsn: 3.282 ± 0.062	1.207GlyPro: 1.207 ± 0.033	1.415GlyGln: 1.415 ± 0.035	2.079GlyArg: 2.079 ± 0.052	3.493GlySer: 3.493 ± 0.054	3.371GlyThr: 3.371 ± 0.059	4.544GlyVal: 4.544 ± 0.066	0.532GlyTrp: 0.532 ± 0.02	2.954GlyTyr: 2.954 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	0.634HisAla: 0.634 ± 0.024	0.237HisCys: 0.237 ± 0.012	0.697HisAsp: 0.697 ± 0.023	0.884HisGlu: 0.884 ± 0.027	0.648HisPhe: 0.648 ± 0.024	0.995HisGly: 0.995 ± 0.026	0.294HisHis: 0.294 ± 0.018	1.385HisIle: 1.385 ± 0.036	1.088HisLys: 1.088 ± 0.032	1.205HisLeu: 1.205 ± 0.035	0.392HisMet: 0.392 ± 0.018	0.821HisAsn: 0.821 ± 0.024	0.589HisPro: 0.589 ± 0.026	0.367HisGln: 0.367 ± 0.017	0.51HisArg: 0.51 ± 0.02	0.889HisSer: 0.889 ± 0.025	0.665HisThr: 0.665 ± 0.026	0.773HisVal: 0.773 ± 0.026	0.149HisTrp: 0.149 ± 0.012	0.61HisTyr: 0.61 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.656IleAla: 5.656 ± 0.068	1.202IleCys: 1.202 ± 0.032	5.787IleAsp: 5.787 ± 0.085	7.53IleGlu: 7.53 ± 0.083	4.6IlePhe: 4.6 ± 0.072	5.891IleGly: 5.891 ± 0.081	1.319IleHis: 1.319 ± 0.035	10.069IleIle: 10.069 ± 0.125	9.08IleLys: 9.08 ± 0.091	9.252IleLeu: 9.252 ± 0.097	2.503IleMet: 2.503 ± 0.049	6.659IleAsn: 6.659 ± 0.083	3.138IlePro: 3.138 ± 0.047	2.455IleGln: 2.455 ± 0.048	2.721IleArg: 2.721 ± 0.05	7.253IleSer: 7.253 ± 0.083	4.953IleThr: 4.953 ± 0.065	6.193IleVal: 6.193 ± 0.075	0.585IleTrp: 0.585 ± 0.021	3.822IleTyr: 3.822 ± 0.062	0.0IleXaa: 0.0 ± 0.0
Lys	4.936LysAla: 4.936 ± 0.075	0.756LysCys: 0.756 ± 0.031	5.674LysAsp: 5.674 ± 0.064	8.993LysGlu: 8.993 ± 0.096	3.374LysPhe: 3.374 ± 0.056	4.939LysGly: 4.939 ± 0.071	1.099LysHis: 1.099 ± 0.03	8.888LysIle: 8.888 ± 0.095	8.09LysLys: 8.09 ± 0.08	7.374LysLeu: 7.374 ± 0.092	2.312LysMet: 2.312 ± 0.045	6.483LysAsn: 6.483 ± 0.078	1.978LysPro: 1.978 ± 0.043	2.159LysGln: 2.159 ± 0.04	2.804LysArg: 2.804 ± 0.056	5.157LysSer: 5.157 ± 0.065	4.204LysThr: 4.204 ± 0.063	5.728LysVal: 5.728 ± 0.072	0.709LysTrp: 0.709 ± 0.026	4.072LysTyr: 4.072 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	5.096LeuAla: 5.096 ± 0.07	1.065LeuCys: 1.065 ± 0.03	4.985LeuAsp: 4.985 ± 0.066	6.467LeuGlu: 6.467 ± 0.082	4.016LeuPhe: 4.016 ± 0.061	5.701LeuGly: 5.701 ± 0.071	1.072LeuHis: 1.072 ± 0.031	8.635LeuIle: 8.635 ± 0.091	8.559LeuLys: 8.559 ± 0.086	7.996LeuLeu: 7.996 ± 0.102	2.431LeuMet: 2.431 ± 0.04	6.019LeuAsn: 6.019 ± 0.081	2.837LeuPro: 2.837 ± 0.054	2.267LeuGln: 2.267 ± 0.044	2.752LeuArg: 2.752 ± 0.051	6.755LeuSer: 6.755 ± 0.086	4.42LeuThr: 4.42 ± 0.066	5.458LeuVal: 5.458 ± 0.066	0.64LeuTrp: 0.64 ± 0.024	3.323LeuTyr: 3.323 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	1.671MetAla: 1.671 ± 0.041	0.243MetCys: 0.243 ± 0.015	1.688MetAsp: 1.688 ± 0.034	2.009MetGlu: 2.009 ± 0.04	1.016MetPhe: 1.016 ± 0.03	1.801MetGly: 1.801 ± 0.038	0.335MetHis: 0.335 ± 0.013	2.417MetIle: 2.417 ± 0.049	2.709MetLys: 2.709 ± 0.046	2.229MetLeu: 2.229 ± 0.046	0.703MetMet: 0.703 ± 0.027	1.825MetAsn: 1.825 ± 0.041	0.897MetPro: 0.897 ± 0.031	0.655MetGln: 0.655 ± 0.025	0.83MetArg: 0.83 ± 0.026	1.66MetSer: 1.66 ± 0.037	1.18MetThr: 1.18 ± 0.03	1.731MetVal: 1.731 ± 0.039	0.169MetTrp: 0.169 ± 0.012	0.91MetTyr: 0.91 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.843AsnAla: 2.843 ± 0.043	0.745AsnCys: 0.745 ± 0.031	3.086AsnAsp: 3.086 ± 0.05	4.958AsnGlu: 4.958 ± 0.073	2.808AsnPhe: 2.808 ± 0.054	3.56AsnGly: 3.56 ± 0.059	0.902AsnHis: 0.902 ± 0.03	6.968AsnIle: 6.968 ± 0.078	6.238AsnLys: 6.238 ± 0.073	5.819AsnLeu: 5.819 ± 0.08	1.65AsnMet: 1.65 ± 0.04	4.591AsnAsn: 4.591 ± 0.063	2.069AsnPro: 2.069 ± 0.04	1.487AsnGln: 1.487 ± 0.03	1.88AsnArg: 1.88 ± 0.042	4.201AsnSer: 4.201 ± 0.058	3.031AsnThr: 3.031 ± 0.052	3.469AsnVal: 3.469 ± 0.053	0.517AsnTrp: 0.517 ± 0.023	2.958AsnTyr: 2.958 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	1.364ProAla: 1.364 ± 0.033	0.307ProCys: 0.307 ± 0.015	1.454ProAsp: 1.454 ± 0.037	2.236ProGlu: 2.236 ± 0.043	1.399ProPhe: 1.399 ± 0.031	1.627ProGly: 1.627 ± 0.046	0.533ProHis: 0.533 ± 0.022	2.684ProIle: 2.684 ± 0.049	1.98ProLys: 1.98 ± 0.036	2.53ProLeu: 2.53 ± 0.043	0.711ProMet: 0.711 ± 0.022	1.465ProAsn: 1.465 ± 0.034	0.581ProPro: 0.581 ± 0.021	0.764ProGln: 0.764 ± 0.027	0.755ProArg: 0.755 ± 0.023	1.739ProSer: 1.739 ± 0.039	1.484ProThr: 1.484 ± 0.041	1.891ProVal: 1.891 ± 0.037	0.255ProTrp: 0.255 ± 0.016	1.282ProTyr: 1.282 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	1.324GlnAla: 1.324 ± 0.033	0.297GlnCys: 0.297 ± 0.018	1.14GlnAsp: 1.14 ± 0.035	1.712GlnGlu: 1.712 ± 0.038	1.013GlnPhe: 1.013 ± 0.029	1.593GlnGly: 1.593 ± 0.039	0.371GlnHis: 0.371 ± 0.017	2.229GlnIle: 2.229 ± 0.043	2.049GlnLys: 2.049 ± 0.043	2.331GlnLeu: 2.331 ± 0.044	0.693GlnMet: 0.693 ± 0.021	1.523GlnAsn: 1.523 ± 0.034	0.617GlnPro: 0.617 ± 0.023	0.759GlnGln: 0.759 ± 0.026	0.868GlnArg: 0.868 ± 0.028	1.419GlnSer: 1.419 ± 0.036	1.1GlnThr: 1.1 ± 0.031	1.588GlnVal: 1.588 ± 0.035	0.294GlnTrp: 0.294 ± 0.017	1.065GlnTyr: 1.065 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	1.537ArgAla: 1.537 ± 0.033	0.405ArgCys: 0.405 ± 0.018	1.61ArgAsp: 1.61 ± 0.039	2.625ArgGlu: 2.625 ± 0.055	1.413ArgPhe: 1.413 ± 0.036	1.68ArgGly: 1.68 ± 0.044	0.436ArgHis: 0.436 ± 0.022	3.128ArgIle: 3.128 ± 0.058	3.08ArgLys: 3.08 ± 0.051	2.611ArgLeu: 2.611 ± 0.047	0.923ArgMet: 0.923 ± 0.027	1.944ArgAsn: 1.944 ± 0.038	0.727ArgPro: 0.727 ± 0.025	0.783ArgGln: 0.783 ± 0.021	1.192ArgArg: 1.192 ± 0.035	1.438ArgSer: 1.438 ± 0.032	1.604ArgThr: 1.604 ± 0.036	2.041ArgVal: 2.041 ± 0.042	0.278ArgTrp: 0.278 ± 0.015	1.315ArgTyr: 1.315 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	3.118SerAla: 3.118 ± 0.061	0.71SerCys: 0.71 ± 0.026	3.125SerAsp: 3.125 ± 0.054	4.452SerGlu: 4.452 ± 0.061	3.3SerPhe: 3.3 ± 0.052	4.206SerGly: 4.206 ± 0.059	0.935SerHis: 0.935 ± 0.028	6.902SerIle: 6.902 ± 0.089	5.611SerLys: 5.611 ± 0.071	6.197SerLeu: 6.197 ± 0.085	1.694SerMet: 1.694 ± 0.04	3.994SerAsn: 3.994 ± 0.06	1.645SerPro: 1.645 ± 0.039	1.601SerGln: 1.601 ± 0.036	2.041SerArg: 2.041 ± 0.039	4.404SerSer: 4.404 ± 0.081	3.302SerThr: 3.302 ± 0.062	3.806SerVal: 3.806 ± 0.057	0.485SerTrp: 0.485 ± 0.021	2.635SerTyr: 2.635 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	2.862ThrAla: 2.862 ± 0.052	0.501ThrCys: 0.501 ± 0.022	2.444ThrAsp: 2.444 ± 0.057	3.247ThrGlu: 3.247 ± 0.05	2.347ThrPhe: 2.347 ± 0.05	3.65ThrGly: 3.65 ± 0.07	0.791ThrHis: 0.791 ± 0.027	5.075ThrIle: 5.075 ± 0.062	3.92ThrLys: 3.92 ± 0.054	4.798ThrLeu: 4.798 ± 0.067	1.258ThrMet: 1.258 ± 0.031	2.934ThrAsn: 2.934 ± 0.044	1.734ThrPro: 1.734 ± 0.039	1.081ThrGln: 1.081 ± 0.026	1.423ThrArg: 1.423 ± 0.032	3.324ThrSer: 3.324 ± 0.067	2.857ThrThr: 2.857 ± 0.077	3.198ThrVal: 3.198 ± 0.056	0.391ThrTrp: 0.391 ± 0.017	1.99ThrTyr: 1.99 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	3.82ValAla: 3.82 ± 0.065	0.766ValCys: 0.766 ± 0.025	3.833ValAsp: 3.833 ± 0.059	4.78ValGlu: 4.78 ± 0.066	2.971ValPhe: 2.971 ± 0.053	4.099ValGly: 4.099 ± 0.066	0.839ValHis: 0.839 ± 0.029	5.853ValIle: 5.853 ± 0.08	5.254ValLys: 5.254 ± 0.067	5.764ValLeu: 5.764 ± 0.063	1.591ValMet: 1.591 ± 0.04	3.575ValAsn: 3.575 ± 0.053	1.874ValPro: 1.874 ± 0.037	1.468ValGln: 1.468 ± 0.032	1.771ValArg: 1.771 ± 0.039	4.219ValSer: 4.219 ± 0.061	3.245ValThr: 3.245 ± 0.055	4.388ValVal: 4.388 ± 0.064	0.46ValTrp: 0.46 ± 0.021	2.44ValTyr: 2.44 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.429TrpAla: 0.429 ± 0.02	0.096TrpCys: 0.096 ± 0.009	0.492TrpAsp: 0.492 ± 0.02	0.531TrpGlu: 0.531 ± 0.021	0.381TrpPhe: 0.381 ± 0.018	0.56TrpGly: 0.56 ± 0.025	0.124TrpHis: 0.124 ± 0.01	0.713TrpIle: 0.713 ± 0.027	0.55TrpLys: 0.55 ± 0.021	0.61TrpLeu: 0.61 ± 0.025	0.217TrpMet: 0.217 ± 0.013	0.534TrpAsn: 0.534 ± 0.023	0.208TrpPro: 0.208 ± 0.013	0.266TrpGln: 0.266 ± 0.015	0.267TrpArg: 0.267 ± 0.016	0.45TrpSer: 0.45 ± 0.02	0.387TrpThr: 0.387 ± 0.022	0.523TrpVal: 0.523 ± 0.021	0.096TrpTrp: 0.096 ± 0.009	0.335TrpTyr: 0.335 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.978TyrAla: 1.978 ± 0.037	0.53TyrCys: 0.53 ± 0.019	2.463TyrAsp: 2.463 ± 0.056	3.018TyrGlu: 3.018 ± 0.055	2.279TyrPhe: 2.279 ± 0.044	2.621TyrGly: 2.621 ± 0.052	0.64TyrHis: 0.64 ± 0.024	4.013TyrIle: 4.013 ± 0.064	3.735TyrLys: 3.735 ± 0.055	3.966TyrLeu: 3.966 ± 0.054	1.02TyrMet: 1.02 ± 0.026	2.864TyrAsn: 2.864 ± 0.05	1.329TyrPro: 1.329 ± 0.039	0.918TyrGln: 0.918 ± 0.03	1.43TyrArg: 1.43 ± 0.037	2.919TyrSer: 2.919 ± 0.045	2.069TyrThr: 2.069 ± 0.043	2.319TyrVal: 2.319 ± 0.048	0.349TyrTrp: 0.349 ± 0.017	2.067TyrTyr: 2.067 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4177 proteins (1287820 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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