Amino acid dipepetide frequency for Metschnikowia aff. pulcherrima

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.23AlaAla: 6.23 ± 0.083	0.955AlaCys: 0.955 ± 0.027	3.826AlaAsp: 3.826 ± 0.044	4.956AlaGlu: 4.956 ± 0.061	3.031AlaPhe: 3.031 ± 0.035	4.082AlaGly: 4.082 ± 0.054	1.713AlaHis: 1.713 ± 0.028	3.823AlaIle: 3.823 ± 0.042	4.788AlaLys: 4.788 ± 0.054	7.484AlaLeu: 7.484 ± 0.07	1.529AlaMet: 1.529 ± 0.025	3.277AlaAsn: 3.277 ± 0.032	3.452AlaPro: 3.452 ± 0.051	3.028AlaGln: 3.028 ± 0.043	3.689AlaArg: 3.689 ± 0.045	6.279AlaSer: 6.279 ± 0.069	4.128AlaThr: 4.128 ± 0.057	4.513AlaVal: 4.513 ± 0.049	0.671AlaTrp: 0.671 ± 0.018	2.117AlaTyr: 2.117 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	0.871CysAla: 0.871 ± 0.025	0.224CysCys: 0.224 ± 0.01	0.725CysAsp: 0.725 ± 0.02	0.681CysGlu: 0.681 ± 0.014	0.651CysPhe: 0.651 ± 0.017	0.867CysGly: 0.867 ± 0.02	0.338CysHis: 0.338 ± 0.012	0.684CysIle: 0.684 ± 0.017	0.619CysLys: 0.619 ± 0.014	1.421CysLeu: 1.421 ± 0.024	0.264CysMet: 0.264 ± 0.009	0.479CysAsn: 0.479 ± 0.013	0.525CysPro: 0.525 ± 0.014	0.371CysGln: 0.371 ± 0.012	0.543CysArg: 0.543 ± 0.015	0.871CysSer: 0.871 ± 0.018	0.608CysThr: 0.608 ± 0.015	0.856CysVal: 0.856 ± 0.019	0.15CysTrp: 0.15 ± 0.009	0.404CysTyr: 0.404 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.121AspAla: 4.121 ± 0.043	0.609AspCys: 0.609 ± 0.016	4.002AspAsp: 4.002 ± 0.064	4.711AspGlu: 4.711 ± 0.052	2.863AspPhe: 2.863 ± 0.037	3.113AspGly: 3.113 ± 0.059	1.277AspHis: 1.277 ± 0.021	3.235AspIle: 3.235 ± 0.035	2.948AspLys: 2.948 ± 0.036	6.274AspLeu: 6.274 ± 0.064	1.262AspMet: 1.262 ± 0.021	2.146AspAsn: 2.146 ± 0.029	2.523AspPro: 2.523 ± 0.031	1.75AspGln: 1.75 ± 0.024	2.177AspArg: 2.177 ± 0.032	4.634AspSer: 4.634 ± 0.052	2.969AspThr: 2.969 ± 0.041	3.77AspVal: 3.77 ± 0.04	0.622AspTrp: 0.622 ± 0.015	1.972AspTyr: 1.972 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	4.487GluAla: 4.487 ± 0.051	0.711GluCys: 0.711 ± 0.024	4.018GluAsp: 4.018 ± 0.053	5.198GluGlu: 5.198 ± 0.072	2.739GluPhe: 2.739 ± 0.03	2.805GluGly: 2.805 ± 0.04	1.418GluHis: 1.418 ± 0.024	4.048GluIle: 4.048 ± 0.048	5.251GluLys: 5.251 ± 0.061	6.674GluLeu: 6.674 ± 0.067	1.387GluMet: 1.387 ± 0.022	3.914GluAsn: 3.914 ± 0.042	2.495GluPro: 2.495 ± 0.037	2.465GluGln: 2.465 ± 0.036	3.085GluArg: 3.085 ± 0.037	5.144GluSer: 5.144 ± 0.057	3.957GluThr: 3.957 ± 0.05	3.594GluVal: 3.594 ± 0.041	0.633GluTrp: 0.633 ± 0.015	2.094GluTyr: 2.094 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.298PheAla: 3.298 ± 0.039	0.614PheCys: 0.614 ± 0.015	2.8PheAsp: 2.8 ± 0.032	2.864PheGlu: 2.864 ± 0.035	2.137PhePhe: 2.137 ± 0.038	2.897PheGly: 2.897 ± 0.045	1.071PheHis: 1.071 ± 0.021	2.232PheIle: 2.232 ± 0.035	2.432PheLys: 2.432 ± 0.032	4.55PheLeu: 4.55 ± 0.05	0.967PheMet: 0.967 ± 0.019	1.931PheAsn: 1.931 ± 0.026	1.852PhePro: 1.852 ± 0.035	1.664PheGln: 1.664 ± 0.024	1.965PheArg: 1.965 ± 0.027	3.71PheSer: 3.71 ± 0.037	2.463PheThr: 2.463 ± 0.045	3.084PheVal: 3.084 ± 0.034	0.575PheTrp: 0.575 ± 0.016	1.461PheTyr: 1.461 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	3.968GlyAla: 3.968 ± 0.051	0.704GlyCys: 0.704 ± 0.017	2.986GlyAsp: 2.986 ± 0.036	3.398GlyGlu: 3.398 ± 0.039	2.653GlyPhe: 2.653 ± 0.035	3.531GlyGly: 3.531 ± 0.057	1.457GlyHis: 1.457 ± 0.028	3.063GlyIle: 3.063 ± 0.034	3.571GlyLys: 3.571 ± 0.041	5.697GlyLeu: 5.697 ± 0.063	1.113GlyMet: 1.113 ± 0.021	2.486GlyAsn: 2.486 ± 0.032	2.226GlyPro: 2.226 ± 0.036	1.95GlyGln: 1.95 ± 0.035	2.422GlyArg: 2.422 ± 0.031	4.81GlySer: 4.81 ± 0.08	3.07GlyThr: 3.07 ± 0.043	3.766GlyVal: 3.766 ± 0.068	0.636GlyTrp: 0.636 ± 0.016	1.821GlyTyr: 1.821 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.612HisAla: 1.612 ± 0.024	0.3HisCys: 0.3 ± 0.009	1.353HisAsp: 1.353 ± 0.023	1.614HisGlu: 1.614 ± 0.029	1.115HisPhe: 1.115 ± 0.022	1.392HisGly: 1.392 ± 0.024	0.718HisHis: 0.718 ± 0.019	1.328HisIle: 1.328 ± 0.023	1.348HisLys: 1.348 ± 0.019	2.518HisLeu: 2.518 ± 0.039	0.594HisMet: 0.594 ± 0.021	1.031HisAsn: 1.031 ± 0.02	1.201HisPro: 1.201 ± 0.022	0.934HisGln: 0.934 ± 0.02	1.165HisArg: 1.165 ± 0.022	1.826HisSer: 1.826 ± 0.031	1.393HisThr: 1.393 ± 0.029	1.604HisVal: 1.604 ± 0.024	0.227HisTrp: 0.227 ± 0.009	0.8HisTyr: 0.8 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	3.794IleAla: 3.794 ± 0.035	0.772IleCys: 0.772 ± 0.018	3.396IleAsp: 3.396 ± 0.04	3.501IleGlu: 3.501 ± 0.046	2.331IlePhe: 2.331 ± 0.033	2.86IleGly: 2.86 ± 0.041	1.297IleHis: 1.297 ± 0.022	2.732IleIle: 2.732 ± 0.033	3.048IleLys: 3.048 ± 0.035	5.471IleLeu: 5.471 ± 0.048	1.127IleMet: 1.127 ± 0.019	2.413IleAsn: 2.413 ± 0.029	2.687IlePro: 2.687 ± 0.033	1.889IleGln: 1.889 ± 0.029	2.519IleArg: 2.519 ± 0.029	4.663IleSer: 4.663 ± 0.047	2.937IleThr: 2.937 ± 0.032	3.574IleVal: 3.574 ± 0.04	0.558IleTrp: 0.558 ± 0.015	1.684IleTyr: 1.684 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	4.37LysAla: 4.37 ± 0.046	0.712LysCys: 0.712 ± 0.015	3.396LysAsp: 3.396 ± 0.038	4.01LysGlu: 4.01 ± 0.049	2.639LysPhe: 2.639 ± 0.03	2.798LysGly: 2.798 ± 0.033	1.58LysHis: 1.58 ± 0.023	3.484LysIle: 3.484 ± 0.04	5.069LysLys: 5.069 ± 0.068	6.845LysLeu: 6.845 ± 0.066	1.314LysMet: 1.314 ± 0.023	3.132LysAsn: 3.132 ± 0.037	2.971LysPro: 2.971 ± 0.045	2.453LysGln: 2.453 ± 0.036	3.571LysArg: 3.571 ± 0.049	4.723LysSer: 4.723 ± 0.054	3.674LysThr: 3.674 ± 0.038	3.724LysVal: 3.724 ± 0.039	0.681LysTrp: 0.681 ± 0.016	2.134LysTyr: 2.134 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	8.354LeuAla: 8.354 ± 0.066	1.344LeuCys: 1.344 ± 0.021	5.806LeuAsp: 5.806 ± 0.05	6.588LeuGlu: 6.588 ± 0.064	4.41LeuPhe: 4.41 ± 0.053	5.663LeuGly: 5.663 ± 0.055	2.49LeuHis: 2.49 ± 0.031	5.182LeuIle: 5.182 ± 0.049	6.687LeuLys: 6.687 ± 0.06	10.603LeuLeu: 10.603 ± 0.092	2.173LeuMet: 2.173 ± 0.033	4.679LeuAsn: 4.679 ± 0.045	4.986LeuPro: 4.986 ± 0.051	4.482LeuGln: 4.482 ± 0.053	5.581LeuArg: 5.581 ± 0.054	8.576LeuSer: 8.576 ± 0.066	5.671LeuThr: 5.671 ± 0.056	6.373LeuVal: 6.373 ± 0.061	0.998LeuTrp: 0.998 ± 0.018	3.037LeuTyr: 3.037 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	1.753MetAla: 1.753 ± 0.025	0.27MetCys: 0.27 ± 0.01	1.156MetAsp: 1.156 ± 0.021	1.213MetGlu: 1.213 ± 0.027	0.861MetPhe: 0.861 ± 0.019	1.201MetGly: 1.201 ± 0.021	0.459MetHis: 0.459 ± 0.013	1.042MetIle: 1.042 ± 0.02	1.344MetLys: 1.344 ± 0.023	2.067MetLeu: 2.067 ± 0.031	0.511MetMet: 0.511 ± 0.015	1.022MetAsn: 1.022 ± 0.019	1.052MetPro: 1.052 ± 0.023	0.733MetGln: 0.733 ± 0.017	1.139MetArg: 1.139 ± 0.026	2.026MetSer: 2.026 ± 0.025	1.143MetThr: 1.143 ± 0.023	1.234MetVal: 1.234 ± 0.019	0.185MetTrp: 0.185 ± 0.008	0.607MetTyr: 0.607 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.316AsnAla: 3.316 ± 0.038	0.542AsnCys: 0.542 ± 0.016	2.728AsnAsp: 2.728 ± 0.039	3.018AsnGlu: 3.018 ± 0.035	2.142AsnPhe: 2.142 ± 0.031	2.903AsnGly: 2.903 ± 0.035	1.047AsnHis: 1.047 ± 0.022	2.483AsnIle: 2.483 ± 0.032	2.504AsnLys: 2.504 ± 0.032	4.777AsnLeu: 4.777 ± 0.047	1.042AsnMet: 1.042 ± 0.02	2.114AsnAsn: 2.114 ± 0.034	2.252AsnPro: 2.252 ± 0.032	1.517AsnGln: 1.517 ± 0.027	1.922AsnArg: 1.922 ± 0.029	3.822AsnSer: 3.822 ± 0.058	2.745AsnThr: 2.745 ± 0.032	2.96AsnVal: 2.96 ± 0.034	0.525AsnTrp: 0.525 ± 0.013	1.577AsnTyr: 1.577 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	3.542ProAla: 3.542 ± 0.048	0.388ProCys: 0.388 ± 0.011	2.403ProAsp: 2.403 ± 0.035	3.667ProGlu: 3.667 ± 0.048	2.049ProPhe: 2.049 ± 0.028	2.575ProGly: 2.575 ± 0.042	1.12ProHis: 1.12 ± 0.023	2.327ProIle: 2.327 ± 0.029	2.866ProLys: 2.866 ± 0.037	4.501ProLeu: 4.501 ± 0.051	0.859ProMet: 0.859 ± 0.015	2.007ProAsn: 2.007 ± 0.03	2.642ProPro: 2.642 ± 0.07	2.241ProGln: 2.241 ± 0.037	2.182ProArg: 2.182 ± 0.034	4.02ProSer: 4.02 ± 0.075	2.595ProThr: 2.595 ± 0.041	3.218ProVal: 3.218 ± 0.048	0.422ProTrp: 0.422 ± 0.012	1.345ProTyr: 1.345 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	2.785GlnAla: 2.785 ± 0.037	0.384GlnCys: 0.384 ± 0.011	1.934GlnAsp: 1.934 ± 0.029	2.427GlnGlu: 2.427 ± 0.032	1.642GlnPhe: 1.642 ± 0.027	1.89GlnGly: 1.89 ± 0.029	0.933GlnHis: 0.933 ± 0.022	2.318GlnIle: 2.318 ± 0.029	2.724GlnLys: 2.724 ± 0.033	4.037GlnLeu: 4.037 ± 0.047	0.918GlnMet: 0.918 ± 0.018	2.166GlnAsn: 2.166 ± 0.031	1.768GlnPro: 1.768 ± 0.035	2.141GlnGln: 2.141 ± 0.067	1.929GlnArg: 1.929 ± 0.027	2.685GlnSer: 2.685 ± 0.031	2.158GlnThr: 2.158 ± 0.032	2.24GlnVal: 2.24 ± 0.031	0.382GlnTrp: 0.382 ± 0.013	1.215GlnTyr: 1.215 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	3.453ArgAla: 3.453 ± 0.044	0.564ArgCys: 0.564 ± 0.016	2.766ArgAsp: 2.766 ± 0.027	3.098ArgGlu: 3.098 ± 0.038	2.224ArgPhe: 2.224 ± 0.031	2.404ArgGly: 2.404 ± 0.035	1.225ArgHis: 1.225 ± 0.02	2.604ArgIle: 2.604 ± 0.032	3.643ArgLys: 3.643 ± 0.045	5.259ArgLeu: 5.259 ± 0.051	0.981ArgMet: 0.981 ± 0.021	2.324ArgAsn: 2.324 ± 0.033	2.184ArgPro: 2.184 ± 0.034	2.018ArgGln: 2.018 ± 0.03	3.004ArgArg: 3.004 ± 0.041	3.63ArgSer: 3.63 ± 0.045	2.325ArgThr: 2.325 ± 0.029	2.925ArgVal: 2.925 ± 0.034	0.487ArgTrp: 0.487 ± 0.012	1.487ArgTyr: 1.487 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	6.126SerAla: 6.126 ± 0.078	0.844SerCys: 0.844 ± 0.019	4.648SerAsp: 4.648 ± 0.053	5.301SerGlu: 5.301 ± 0.045	3.633SerPhe: 3.633 ± 0.052	5.041SerGly: 5.041 ± 0.073	2.101SerHis: 2.101 ± 0.038	4.148SerIle: 4.148 ± 0.047	4.706SerLys: 4.706 ± 0.043	8.806SerLeu: 8.806 ± 0.074	1.714SerMet: 1.714 ± 0.029	3.365SerAsn: 3.365 ± 0.043	3.97SerPro: 3.97 ± 0.054	3.219SerGln: 3.219 ± 0.037	4.111SerArg: 4.111 ± 0.05	8.56SerSer: 8.56 ± 0.233	4.934SerThr: 4.934 ± 0.111	5.374SerVal: 5.374 ± 0.071	0.787SerTrp: 0.787 ± 0.019	2.262SerTyr: 2.262 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	3.907ThrAla: 3.907 ± 0.041	0.712ThrCys: 0.712 ± 0.017	2.88ThrAsp: 2.88 ± 0.048	3.413ThrGlu: 3.413 ± 0.038	2.504ThrPhe: 2.504 ± 0.036	3.616ThrGly: 3.616 ± 0.1	1.352ThrHis: 1.352 ± 0.025	3.017ThrIle: 3.017 ± 0.037	3.391ThrLys: 3.391 ± 0.041	5.562ThrLeu: 5.562 ± 0.051	1.059ThrMet: 1.059 ± 0.021	2.624ThrAsn: 2.624 ± 0.056	3.196ThrPro: 3.196 ± 0.059	2.17ThrGln: 2.17 ± 0.03	2.699ThrArg: 2.699 ± 0.034	5.046ThrSer: 5.046 ± 0.127	3.818ThrThr: 3.818 ± 0.213	3.658ThrVal: 3.658 ± 0.091	0.684ThrTrp: 0.684 ± 0.043	1.708ThrTyr: 1.708 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	4.717ValAla: 4.717 ± 0.055	0.852ValCys: 0.852 ± 0.017	3.647ValAsp: 3.647 ± 0.041	3.91ValGlu: 3.91 ± 0.066	2.939ValPhe: 2.939 ± 0.035	3.257ValGly: 3.257 ± 0.039	1.457ValHis: 1.457 ± 0.025	3.299ValIle: 3.299 ± 0.041	3.812ValLys: 3.812 ± 0.048	6.666ValLeu: 6.666 ± 0.058	1.3ValMet: 1.3 ± 0.024	2.75ValAsn: 2.75 ± 0.035	3.336ValPro: 3.336 ± 0.056	2.146ValGln: 2.146 ± 0.034	2.919ValArg: 2.919 ± 0.034	5.612ValSer: 5.612 ± 0.048	3.851ValThr: 3.851 ± 0.103	4.404ValVal: 4.404 ± 0.068	0.677ValTrp: 0.677 ± 0.018	1.934ValTyr: 1.934 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	0.747TrpAla: 0.747 ± 0.019	0.204TrpCys: 0.204 ± 0.008	0.627TrpAsp: 0.627 ± 0.015	0.561TrpGlu: 0.561 ± 0.014	0.489TrpPhe: 0.489 ± 0.013	0.579TrpGly: 0.579 ± 0.016	0.239TrpHis: 0.239 ± 0.009	0.551TrpIle: 0.551 ± 0.014	0.697TrpLys: 0.697 ± 0.019	1.152TrpLeu: 1.152 ± 0.019	0.224TrpMet: 0.224 ± 0.01	0.525TrpAsn: 0.525 ± 0.014	0.36TrpPro: 0.36 ± 0.011	0.372TrpGln: 0.372 ± 0.012	0.576TrpArg: 0.576 ± 0.015	0.703TrpSer: 0.703 ± 0.016	0.676TrpThr: 0.676 ± 0.056	0.624TrpVal: 0.624 ± 0.019	0.169TrpTrp: 0.169 ± 0.009	0.364TrpTyr: 0.364 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.122TyrAla: 2.122 ± 0.031	0.446TyrCys: 0.446 ± 0.012	1.88TyrAsp: 1.88 ± 0.028	1.988TyrGlu: 1.988 ± 0.026	1.515TyrPhe: 1.515 ± 0.026	1.856TyrGly: 1.856 ± 0.027	0.782TyrHis: 0.782 ± 0.016	1.648TyrIle: 1.648 ± 0.025	1.832TyrLys: 1.832 ± 0.028	3.319TyrLeu: 3.319 ± 0.038	0.682TyrMet: 0.682 ± 0.014	1.548TyrAsn: 1.548 ± 0.022	1.291TyrPro: 1.291 ± 0.028	1.135TyrGln: 1.135 ± 0.02	1.405TyrArg: 1.405 ± 0.024	2.309TyrSer: 2.309 ± 0.033	1.902TyrThr: 1.902 ± 0.067	1.993TyrVal: 1.993 ± 0.031	0.37TyrTrp: 0.37 ± 0.016	1.179TyrTyr: 1.179 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5795 proteins (2902063 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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