Amino acid dipepetide frequency for Geobacter argillaceus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.237AlaAla: 11.237 ± 0.145	1.322AlaCys: 1.322 ± 0.037	5.17AlaAsp: 5.17 ± 0.056	6.268AlaGlu: 6.268 ± 0.1	3.669AlaPhe: 3.669 ± 0.055	8.974AlaGly: 8.974 ± 0.104	1.711AlaHis: 1.711 ± 0.039	5.834AlaIle: 5.834 ± 0.073	4.213AlaLys: 4.213 ± 0.075	9.907AlaLeu: 9.907 ± 0.107	2.613AlaMet: 2.613 ± 0.05	2.773AlaAsn: 2.773 ± 0.05	3.809AlaPro: 3.809 ± 0.081	2.621AlaGln: 2.621 ± 0.046	5.98AlaArg: 5.98 ± 0.087	4.989AlaSer: 4.989 ± 0.076	5.63AlaThr: 5.63 ± 0.078	7.482AlaVal: 7.482 ± 0.081	0.978AlaTrp: 0.978 ± 0.029	2.343AlaTyr: 2.343 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.045CysAla: 1.045 ± 0.033	0.228CysCys: 0.228 ± 0.015	0.633CysAsp: 0.633 ± 0.021	0.547CysGlu: 0.547 ± 0.022	0.463CysPhe: 0.463 ± 0.022	1.299CysGly: 1.299 ± 0.039	0.794CysHis: 0.794 ± 0.09	0.65CysIle: 0.65 ± 0.025	0.392CysLys: 0.392 ± 0.017	1.113CysLeu: 1.113 ± 0.033	0.283CysMet: 0.283 ± 0.014	0.401CysAsn: 0.401 ± 0.019	0.703CysPro: 0.703 ± 0.031	0.385CysGln: 0.385 ± 0.019	0.927CysArg: 0.927 ± 0.028	0.888CysSer: 0.888 ± 0.029	0.673CysThr: 0.673 ± 0.026	0.72CysVal: 0.72 ± 0.023	0.129CysTrp: 0.129 ± 0.011	0.418CysTyr: 0.418 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	4.365AspAla: 4.365 ± 0.057	0.644AspCys: 0.644 ± 0.029	2.623AspAsp: 2.623 ± 0.052	3.559AspGlu: 3.559 ± 0.069	2.167AspPhe: 2.167 ± 0.041	4.23AspGly: 4.23 ± 0.06	1.0AspHis: 1.0 ± 0.032	3.193AspIle: 3.193 ± 0.059	2.254AspLys: 2.254 ± 0.054	5.723AspLeu: 5.723 ± 0.077	1.136AspMet: 1.136 ± 0.032	1.652AspAsn: 1.652 ± 0.035	2.694AspPro: 2.694 ± 0.05	1.602AspGln: 1.602 ± 0.038	3.597AspArg: 3.597 ± 0.061	2.518AspSer: 2.518 ± 0.05	2.522AspThr: 2.522 ± 0.051	3.408AspVal: 3.408 ± 0.054	0.615AspTrp: 0.615 ± 0.024	1.704AspTyr: 1.704 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	5.866GluAla: 5.866 ± 0.087	0.588GluCys: 0.588 ± 0.023	2.374GluAsp: 2.374 ± 0.047	4.874GluGlu: 4.874 ± 0.09	2.277GluPhe: 2.277 ± 0.046	4.264GluGly: 4.264 ± 0.063	1.205GluHis: 1.205 ± 0.033	4.189GluIle: 4.189 ± 0.076	3.769GluLys: 3.769 ± 0.074	7.306GluLeu: 7.306 ± 0.092	1.824GluMet: 1.824 ± 0.042	1.949GluAsn: 1.949 ± 0.038	2.32GluPro: 2.32 ± 0.046	2.76GluGln: 2.76 ± 0.047	5.012GluArg: 5.012 ± 0.085	2.912GluSer: 2.912 ± 0.05	3.298GluThr: 3.298 ± 0.064	4.376GluVal: 4.376 ± 0.071	0.582GluTrp: 0.582 ± 0.022	1.689GluTyr: 1.689 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.718PheAla: 3.718 ± 0.059	0.623PheCys: 0.623 ± 0.024	2.26PheAsp: 2.26 ± 0.042	1.884PheGlu: 1.884 ± 0.038	1.745PhePhe: 1.745 ± 0.038	3.35PheGly: 3.35 ± 0.059	0.811PheHis: 0.811 ± 0.03	2.162PheIle: 2.162 ± 0.042	1.52PheLys: 1.52 ± 0.035	4.065PheLeu: 4.065 ± 0.068	0.929PheMet: 0.929 ± 0.027	1.392PheAsn: 1.392 ± 0.032	1.896PhePro: 1.896 ± 0.037	1.109PheGln: 1.109 ± 0.031	2.485PheArg: 2.485 ± 0.05	2.772PheSer: 2.772 ± 0.048	2.482PheThr: 2.482 ± 0.047	2.803PheVal: 2.803 ± 0.045	0.459PheTrp: 0.459 ± 0.021	1.141PheTyr: 1.141 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	7.015GlyAla: 7.015 ± 0.09	1.213GlyCys: 1.213 ± 0.04	3.888GlyAsp: 3.888 ± 0.069	5.044GlyGlu: 5.044 ± 0.071	3.393GlyPhe: 3.393 ± 0.054	6.725GlyGly: 6.725 ± 0.105	1.573GlyHis: 1.573 ± 0.034	5.723GlyIle: 5.723 ± 0.075	4.699GlyLys: 4.699 ± 0.077	7.599GlyLeu: 7.599 ± 0.096	2.448GlyMet: 2.448 ± 0.043	2.855GlyAsn: 2.855 ± 0.06	2.404GlyPro: 2.404 ± 0.045	2.475GlyGln: 2.475 ± 0.052	5.098GlyArg: 5.098 ± 0.069	4.921GlySer: 4.921 ± 0.089	5.118GlyThr: 5.118 ± 0.102	6.108GlyVal: 6.108 ± 0.075	0.988GlyTrp: 0.988 ± 0.03	2.7GlyTyr: 2.7 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.725HisAla: 1.725 ± 0.047	0.309HisCys: 0.309 ± 0.016	1.188HisAsp: 1.188 ± 0.031	1.199HisGlu: 1.199 ± 0.033	0.878HisPhe: 0.878 ± 0.025	1.837HisGly: 1.837 ± 0.05	0.546HisHis: 0.546 ± 0.025	1.048HisIle: 1.048 ± 0.035	0.751HisLys: 0.751 ± 0.027	2.236HisLeu: 2.236 ± 0.047	0.415HisMet: 0.415 ± 0.018	0.72HisAsn: 0.72 ± 0.025	1.259HisPro: 1.259 ± 0.033	0.676HisGln: 0.676 ± 0.022	1.323HisArg: 1.323 ± 0.031	1.018HisSer: 1.018 ± 0.036	0.989HisThr: 0.989 ± 0.031	1.198HisVal: 1.198 ± 0.03	0.213HisTrp: 0.213 ± 0.013	0.638HisTyr: 0.638 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.952IleAla: 5.952 ± 0.076	0.769IleCys: 0.769 ± 0.026	3.625IleAsp: 3.625 ± 0.058	3.507IleGlu: 3.507 ± 0.055	2.289IlePhe: 2.289 ± 0.044	4.824IleGly: 4.824 ± 0.068	1.195IleHis: 1.195 ± 0.029	3.442IleIle: 3.442 ± 0.057	2.561IleLys: 2.561 ± 0.055	5.511IleLeu: 5.511 ± 0.081	1.257IleMet: 1.257 ± 0.033	2.12IleAsn: 2.12 ± 0.044	3.095IlePro: 3.095 ± 0.052	1.56IleGln: 1.56 ± 0.039	3.755IleArg: 3.755 ± 0.049	3.524IleSer: 3.524 ± 0.054	3.509IleThr: 3.509 ± 0.058	4.502IleVal: 4.502 ± 0.062	0.48IleTrp: 0.48 ± 0.017	1.571IleTyr: 1.571 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.48LysAla: 4.48 ± 0.085	0.451LysCys: 0.451 ± 0.024	2.37LysAsp: 2.37 ± 0.051	3.584LysGlu: 3.584 ± 0.068	1.287LysPhe: 1.287 ± 0.033	4.157LysGly: 4.157 ± 0.063	0.848LysHis: 0.848 ± 0.03	2.709LysIle: 2.709 ± 0.056	3.01LysLys: 3.01 ± 0.061	4.164LysLeu: 4.164 ± 0.062	1.245LysMet: 1.245 ± 0.035	1.66LysAsn: 1.66 ± 0.04	2.164LysPro: 2.164 ± 0.044	1.607LysGln: 1.607 ± 0.044	2.871LysArg: 2.871 ± 0.047	2.461LysSer: 2.461 ± 0.048	2.485LysThr: 2.485 ± 0.054	3.525LysVal: 3.525 ± 0.064	0.399LysTrp: 0.399 ± 0.018	1.211LysTyr: 1.211 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	11.655LeuAla: 11.655 ± 0.133	1.232LeuCys: 1.232 ± 0.031	5.365LeuAsp: 5.365 ± 0.073	6.369LeuGlu: 6.369 ± 0.099	4.274LeuPhe: 4.274 ± 0.071	7.652LeuGly: 7.652 ± 0.085	2.018LeuHis: 2.018 ± 0.042	5.34LeuIle: 5.34 ± 0.072	5.158LeuLys: 5.158 ± 0.065	11.352LeuLeu: 11.352 ± 0.133	2.22LeuMet: 2.22 ± 0.043	3.292LeuAsn: 3.292 ± 0.055	5.314LeuPro: 5.314 ± 0.071	3.267LeuGln: 3.267 ± 0.048	6.158LeuArg: 6.158 ± 0.084	6.033LeuSer: 6.033 ± 0.074	5.911LeuThr: 5.911 ± 0.078	7.676LeuVal: 7.676 ± 0.074	0.869LeuTrp: 0.869 ± 0.031	2.664LeuTyr: 2.664 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.82MetAla: 2.82 ± 0.051	0.186MetCys: 0.186 ± 0.012	1.153MetAsp: 1.153 ± 0.031	1.56MetGlu: 1.56 ± 0.036	0.752MetPhe: 0.752 ± 0.024	1.912MetGly: 1.912 ± 0.039	0.452MetHis: 0.452 ± 0.017	1.334MetIle: 1.334 ± 0.031	1.533MetLys: 1.533 ± 0.039	2.368MetLeu: 2.368 ± 0.052	0.593MetMet: 0.593 ± 0.021	0.942MetAsn: 0.942 ± 0.026	1.235MetPro: 1.235 ± 0.029	0.811MetGln: 0.811 ± 0.025	1.354MetArg: 1.354 ± 0.03	1.368MetSer: 1.368 ± 0.034	1.554MetThr: 1.554 ± 0.035	1.904MetVal: 1.904 ± 0.039	0.142MetTrp: 0.142 ± 0.011	0.412MetTyr: 0.412 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.828AsnAla: 2.828 ± 0.052	0.49AsnCys: 0.49 ± 0.023	1.608AsnAsp: 1.608 ± 0.036	1.688AsnGlu: 1.688 ± 0.04	1.204AsnPhe: 1.204 ± 0.032	2.814AsnGly: 2.814 ± 0.069	0.612AsnHis: 0.612 ± 0.023	2.063AsnIle: 2.063 ± 0.04	1.299AsnLys: 1.299 ± 0.037	3.519AsnLeu: 3.519 ± 0.045	0.719AsnMet: 0.719 ± 0.025	1.123AsnAsn: 1.123 ± 0.04	2.061AsnPro: 2.061 ± 0.041	1.007AsnGln: 1.007 ± 0.034	2.353AsnArg: 2.353 ± 0.048	1.877AsnSer: 1.877 ± 0.043	1.599AsnThr: 1.599 ± 0.048	2.29AsnVal: 2.29 ± 0.054	0.393AsnTrp: 0.393 ± 0.016	1.01AsnTyr: 1.01 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	4.973ProAla: 4.973 ± 0.091	0.471ProCys: 0.471 ± 0.019	2.847ProAsp: 2.847 ± 0.044	3.464ProGlu: 3.464 ± 0.054	1.997ProPhe: 1.997 ± 0.047	3.848ProGly: 3.848 ± 0.057	0.934ProHis: 0.934 ± 0.032	2.16ProIle: 2.16 ± 0.049	1.801ProLys: 1.801 ± 0.042	4.921ProLeu: 4.921 ± 0.063	0.988ProMet: 0.988 ± 0.025	1.261ProAsn: 1.261 ± 0.034	2.214ProPro: 2.214 ± 0.055	1.402ProGln: 1.402 ± 0.039	2.243ProArg: 2.243 ± 0.046	2.296ProSer: 2.296 ± 0.042	2.478ProThr: 2.478 ± 0.049	4.064ProVal: 4.064 ± 0.067	0.523ProTrp: 0.523 ± 0.022	1.342ProTyr: 1.342 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.232GlnAla: 3.232 ± 0.05	0.345GlnCys: 0.345 ± 0.019	1.246GlnAsp: 1.246 ± 0.033	2.241GlnGlu: 2.241 ± 0.046	1.127GlnPhe: 1.127 ± 0.029	2.397GlnGly: 2.397 ± 0.041	0.644GlnHis: 0.644 ± 0.022	1.852GlnIle: 1.852 ± 0.039	1.642GlnLys: 1.642 ± 0.041	3.366GlnLeu: 3.366 ± 0.05	0.851GlnMet: 0.851 ± 0.025	1.019GlnAsn: 1.019 ± 0.031	1.38GlnPro: 1.38 ± 0.038	1.4GlnGln: 1.4 ± 0.039	2.221GlnArg: 2.221 ± 0.041	1.655GlnSer: 1.655 ± 0.037	1.649GlnThr: 1.649 ± 0.041	2.634GlnVal: 2.634 ± 0.051	0.335GlnTrp: 0.335 ± 0.018	0.848GlnTyr: 0.848 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	4.751ArgAla: 4.751 ± 0.07	0.712ArgCys: 0.712 ± 0.025	3.304ArgAsp: 3.304 ± 0.05	5.199ArgGlu: 5.199 ± 0.094	2.88ArgPhe: 2.88 ± 0.054	4.046ArgGly: 4.046 ± 0.064	1.463ArgHis: 1.463 ± 0.035	4.206ArgIle: 4.206 ± 0.061	3.084ArgLys: 3.084 ± 0.055	7.427ArgLeu: 7.427 ± 0.111	1.668ArgMet: 1.668 ± 0.033	2.071ArgAsn: 2.071 ± 0.039	2.542ArgPro: 2.542 ± 0.052	2.648ArgGln: 2.648 ± 0.052	4.119ArgArg: 4.119 ± 0.085	3.344ArgSer: 3.344 ± 0.052	3.079ArgThr: 3.079 ± 0.05	4.411ArgVal: 4.411 ± 0.064	0.71ArgTrp: 0.71 ± 0.027	2.014ArgTyr: 2.014 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.125SerAla: 5.125 ± 0.081	0.849SerCys: 0.849 ± 0.033	2.768SerAsp: 2.768 ± 0.046	2.815SerGlu: 2.815 ± 0.051	2.58SerPhe: 2.58 ± 0.041	5.428SerGly: 5.428 ± 0.095	1.204SerHis: 1.204 ± 0.032	3.21SerIle: 3.21 ± 0.058	1.919SerLys: 1.919 ± 0.044	6.16SerLeu: 6.16 ± 0.077	1.303SerMet: 1.303 ± 0.031	1.566SerAsn: 1.566 ± 0.042	2.739SerPro: 2.739 ± 0.047	1.697SerGln: 1.697 ± 0.04	3.661SerArg: 3.661 ± 0.058	3.545SerSer: 3.545 ± 0.07	2.888SerThr: 2.888 ± 0.06	4.034SerVal: 4.034 ± 0.061	0.653SerTrp: 0.653 ± 0.022	1.681SerTyr: 1.681 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	5.686ThrAla: 5.686 ± 0.094	0.72ThrCys: 0.72 ± 0.035	2.726ThrAsp: 2.726 ± 0.048	2.865ThrGlu: 2.865 ± 0.059	2.326ThrPhe: 2.326 ± 0.049	5.578ThrGly: 5.578 ± 0.092	0.972ThrHis: 0.972 ± 0.025	3.698ThrIle: 3.698 ± 0.054	2.028ThrLys: 2.028 ± 0.038	5.869ThrLeu: 5.869 ± 0.078	1.323ThrMet: 1.323 ± 0.036	1.733ThrAsn: 1.733 ± 0.047	3.167ThrPro: 3.167 ± 0.058	1.3ThrGln: 1.3 ± 0.038	2.935ThrArg: 2.935 ± 0.052	3.046ThrSer: 3.046 ± 0.065	3.462ThrThr: 3.462 ± 0.087	4.979ThrVal: 4.979 ± 0.082	0.503ThrTrp: 0.503 ± 0.021	1.424ThrTyr: 1.424 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	7.957ValAla: 7.957 ± 0.086	0.95ValCys: 0.95 ± 0.032	3.929ValAsp: 3.929 ± 0.058	4.705ValGlu: 4.705 ± 0.072	2.645ValPhe: 2.645 ± 0.043	5.437ValGly: 5.437 ± 0.077	1.302ValHis: 1.302 ± 0.033	4.521ValIle: 4.521 ± 0.077	3.58ValLys: 3.58 ± 0.061	6.797ValLeu: 6.797 ± 0.079	1.84ValMet: 1.84 ± 0.043	2.663ValAsn: 2.663 ± 0.044	3.451ValPro: 3.451 ± 0.058	2.167ValGln: 2.167 ± 0.044	4.657ValArg: 4.657 ± 0.063	4.435ValSer: 4.435 ± 0.064	5.023ValThr: 5.023 ± 0.086	6.249ValVal: 6.249 ± 0.084	0.695ValTrp: 0.695 ± 0.025	1.746ValTyr: 1.746 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.707TrpAla: 0.707 ± 0.026	0.127TrpCys: 0.127 ± 0.008	0.52TrpAsp: 0.52 ± 0.024	0.629TrpGlu: 0.629 ± 0.025	0.433TrpPhe: 0.433 ± 0.019	0.803TrpGly: 0.803 ± 0.026	0.259TrpHis: 0.259 ± 0.014	0.492TrpIle: 0.492 ± 0.025	0.47TrpLys: 0.47 ± 0.018	1.192TrpLeu: 1.192 ± 0.037	0.233TrpMet: 0.233 ± 0.013	0.409TrpAsn: 0.409 ± 0.016	0.406TrpPro: 0.406 ± 0.02	0.591TrpGln: 0.591 ± 0.024	0.689TrpArg: 0.689 ± 0.026	0.582TrpSer: 0.582 ± 0.023	0.468TrpThr: 0.468 ± 0.02	0.656TrpVal: 0.656 ± 0.024	0.151TrpTrp: 0.151 ± 0.01	0.318TrpTyr: 0.318 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.387TyrAla: 2.387 ± 0.046	0.465TyrCys: 0.465 ± 0.024	1.608TyrAsp: 1.608 ± 0.043	1.434TyrGlu: 1.434 ± 0.031	1.22TyrPhe: 1.22 ± 0.036	2.41TyrGly: 2.41 ± 0.047	0.625TyrHis: 0.625 ± 0.023	1.223TyrIle: 1.223 ± 0.034	1.003TyrLys: 1.003 ± 0.029	3.224TyrLeu: 3.224 ± 0.052	0.496TyrMet: 0.496 ± 0.021	0.954TyrAsn: 0.954 ± 0.036	1.374TyrPro: 1.374 ± 0.03	1.001TyrGln: 1.001 ± 0.028	2.24TyrArg: 2.24 ± 0.051	1.643TyrSer: 1.643 ± 0.042	1.521TyrThr: 1.521 ± 0.044	1.729TyrVal: 1.729 ± 0.034	0.318TyrTrp: 0.318 ± 0.017	0.984TyrTyr: 0.984 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3944 proteins (1295148 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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