Amino acid dipepetide frequency for Pseudidiomarina planktonica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.778AlaAla: 10.778 ± 0.171	0.875AlaCys: 0.875 ± 0.036	6.143AlaAsp: 6.143 ± 0.083	7.383AlaGlu: 7.383 ± 0.112	3.383AlaPhe: 3.383 ± 0.062	7.254AlaGly: 7.254 ± 0.105	1.734AlaHis: 1.734 ± 0.048	5.661AlaIle: 5.661 ± 0.093	4.183AlaLys: 4.183 ± 0.088	10.726AlaLeu: 10.726 ± 0.157	2.663AlaMet: 2.663 ± 0.068	3.634AlaAsn: 3.634 ± 0.07	3.587AlaPro: 3.587 ± 0.076	4.682AlaGln: 4.682 ± 0.083	4.97AlaArg: 4.97 ± 0.081	5.584AlaSer: 5.584 ± 0.093	5.148AlaThr: 5.148 ± 0.091	7.049AlaVal: 7.049 ± 0.1	1.066AlaTrp: 1.066 ± 0.035	2.417AlaTyr: 2.417 ± 0.068	0.0AlaXaa: 0.0 ± 0.0
Cys	0.854CysAla: 0.854 ± 0.028	0.124CysCys: 0.124 ± 0.013	0.49CysAsp: 0.49 ± 0.028	0.563CysGlu: 0.563 ± 0.03	0.331CysPhe: 0.331 ± 0.016	0.764CysGly: 0.764 ± 0.034	0.254CysHis: 0.254 ± 0.019	0.396CysIle: 0.396 ± 0.026	0.294CysLys: 0.294 ± 0.019	0.803CysLeu: 0.803 ± 0.033	0.196CysMet: 0.196 ± 0.017	0.278CysAsn: 0.278 ± 0.019	0.41CysPro: 0.41 ± 0.025	0.425CysGln: 0.425 ± 0.023	0.459CysArg: 0.459 ± 0.027	0.554CysSer: 0.554 ± 0.026	0.391CysThr: 0.391 ± 0.022	0.565CysVal: 0.565 ± 0.027	0.123CysTrp: 0.123 ± 0.013	0.264CysTyr: 0.264 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	5.36AspAla: 5.36 ± 0.09	0.484AspCys: 0.484 ± 0.024	3.441AspAsp: 3.441 ± 0.094	3.958AspGlu: 3.958 ± 0.087	2.481AspPhe: 2.481 ± 0.058	3.811AspGly: 3.811 ± 0.095	1.186AspHis: 1.186 ± 0.042	3.743AspIle: 3.743 ± 0.075	2.579AspLys: 2.579 ± 0.069	5.438AspLeu: 5.438 ± 0.078	1.452AspMet: 1.452 ± 0.052	2.273AspAsn: 2.273 ± 0.061	2.156AspPro: 2.156 ± 0.056	2.239AspGln: 2.239 ± 0.056	2.586AspArg: 2.586 ± 0.056	3.38AspSer: 3.38 ± 0.076	2.894AspThr: 2.894 ± 0.069	4.07AspVal: 4.07 ± 0.077	0.928AspTrp: 0.928 ± 0.035	2.239AspTyr: 2.239 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	5.84GluAla: 5.84 ± 0.108	0.396GluCys: 0.396 ± 0.023	2.879GluAsp: 2.879 ± 0.077	3.551GluGlu: 3.551 ± 0.096	2.649GluPhe: 2.649 ± 0.064	3.494GluGly: 3.494 ± 0.076	1.801GluHis: 1.801 ± 0.047	3.336GluIle: 3.336 ± 0.08	2.769GluLys: 2.769 ± 0.068	8.087GluLeu: 8.087 ± 0.097	1.504GluMet: 1.504 ± 0.052	2.32GluAsn: 2.32 ± 0.059	2.522GluPro: 2.522 ± 0.065	4.978GluGln: 4.978 ± 0.097	4.417GluArg: 4.417 ± 0.077	3.298GluSer: 3.298 ± 0.076	3.147GluThr: 3.147 ± 0.065	4.642GluVal: 4.642 ± 0.086	0.664GluTrp: 0.664 ± 0.032	1.725GluTyr: 1.725 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	3.829PheAla: 3.829 ± 0.077	0.382PheCys: 0.382 ± 0.025	2.462PheAsp: 2.462 ± 0.071	2.344PheGlu: 2.344 ± 0.051	1.549PhePhe: 1.549 ± 0.05	3.145PheGly: 3.145 ± 0.068	0.744PheHis: 0.744 ± 0.033	2.346PheIle: 2.346 ± 0.055	1.523PheLys: 1.523 ± 0.047	3.189PheLeu: 3.189 ± 0.067	0.94PheMet: 0.94 ± 0.038	1.627PheAsn: 1.627 ± 0.048	1.376PhePro: 1.376 ± 0.038	1.296PheGln: 1.296 ± 0.041	1.904PheArg: 1.904 ± 0.052	2.857PheSer: 2.857 ± 0.062	2.306PheThr: 2.306 ± 0.063	2.706PheVal: 2.706 ± 0.067	0.494PheTrp: 0.494 ± 0.025	1.257PheTyr: 1.257 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	5.891GlyAla: 5.891 ± 0.085	0.751GlyCys: 0.751 ± 0.032	3.956GlyAsp: 3.956 ± 0.071	4.526GlyGlu: 4.526 ± 0.08	3.165GlyPhe: 3.165 ± 0.067	5.161GlyGly: 5.161 ± 0.099	1.622GlyHis: 1.622 ± 0.044	4.315GlyIle: 4.315 ± 0.074	3.362GlyLys: 3.362 ± 0.067	7.002GlyLeu: 7.002 ± 0.102	1.978GlyMet: 1.978 ± 0.056	2.613GlyAsn: 2.613 ± 0.081	1.899GlyPro: 1.899 ± 0.049	2.92GlyGln: 2.92 ± 0.06	3.648GlyArg: 3.648 ± 0.067	4.245GlySer: 4.245 ± 0.076	3.538GlyThr: 3.538 ± 0.075	5.419GlyVal: 5.419 ± 0.094	1.016GlyTrp: 1.016 ± 0.039	2.424GlyTyr: 2.424 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	1.91HisAla: 1.91 ± 0.053	0.301HisCys: 0.301 ± 0.021	1.227HisAsp: 1.227 ± 0.048	1.362HisGlu: 1.362 ± 0.048	0.937HisPhe: 0.937 ± 0.036	1.721HisGly: 1.721 ± 0.041	0.62HisHis: 0.62 ± 0.032	1.262HisIle: 1.262 ± 0.044	0.885HisLys: 0.885 ± 0.033	2.095HisLeu: 2.095 ± 0.053	0.507HisMet: 0.507 ± 0.022	0.764HisAsn: 0.764 ± 0.034	1.271HisPro: 1.271 ± 0.044	1.281HisGln: 1.281 ± 0.042	1.168HisArg: 1.168 ± 0.039	1.311HisSer: 1.311 ± 0.043	1.032HisThr: 1.032 ± 0.043	1.291HisVal: 1.291 ± 0.048	0.389HisTrp: 0.389 ± 0.022	0.834HisTyr: 0.834 ± 0.036	0.0HisXaa: 0.0 ± 0.0
Ile	6.024IleAla: 6.024 ± 0.104	0.542IleCys: 0.542 ± 0.026	3.663IleAsp: 3.663 ± 0.071	3.968IleGlu: 3.968 ± 0.073	1.751IlePhe: 1.751 ± 0.059	4.314IleGly: 4.314 ± 0.097	1.123IleHis: 1.123 ± 0.035	3.004IleIle: 3.004 ± 0.068	2.277IleLys: 2.277 ± 0.066	4.64IleLeu: 4.64 ± 0.083	1.188IleMet: 1.188 ± 0.041	2.185IleAsn: 2.185 ± 0.056	2.434IlePro: 2.434 ± 0.06	2.083IleGln: 2.083 ± 0.059	2.86IleArg: 2.86 ± 0.058	3.671IleSer: 3.671 ± 0.07	3.36IleThr: 3.36 ± 0.065	3.634IleVal: 3.634 ± 0.073	0.596IleTrp: 0.596 ± 0.029	1.514IleTyr: 1.514 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.159LysAla: 4.159 ± 0.096	0.249LysCys: 0.249 ± 0.021	2.102LysAsp: 2.102 ± 0.056	2.394LysGlu: 2.394 ± 0.063	1.397LysPhe: 1.397 ± 0.045	2.414LysGly: 2.414 ± 0.062	1.051LysHis: 1.051 ± 0.035	1.998LysIle: 1.998 ± 0.056	1.955LysLys: 1.955 ± 0.07	4.626LysLeu: 4.626 ± 0.086	0.969LysMet: 0.969 ± 0.037	1.564LysAsn: 1.564 ± 0.047	2.223LysPro: 2.223 ± 0.054	2.422LysGln: 2.422 ± 0.054	2.756LysArg: 2.756 ± 0.07	2.442LysSer: 2.442 ± 0.061	2.207LysThr: 2.207 ± 0.057	3.091LysVal: 3.091 ± 0.076	0.434LysTrp: 0.434 ± 0.024	1.049LysTyr: 1.049 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	11.727LeuAla: 11.727 ± 0.148	0.876LeuCys: 0.876 ± 0.03	5.557LeuAsp: 5.557 ± 0.078	6.292LeuGlu: 6.292 ± 0.09	3.692LeuPhe: 3.692 ± 0.075	6.922LeuGly: 6.922 ± 0.105	2.241LeuHis: 2.241 ± 0.055	5.325LeuIle: 5.325 ± 0.092	4.355LeuLys: 4.355 ± 0.08	11.453LeuLeu: 11.453 ± 0.181	2.512LeuMet: 2.512 ± 0.053	4.123LeuAsn: 4.123 ± 0.079	5.14LeuPro: 5.14 ± 0.094	5.666LeuGln: 5.666 ± 0.125	5.838LeuArg: 5.838 ± 0.108	6.895LeuSer: 6.895 ± 0.105	6.424LeuThr: 6.424 ± 0.1	7.555LeuVal: 7.555 ± 0.107	1.225LeuTrp: 1.225 ± 0.044	2.505LeuTyr: 2.505 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.666MetAla: 2.666 ± 0.061	0.131MetCys: 0.131 ± 0.012	1.12MetAsp: 1.12 ± 0.039	1.164MetGlu: 1.164 ± 0.039	0.816MetPhe: 0.816 ± 0.033	1.573MetGly: 1.573 ± 0.046	0.503MetHis: 0.503 ± 0.027	1.226MetIle: 1.226 ± 0.043	1.139MetLys: 1.139 ± 0.04	2.744MetLeu: 2.744 ± 0.058	0.676MetMet: 0.676 ± 0.03	0.977MetAsn: 0.977 ± 0.035	1.241MetPro: 1.241 ± 0.036	1.308MetGln: 1.308 ± 0.042	1.339MetArg: 1.339 ± 0.047	1.671MetSer: 1.671 ± 0.046	1.57MetThr: 1.57 ± 0.046	1.754MetVal: 1.754 ± 0.047	0.216MetTrp: 0.216 ± 0.016	0.533MetTyr: 0.533 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.396AsnAla: 3.396 ± 0.076	0.358AsnCys: 0.358 ± 0.025	2.253AsnAsp: 2.253 ± 0.06	2.402AsnGlu: 2.402 ± 0.06	1.451AsnPhe: 1.451 ± 0.052	2.767AsnGly: 2.767 ± 0.071	0.776AsnHis: 0.776 ± 0.032	2.102AsnIle: 2.102 ± 0.059	1.58AsnLys: 1.58 ± 0.041	3.601AsnLeu: 3.601 ± 0.065	0.869AsnMet: 0.869 ± 0.031	1.652AsnAsn: 1.652 ± 0.06	1.99AsnPro: 1.99 ± 0.056	1.858AsnGln: 1.858 ± 0.052	1.921AsnArg: 1.921 ± 0.054	2.314AsnSer: 2.314 ± 0.072	2.106AsnThr: 2.106 ± 0.057	2.305AsnVal: 2.305 ± 0.058	0.664AsnTrp: 0.664 ± 0.033	1.299AsnTyr: 1.299 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	4.343ProAla: 4.343 ± 0.092	0.265ProCys: 0.265 ± 0.02	2.765ProAsp: 2.765 ± 0.053	3.51ProGlu: 3.51 ± 0.073	1.583ProPhe: 1.583 ± 0.046	2.97ProGly: 2.97 ± 0.067	0.884ProHis: 0.884 ± 0.034	2.083ProIle: 2.083 ± 0.047	1.672ProLys: 1.672 ± 0.049	4.445ProLeu: 4.445 ± 0.095	0.963ProMet: 0.963 ± 0.033	1.591ProAsn: 1.591 ± 0.044	1.432ProPro: 1.432 ± 0.051	2.033ProGln: 2.033 ± 0.051	1.729ProArg: 1.729 ± 0.049	2.082ProSer: 2.082 ± 0.051	2.207ProThr: 2.207 ± 0.055	3.47ProVal: 3.47 ± 0.07	0.582ProTrp: 0.582 ± 0.025	1.176ProTyr: 1.176 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	5.315GlnAla: 5.315 ± 0.108	0.334GlnCys: 0.334 ± 0.022	2.047GlnAsp: 2.047 ± 0.046	2.779GlnGlu: 2.779 ± 0.062	1.626GlnPhe: 1.626 ± 0.042	3.084GlnGly: 3.084 ± 0.063	1.525GlnHis: 1.525 ± 0.05	2.185GlnIle: 2.185 ± 0.06	1.653GlnLys: 1.653 ± 0.048	6.863GlnLeu: 6.863 ± 0.131	0.988GlnMet: 0.988 ± 0.034	1.598GlnAsn: 1.598 ± 0.042	2.428GlnPro: 2.428 ± 0.056	5.51GlnGln: 5.51 ± 0.155	3.703GlnArg: 3.703 ± 0.071	2.829GlnSer: 2.829 ± 0.064	2.256GlnThr: 2.256 ± 0.051	3.973GlnVal: 3.973 ± 0.085	0.821GlnTrp: 0.821 ± 0.032	1.123GlnTyr: 1.123 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	4.55ArgAla: 4.55 ± 0.077	0.407ArgCys: 0.407 ± 0.023	3.26ArgAsp: 3.26 ± 0.074	3.888ArgGlu: 3.888 ± 0.073	2.371ArgPhe: 2.371 ± 0.063	3.358ArgGly: 3.358 ± 0.066	1.321ArgHis: 1.321 ± 0.045	3.25ArgIle: 3.25 ± 0.069	2.352ArgLys: 2.352 ± 0.056	5.995ArgLeu: 5.995 ± 0.095	1.391ArgMet: 1.391 ± 0.042	2.052ArgAsn: 2.052 ± 0.05	2.009ArgPro: 2.009 ± 0.054	3.117ArgGln: 3.117 ± 0.067	3.231ArgArg: 3.231 ± 0.079	3.147ArgSer: 3.147 ± 0.06	2.402ArgThr: 2.402 ± 0.066	3.934ArgVal: 3.934 ± 0.073	0.933ArgTrp: 0.933 ± 0.036	1.944ArgTyr: 1.944 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.006SerAla: 6.006 ± 0.098	0.549SerCys: 0.549 ± 0.027	3.61SerAsp: 3.61 ± 0.079	3.746SerGlu: 3.746 ± 0.079	2.51SerPhe: 2.51 ± 0.058	5.007SerGly: 5.007 ± 0.099	1.28SerHis: 1.28 ± 0.043	3.172SerIle: 3.172 ± 0.071	2.462SerLys: 2.462 ± 0.072	6.181SerLeu: 6.181 ± 0.103	1.584SerMet: 1.584 ± 0.049	2.251SerAsn: 2.251 ± 0.059	2.236SerPro: 2.236 ± 0.055	2.629SerGln: 2.629 ± 0.066	3.163SerArg: 3.163 ± 0.067	3.91SerSer: 3.91 ± 0.093	3.01SerThr: 3.01 ± 0.075	4.428SerVal: 4.428 ± 0.083	0.915SerTrp: 0.915 ± 0.032	1.922SerTyr: 1.922 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	5.396ThrAla: 5.396 ± 0.093	0.42ThrCys: 0.42 ± 0.027	3.454ThrAsp: 3.454 ± 0.074	3.563ThrGlu: 3.563 ± 0.07	1.906ThrPhe: 1.906 ± 0.051	4.157ThrGly: 4.157 ± 0.07	1.041ThrHis: 1.041 ± 0.037	3.013ThrIle: 3.013 ± 0.062	2.031ThrLys: 2.031 ± 0.051	5.837ThrLeu: 5.837 ± 0.101	1.159ThrMet: 1.159 ± 0.035	1.96ThrAsn: 1.96 ± 0.06	2.581ThrPro: 2.581 ± 0.061	2.204ThrGln: 2.204 ± 0.056	2.687ThrArg: 2.687 ± 0.059	3.233ThrSer: 3.233 ± 0.077	3.039ThrThr: 3.039 ± 0.069	3.79ThrVal: 3.79 ± 0.078	0.544ThrTrp: 0.544 ± 0.027	1.389ThrTyr: 1.389 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	7.628ValAla: 7.628 ± 0.118	0.625ValCys: 0.625 ± 0.031	4.071ValAsp: 4.071 ± 0.077	4.325ValGlu: 4.325 ± 0.097	2.752ValPhe: 2.752 ± 0.069	4.74ValGly: 4.74 ± 0.074	1.338ValHis: 1.338 ± 0.04	4.495ValIle: 4.495 ± 0.078	3.058ValLys: 3.058 ± 0.074	7.286ValLeu: 7.286 ± 0.111	1.914ValMet: 1.914 ± 0.055	2.82ValAsn: 2.82 ± 0.063	2.967ValPro: 2.967 ± 0.065	2.796ValGln: 2.796 ± 0.059	3.728ValArg: 3.728 ± 0.074	4.668ValSer: 4.668 ± 0.093	4.531ValThr: 4.531 ± 0.087	5.742ValVal: 5.742 ± 0.091	0.825ValTrp: 0.825 ± 0.035	1.782ValTyr: 1.782 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.808TrpAla: 0.808 ± 0.035	0.132TrpCys: 0.132 ± 0.012	0.563TrpAsp: 0.563 ± 0.028	0.585TrpGlu: 0.585 ± 0.03	0.658TrpPhe: 0.658 ± 0.034	0.736TrpGly: 0.736 ± 0.032	0.405TrpHis: 0.405 ± 0.024	0.553TrpIle: 0.553 ± 0.028	0.317TrpLys: 0.317 ± 0.021	2.171TrpLeu: 2.171 ± 0.065	0.314TrpMet: 0.314 ± 0.02	0.394TrpAsn: 0.394 ± 0.022	0.565TrpPro: 0.565 ± 0.029	1.333TrpGln: 1.333 ± 0.048	0.978TrpArg: 0.978 ± 0.041	0.714TrpSer: 0.714 ± 0.035	0.412TrpThr: 0.412 ± 0.025	0.864TrpVal: 0.864 ± 0.034	0.279TrpTrp: 0.279 ± 0.02	0.382TrpTyr: 0.382 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.44TyrAla: 2.44 ± 0.06	0.337TyrCys: 0.337 ± 0.02	1.635TyrAsp: 1.635 ± 0.048	1.716TyrGlu: 1.716 ± 0.046	1.267TyrPhe: 1.267 ± 0.049	2.057TyrGly: 2.057 ± 0.055	0.72TyrHis: 0.72 ± 0.032	1.365TyrIle: 1.365 ± 0.045	1.054TyrLys: 1.054 ± 0.04	3.141TyrLeu: 3.141 ± 0.065	0.597TyrMet: 0.597 ± 0.031	0.99TyrAsn: 0.99 ± 0.037	1.318TyrPro: 1.318 ± 0.04	1.86TyrGln: 1.86 ± 0.049	1.828TyrArg: 1.828 ± 0.052	1.767TyrSer: 1.767 ± 0.058	1.425TyrThr: 1.425 ± 0.05	1.812TyrVal: 1.812 ± 0.043	0.449TyrTrp: 0.449 ± 0.025	0.895TyrTyr: 0.895 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2385 proteins (795332 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---