Amino acid dipepetide frequency for Lactobacillus ghanensis DSM 18630

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.9AlaAla: 9.9 ± 0.178	0.551AlaCys: 0.551 ± 0.024	4.981AlaAsp: 4.981 ± 0.082	4.726AlaGlu: 4.726 ± 0.095	3.109AlaPhe: 3.109 ± 0.072	6.234AlaGly: 6.234 ± 0.107	1.33AlaHis: 1.33 ± 0.046	5.938AlaIle: 5.938 ± 0.102	5.913AlaLys: 5.913 ± 0.104	7.551AlaLeu: 7.551 ± 0.118	1.831AlaMet: 1.831 ± 0.054	3.525AlaAsn: 3.525 ± 0.079	2.19AlaPro: 2.19 ± 0.055	3.893AlaGln: 3.893 ± 0.099	2.538AlaArg: 2.538 ± 0.064	4.243AlaSer: 4.243 ± 0.091	4.858AlaThr: 4.858 ± 0.095	6.127AlaVal: 6.127 ± 0.095	0.782AlaTrp: 0.782 ± 0.034	2.427AlaTyr: 2.427 ± 0.061	0.003AlaXaa: 0.003 ± 0.002
Cys	0.413CysAla: 0.413 ± 0.022	0.079CysCys: 0.079 ± 0.012	0.305CysAsp: 0.305 ± 0.023	0.3CysGlu: 0.3 ± 0.019	0.325CysPhe: 0.325 ± 0.021	0.584CysGly: 0.584 ± 0.025	0.191CysHis: 0.191 ± 0.016	0.345CysIle: 0.345 ± 0.025	0.213CysLys: 0.213 ± 0.016	0.841CysLeu: 0.841 ± 0.037	0.147CysMet: 0.147 ± 0.015	0.222CysAsn: 0.222 ± 0.018	0.258CysPro: 0.258 ± 0.018	0.421CysGln: 0.421 ± 0.022	0.29CysArg: 0.29 ± 0.018	0.459CysSer: 0.459 ± 0.024	0.281CysThr: 0.281 ± 0.019	0.365CysVal: 0.365 ± 0.022	0.12CysTrp: 0.12 ± 0.013	0.292CysTyr: 0.292 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.026AspAla: 3.026 ± 0.072	0.338AspCys: 0.338 ± 0.023	2.415AspAsp: 2.415 ± 0.068	3.071AspGlu: 3.071 ± 0.07	2.753AspPhe: 2.753 ± 0.056	2.947AspGly: 2.947 ± 0.079	1.162AspHis: 1.162 ± 0.046	2.999AspIle: 2.999 ± 0.066	2.821AspLys: 2.821 ± 0.073	5.607AspLeu: 5.607 ± 0.107	1.107AspMet: 1.107 ± 0.043	2.182AspAsn: 2.182 ± 0.059	2.101AspPro: 2.101 ± 0.05	3.359AspGln: 3.359 ± 0.07	1.979AspArg: 1.979 ± 0.048	2.729AspSer: 2.729 ± 0.072	2.212AspThr: 2.212 ± 0.062	3.177AspVal: 3.177 ± 0.07	0.604AspTrp: 0.604 ± 0.028	2.241AspTyr: 2.241 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	3.458GluAla: 3.458 ± 0.07	0.238GluCys: 0.238 ± 0.019	2.047GluAsp: 2.047 ± 0.053	2.591GluGlu: 2.591 ± 0.06	2.209GluPhe: 2.209 ± 0.052	2.131GluGly: 2.131 ± 0.069	1.056GluHis: 1.056 ± 0.04	4.403GluIle: 4.403 ± 0.087	4.946GluLys: 4.946 ± 0.09	6.211GluLeu: 6.211 ± 0.11	1.54GluMet: 1.54 ± 0.046	3.046GluAsn: 3.046 ± 0.064	1.538GluPro: 1.538 ± 0.045	3.054GluGln: 3.054 ± 0.064	2.269GluArg: 2.269 ± 0.059	2.283GluSer: 2.283 ± 0.059	2.783GluThr: 2.783 ± 0.068	3.162GluVal: 3.162 ± 0.074	0.437GluTrp: 0.437 ± 0.025	1.647GluTyr: 1.647 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.648PheAla: 3.648 ± 0.074	0.37PheCys: 0.37 ± 0.025	2.487PheAsp: 2.487 ± 0.061	2.267PheGlu: 2.267 ± 0.052	2.233PhePhe: 2.233 ± 0.072	3.196PheGly: 3.196 ± 0.079	0.834PheHis: 0.834 ± 0.033	3.153PheIle: 3.153 ± 0.071	3.014PheLys: 3.014 ± 0.071	4.501PheLeu: 4.501 ± 0.102	1.06PheMet: 1.06 ± 0.042	2.307PheAsn: 2.307 ± 0.055	1.556PhePro: 1.556 ± 0.048	1.667PheGln: 1.667 ± 0.045	1.393PheArg: 1.393 ± 0.046	3.45PheSer: 3.45 ± 0.07	2.327PheThr: 2.327 ± 0.055	2.837PheVal: 2.837 ± 0.075	0.614PheTrp: 0.614 ± 0.033	1.738PheTyr: 1.738 ± 0.049	0.001PheXaa: 0.001 ± 0.001
Gly	4.56GlyAla: 4.56 ± 0.087	0.538GlyCys: 0.538 ± 0.028	2.769GlyAsp: 2.769 ± 0.066	2.973GlyGlu: 2.973 ± 0.066	3.196GlyPhe: 3.196 ± 0.071	4.318GlyGly: 4.318 ± 0.088	1.326GlyHis: 1.326 ± 0.038	5.676GlyIle: 5.676 ± 0.105	5.057GlyLys: 5.057 ± 0.078	6.448GlyLeu: 6.448 ± 0.112	1.784GlyMet: 1.784 ± 0.055	2.847GlyAsn: 2.847 ± 0.064	1.543GlyPro: 1.543 ± 0.049	3.045GlyGln: 3.045 ± 0.073	2.415GlyArg: 2.415 ± 0.065	4.09GlySer: 4.09 ± 0.075	3.969GlyThr: 3.969 ± 0.089	4.478GlyVal: 4.478 ± 0.082	0.826GlyTrp: 0.826 ± 0.034	2.637GlyTyr: 2.637 ± 0.056	0.003GlyXaa: 0.003 ± 0.002
His	1.282HisAla: 1.282 ± 0.041	0.167HisCys: 0.167 ± 0.015	1.066HisAsp: 1.066 ± 0.034	1.035HisGlu: 1.035 ± 0.038	1.126HisPhe: 1.126 ± 0.042	1.479HisGly: 1.479 ± 0.044	0.662HisHis: 0.662 ± 0.033	1.098HisIle: 1.098 ± 0.04	0.905HisLys: 0.905 ± 0.041	2.267HisLeu: 2.267 ± 0.052	0.342HisMet: 0.342 ± 0.023	0.844HisAsn: 0.844 ± 0.036	1.016HisPro: 1.016 ± 0.038	1.421HisGln: 1.421 ± 0.049	0.877HisArg: 0.877 ± 0.036	1.117HisSer: 1.117 ± 0.044	0.895HisThr: 0.895 ± 0.037	1.146HisVal: 1.146 ± 0.04	0.312HisTrp: 0.312 ± 0.026	0.953HisTyr: 0.953 ± 0.036	0.0HisXaa: 0.0 ± 0.0
Ile	6.443IleAla: 6.443 ± 0.096	0.673IleCys: 0.673 ± 0.033	3.971IleAsp: 3.971 ± 0.077	3.657IleGlu: 3.657 ± 0.074	3.391IlePhe: 3.391 ± 0.095	5.377IleGly: 5.377 ± 0.119	1.169IleHis: 1.169 ± 0.041	5.849IleIle: 5.849 ± 0.123	5.303IleLys: 5.303 ± 0.087	7.1IleLeu: 7.1 ± 0.116	1.643IleMet: 1.643 ± 0.048	3.889IleAsn: 3.889 ± 0.078	2.821IlePro: 2.821 ± 0.065	2.565IleGln: 2.565 ± 0.064	2.61IleArg: 2.61 ± 0.061	5.077IleSer: 5.077 ± 0.089	4.28IleThr: 4.28 ± 0.088	5.045IleVal: 5.045 ± 0.102	0.658IleTrp: 0.658 ± 0.026	2.49IleTyr: 2.49 ± 0.062	0.0IleXaa: 0.0 ± 0.0
Lys	4.653LysAla: 4.653 ± 0.085	0.261LysCys: 0.261 ± 0.018	3.112LysAsp: 3.112 ± 0.081	3.958LysGlu: 3.958 ± 0.092	2.567LysPhe: 2.567 ± 0.067	3.047LysGly: 3.047 ± 0.071	1.27LysHis: 1.27 ± 0.045	6.045LysIle: 6.045 ± 0.08	6.254LysLys: 6.254 ± 0.135	7.379LysLeu: 7.379 ± 0.118	2.347LysMet: 2.347 ± 0.055	4.133LysAsn: 4.133 ± 0.092	2.047LysPro: 2.047 ± 0.059	4.421LysGln: 4.421 ± 0.093	3.039LysArg: 3.039 ± 0.067	3.596LysSer: 3.596 ± 0.069	4.338LysThr: 4.338 ± 0.09	4.403LysVal: 4.403 ± 0.076	0.702LysTrp: 0.702 ± 0.028	2.775LysTyr: 2.775 ± 0.058	0.0LysXaa: 0.0 ± 0.0
Leu	9.797LeuAla: 9.797 ± 0.131	0.635LeuCys: 0.635 ± 0.034	4.933LeuAsp: 4.933 ± 0.089	4.89LeuGlu: 4.89 ± 0.089	4.544LeuPhe: 4.544 ± 0.099	6.75LeuGly: 6.75 ± 0.113	1.865LeuHis: 1.865 ± 0.045	7.962LeuIle: 7.962 ± 0.14	7.701LeuLys: 7.701 ± 0.101	11.639LeuLeu: 11.639 ± 0.191	2.368LeuMet: 2.368 ± 0.064	5.337LeuAsn: 5.337 ± 0.087	4.565LeuPro: 4.565 ± 0.092	5.164LeuGln: 5.164 ± 0.125	3.95LeuArg: 3.95 ± 0.089	6.491LeuSer: 6.491 ± 0.098	7.253LeuThr: 7.253 ± 0.108	6.705LeuVal: 6.705 ± 0.114	0.854LeuTrp: 0.854 ± 0.032	2.769LeuTyr: 2.769 ± 0.067	0.001LeuXaa: 0.001 ± 0.001
Met	1.86MetAla: 1.86 ± 0.051	0.108MetCys: 0.108 ± 0.013	1.04MetAsp: 1.04 ± 0.043	1.038MetGlu: 1.038 ± 0.034	0.853MetPhe: 0.853 ± 0.032	1.591MetGly: 1.591 ± 0.051	0.407MetHis: 0.407 ± 0.028	1.948MetIle: 1.948 ± 0.056	1.932MetLys: 1.932 ± 0.047	2.299MetLeu: 2.299 ± 0.064	0.616MetMet: 0.616 ± 0.031	1.25MetAsn: 1.25 ± 0.04	0.919MetPro: 0.919 ± 0.039	1.183MetGln: 1.183 ± 0.049	0.82MetArg: 0.82 ± 0.03	1.416MetSer: 1.416 ± 0.045	1.579MetThr: 1.579 ± 0.049	1.625MetVal: 1.625 ± 0.053	0.152MetTrp: 0.152 ± 0.015	0.626MetTyr: 0.626 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	2.979AsnAla: 2.979 ± 0.073	0.345AsnCys: 0.345 ± 0.024	2.55AsnAsp: 2.55 ± 0.068	2.609AsnGlu: 2.609 ± 0.061	2.399AsnPhe: 2.399 ± 0.055	3.521AsnGly: 3.521 ± 0.096	1.162AsnHis: 1.162 ± 0.042	3.084AsnIle: 3.084 ± 0.066	3.085AsnLys: 3.085 ± 0.075	5.116AsnLeu: 5.116 ± 0.077	1.02AsnMet: 1.02 ± 0.037	2.684AsnAsn: 2.684 ± 0.081	1.954AsnPro: 1.954 ± 0.051	3.297AsnGln: 3.297 ± 0.077	1.813AsnArg: 1.813 ± 0.057	3.106AsnSer: 3.106 ± 0.076	2.237AsnThr: 2.237 ± 0.066	2.829AsnVal: 2.829 ± 0.067	0.757AsnTrp: 0.757 ± 0.032	2.245AsnTyr: 2.245 ± 0.064	0.0AsnXaa: 0.0 ± 0.0
Pro	3.408ProAla: 3.408 ± 0.066	0.182ProCys: 0.182 ± 0.015	1.951ProAsp: 1.951 ± 0.058	2.356ProGlu: 2.356 ± 0.062	1.709ProPhe: 1.709 ± 0.049	2.037ProGly: 2.037 ± 0.054	0.727ProHis: 0.727 ± 0.032	2.487ProIle: 2.487 ± 0.06	2.098ProLys: 2.098 ± 0.054	3.779ProLeu: 3.779 ± 0.079	0.61ProMet: 0.61 ± 0.027	1.657ProAsn: 1.657 ± 0.049	0.678ProPro: 0.678 ± 0.03	2.043ProGln: 2.043 ± 0.06	1.178ProArg: 1.178 ± 0.041	1.738ProSer: 1.738 ± 0.051	2.43ProThr: 2.43 ± 0.059	2.629ProVal: 2.629 ± 0.058	0.362ProTrp: 0.362 ± 0.025	1.258ProTyr: 1.258 ± 0.042	0.001ProXaa: 0.001 ± 0.001
Gln	5.128GlnAla: 5.128 ± 0.101	0.171GlnCys: 0.171 ± 0.013	1.876GlnAsp: 1.876 ± 0.045	2.459GlnGlu: 2.459 ± 0.061	1.679GlnPhe: 1.679 ± 0.049	2.589GlnGly: 2.589 ± 0.056	1.335GlnHis: 1.335 ± 0.048	3.765GlnIle: 3.765 ± 0.081	3.957GlnLys: 3.957 ± 0.082	6.826GlnLeu: 6.826 ± 0.165	1.213GlnMet: 1.213 ± 0.046	2.315GlnAsn: 2.315 ± 0.061	1.994GlnPro: 1.994 ± 0.054	5.458GlnGln: 5.458 ± 0.181	2.628GlnArg: 2.628 ± 0.066	2.557GlnSer: 2.557 ± 0.057	3.363GlnThr: 3.363 ± 0.082	3.863GlnVal: 3.863 ± 0.075	0.423GlnTrp: 0.423 ± 0.021	1.504GlnTyr: 1.504 ± 0.052	0.0GlnXaa: 0.0 ± 0.0
Arg	2.434ArgAla: 2.434 ± 0.061	0.237ArgCys: 0.237 ± 0.02	1.701ArgAsp: 1.701 ± 0.048	2.019ArgGlu: 2.019 ± 0.063	1.74ArgPhe: 1.74 ± 0.051	2.105ArgGly: 2.105 ± 0.056	0.935ArgHis: 0.935 ± 0.036	2.936ArgIle: 2.936 ± 0.073	2.771ArgLys: 2.771 ± 0.062	4.183ArgLeu: 4.183 ± 0.085	0.923ArgMet: 0.923 ± 0.035	1.754ArgAsn: 1.754 ± 0.05	1.482ArgPro: 1.482 ± 0.046	2.797ArgGln: 2.797 ± 0.068	1.978ArgArg: 1.978 ± 0.056	2.172ArgSer: 2.172 ± 0.061	1.922ArgThr: 1.922 ± 0.053	2.311ArgVal: 2.311 ± 0.057	0.389ArgTrp: 0.389 ± 0.022	1.458ArgTyr: 1.458 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	4.679SerAla: 4.679 ± 0.094	0.364SerCys: 0.364 ± 0.025	2.891SerAsp: 2.891 ± 0.069	2.962SerGlu: 2.962 ± 0.073	3.033SerPhe: 3.033 ± 0.066	4.461SerGly: 4.461 ± 0.088	1.187SerHis: 1.187 ± 0.038	3.957SerIle: 3.957 ± 0.082	3.764SerLys: 3.764 ± 0.08	6.588SerLeu: 6.588 ± 0.101	1.238SerMet: 1.238 ± 0.036	2.808SerAsn: 2.808 ± 0.072	1.883SerPro: 1.883 ± 0.061	3.07SerGln: 3.07 ± 0.071	2.297SerArg: 2.297 ± 0.056	4.585SerSer: 4.585 ± 0.189	3.404SerThr: 3.404 ± 0.12	3.784SerVal: 3.784 ± 0.072	0.772SerTrp: 0.772 ± 0.036	2.161SerTyr: 2.161 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	6.033ThrAla: 6.033 ± 0.107	0.302ThrCys: 0.302 ± 0.022	3.185ThrAsp: 3.185 ± 0.072	2.974ThrGlu: 2.974 ± 0.064	2.49ThrPhe: 2.49 ± 0.061	4.513ThrGly: 4.513 ± 0.096	0.981ThrHis: 0.981 ± 0.039	4.243ThrIle: 4.243 ± 0.083	3.83ThrLys: 3.83 ± 0.077	5.365ThrLeu: 5.365 ± 0.089	1.198ThrMet: 1.198 ± 0.041	2.828ThrAsn: 2.828 ± 0.067	2.402ThrPro: 2.402 ± 0.058	2.197ThrGln: 2.197 ± 0.06	1.71ThrArg: 1.71 ± 0.048	3.634ThrSer: 3.634 ± 0.088	4.024ThrThr: 4.024 ± 0.111	4.362ThrVal: 4.362 ± 0.104	0.556ThrTrp: 0.556 ± 0.031	1.765ThrTyr: 1.765 ± 0.051	0.003ThrXaa: 0.003 ± 0.002
Val	6.084ValAla: 6.084 ± 0.099	0.535ValCys: 0.535 ± 0.028	3.323ValAsp: 3.323 ± 0.071	3.283ValGlu: 3.283 ± 0.071	2.928ValPhe: 2.928 ± 0.068	4.482ValGly: 4.482 ± 0.08	1.087ValHis: 1.087 ± 0.037	5.501ValIle: 5.501 ± 0.096	4.784ValLys: 4.784 ± 0.093	6.492ValLeu: 6.492 ± 0.104	1.437ValMet: 1.437 ± 0.045	3.12ValAsn: 3.12 ± 0.069	2.577ValPro: 2.577 ± 0.065	2.315ValGln: 2.315 ± 0.06	2.197ValArg: 2.197 ± 0.052	4.393ValSer: 4.393 ± 0.081	4.136ValThr: 4.136 ± 0.073	4.715ValVal: 4.715 ± 0.08	0.586ValTrp: 0.586 ± 0.03	2.214ValTyr: 2.214 ± 0.069	0.0ValXaa: 0.0 ± 0.0
Trp	0.566TrpAla: 0.566 ± 0.033	0.08TrpCys: 0.08 ± 0.012	0.449TrpAsp: 0.449 ± 0.022	0.44TrpGlu: 0.44 ± 0.025	0.46TrpPhe: 0.46 ± 0.027	0.697TrpGly: 0.697 ± 0.031	0.283TrpHis: 0.283 ± 0.02	0.695TrpIle: 0.695 ± 0.034	0.578TrpLys: 0.578 ± 0.031	1.532TrpLeu: 1.532 ± 0.055	0.269TrpMet: 0.269 ± 0.019	0.508TrpAsn: 0.508 ± 0.026	0.317TrpPro: 0.317 ± 0.022	0.86TrpGln: 0.86 ± 0.041	0.459TrpArg: 0.459 ± 0.024	0.665TrpSer: 0.665 ± 0.031	0.524TrpThr: 0.524 ± 0.026	0.57TrpVal: 0.57 ± 0.025	0.138TrpTrp: 0.138 ± 0.014	0.417TrpTyr: 0.417 ± 0.031	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.296TyrAla: 2.296 ± 0.054	0.277TyrCys: 0.277 ± 0.021	1.78TyrAsp: 1.78 ± 0.051	1.447TyrGlu: 1.447 ± 0.043	1.909TyrPhe: 1.909 ± 0.052	2.438TyrGly: 2.438 ± 0.062	1.038TyrHis: 1.038 ± 0.038	1.926TyrIle: 1.926 ± 0.06	1.42TyrLys: 1.42 ± 0.047	4.449TyrLeu: 4.449 ± 0.094	0.567TyrMet: 0.567 ± 0.028	1.536TyrAsn: 1.536 ± 0.053	1.479TyrPro: 1.479 ± 0.047	2.871TyrGln: 2.871 ± 0.067	1.803TyrArg: 1.803 ± 0.057	2.089TyrSer: 2.089 ± 0.064	1.781TyrThr: 1.781 ± 0.057	2.054TyrVal: 2.054 ± 0.049	0.46TyrTrp: 0.46 ± 0.027	1.585TyrTyr: 1.585 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.21XaaXaa: 0.21 ± 0.095

Statistics based on 2384 proteins (747846 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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