Amino acid dipepetide frequency for Streptococcus phage Javan502

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.634AlaAla: 4.634 ± 0.921
0.189AlaCys: 0.189 ± 0.125
4.256AlaAsp: 4.256 ± 0.875
6.337AlaGlu: 6.337 ± 0.71
2.27AlaPhe: 2.27 ± 0.551
4.067AlaGly: 4.067 ± 0.885
1.419AlaHis: 1.419 ± 0.438
7.472AlaIle: 7.472 ± 1.114
8.512AlaLys: 8.512 ± 1.156
5.297AlaLeu: 5.297 ± 0.726
1.797AlaMet: 1.797 ± 0.472
4.351AlaAsn: 4.351 ± 0.685
0.946AlaPro: 0.946 ± 0.233
3.121AlaGln: 3.121 ± 0.496
2.554AlaArg: 2.554 ± 0.45
4.445AlaSer: 4.445 ± 0.743
4.351AlaThr: 4.351 ± 0.6
4.918AlaVal: 4.918 ± 0.596
1.23AlaTrp: 1.23 ± 0.261
1.892AlaTyr: 1.892 ± 0.347
0.0AlaXaa: 0.0 ± 0.0
Cys
0.189CysAla: 0.189 ± 0.14
0.189CysCys: 0.189 ± 0.141
0.378CysAsp: 0.378 ± 0.193
0.567CysGlu: 0.567 ± 0.269
0.284CysPhe: 0.284 ± 0.151
0.757CysGly: 0.757 ± 0.267
0.095CysHis: 0.095 ± 0.093
0.189CysIle: 0.189 ± 0.161
0.567CysLys: 0.567 ± 0.248
0.757CysLeu: 0.757 ± 0.277
0.189CysMet: 0.189 ± 0.128
0.284CysAsn: 0.284 ± 0.159
0.0CysPro: 0.0 ± 0.0
0.095CysGln: 0.095 ± 0.079
0.662CysArg: 0.662 ± 0.228
0.473CysSer: 0.473 ± 0.225
0.095CysThr: 0.095 ± 0.087
0.473CysVal: 0.473 ± 0.243
0.095CysTrp: 0.095 ± 0.091
0.378CysTyr: 0.378 ± 0.224
0.0CysXaa: 0.0 ± 0.0
Asp
4.351AspAla: 4.351 ± 0.666
0.851AspCys: 0.851 ± 0.295
4.824AspAsp: 4.824 ± 0.79
4.824AspGlu: 4.824 ± 0.769
2.459AspPhe: 2.459 ± 0.444
4.729AspGly: 4.729 ± 0.705
0.284AspHis: 0.284 ± 0.15
5.297AspIle: 5.297 ± 0.587
5.297AspLys: 5.297 ± 0.732
6.526AspLeu: 6.526 ± 0.763
1.23AspMet: 1.23 ± 0.307
4.256AspAsn: 4.256 ± 0.616
1.986AspPro: 1.986 ± 0.519
1.513AspGln: 1.513 ± 0.353
1.513AspArg: 1.513 ± 0.356
3.499AspSer: 3.499 ± 0.605
3.878AspThr: 3.878 ± 0.851
4.351AspVal: 4.351 ± 0.553
1.23AspTrp: 1.23 ± 0.356
2.932AspTyr: 2.932 ± 0.592
0.0AspXaa: 0.0 ± 0.0
Glu
5.107GluAla: 5.107 ± 0.657
0.378GluCys: 0.378 ± 0.203
3.783GluAsp: 3.783 ± 0.646
5.107GluGlu: 5.107 ± 0.972
3.216GluPhe: 3.216 ± 0.591
4.067GluGly: 4.067 ± 0.608
1.324GluHis: 1.324 ± 0.317
5.297GluIle: 5.297 ± 0.769
5.959GluLys: 5.959 ± 0.752
7.472GluLeu: 7.472 ± 1.056
1.797GluMet: 1.797 ± 0.354
3.31GluAsn: 3.31 ± 0.659
2.175GluPro: 2.175 ± 0.549
3.972GluGln: 3.972 ± 0.776
2.365GluArg: 2.365 ± 0.575
3.878GluSer: 3.878 ± 0.615
3.972GluThr: 3.972 ± 0.648
4.067GluVal: 4.067 ± 0.701
0.851GluTrp: 0.851 ± 0.293
2.27GluTyr: 2.27 ± 0.557
0.0GluXaa: 0.0 ± 0.0
Phe
3.027PheAla: 3.027 ± 0.642
0.284PheCys: 0.284 ± 0.165
3.689PheAsp: 3.689 ± 0.49
3.499PheGlu: 3.499 ± 0.675
1.702PhePhe: 1.702 ± 0.376
2.743PheGly: 2.743 ± 0.38
0.567PheHis: 0.567 ± 0.304
2.175PheIle: 2.175 ± 0.373
3.216PheLys: 3.216 ± 0.536
2.365PheLeu: 2.365 ± 0.517
1.04PheMet: 1.04 ± 0.376
2.459PheAsn: 2.459 ± 0.46
1.04PhePro: 1.04 ± 0.398
0.946PheGln: 0.946 ± 0.295
1.702PheArg: 1.702 ± 0.368
2.175PheSer: 2.175 ± 0.408
2.081PheThr: 2.081 ± 0.537
2.743PheVal: 2.743 ± 0.501
0.473PheTrp: 0.473 ± 0.223
1.513PheTyr: 1.513 ± 0.414
0.0PheXaa: 0.0 ± 0.0
Gly
4.918GlyAla: 4.918 ± 0.963
0.284GlyCys: 0.284 ± 0.172
4.54GlyAsp: 4.54 ± 0.631
4.445GlyGlu: 4.445 ± 0.711
3.31GlyPhe: 3.31 ± 0.753
4.54GlyGly: 4.54 ± 0.869
0.946GlyHis: 0.946 ± 0.258
5.959GlyIle: 5.959 ± 0.847
5.675GlyLys: 5.675 ± 0.732
5.959GlyLeu: 5.959 ± 0.76
1.513GlyMet: 1.513 ± 0.522
3.405GlyAsn: 3.405 ± 0.564
1.513GlyPro: 1.513 ± 0.547
2.459GlyGln: 2.459 ± 0.528
2.365GlyArg: 2.365 ± 0.438
2.932GlySer: 2.932 ± 0.478
3.499GlyThr: 3.499 ± 0.619
3.121GlyVal: 3.121 ± 0.622
0.662GlyTrp: 0.662 ± 0.254
3.499GlyTyr: 3.499 ± 0.568
0.0GlyXaa: 0.0 ± 0.0
His
1.04HisAla: 1.04 ± 0.383
0.284HisCys: 0.284 ± 0.13
1.23HisAsp: 1.23 ± 0.383
1.702HisGlu: 1.702 ± 0.354
0.662HisPhe: 0.662 ± 0.188
0.851HisGly: 0.851 ± 0.301
0.378HisHis: 0.378 ± 0.211
0.851HisIle: 0.851 ± 0.302
0.662HisLys: 0.662 ± 0.228
1.324HisLeu: 1.324 ± 0.398
0.284HisMet: 0.284 ± 0.149
0.662HisAsn: 0.662 ± 0.257
0.662HisPro: 0.662 ± 0.306
0.662HisGln: 0.662 ± 0.27
0.757HisArg: 0.757 ± 0.264
0.851HisSer: 0.851 ± 0.28
0.567HisThr: 0.567 ± 0.243
0.662HisVal: 0.662 ± 0.241
0.095HisTrp: 0.095 ± 0.093
0.473HisTyr: 0.473 ± 0.225
0.0HisXaa: 0.0 ± 0.0
Ile
4.634IleAla: 4.634 ± 0.611
0.378IleCys: 0.378 ± 0.231
6.526IleAsp: 6.526 ± 0.977
5.769IleGlu: 5.769 ± 0.966
3.027IlePhe: 3.027 ± 0.589
3.972IleGly: 3.972 ± 0.968
1.04IleHis: 1.04 ± 0.349
3.594IleIle: 3.594 ± 0.539
7.566IleLys: 7.566 ± 0.831
5.391IleLeu: 5.391 ± 0.599
1.986IleMet: 1.986 ± 0.572
3.594IleAsn: 3.594 ± 0.724
2.365IlePro: 2.365 ± 0.464
2.554IleGln: 2.554 ± 0.539
2.743IleArg: 2.743 ± 0.581
4.729IleSer: 4.729 ± 0.97
4.729IleThr: 4.729 ± 0.715
4.351IleVal: 4.351 ± 0.682
0.473IleTrp: 0.473 ± 0.225
1.892IleTyr: 1.892 ± 0.517
0.0IleXaa: 0.0 ± 0.0
Lys
6.715LysAla: 6.715 ± 0.811
0.284LysCys: 0.284 ± 0.163
6.242LysAsp: 6.242 ± 0.97
5.202LysGlu: 5.202 ± 0.746
2.743LysPhe: 2.743 ± 0.446
5.107LysGly: 5.107 ± 0.777
1.702LysHis: 1.702 ± 0.401
5.959LysIle: 5.959 ± 1.033
9.742LysLys: 9.742 ± 1.34
6.337LysLeu: 6.337 ± 0.84
2.554LysMet: 2.554 ± 0.571
4.824LysAsn: 4.824 ± 0.701
3.499LysPro: 3.499 ± 0.577
4.54LysGln: 4.54 ± 0.784
4.067LysArg: 4.067 ± 0.668
6.431LysSer: 6.431 ± 0.838
6.621LysThr: 6.621 ± 0.779
7.377LysVal: 7.377 ± 0.96
0.946LysTrp: 0.946 ± 0.321
3.594LysTyr: 3.594 ± 0.53
0.0LysXaa: 0.0 ± 0.0
Leu
7.756LeuAla: 7.756 ± 0.738
0.378LeuCys: 0.378 ± 0.171
5.959LeuAsp: 5.959 ± 0.71
5.58LeuGlu: 5.58 ± 1.013
3.027LeuPhe: 3.027 ± 0.487
5.486LeuGly: 5.486 ± 0.96
1.23LeuHis: 1.23 ± 0.367
4.634LeuIle: 4.634 ± 0.686
8.796LeuLys: 8.796 ± 0.78
6.431LeuLeu: 6.431 ± 0.902
1.513LeuMet: 1.513 ± 0.376
4.162LeuAsn: 4.162 ± 0.479
2.459LeuPro: 2.459 ± 0.417
3.499LeuGln: 3.499 ± 0.629
3.31LeuArg: 3.31 ± 0.592
6.431LeuSer: 6.431 ± 0.985
4.162LeuThr: 4.162 ± 0.661
5.58LeuVal: 5.58 ± 0.795
0.662LeuTrp: 0.662 ± 0.26
1.892LeuTyr: 1.892 ± 0.449
0.0LeuXaa: 0.0 ± 0.0
Met
2.175MetAla: 2.175 ± 0.536
0.095MetCys: 0.095 ± 0.093
1.608MetAsp: 1.608 ± 0.446
1.702MetGlu: 1.702 ± 0.499
0.567MetPhe: 0.567 ± 0.236
1.702MetGly: 1.702 ± 0.436
0.378MetHis: 0.378 ± 0.184
1.892MetIle: 1.892 ± 0.467
1.608MetLys: 1.608 ± 0.446
1.419MetLeu: 1.419 ± 0.263
0.378MetMet: 0.378 ± 0.164
1.135MetAsn: 1.135 ± 0.351
0.851MetPro: 0.851 ± 0.312
1.04MetGln: 1.04 ± 0.3
0.473MetArg: 0.473 ± 0.187
1.513MetSer: 1.513 ± 0.334
1.702MetThr: 1.702 ± 0.354
1.892MetVal: 1.892 ± 0.444
0.284MetTrp: 0.284 ± 0.145
1.135MetTyr: 1.135 ± 0.287
0.0MetXaa: 0.0 ± 0.0
Asn
4.351AsnAla: 4.351 ± 0.733
0.567AsnCys: 0.567 ± 0.217
1.513AsnAsp: 1.513 ± 0.323
3.31AsnGlu: 3.31 ± 0.496
2.459AsnPhe: 2.459 ± 0.545
4.351AsnGly: 4.351 ± 0.765
0.757AsnHis: 0.757 ± 0.325
3.121AsnIle: 3.121 ± 0.494
5.391AsnLys: 5.391 ± 1.021
4.824AsnLeu: 4.824 ± 0.606
1.324AsnMet: 1.324 ± 0.351
1.892AsnAsn: 1.892 ± 0.394
1.797AsnPro: 1.797 ± 0.431
2.554AsnGln: 2.554 ± 0.479
1.797AsnArg: 1.797 ± 0.574
3.31AsnSer: 3.31 ± 0.608
2.365AsnThr: 2.365 ± 0.464
2.648AsnVal: 2.648 ± 0.464
0.567AsnTrp: 0.567 ± 0.194
2.932AsnTyr: 2.932 ± 0.572
0.0AsnXaa: 0.0 ± 0.0
Pro
2.459ProAla: 2.459 ± 0.647
0.189ProCys: 0.189 ± 0.127
2.743ProAsp: 2.743 ± 0.599
1.702ProGlu: 1.702 ± 0.437
1.23ProPhe: 1.23 ± 0.323
1.135ProGly: 1.135 ± 0.327
0.284ProHis: 0.284 ± 0.154
2.554ProIle: 2.554 ± 0.495
4.162ProLys: 4.162 ± 0.618
1.513ProLeu: 1.513 ± 0.332
0.662ProMet: 0.662 ± 0.193
1.419ProAsn: 1.419 ± 0.403
0.473ProPro: 0.473 ± 0.179
0.757ProGln: 0.757 ± 0.299
0.757ProArg: 0.757 ± 0.294
2.175ProSer: 2.175 ± 0.535
1.608ProThr: 1.608 ± 0.479
0.946ProVal: 0.946 ± 0.276
0.189ProTrp: 0.189 ± 0.123
1.23ProTyr: 1.23 ± 0.403
0.0ProXaa: 0.0 ± 0.0
Gln
3.027GlnAla: 3.027 ± 0.768
0.095GlnCys: 0.095 ± 0.09
1.892GlnAsp: 1.892 ± 0.367
2.554GlnGlu: 2.554 ± 0.763
1.608GlnPhe: 1.608 ± 0.495
2.459GlnGly: 2.459 ± 0.553
0.567GlnHis: 0.567 ± 0.216
2.554GlnIle: 2.554 ± 0.604
3.783GlnLys: 3.783 ± 0.823
3.499GlnLeu: 3.499 ± 0.612
0.662GlnMet: 0.662 ± 0.288
2.932GlnAsn: 2.932 ± 0.595
1.23GlnPro: 1.23 ± 0.388
1.04GlnGln: 1.04 ± 0.271
1.892GlnArg: 1.892 ± 0.504
2.932GlnSer: 2.932 ± 0.504
2.365GlnThr: 2.365 ± 0.621
2.27GlnVal: 2.27 ± 0.369
0.662GlnTrp: 0.662 ± 0.348
0.851GlnTyr: 0.851 ± 0.265
0.0GlnXaa: 0.0 ± 0.0
Arg
2.743ArgAla: 2.743 ± 0.579
0.473ArgCys: 0.473 ± 0.215
1.608ArgAsp: 1.608 ± 0.417
3.405ArgGlu: 3.405 ± 0.667
1.324ArgPhe: 1.324 ± 0.441
2.175ArgGly: 2.175 ± 0.432
0.473ArgHis: 0.473 ± 0.224
2.837ArgIle: 2.837 ± 0.488
3.31ArgLys: 3.31 ± 0.56
4.634ArgLeu: 4.634 ± 0.657
0.662ArgMet: 0.662 ± 0.286
1.986ArgAsn: 1.986 ± 0.403
1.04ArgPro: 1.04 ± 0.312
1.135ArgGln: 1.135 ± 0.349
1.135ArgArg: 1.135 ± 0.412
1.608ArgSer: 1.608 ± 0.426
1.986ArgThr: 1.986 ± 0.445
2.365ArgVal: 2.365 ± 0.429
0.473ArgTrp: 0.473 ± 0.202
1.892ArgTyr: 1.892 ± 0.455
0.0ArgXaa: 0.0 ± 0.0
Ser
5.107SerAla: 5.107 ± 1.479
0.567SerCys: 0.567 ± 0.242
4.162SerAsp: 4.162 ± 0.702
3.499SerGlu: 3.499 ± 0.522
3.216SerPhe: 3.216 ± 0.577
5.486SerGly: 5.486 ± 0.944
0.757SerHis: 0.757 ± 0.291
4.729SerIle: 4.729 ± 0.523
5.202SerLys: 5.202 ± 0.878
5.864SerLeu: 5.864 ± 0.951
1.797SerMet: 1.797 ± 0.361
3.31SerAsn: 3.31 ± 0.578
1.324SerPro: 1.324 ± 0.343
2.365SerGln: 2.365 ± 0.557
2.081SerArg: 2.081 ± 0.776
5.107SerSer: 5.107 ± 0.898
3.121SerThr: 3.121 ± 0.555
3.783SerVal: 3.783 ± 0.562
0.567SerTrp: 0.567 ± 0.228
2.554SerTyr: 2.554 ± 0.565
0.0SerXaa: 0.0 ± 0.0
Thr
4.634ThrAla: 4.634 ± 0.63
0.284ThrCys: 0.284 ± 0.161
3.027ThrAsp: 3.027 ± 0.514
3.783ThrGlu: 3.783 ± 0.63
2.365ThrPhe: 2.365 ± 0.38
4.54ThrGly: 4.54 ± 0.73
0.757ThrHis: 0.757 ± 0.211
4.918ThrIle: 4.918 ± 0.78
4.824ThrLys: 4.824 ± 0.506
5.202ThrLeu: 5.202 ± 0.783
1.135ThrMet: 1.135 ± 0.281
2.554ThrAsn: 2.554 ± 0.358
1.513ThrPro: 1.513 ± 0.307
2.554ThrGln: 2.554 ± 0.602
1.608ThrArg: 1.608 ± 0.444
4.162ThrSer: 4.162 ± 0.598
3.216ThrThr: 3.216 ± 0.53
5.013ThrVal: 5.013 ± 0.654
0.662ThrTrp: 0.662 ± 0.263
2.175ThrTyr: 2.175 ± 0.428
0.0ThrXaa: 0.0 ± 0.0
Val
3.405ValAla: 3.405 ± 0.577
0.284ValCys: 0.284 ± 0.153
4.54ValAsp: 4.54 ± 0.585
4.54ValGlu: 4.54 ± 0.685
2.27ValPhe: 2.27 ± 0.432
4.256ValGly: 4.256 ± 0.676
0.757ValHis: 0.757 ± 0.31
4.256ValIle: 4.256 ± 0.655
5.391ValLys: 5.391 ± 0.553
4.351ValLeu: 4.351 ± 0.627
1.797ValMet: 1.797 ± 0.403
3.121ValAsn: 3.121 ± 0.443
1.986ValPro: 1.986 ± 0.442
2.648ValGln: 2.648 ± 0.491
2.743ValArg: 2.743 ± 0.629
4.351ValSer: 4.351 ± 0.531
6.148ValThr: 6.148 ± 0.835
4.445ValVal: 4.445 ± 0.654
0.378ValTrp: 0.378 ± 0.185
1.702ValTyr: 1.702 ± 0.394
0.0ValXaa: 0.0 ± 0.0
Trp
0.851TrpAla: 0.851 ± 0.368
0.189TrpCys: 0.189 ± 0.116
0.284TrpAsp: 0.284 ± 0.155
0.851TrpGlu: 0.851 ± 0.321
0.284TrpPhe: 0.284 ± 0.14
1.23TrpGly: 1.23 ± 0.412
0.284TrpHis: 0.284 ± 0.198
0.473TrpIle: 0.473 ± 0.212
0.946TrpLys: 0.946 ± 0.351
1.135TrpLeu: 1.135 ± 0.337
0.189TrpMet: 0.189 ± 0.169
0.378TrpAsn: 0.378 ± 0.146
0.095TrpPro: 0.095 ± 0.093
0.378TrpGln: 0.378 ± 0.186
0.757TrpArg: 0.757 ± 0.305
1.135TrpSer: 1.135 ± 0.299
0.473TrpThr: 0.473 ± 0.201
0.378TrpVal: 0.378 ± 0.179
0.095TrpTrp: 0.095 ± 0.09
0.662TrpTyr: 0.662 ± 0.218
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.932TyrAla: 2.932 ± 0.598
0.473TyrCys: 0.473 ± 0.234
3.027TyrAsp: 3.027 ± 0.591
1.986TyrGlu: 1.986 ± 0.499
1.513TyrPhe: 1.513 ± 0.431
1.892TyrGly: 1.892 ± 0.415
0.662TyrHis: 0.662 ± 0.236
2.554TyrIle: 2.554 ± 0.373
3.878TyrLys: 3.878 ± 0.698
2.648TyrLeu: 2.648 ± 0.503
0.946TyrMet: 0.946 ± 0.298
1.797TyrAsn: 1.797 ± 0.428
1.23TyrPro: 1.23 ± 0.273
1.04TyrGln: 1.04 ± 0.278
1.986TyrArg: 1.986 ± 0.568
2.459TyrSer: 2.459 ± 0.553
1.986TyrThr: 1.986 ± 0.446
1.986TyrVal: 1.986 ± 0.338
0.473TyrTrp: 0.473 ± 0.202
1.513TyrTyr: 1.513 ± 0.446
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 52 proteins (10574 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski