Amino acid dipepetide frequency for Paenibacillus popilliae ATCC 14706

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.19AlaAla: 9.19 ± 0.143	0.887AlaCys: 0.887 ± 0.03	4.528AlaAsp: 4.528 ± 0.063	6.231AlaGlu: 6.231 ± 0.098	3.127AlaPhe: 3.127 ± 0.061	6.667AlaGly: 6.667 ± 0.103	1.642AlaHis: 1.642 ± 0.037	5.287AlaIle: 5.287 ± 0.075	4.363AlaLys: 4.363 ± 0.076	8.367AlaLeu: 8.367 ± 0.106	2.589AlaMet: 2.589 ± 0.052	2.727AlaAsn: 2.727 ± 0.05	2.798AlaPro: 2.798 ± 0.069	3.065AlaGln: 3.065 ± 0.052	4.23AlaArg: 4.23 ± 0.081	5.041AlaSer: 5.041 ± 0.069	3.714AlaThr: 3.714 ± 0.056	6.484AlaVal: 6.484 ± 0.092	1.119AlaTrp: 1.119 ± 0.036	2.758AlaTyr: 2.758 ± 0.066	0.0AlaXaa: 0.0 ± 0.0
Cys	0.628CysAla: 0.628 ± 0.028	0.145CysCys: 0.145 ± 0.012	0.453CysAsp: 0.453 ± 0.022	0.475CysGlu: 0.475 ± 0.024	0.367CysPhe: 0.367 ± 0.021	0.834CysGly: 0.834 ± 0.034	0.241CysHis: 0.241 ± 0.016	0.579CysIle: 0.579 ± 0.025	0.431CysLys: 0.431 ± 0.023	0.819CysLeu: 0.819 ± 0.03	0.255CysMet: 0.255 ± 0.015	0.374CysAsn: 0.374 ± 0.025	0.434CysPro: 0.434 ± 0.022	0.264CysGln: 0.264 ± 0.016	0.599CysArg: 0.599 ± 0.023	0.65CysSer: 0.65 ± 0.028	0.487CysThr: 0.487 ± 0.025	0.555CysVal: 0.555 ± 0.025	0.111CysTrp: 0.111 ± 0.011	0.341CysTyr: 0.341 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.231AspAla: 4.231 ± 0.083	0.456AspCys: 0.456 ± 0.022	2.646AspAsp: 2.646 ± 0.053	4.081AspGlu: 4.081 ± 0.069	1.875AspPhe: 1.875 ± 0.038	3.894AspGly: 3.894 ± 0.063	1.071AspHis: 1.071 ± 0.036	3.863AspIle: 3.863 ± 0.074	2.917AspLys: 2.917 ± 0.058	4.595AspLeu: 4.595 ± 0.075	1.723AspMet: 1.723 ± 0.041	1.856AspAsn: 1.856 ± 0.044	2.302AspPro: 2.302 ± 0.05	1.728AspGln: 1.728 ± 0.041	3.03AspArg: 3.03 ± 0.053	2.707AspSer: 2.707 ± 0.052	2.634AspThr: 2.634 ± 0.052	3.914AspVal: 3.914 ± 0.067	0.749AspTrp: 0.749 ± 0.029	1.944AspTyr: 1.944 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	6.883GluAla: 6.883 ± 0.098	0.518GluCys: 0.518 ± 0.022	3.172GluAsp: 3.172 ± 0.062	5.97GluGlu: 5.97 ± 0.096	2.151GluPhe: 2.151 ± 0.05	4.506GluGly: 4.506 ± 0.09	1.699GluHis: 1.699 ± 0.048	4.212GluIle: 4.212 ± 0.072	4.041GluLys: 4.041 ± 0.068	7.049GluLeu: 7.049 ± 0.085	2.364GluMet: 2.364 ± 0.054	2.378GluAsn: 2.378 ± 0.052	2.477GluPro: 2.477 ± 0.059	4.151GluGln: 4.151 ± 0.082	5.288GluArg: 5.288 ± 0.092	3.332GluSer: 3.332 ± 0.062	3.158GluThr: 3.158 ± 0.063	4.821GluVal: 4.821 ± 0.082	0.949GluTrp: 0.949 ± 0.035	1.993GluTyr: 1.993 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.111PheAla: 3.111 ± 0.068	0.402PheCys: 0.402 ± 0.02	2.173PheAsp: 2.173 ± 0.048	2.402PheGlu: 2.402 ± 0.047	1.664PhePhe: 1.664 ± 0.051	3.082PheGly: 3.082 ± 0.056	0.919PheHis: 0.919 ± 0.032	2.821PheIle: 2.821 ± 0.06	1.729PheLys: 1.729 ± 0.045	3.489PheLeu: 3.489 ± 0.076	1.077PheMet: 1.077 ± 0.038	1.312PheAsn: 1.312 ± 0.036	1.5PhePro: 1.5 ± 0.041	1.369PheGln: 1.369 ± 0.036	2.088PheArg: 2.088 ± 0.042	2.368PheSer: 2.368 ± 0.061	2.354PheThr: 2.354 ± 0.05	2.862PheVal: 2.862 ± 0.056	0.449PheTrp: 0.449 ± 0.024	1.338PheTyr: 1.338 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	5.357GlyAla: 5.357 ± 0.09	0.828GlyCys: 0.828 ± 0.036	3.485GlyAsp: 3.485 ± 0.067	4.803GlyGlu: 4.803 ± 0.089	2.905GlyPhe: 2.905 ± 0.052	5.25GlyGly: 5.25 ± 0.092	1.615GlyHis: 1.615 ± 0.045	5.26GlyIle: 5.26 ± 0.07	4.497GlyLys: 4.497 ± 0.096	6.682GlyLeu: 6.682 ± 0.085	2.507GlyMet: 2.507 ± 0.051	2.498GlyAsn: 2.498 ± 0.058	1.891GlyPro: 1.891 ± 0.046	2.819GlyGln: 2.819 ± 0.06	3.921GlyArg: 3.921 ± 0.078	4.429GlySer: 4.429 ± 0.076	4.534GlyThr: 4.534 ± 0.074	5.244GlyVal: 5.244 ± 0.075	1.038GlyTrp: 1.038 ± 0.032	2.79GlyTyr: 2.79 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	1.848HisAla: 1.848 ± 0.041	0.237HisCys: 0.237 ± 0.015	1.1HisAsp: 1.1 ± 0.035	1.352HisGlu: 1.352 ± 0.034	0.913HisPhe: 0.913 ± 0.036	1.7HisGly: 1.7 ± 0.041	0.742HisHis: 0.742 ± 0.035	1.661HisIle: 1.661 ± 0.069	0.934HisLys: 0.934 ± 0.037	2.175HisLeu: 2.175 ± 0.052	0.629HisMet: 0.629 ± 0.025	0.72HisAsn: 0.72 ± 0.025	1.394HisPro: 1.394 ± 0.038	0.917HisGln: 0.917 ± 0.032	1.375HisArg: 1.375 ± 0.04	1.334HisSer: 1.334 ± 0.036	1.196HisThr: 1.196 ± 0.033	1.659HisVal: 1.659 ± 0.044	0.295HisTrp: 0.295 ± 0.016	0.856HisTyr: 0.856 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.046IleAla: 6.046 ± 0.081	0.649IleCys: 0.649 ± 0.027	3.786IleAsp: 3.786 ± 0.07	4.621IleGlu: 4.621 ± 0.072	2.237IlePhe: 2.237 ± 0.06	5.425IleGly: 5.425 ± 0.087	1.584IleHis: 1.584 ± 0.038	3.901IleIle: 3.901 ± 0.067	2.875IleLys: 2.875 ± 0.062	5.214IleLeu: 5.214 ± 0.083	1.607IleMet: 1.607 ± 0.038	2.103IleAsn: 2.103 ± 0.05	3.045IlePro: 3.045 ± 0.056	2.565IleGln: 2.565 ± 0.057	4.191IleArg: 4.191 ± 0.063	3.819IleSer: 3.819 ± 0.061	3.561IleThr: 3.561 ± 0.066	5.332IleVal: 5.332 ± 0.077	0.628IleTrp: 0.628 ± 0.024	2.015IleTyr: 2.015 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.188LysAla: 4.188 ± 0.072	0.309LysCys: 0.309 ± 0.017	2.807LysAsp: 2.807 ± 0.059	4.406LysGlu: 4.406 ± 0.074	1.484LysPhe: 1.484 ± 0.043	3.445LysGly: 3.445 ± 0.067	1.18LysHis: 1.18 ± 0.037	2.916LysIle: 2.916 ± 0.063	3.508LysLys: 3.508 ± 0.081	5.448LysLeu: 5.448 ± 0.076	1.731LysMet: 1.731 ± 0.048	2.002LysAsn: 2.002 ± 0.055	2.328LysPro: 2.328 ± 0.059	2.824LysGln: 2.824 ± 0.068	3.323LysArg: 3.323 ± 0.067	2.751LysSer: 2.751 ± 0.055	2.784LysThr: 2.784 ± 0.071	3.546LysVal: 3.546 ± 0.067	0.677LysTrp: 0.677 ± 0.026	1.779LysTyr: 1.779 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	8.48LeuAla: 8.48 ± 0.11	0.933LeuCys: 0.933 ± 0.032	5.182LeuAsp: 5.182 ± 0.076	6.263LeuGlu: 6.263 ± 0.088	4.16LeuPhe: 4.16 ± 0.082	6.5LeuGly: 6.5 ± 0.09	2.412LeuHis: 2.412 ± 0.054	5.842LeuIle: 5.842 ± 0.089	5.04LeuLys: 5.04 ± 0.078	10.243LeuLeu: 10.243 ± 0.145	2.469LeuMet: 2.469 ± 0.055	3.537LeuAsn: 3.537 ± 0.063	4.281LeuPro: 4.281 ± 0.078	4.289LeuGln: 4.289 ± 0.079	5.342LeuArg: 5.342 ± 0.085	6.248LeuSer: 6.248 ± 0.095	5.3LeuThr: 5.3 ± 0.071	6.205LeuVal: 6.205 ± 0.087	1.004LeuTrp: 1.004 ± 0.035	2.948LeuTyr: 2.948 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	2.388MetAla: 2.388 ± 0.05	0.196MetCys: 0.196 ± 0.013	1.55MetAsp: 1.55 ± 0.036	2.275MetGlu: 2.275 ± 0.047	0.999MetPhe: 0.999 ± 0.03	1.766MetGly: 1.766 ± 0.047	0.57MetHis: 0.57 ± 0.023	1.977MetIle: 1.977 ± 0.042	2.304MetLys: 2.304 ± 0.055	3.104MetLeu: 3.104 ± 0.052	1.126MetMet: 1.126 ± 0.043	1.571MetAsn: 1.571 ± 0.044	1.244MetPro: 1.244 ± 0.039	1.133MetGln: 1.133 ± 0.032	1.588MetArg: 1.588 ± 0.047	1.775MetSer: 1.775 ± 0.04	1.825MetThr: 1.825 ± 0.059	1.83MetVal: 1.83 ± 0.045	0.228MetTrp: 0.228 ± 0.015	0.773MetTyr: 0.773 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.649AsnAla: 2.649 ± 0.056	0.293AsnCys: 0.293 ± 0.019	1.842AsnAsp: 1.842 ± 0.04	2.593AsnGlu: 2.593 ± 0.057	1.171AsnPhe: 1.171 ± 0.044	3.156AsnGly: 3.156 ± 0.064	0.821AsnHis: 0.821 ± 0.031	2.328AsnIle: 2.328 ± 0.05	2.075AsnLys: 2.075 ± 0.048	3.01AsnLeu: 3.01 ± 0.061	1.1AsnMet: 1.1 ± 0.033	1.513AsnAsn: 1.513 ± 0.049	1.86AsnPro: 1.86 ± 0.046	1.42AsnGln: 1.42 ± 0.039	2.314AsnArg: 2.314 ± 0.047	1.868AsnSer: 1.868 ± 0.044	1.767AsnThr: 1.767 ± 0.045	2.626AsnVal: 2.626 ± 0.054	0.474AsnTrp: 0.474 ± 0.02	1.209AsnTyr: 1.209 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	3.366ProAla: 3.366 ± 0.071	0.312ProCys: 0.312 ± 0.018	2.691ProAsp: 2.691 ± 0.053	3.436ProGlu: 3.436 ± 0.065	1.863ProPhe: 1.863 ± 0.043	2.95ProGly: 2.95 ± 0.064	1.015ProHis: 1.015 ± 0.037	2.426ProIle: 2.426 ± 0.06	1.84ProLys: 1.84 ± 0.04	3.894ProLeu: 3.894 ± 0.073	1.014ProMet: 1.014 ± 0.03	1.549ProAsn: 1.549 ± 0.037	1.414ProPro: 1.414 ± 0.05	1.548ProGln: 1.548 ± 0.045	1.607ProArg: 1.607 ± 0.04	2.475ProSer: 2.475 ± 0.051	1.982ProThr: 1.982 ± 0.053	3.232ProVal: 3.232 ± 0.06	0.48ProTrp: 0.48 ± 0.021	1.54ProTyr: 1.54 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.218GlnAla: 4.218 ± 0.087	0.294GlnCys: 0.294 ± 0.017	1.824GlnAsp: 1.824 ± 0.047	3.012GlnGlu: 3.012 ± 0.061	1.564GlnPhe: 1.564 ± 0.045	2.602GlnGly: 2.602 ± 0.05	0.95GlnHis: 0.95 ± 0.035	2.473GlnIle: 2.473 ± 0.061	1.937GlnLys: 1.937 ± 0.048	4.244GlnLeu: 4.244 ± 0.078	1.313GlnMet: 1.313 ± 0.037	1.232GlnAsn: 1.232 ± 0.042	1.687GlnPro: 1.687 ± 0.05	2.261GlnGln: 2.261 ± 0.061	2.369GlnArg: 2.369 ± 0.055	2.171GlnSer: 2.171 ± 0.046	1.962GlnThr: 1.962 ± 0.051	2.808GlnVal: 2.808 ± 0.055	0.567GlnTrp: 0.567 ± 0.026	1.333GlnTyr: 1.333 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	3.949ArgAla: 3.949 ± 0.071	0.482ArgCys: 0.482 ± 0.025	2.795ArgAsp: 2.795 ± 0.058	4.218ArgGlu: 4.218 ± 0.079	2.373ArgPhe: 2.373 ± 0.046	3.337ArgGly: 3.337 ± 0.062	1.453ArgHis: 1.453 ± 0.057	4.221ArgIle: 4.221 ± 0.059	3.205ArgLys: 3.205 ± 0.064	6.16ArgLeu: 6.16 ± 0.109	2.015ArgMet: 2.015 ± 0.05	2.047ArgAsn: 2.047 ± 0.045	2.125ArgPro: 2.125 ± 0.048	2.505ArgGln: 2.505 ± 0.053	3.474ArgArg: 3.474 ± 0.076	3.329ArgSer: 3.329 ± 0.066	3.003ArgThr: 3.003 ± 0.058	3.712ArgVal: 3.712 ± 0.064	0.725ArgTrp: 0.725 ± 0.026	2.075ArgTyr: 2.075 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	4.556SerAla: 4.556 ± 0.075	0.48SerCys: 0.48 ± 0.025	2.89SerAsp: 2.89 ± 0.059	3.627SerGlu: 3.627 ± 0.067	2.748SerPhe: 2.748 ± 0.052	4.936SerGly: 4.936 ± 0.073	1.206SerHis: 1.206 ± 0.033	4.001SerIle: 4.001 ± 0.075	2.908SerLys: 2.908 ± 0.061	5.665SerLeu: 5.665 ± 0.096	1.685SerMet: 1.685 ± 0.041	2.083SerAsn: 2.083 ± 0.041	2.348SerPro: 2.348 ± 0.049	1.934SerGln: 1.934 ± 0.047	3.213SerArg: 3.213 ± 0.061	3.654SerSer: 3.654 ± 0.073	3.02SerThr: 3.02 ± 0.057	4.29SerVal: 4.29 ± 0.069	0.721SerTrp: 0.721 ± 0.027	2.036SerTyr: 2.036 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	4.615ThrAla: 4.615 ± 0.07	0.461ThrCys: 0.461 ± 0.025	2.853ThrAsp: 2.853 ± 0.062	3.428ThrGlu: 3.428 ± 0.058	2.204ThrPhe: 2.204 ± 0.051	4.49ThrGly: 4.49 ± 0.078	1.094ThrHis: 1.094 ± 0.033	3.568ThrIle: 3.568 ± 0.073	2.565ThrLys: 2.565 ± 0.061	5.176ThrLeu: 5.176 ± 0.069	1.506ThrMet: 1.506 ± 0.042	1.895ThrAsn: 1.895 ± 0.051	2.489ThrPro: 2.489 ± 0.052	1.548ThrGln: 1.548 ± 0.034	2.356ThrArg: 2.356 ± 0.051	3.032ThrSer: 3.032 ± 0.056	2.737ThrThr: 2.737 ± 0.062	4.415ThrVal: 4.415 ± 0.074	0.6ThrTrp: 0.6 ± 0.021	1.878ThrTyr: 1.878 ± 0.068	0.0ThrXaa: 0.0 ± 0.0
Val	5.604ValAla: 5.604 ± 0.076	0.71ValCys: 0.71 ± 0.028	3.954ValAsp: 3.954 ± 0.068	4.859ValGlu: 4.859 ± 0.079	2.718ValPhe: 2.718 ± 0.061	4.615ValGly: 4.615 ± 0.079	1.671ValHis: 1.671 ± 0.041	4.844ValIle: 4.844 ± 0.071	4.009ValLys: 4.009 ± 0.083	6.999ValLeu: 6.999 ± 0.099	2.075ValMet: 2.075 ± 0.049	2.849ValAsn: 2.849 ± 0.057	3.197ValPro: 3.197 ± 0.054	2.799ValGln: 2.799 ± 0.049	4.112ValArg: 4.112 ± 0.075	4.38ValSer: 4.38 ± 0.064	4.393ValThr: 4.393 ± 0.086	5.157ValVal: 5.157 ± 0.078	0.739ValTrp: 0.739 ± 0.028	2.269ValTyr: 2.269 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.819TrpAla: 0.819 ± 0.027	0.117TrpCys: 0.117 ± 0.011	0.633TrpAsp: 0.633 ± 0.025	0.764TrpGlu: 0.764 ± 0.027	0.506TrpPhe: 0.506 ± 0.023	0.734TrpGly: 0.734 ± 0.026	0.277TrpHis: 0.277 ± 0.019	0.869TrpIle: 0.869 ± 0.034	0.694TrpLys: 0.694 ± 0.028	1.457TrpLeu: 1.457 ± 0.048	0.45TrpMet: 0.45 ± 0.021	0.6TrpAsn: 0.6 ± 0.026	0.364TrpPro: 0.364 ± 0.023	0.458TrpGln: 0.458 ± 0.023	0.639TrpArg: 0.639 ± 0.023	0.75TrpSer: 0.75 ± 0.027	0.685TrpThr: 0.685 ± 0.026	0.803TrpVal: 0.803 ± 0.029	0.167TrpTrp: 0.167 ± 0.015	0.361TrpTyr: 0.361 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.685TyrAla: 2.685 ± 0.056	0.332TyrCys: 0.332 ± 0.018	1.853TyrAsp: 1.853 ± 0.056	2.296TyrGlu: 2.296 ± 0.047	1.483TyrPhe: 1.483 ± 0.044	2.464TyrGly: 2.464 ± 0.058	0.875TyrHis: 0.875 ± 0.031	2.153TyrIle: 2.153 ± 0.044	1.563TyrLys: 1.563 ± 0.044	2.888TyrLeu: 2.888 ± 0.056	0.989TyrMet: 0.989 ± 0.033	1.244TyrAsn: 1.244 ± 0.04	1.455TyrPro: 1.455 ± 0.039	1.227TyrGln: 1.227 ± 0.035	2.143TyrArg: 2.143 ± 0.053	1.888TyrSer: 1.888 ± 0.044	1.812TyrThr: 1.812 ± 0.048	2.459TyrVal: 2.459 ± 0.05	0.427TyrTrp: 0.427 ± 0.02	1.383TyrTyr: 1.383 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3844 proteins (989251 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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