Amino acid dipepetide frequency for Natronoarchaeum philippinense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.528AlaAla: 14.528 ± 0.182	0.665AlaCys: 0.665 ± 0.025	10.879AlaAsp: 10.879 ± 0.134	9.34AlaGlu: 9.34 ± 0.115	3.736AlaPhe: 3.736 ± 0.063	9.727AlaGly: 9.727 ± 0.11	1.796AlaHis: 1.796 ± 0.044	4.957AlaIle: 4.957 ± 0.077	1.758AlaLys: 1.758 ± 0.052	10.528AlaLeu: 10.528 ± 0.131	2.11AlaMet: 2.11 ± 0.051	2.246AlaAsn: 2.246 ± 0.059	4.173AlaPro: 4.173 ± 0.068	2.411AlaGln: 2.411 ± 0.047	6.221AlaArg: 6.221 ± 0.097	5.921AlaSer: 5.921 ± 0.096	6.723AlaThr: 6.723 ± 0.111	10.896AlaVal: 10.896 ± 0.137	1.098AlaTrp: 1.098 ± 0.036	2.642AlaTyr: 2.642 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.581CysAla: 0.581 ± 0.03	0.075CysCys: 0.075 ± 0.009	0.608CysAsp: 0.608 ± 0.032	0.6CysGlu: 0.6 ± 0.029	0.174CysPhe: 0.174 ± 0.013	0.855CysGly: 0.855 ± 0.04	0.165CysHis: 0.165 ± 0.014	0.242CysIle: 0.242 ± 0.017	0.101CysLys: 0.101 ± 0.01	0.461CysLeu: 0.461 ± 0.024	0.11CysMet: 0.11 ± 0.011	0.208CysAsn: 0.208 ± 0.017	0.542CysPro: 0.542 ± 0.028	0.171CysGln: 0.171 ± 0.013	0.453CysArg: 0.453 ± 0.023	0.43CysSer: 0.43 ± 0.02	0.392CysThr: 0.392 ± 0.021	0.48CysVal: 0.48 ± 0.022	0.095CysTrp: 0.095 ± 0.01	0.198CysTyr: 0.198 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	13.149AspAla: 13.149 ± 0.158	0.659AspCys: 0.659 ± 0.032	9.047AspAsp: 9.047 ± 0.136	8.726AspGlu: 8.726 ± 0.138	1.914AspPhe: 1.914 ± 0.047	8.588AspGly: 8.588 ± 0.124	1.812AspHis: 1.812 ± 0.047	3.174AspIle: 3.174 ± 0.069	1.064AspLys: 1.064 ± 0.036	7.278AspLeu: 7.278 ± 0.098	1.254AspMet: 1.254 ± 0.042	1.46AspAsn: 1.46 ± 0.051	4.512AspPro: 4.512 ± 0.077	1.995AspGln: 1.995 ± 0.052	6.814AspArg: 6.814 ± 0.101	3.855AspSer: 3.855 ± 0.085	3.88AspThr: 3.88 ± 0.059	7.633AspVal: 7.633 ± 0.102	1.057AspTrp: 1.057 ± 0.04	1.938AspTyr: 1.938 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	8.389GluAla: 8.389 ± 0.13	0.617GluCys: 0.617 ± 0.036	6.464GluAsp: 6.464 ± 0.099	6.9GluGlu: 6.9 ± 0.135	3.201GluPhe: 3.201 ± 0.058	5.234GluGly: 5.234 ± 0.074	2.225GluHis: 2.225 ± 0.055	4.217GluIle: 4.217 ± 0.095	1.752GluLys: 1.752 ± 0.05	7.988GluLeu: 7.988 ± 0.109	2.005GluMet: 2.005 ± 0.053	2.346GluAsn: 2.346 ± 0.054	3.768GluPro: 3.768 ± 0.064	3.363GluGln: 3.363 ± 0.072	7.892GluArg: 7.892 ± 0.111	4.927GluSer: 4.927 ± 0.086	5.963GluThr: 5.963 ± 0.102	5.632GluVal: 5.632 ± 0.086	1.195GluTrp: 1.195 ± 0.04	2.928GluTyr: 2.928 ± 0.061	0.0GluXaa: 0.0 ± 0.0
Phe	3.445PheAla: 3.445 ± 0.062	0.251PheCys: 0.251 ± 0.016	3.349PheAsp: 3.349 ± 0.071	3.324PheGlu: 3.324 ± 0.063	1.022PhePhe: 1.022 ± 0.034	3.068PheGly: 3.068 ± 0.06	0.594PheHis: 0.594 ± 0.024	0.971PheIle: 0.971 ± 0.037	0.494PheLys: 0.494 ± 0.024	2.671PheLeu: 2.671 ± 0.06	0.508PheMet: 0.508 ± 0.026	0.632PheAsn: 0.632 ± 0.029	1.317PhePro: 1.317 ± 0.036	0.819PheGln: 0.819 ± 0.03	1.729PheArg: 1.729 ± 0.047	1.698PheSer: 1.698 ± 0.046	1.632PheThr: 1.632 ± 0.038	3.278PheVal: 3.278 ± 0.065	0.381PheTrp: 0.381 ± 0.022	0.829PheTyr: 0.829 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	8.773GlyAla: 8.773 ± 0.133	0.665GlyCys: 0.665 ± 0.026	7.156GlyAsp: 7.156 ± 0.112	7.28GlyGlu: 7.28 ± 0.103	2.973GlyPhe: 2.973 ± 0.064	7.648GlyGly: 7.648 ± 0.148	1.659GlyHis: 1.659 ± 0.04	4.0GlyIle: 4.0 ± 0.076	1.8GlyLys: 1.8 ± 0.046	6.985GlyLeu: 6.985 ± 0.106	1.624GlyMet: 1.624 ± 0.046	1.956GlyAsn: 1.956 ± 0.058	3.298GlyPro: 3.298 ± 0.069	2.221GlyGln: 2.221 ± 0.052	4.864GlyArg: 4.864 ± 0.077	4.985GlySer: 4.985 ± 0.092	5.449GlyThr: 5.449 ± 0.09	8.102GlyVal: 8.102 ± 0.106	1.107GlyTrp: 1.107 ± 0.036	2.537GlyTyr: 2.537 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.975HisAla: 1.975 ± 0.046	0.21HisCys: 0.21 ± 0.015	1.866HisAsp: 1.866 ± 0.053	1.748HisGlu: 1.748 ± 0.039	0.547HisPhe: 0.547 ± 0.022	1.93HisGly: 1.93 ± 0.048	0.508HisHis: 0.508 ± 0.025	0.598HisIle: 0.598 ± 0.026	0.322HisLys: 0.322 ± 0.018	1.661HisLeu: 1.661 ± 0.046	0.273HisMet: 0.273 ± 0.018	0.472HisAsn: 0.472 ± 0.021	1.171HisPro: 1.171 ± 0.039	0.5HisGln: 0.5 ± 0.024	1.279HisArg: 1.279 ± 0.036	0.874HisSer: 0.874 ± 0.034	1.04HisThr: 1.04 ± 0.035	1.943HisVal: 1.943 ± 0.048	0.227HisTrp: 0.227 ± 0.017	0.605HisTyr: 0.605 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	4.853IleAla: 4.853 ± 0.074	0.261IleCys: 0.261 ± 0.018	4.485IleAsp: 4.485 ± 0.08	4.801IleGlu: 4.801 ± 0.078	0.931IlePhe: 0.931 ± 0.036	3.994IleGly: 3.994 ± 0.067	0.81IleHis: 0.81 ± 0.029	1.162IleIle: 1.162 ± 0.044	0.773IleLys: 0.773 ± 0.029	2.709IleLeu: 2.709 ± 0.062	0.481IleMet: 0.481 ± 0.027	1.012IleAsn: 1.012 ± 0.037	1.947IlePro: 1.947 ± 0.051	1.04IleGln: 1.04 ± 0.035	2.433IleArg: 2.433 ± 0.05	2.103IleSer: 2.103 ± 0.051	2.314IleThr: 2.314 ± 0.055	3.894IleVal: 3.894 ± 0.08	0.305IleTrp: 0.305 ± 0.02	0.952IleTyr: 0.952 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	1.644LysAla: 1.644 ± 0.042	0.115LysCys: 0.115 ± 0.012	1.13LysAsp: 1.13 ± 0.041	1.286LysGlu: 1.286 ± 0.044	0.536LysPhe: 0.536 ± 0.023	1.283LysGly: 1.283 ± 0.041	0.459LysHis: 0.459 ± 0.024	0.842LysIle: 0.842 ± 0.037	0.575LysLys: 0.575 ± 0.033	1.709LysLeu: 1.709 ± 0.044	0.382LysMet: 0.382 ± 0.024	0.584LysAsn: 0.584 ± 0.029	0.87LysPro: 0.87 ± 0.034	0.727LysGln: 0.727 ± 0.032	1.561LysArg: 1.561 ± 0.043	1.119LysSer: 1.119 ± 0.036	1.183LysThr: 1.183 ± 0.037	1.208LysVal: 1.208 ± 0.037	0.213LysTrp: 0.213 ± 0.016	0.561LysTyr: 0.561 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	10.865LeuAla: 10.865 ± 0.143	0.591LeuCys: 0.591 ± 0.028	8.565LeuAsp: 8.565 ± 0.117	6.246LeuGlu: 6.246 ± 0.099	3.068LeuPhe: 3.068 ± 0.074	7.578LeuGly: 7.578 ± 0.113	1.466LeuHis: 1.466 ± 0.04	2.99LeuIle: 2.99 ± 0.075	1.492LeuLys: 1.492 ± 0.038	8.467LeuLeu: 8.467 ± 0.142	1.325LeuMet: 1.325 ± 0.04	1.667LeuAsn: 1.667 ± 0.045	3.975LeuPro: 3.975 ± 0.063	2.198LeuGln: 2.198 ± 0.046	5.515LeuArg: 5.515 ± 0.087	5.667LeuSer: 5.667 ± 0.087	4.977LeuThr: 4.977 ± 0.072	8.062LeuVal: 8.062 ± 0.118	0.927LeuTrp: 0.927 ± 0.035	2.265LeuTyr: 2.265 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	1.852MetAla: 1.852 ± 0.048	0.1MetCys: 0.1 ± 0.012	1.214MetAsp: 1.214 ± 0.04	1.08MetGlu: 1.08 ± 0.036	0.486MetPhe: 0.486 ± 0.026	1.432MetGly: 1.432 ± 0.045	0.356MetHis: 0.356 ± 0.018	0.763MetIle: 0.763 ± 0.031	0.424MetLys: 0.424 ± 0.019	1.628MetLeu: 1.628 ± 0.047	0.324MetMet: 0.324 ± 0.021	0.591MetAsn: 0.591 ± 0.028	0.84MetPro: 0.84 ± 0.029	0.561MetGln: 0.561 ± 0.024	1.02MetArg: 1.02 ± 0.03	1.537MetSer: 1.537 ± 0.048	1.565MetThr: 1.565 ± 0.043	1.26MetVal: 1.26 ± 0.035	0.154MetTrp: 0.154 ± 0.013	0.391MetTyr: 0.391 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.588AsnAla: 2.588 ± 0.055	0.208AsnCys: 0.208 ± 0.017	1.823AsnAsp: 1.823 ± 0.046	1.815AsnGlu: 1.815 ± 0.054	0.696AsnPhe: 0.696 ± 0.029	1.987AsnGly: 1.987 ± 0.056	0.529AsnHis: 0.529 ± 0.025	0.837AsnIle: 0.837 ± 0.032	0.426AsnLys: 0.426 ± 0.023	1.895AsnLeu: 1.895 ± 0.042	0.416AsnMet: 0.416 ± 0.022	0.556AsnAsn: 0.556 ± 0.027	1.421AsnPro: 1.421 ± 0.043	0.638AsnGln: 0.638 ± 0.033	1.561AsnArg: 1.561 ± 0.041	1.062AsnSer: 1.062 ± 0.037	1.239AsnThr: 1.239 ± 0.038	2.218AsnVal: 2.218 ± 0.042	0.348AsnTrp: 0.348 ± 0.021	0.662AsnTyr: 0.662 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	4.637ProAla: 4.637 ± 0.088	0.233ProCys: 0.233 ± 0.016	5.061ProAsp: 5.061 ± 0.082	4.739ProGlu: 4.739 ± 0.068	1.557ProPhe: 1.557 ± 0.042	3.591ProGly: 3.591 ± 0.068	0.912ProHis: 0.912 ± 0.034	2.074ProIle: 2.074 ± 0.05	0.797ProLys: 0.797 ± 0.029	3.441ProLeu: 3.441 ± 0.069	0.865ProMet: 0.865 ± 0.03	1.124ProAsn: 1.124 ± 0.036	2.126ProPro: 2.126 ± 0.054	1.007ProGln: 1.007 ± 0.029	2.105ProArg: 2.105 ± 0.041	2.63ProSer: 2.63 ± 0.051	2.987ProThr: 2.987 ± 0.06	3.935ProVal: 3.935 ± 0.068	0.515ProTrp: 0.515 ± 0.023	1.081ProTyr: 1.081 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.512GlnAla: 2.512 ± 0.054	0.172GlnCys: 0.172 ± 0.012	1.586GlnAsp: 1.586 ± 0.043	1.722GlnGlu: 1.722 ± 0.049	1.166GlnPhe: 1.166 ± 0.035	1.688GlnGly: 1.688 ± 0.045	0.593GlnHis: 0.593 ± 0.026	1.297GlnIle: 1.297 ± 0.039	0.622GlnLys: 0.622 ± 0.025	2.622GlnLeu: 2.622 ± 0.055	0.616GlnMet: 0.616 ± 0.023	0.827GlnAsn: 0.827 ± 0.029	1.253GlnPro: 1.253 ± 0.042	1.262GlnGln: 1.262 ± 0.044	2.143GlnArg: 2.143 ± 0.056	1.93GlnSer: 1.93 ± 0.045	1.832GlnThr: 1.832 ± 0.044	1.878GlnVal: 1.878 ± 0.043	0.352GlnTrp: 0.352 ± 0.019	0.873GlnTyr: 0.873 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	6.396ArgAla: 6.396 ± 0.095	0.456ArgCys: 0.456 ± 0.028	5.186ArgAsp: 5.186 ± 0.084	6.785ArgGlu: 6.785 ± 0.122	2.174ArgPhe: 2.174 ± 0.045	4.355ArgGly: 4.355 ± 0.066	1.232ArgHis: 1.232 ± 0.036	3.066ArgIle: 3.066 ± 0.055	1.459ArgLys: 1.459 ± 0.047	5.77ArgLeu: 5.77 ± 0.089	1.255ArgMet: 1.255 ± 0.039	1.592ArgAsn: 1.592 ± 0.045	2.485ArgPro: 2.485 ± 0.052	1.997ArgGln: 1.997 ± 0.053	5.08ArgArg: 5.08 ± 0.094	3.967ArgSer: 3.967 ± 0.064	3.781ArgThr: 3.781 ± 0.078	5.053ArgVal: 5.053 ± 0.081	0.844ArgTrp: 0.844 ± 0.031	1.84ArgTyr: 1.84 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.686SerAla: 5.686 ± 0.077	0.313SerCys: 0.313 ± 0.02	4.665SerAsp: 4.665 ± 0.091	4.367SerGlu: 4.367 ± 0.078	1.824SerPhe: 1.824 ± 0.047	5.595SerGly: 5.595 ± 0.089	1.063SerHis: 1.063 ± 0.036	2.631SerIle: 2.631 ± 0.053	1.141SerLys: 1.141 ± 0.033	4.696SerLeu: 4.696 ± 0.073	1.108SerMet: 1.108 ± 0.034	1.387SerAsn: 1.387 ± 0.04	2.596SerPro: 2.596 ± 0.059	1.521SerGln: 1.521 ± 0.044	3.03SerArg: 3.03 ± 0.058	3.215SerSer: 3.215 ± 0.082	3.586SerThr: 3.586 ± 0.068	4.894SerVal: 4.894 ± 0.083	0.63SerTrp: 0.63 ± 0.03	1.486SerTyr: 1.486 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	6.771ThrAla: 6.771 ± 0.087	0.367ThrCys: 0.367 ± 0.023	5.249ThrAsp: 5.249 ± 0.085	4.385ThrGlu: 4.385 ± 0.068	2.054ThrPhe: 2.054 ± 0.051	5.603ThrGly: 5.603 ± 0.084	1.059ThrHis: 1.059 ± 0.038	3.025ThrIle: 3.025 ± 0.065	0.955ThrLys: 0.955 ± 0.031	5.419ThrLeu: 5.419 ± 0.077	1.013ThrMet: 1.013 ± 0.038	1.417ThrAsn: 1.417 ± 0.044	3.254ThrPro: 3.254 ± 0.057	1.309ThrGln: 1.309 ± 0.04	2.92ThrArg: 2.92 ± 0.056	2.85ThrSer: 2.85 ± 0.064	4.033ThrThr: 4.033 ± 0.079	6.344ThrVal: 6.344 ± 0.093	0.609ThrTrp: 0.609 ± 0.026	1.615ThrTyr: 1.615 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	10.02ValAla: 10.02 ± 0.135	0.621ValCys: 0.621 ± 0.03	7.976ValAsp: 7.976 ± 0.09	8.381ValGlu: 8.381 ± 0.097	2.698ValPhe: 2.698 ± 0.062	7.885ValGly: 7.885 ± 0.12	1.618ValHis: 1.618 ± 0.038	3.216ValIle: 3.216 ± 0.062	1.308ValLys: 1.308 ± 0.041	8.222ValLeu: 8.222 ± 0.11	1.289ValMet: 1.289 ± 0.043	1.835ValAsn: 1.835 ± 0.044	4.205ValPro: 4.205 ± 0.07	2.032ValGln: 2.032 ± 0.044	5.377ValArg: 5.377 ± 0.086	4.686ValSer: 4.686 ± 0.074	5.492ValThr: 5.492 ± 0.082	8.54ValVal: 8.54 ± 0.128	0.862ValTrp: 0.862 ± 0.03	2.118ValTyr: 2.118 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.999TrpAla: 0.999 ± 0.034	0.108TrpCys: 0.108 ± 0.012	0.798TrpAsp: 0.798 ± 0.035	0.833TrpGlu: 0.833 ± 0.03	0.446TrpPhe: 0.446 ± 0.022	0.756TrpGly: 0.756 ± 0.03	0.261TrpHis: 0.261 ± 0.017	0.537TrpIle: 0.537 ± 0.029	0.279TrpLys: 0.279 ± 0.018	1.218TrpLeu: 1.218 ± 0.037	0.248TrpMet: 0.248 ± 0.017	0.391TrpAsn: 0.391 ± 0.02	0.454TrpPro: 0.454 ± 0.026	0.383TrpGln: 0.383 ± 0.019	0.846TrpArg: 0.846 ± 0.031	0.692TrpSer: 0.692 ± 0.029	0.819TrpThr: 0.819 ± 0.026	0.757TrpVal: 0.757 ± 0.032	0.198TrpTrp: 0.198 ± 0.015	0.404TrpTyr: 0.404 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.691TyrAla: 2.691 ± 0.058	0.253TyrCys: 0.253 ± 0.016	2.702TyrAsp: 2.702 ± 0.059	2.65TyrGlu: 2.65 ± 0.056	0.812TyrPhe: 0.812 ± 0.028	2.282TyrGly: 2.282 ± 0.05	0.633TyrHis: 0.633 ± 0.027	0.66TyrIle: 0.66 ± 0.029	0.444TyrLys: 0.444 ± 0.022	2.542TyrLeu: 2.542 ± 0.058	0.371TyrMet: 0.371 ± 0.019	0.623TyrAsn: 0.623 ± 0.03	1.208TyrPro: 1.208 ± 0.036	0.79TyrGln: 0.79 ± 0.034	1.933TyrArg: 1.933 ± 0.055	1.286TyrSer: 1.286 ± 0.036	1.362TyrThr: 1.362 ± 0.043	2.374TyrVal: 2.374 ± 0.047	0.309TyrTrp: 0.309 ± 0.022	0.839TyrTyr: 0.839 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3284 proteins (928822 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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