Amino acid dipepetide frequency for Euhalothece natronophila Z-M001

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.257AlaAla: 5.257 ± 0.096	0.787AlaCys: 0.787 ± 0.035	3.424AlaAsp: 3.424 ± 0.074	5.179AlaGlu: 5.179 ± 0.084	2.84AlaPhe: 2.84 ± 0.06	4.91AlaGly: 4.91 ± 0.088	1.244AlaHis: 1.244 ± 0.037	6.205AlaIle: 6.205 ± 0.082	3.825AlaLys: 3.825 ± 0.072	8.02AlaLeu: 8.02 ± 0.093	1.668AlaMet: 1.668 ± 0.042	2.968AlaAsn: 2.968 ± 0.066	2.367AlaPro: 2.367 ± 0.053	4.221AlaGln: 4.221 ± 0.067	3.496AlaArg: 3.496 ± 0.07	4.562AlaSer: 4.562 ± 0.081	4.474AlaThr: 4.474 ± 0.071	5.272AlaVal: 5.272 ± 0.074	0.935AlaTrp: 0.935 ± 0.034	2.252AlaTyr: 2.252 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.586CysAla: 0.586 ± 0.024	0.155CysCys: 0.155 ± 0.014	0.523CysAsp: 0.523 ± 0.027	0.566CysGlu: 0.566 ± 0.024	0.398CysPhe: 0.398 ± 0.018	0.763CysGly: 0.763 ± 0.027	0.302CysHis: 0.302 ± 0.018	0.485CysIle: 0.485 ± 0.026	0.307CysLys: 0.307 ± 0.018	1.075CysLeu: 1.075 ± 0.04	0.115CysMet: 0.115 ± 0.013	0.378CysAsn: 0.378 ± 0.02	0.596CysPro: 0.596 ± 0.029	0.644CysGln: 0.644 ± 0.028	0.475CysArg: 0.475 ± 0.024	0.625CysSer: 0.625 ± 0.025	0.422CysThr: 0.422 ± 0.021	0.536CysVal: 0.536 ± 0.023	0.164CysTrp: 0.164 ± 0.013	0.358CysTyr: 0.358 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	3.017AspAla: 3.017 ± 0.066	0.49AspCys: 0.49 ± 0.021	2.532AspAsp: 2.532 ± 0.098	3.581AspGlu: 3.581 ± 0.09	2.276AspPhe: 2.276 ± 0.055	2.891AspGly: 2.891 ± 0.08	1.092AspHis: 1.092 ± 0.038	3.166AspIle: 3.166 ± 0.052	1.793AspLys: 1.793 ± 0.054	5.607AspLeu: 5.607 ± 0.08	0.748AspMet: 0.748 ± 0.026	2.089AspAsn: 2.089 ± 0.054	2.682AspPro: 2.682 ± 0.072	2.695AspGln: 2.695 ± 0.056	2.971AspArg: 2.971 ± 0.06	3.011AspSer: 3.011 ± 0.063	2.49AspThr: 2.49 ± 0.06	3.027AspVal: 3.027 ± 0.072	0.919AspTrp: 0.919 ± 0.034	2.091AspTyr: 2.091 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	6.488GluAla: 6.488 ± 0.086	0.455GluCys: 0.455 ± 0.022	3.673GluAsp: 3.673 ± 0.089	7.363GluGlu: 7.363 ± 0.14	2.587GluPhe: 2.587 ± 0.061	4.434GluGly: 4.434 ± 0.084	1.006GluHis: 1.006 ± 0.035	5.448GluIle: 5.448 ± 0.084	4.914GluLys: 4.914 ± 0.098	7.684GluLeu: 7.684 ± 0.097	1.662GluMet: 1.662 ± 0.047	3.685GluAsn: 3.685 ± 0.065	2.524GluPro: 2.524 ± 0.063	4.3GluGln: 4.3 ± 0.083	3.604GluArg: 3.604 ± 0.072	3.879GluSer: 3.879 ± 0.075	5.106GluThr: 5.106 ± 0.079	5.115GluVal: 5.115 ± 0.085	0.782GluTrp: 0.782 ± 0.029	1.883GluTyr: 1.883 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	2.881PheAla: 2.881 ± 0.066	0.495PheCys: 0.495 ± 0.025	2.163PheAsp: 2.163 ± 0.055	2.16PheGlu: 2.16 ± 0.048	1.823PhePhe: 1.823 ± 0.053	2.9PheGly: 2.9 ± 0.064	0.752PheHis: 0.752 ± 0.027	2.433PheIle: 2.433 ± 0.056	1.438PheLys: 1.438 ± 0.044	4.527PheLeu: 4.527 ± 0.086	0.662PheMet: 0.662 ± 0.029	1.85PheAsn: 1.85 ± 0.048	2.254PhePro: 2.254 ± 0.05	2.022PheGln: 2.022 ± 0.042	1.896PheArg: 1.896 ± 0.04	3.079PheSer: 3.079 ± 0.067	2.127PheThr: 2.127 ± 0.05	2.187PheVal: 2.187 ± 0.047	0.731PheTrp: 0.731 ± 0.027	1.452PheTyr: 1.452 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	4.354GlyAla: 4.354 ± 0.076	0.695GlyCys: 0.695 ± 0.027	3.277GlyAsp: 3.277 ± 0.08	5.289GlyGlu: 5.289 ± 0.076	3.015GlyPhe: 3.015 ± 0.062	4.82GlyGly: 4.82 ± 0.101	1.146GlyHis: 1.146 ± 0.033	5.041GlyIle: 5.041 ± 0.075	4.224GlyLys: 4.224 ± 0.085	7.032GlyLeu: 7.032 ± 0.103	1.52GlyMet: 1.52 ± 0.05	2.907GlyAsn: 2.907 ± 0.063	1.219GlyPro: 1.219 ± 0.043	2.527GlyGln: 2.527 ± 0.051	3.114GlyArg: 3.114 ± 0.064	3.845GlySer: 3.845 ± 0.078	3.574GlyThr: 3.574 ± 0.067	4.895GlyVal: 4.895 ± 0.09	1.164GlyTrp: 1.164 ± 0.037	2.393GlyTyr: 2.393 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	0.939HisAla: 0.939 ± 0.032	0.282HisCys: 0.282 ± 0.017	0.777HisAsp: 0.777 ± 0.051	0.917HisGlu: 0.917 ± 0.034	0.912HisPhe: 0.912 ± 0.033	1.097HisGly: 1.097 ± 0.035	0.681HisHis: 0.681 ± 0.032	0.922HisIle: 0.922 ± 0.033	0.648HisLys: 0.648 ± 0.029	2.387HisLeu: 2.387 ± 0.052	0.232HisMet: 0.232 ± 0.018	0.77HisAsn: 0.77 ± 0.031	1.343HisPro: 1.343 ± 0.038	1.243HisGln: 1.243 ± 0.043	1.117HisArg: 1.117 ± 0.033	1.201HisSer: 1.201 ± 0.036	0.791HisThr: 0.791 ± 0.031	0.761HisVal: 0.761 ± 0.028	0.445HisTrp: 0.445 ± 0.02	0.856HisTyr: 0.856 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.551IleAla: 6.551 ± 0.085	0.705IleCys: 0.705 ± 0.028	3.417IleAsp: 3.417 ± 0.068	4.534IleGlu: 4.534 ± 0.071	2.577IlePhe: 2.577 ± 0.071	4.318IleGly: 4.318 ± 0.083	1.111IleHis: 1.111 ± 0.034	4.409IleIle: 4.409 ± 0.081	3.025IleLys: 3.025 ± 0.066	6.746IleLeu: 6.746 ± 0.102	0.906IleMet: 0.906 ± 0.031	3.122IleAsn: 3.122 ± 0.062	3.747IlePro: 3.747 ± 0.06	2.82IleGln: 2.82 ± 0.057	3.05IleArg: 3.05 ± 0.059	4.451IleSer: 4.451 ± 0.073	3.978IleThr: 3.978 ± 0.058	3.783IleVal: 3.783 ± 0.075	0.804IleTrp: 0.804 ± 0.03	1.952IleTyr: 1.952 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	3.883LysAla: 3.883 ± 0.075	0.321LysCys: 0.321 ± 0.02	2.145LysAsp: 2.145 ± 0.054	3.927LysGlu: 3.927 ± 0.084	1.47LysPhe: 1.47 ± 0.041	3.002LysGly: 3.002 ± 0.071	0.797LysHis: 0.797 ± 0.031	3.26LysIle: 3.26 ± 0.064	2.995LysLys: 2.995 ± 0.079	4.937LysLeu: 4.937 ± 0.085	1.006LysMet: 1.006 ± 0.036	2.179LysAsn: 2.179 ± 0.05	2.25LysPro: 2.25 ± 0.06	3.174LysGln: 3.174 ± 0.074	2.763LysArg: 2.763 ± 0.059	2.713LysSer: 2.713 ± 0.058	3.172LysThr: 3.172 ± 0.071	3.189LysVal: 3.189 ± 0.062	0.559LysTrp: 0.559 ± 0.024	1.255LysTyr: 1.255 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	8.626LeuAla: 8.626 ± 0.109	0.874LeuCys: 0.874 ± 0.035	5.379LeuAsp: 5.379 ± 0.08	8.85LeuGlu: 8.85 ± 0.1	4.05LeuPhe: 4.05 ± 0.083	7.467LeuGly: 7.467 ± 0.094	1.726LeuHis: 1.726 ± 0.042	7.013LeuIle: 7.013 ± 0.113	5.779LeuLys: 5.779 ± 0.089	10.709LeuLeu: 10.709 ± 0.141	2.099LeuMet: 2.099 ± 0.049	4.75LeuAsn: 4.75 ± 0.071	5.475LeuPro: 5.475 ± 0.081	5.471LeuGln: 5.471 ± 0.081	5.366LeuArg: 5.366 ± 0.08	7.682LeuSer: 7.682 ± 0.084	6.338LeuThr: 6.338 ± 0.074	6.888LeuVal: 6.888 ± 0.094	1.338LeuTrp: 1.338 ± 0.04	2.737LeuTyr: 2.737 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	1.674MetAla: 1.674 ± 0.04	0.097MetCys: 0.097 ± 0.011	0.717MetAsp: 0.717 ± 0.027	1.195MetGlu: 1.195 ± 0.036	0.567MetPhe: 0.567 ± 0.025	1.517MetGly: 1.517 ± 0.043	0.242MetHis: 0.242 ± 0.014	1.263MetIle: 1.263 ± 0.042	1.058MetLys: 1.058 ± 0.036	1.84MetLeu: 1.84 ± 0.049	0.482MetMet: 0.482 ± 0.022	0.809MetAsn: 0.809 ± 0.031	0.783MetPro: 0.783 ± 0.031	0.807MetGln: 0.807 ± 0.033	0.966MetArg: 0.966 ± 0.036	1.415MetSer: 1.415 ± 0.043	1.394MetThr: 1.394 ± 0.036	1.339MetVal: 1.339 ± 0.036	0.134MetTrp: 0.134 ± 0.011	0.357MetTyr: 0.357 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.769AsnAla: 2.769 ± 0.06	0.539AsnCys: 0.539 ± 0.029	1.783AsnAsp: 1.783 ± 0.045	2.34AsnGlu: 2.34 ± 0.051	1.971AsnPhe: 1.971 ± 0.055	2.347AsnGly: 2.347 ± 0.061	1.029AsnHis: 1.029 ± 0.033	2.683AsnIle: 2.683 ± 0.055	1.589AsnLys: 1.589 ± 0.047	5.466AsnLeu: 5.466 ± 0.087	0.672AsnMet: 0.672 ± 0.027	2.074AsnAsn: 2.074 ± 0.068	2.814AsnPro: 2.814 ± 0.06	3.01AsnGln: 3.01 ± 0.068	2.354AsnArg: 2.354 ± 0.05	2.917AsnSer: 2.917 ± 0.063	2.138AsnThr: 2.138 ± 0.05	2.176AsnVal: 2.176 ± 0.047	0.866AsnTrp: 0.866 ± 0.028	1.708AsnTyr: 1.708 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	2.574ProAla: 2.574 ± 0.06	0.381ProCys: 0.381 ± 0.02	2.93ProAsp: 2.93 ± 0.074	4.796ProGlu: 4.796 ± 0.089	1.799ProPhe: 1.799 ± 0.044	2.377ProGly: 2.377 ± 0.056	0.992ProHis: 0.992 ± 0.032	3.017ProIle: 3.017 ± 0.057	2.251ProLys: 2.251 ± 0.05	4.807ProLeu: 4.807 ± 0.081	0.749ProMet: 0.749 ± 0.027	2.273ProAsn: 2.273 ± 0.055	2.34ProPro: 2.34 ± 0.058	2.611ProGln: 2.611 ± 0.063	1.855ProArg: 1.855 ± 0.049	2.907ProSer: 2.907 ± 0.054	2.676ProThr: 2.676 ± 0.058	2.908ProVal: 2.908 ± 0.05	0.699ProTrp: 0.699 ± 0.031	1.476ProTyr: 1.476 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	4.437GlnAla: 4.437 ± 0.077	0.37GlnCys: 0.37 ± 0.019	2.367GlnAsp: 2.367 ± 0.051	4.974GlnGlu: 4.974 ± 0.086	2.113GlnPhe: 2.113 ± 0.048	3.763GlnGly: 3.763 ± 0.067	0.875GlnHis: 0.875 ± 0.031	3.207GlnIle: 3.207 ± 0.066	2.99GlnLys: 2.99 ± 0.063	6.084GlnLeu: 6.084 ± 0.105	1.058GlnMet: 1.058 ± 0.035	2.093GlnAsn: 2.093 ± 0.045	2.4GlnPro: 2.4 ± 0.059	4.012GlnGln: 4.012 ± 0.089	3.118GlnArg: 3.118 ± 0.065	2.817GlnSer: 2.817 ± 0.06	2.786GlnThr: 2.786 ± 0.062	3.78GlnVal: 3.78 ± 0.066	0.891GlnTrp: 0.891 ± 0.031	1.322GlnTyr: 1.322 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	3.454ArgAla: 3.454 ± 0.064	0.516ArgCys: 0.516 ± 0.025	2.798ArgAsp: 2.798 ± 0.057	3.964ArgGlu: 3.964 ± 0.068	2.191ArgPhe: 2.191 ± 0.048	3.028ArgGly: 3.028 ± 0.068	0.966ArgHis: 0.966 ± 0.035	3.092ArgIle: 3.092 ± 0.058	2.444ArgLys: 2.444 ± 0.065	5.797ArgLeu: 5.797 ± 0.083	0.924ArgMet: 0.924 ± 0.034	2.083ArgAsn: 2.083 ± 0.047	1.941ArgPro: 1.941 ± 0.049	3.003ArgGln: 3.003 ± 0.06	3.139ArgArg: 3.139 ± 0.069	3.141ArgSer: 3.141 ± 0.062	2.23ArgThr: 2.23 ± 0.05	3.326ArgVal: 3.326 ± 0.069	0.837ArgTrp: 0.837 ± 0.032	1.937ArgTyr: 1.937 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	4.203SerAla: 4.203 ± 0.074	0.617SerCys: 0.617 ± 0.024	3.276SerAsp: 3.276 ± 0.068	4.645SerGlu: 4.645 ± 0.076	2.486SerPhe: 2.486 ± 0.06	4.308SerGly: 4.308 ± 0.073	1.401SerHis: 1.401 ± 0.041	3.433SerIle: 3.433 ± 0.072	2.589SerLys: 2.589 ± 0.055	7.382SerLeu: 7.382 ± 0.104	1.2SerMet: 1.2 ± 0.03	2.742SerAsn: 2.742 ± 0.054	3.68SerPro: 3.68 ± 0.067	4.006SerGln: 4.006 ± 0.065	3.188SerArg: 3.188 ± 0.069	4.618SerSer: 4.618 ± 0.079	2.909SerThr: 2.909 ± 0.05	3.661SerVal: 3.661 ± 0.068	0.946SerTrp: 0.946 ± 0.035	1.957SerTyr: 1.957 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	4.387ThrAla: 4.387 ± 0.066	0.513ThrCys: 0.513 ± 0.024	2.553ThrAsp: 2.553 ± 0.055	4.089ThrGlu: 4.089 ± 0.064	2.129ThrPhe: 2.129 ± 0.048	4.06ThrGly: 4.06 ± 0.084	0.975ThrHis: 0.975 ± 0.032	3.8ThrIle: 3.8 ± 0.059	2.125ThrLys: 2.125 ± 0.056	6.493ThrLeu: 6.493 ± 0.097	0.871ThrMet: 0.871 ± 0.031	2.014ThrAsn: 2.014 ± 0.052	3.392ThrPro: 3.392 ± 0.065	2.708ThrGln: 2.708 ± 0.056	2.45ThrArg: 2.45 ± 0.047	3.286ThrSer: 3.286 ± 0.055	3.204ThrThr: 3.204 ± 0.07	4.195ThrVal: 4.195 ± 0.059	0.709ThrTrp: 0.709 ± 0.031	1.664ThrTyr: 1.664 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	5.22ValAla: 5.22 ± 0.087	0.61ValCys: 0.61 ± 0.028	3.234ValAsp: 3.234 ± 0.064	4.901ValGlu: 4.901 ± 0.088	2.504ValPhe: 2.504 ± 0.05	4.751ValGly: 4.751 ± 0.081	0.921ValHis: 0.921 ± 0.035	4.675ValIle: 4.675 ± 0.075	3.292ValLys: 3.292 ± 0.065	6.118ValLeu: 6.118 ± 0.08	1.375ValMet: 1.375 ± 0.034	2.664ValAsn: 2.664 ± 0.053	2.676ValPro: 2.676 ± 0.054	2.608ValGln: 2.608 ± 0.052	3.093ValArg: 3.093 ± 0.066	4.3ValSer: 4.3 ± 0.068	3.884ValThr: 3.884 ± 0.069	4.446ValVal: 4.446 ± 0.079	0.79ValTrp: 0.79 ± 0.033	1.864ValTyr: 1.864 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.723TrpAla: 0.723 ± 0.031	0.145TrpCys: 0.145 ± 0.013	0.61TrpAsp: 0.61 ± 0.027	1.385TrpGlu: 1.385 ± 0.042	0.646TrpPhe: 0.646 ± 0.03	1.115TrpGly: 1.115 ± 0.042	0.31TrpHis: 0.31 ± 0.02	0.79TrpIle: 0.79 ± 0.031	0.635TrpLys: 0.635 ± 0.028	2.141TrpLeu: 2.141 ± 0.061	0.296TrpMet: 0.296 ± 0.022	0.58TrpAsn: 0.58 ± 0.03	0.198TrpPro: 0.198 ± 0.016	1.206TrpGln: 1.206 ± 0.038	0.806TrpArg: 0.806 ± 0.029	0.847TrpSer: 0.847 ± 0.031	0.535TrpThr: 0.535 ± 0.024	0.877TrpVal: 0.877 ± 0.029	0.254TrpTrp: 0.254 ± 0.018	0.415TrpTyr: 0.415 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.883TyrAla: 1.883 ± 0.042	0.425TyrCys: 0.425 ± 0.024	1.59TyrAsp: 1.59 ± 0.042	1.936TyrGlu: 1.936 ± 0.049	1.475TyrPhe: 1.475 ± 0.037	2.182TyrGly: 2.182 ± 0.044	0.755TyrHis: 0.755 ± 0.03	1.663TyrIle: 1.663 ± 0.047	1.075TyrLys: 1.075 ± 0.039	3.764TyrLeu: 3.764 ± 0.08	0.41TyrMet: 0.41 ± 0.024	1.217TyrAsn: 1.217 ± 0.037	1.735TyrPro: 1.735 ± 0.046	2.37TyrGln: 2.37 ± 0.063	1.993TyrArg: 1.993 ± 0.048	1.953TyrSer: 1.953 ± 0.045	1.389TyrThr: 1.389 ± 0.038	1.567TyrVal: 1.567 ± 0.043	0.549TyrTrp: 0.549 ± 0.027	1.213TyrTyr: 1.213 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3203 proteins (971495 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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