Amino acid dipepetide frequency for Shahe picorna-like virus 3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.255AlaAla: 4.255 ± 0.915
0.426AlaCys: 0.426 ± 0.226
7.234AlaAsp: 7.234 ± 1.15
3.404AlaGlu: 3.404 ± 0.462
2.553AlaPhe: 2.553 ± 1.341
5.957AlaGly: 5.957 ± 1.82
0.851AlaHis: 0.851 ± 0.897
5.532AlaIle: 5.532 ± 1.105
3.83AlaLys: 3.83 ± 0.013
5.957AlaLeu: 5.957 ± 0.471
2.553AlaMet: 2.553 ± 0.684
4.681AlaAsn: 4.681 ± 2.233
4.681AlaPro: 4.681 ± 0.883
1.702AlaGln: 1.702 ± 0.231
3.83AlaArg: 3.83 ± 0.013
8.936AlaSer: 8.936 ± 2.668
3.83AlaThr: 3.83 ± 0.661
7.234AlaVal: 7.234 ± 1.15
1.277AlaTrp: 1.277 ± 0.004
4.681AlaTyr: 4.681 ± 0.466
0.0AlaXaa: 0.0 ± 0.0
Cys
0.851CysAla: 0.851 ± 0.453
0.426CysCys: 0.426 ± 0.226
0.851CysAsp: 0.851 ± 0.222
1.702CysGlu: 1.702 ± 0.906
0.0CysPhe: 0.0 ± 0.0
1.277CysGly: 1.277 ± 0.67
0.0CysHis: 0.0 ± 0.0
0.426CysIle: 0.426 ± 0.448
0.851CysLys: 0.851 ± 0.222
1.702CysLeu: 1.702 ± 0.906
1.277CysMet: 1.277 ± 0.679
0.851CysAsn: 0.851 ± 0.453
1.277CysPro: 1.277 ± 0.004
0.426CysGln: 0.426 ± 0.226
0.0CysArg: 0.0 ± 0.0
1.277CysSer: 1.277 ± 0.679
1.277CysThr: 1.277 ± 0.679
2.553CysVal: 2.553 ± 0.684
0.0CysTrp: 0.0 ± 0.0
0.426CysTyr: 0.426 ± 0.226
0.0CysXaa: 0.0 ± 0.0
Asp
2.553AspAla: 2.553 ± 0.009
0.851AspCys: 0.851 ± 0.222
3.404AspAsp: 3.404 ± 0.462
2.979AspGlu: 2.979 ± 0.439
4.255AspPhe: 4.255 ± 1.785
1.702AspGly: 1.702 ± 0.231
1.702AspHis: 1.702 ± 0.906
4.255AspIle: 4.255 ± 0.24
2.979AspLys: 2.979 ± 1.585
5.106AspLeu: 5.106 ± 0.693
1.702AspMet: 1.702 ± 0.906
2.553AspAsn: 2.553 ± 1.341
2.979AspPro: 2.979 ± 0.439
0.426AspGln: 0.426 ± 0.226
2.553AspArg: 2.553 ± 0.684
3.83AspSer: 3.83 ± 2.011
2.128AspThr: 2.128 ± 0.457
5.957AspVal: 5.957 ± 0.471
0.851AspTrp: 0.851 ± 0.897
2.553AspTyr: 2.553 ± 0.684
0.0AspXaa: 0.0 ± 0.0
Glu
2.553GluAla: 2.553 ± 1.358
1.702GluCys: 1.702 ± 0.906
1.277GluAsp: 1.277 ± 1.345
2.553GluGlu: 2.553 ± 0.684
4.681GluPhe: 4.681 ± 1.816
1.277GluGly: 1.277 ± 0.679
0.426GluHis: 0.426 ± 0.226
2.128GluIle: 2.128 ± 0.457
2.979GluLys: 2.979 ± 1.585
4.681GluLeu: 4.681 ± 0.466
0.851GluMet: 0.851 ± 0.453
1.277GluAsn: 1.277 ± 0.004
2.128GluPro: 2.128 ± 1.132
0.851GluGln: 0.851 ± 0.453
4.255GluArg: 4.255 ± 0.24
2.979GluSer: 2.979 ± 0.439
2.979GluThr: 2.979 ± 0.91
2.553GluVal: 2.553 ± 0.009
0.426GluTrp: 0.426 ± 0.226
2.128GluTyr: 2.128 ± 0.892
0.0GluXaa: 0.0 ± 0.0
Phe
5.106PheAla: 5.106 ± 2.006
0.851PheCys: 0.851 ± 0.222
1.277PheAsp: 1.277 ± 0.679
2.553PheGlu: 2.553 ± 1.358
2.553PhePhe: 2.553 ± 0.666
1.702PheGly: 1.702 ± 0.231
1.702PheHis: 1.702 ± 0.231
2.128PheIle: 2.128 ± 0.218
3.83PheLys: 3.83 ± 1.363
3.404PheLeu: 3.404 ± 1.811
1.277PheMet: 1.277 ± 0.67
2.979PheAsn: 2.979 ± 0.439
2.553PhePro: 2.553 ± 0.666
0.426PheGln: 0.426 ± 0.448
0.851PheArg: 0.851 ± 0.222
4.255PheSer: 4.255 ± 0.24
3.83PheThr: 3.83 ± 0.661
4.255PheVal: 4.255 ± 0.24
0.851PheTrp: 0.851 ± 0.222
2.128PheTyr: 2.128 ± 0.218
0.0PheXaa: 0.0 ± 0.0
Gly
5.532GlyAla: 5.532 ± 0.244
1.277GlyCys: 1.277 ± 0.679
2.979GlyAsp: 2.979 ± 0.235
2.979GlyGlu: 2.979 ± 0.235
4.255GlyPhe: 4.255 ± 1.589
2.979GlyGly: 2.979 ± 1.789
1.277GlyHis: 1.277 ± 0.679
4.681GlyIle: 4.681 ± 1.141
1.702GlyLys: 1.702 ± 0.444
4.681GlyLeu: 4.681 ± 1.141
0.851GlyMet: 0.851 ± 0.453
3.83GlyAsn: 3.83 ± 1.336
3.404GlyPro: 3.404 ± 0.462
1.277GlyGln: 1.277 ± 0.679
2.128GlyArg: 2.128 ± 0.218
5.957GlySer: 5.957 ± 1.145
5.106GlyThr: 5.106 ± 1.332
7.234GlyVal: 7.234 ± 0.475
0.851GlyTrp: 0.851 ± 0.453
1.702GlyTyr: 1.702 ± 0.444
0.0GlyXaa: 0.0 ± 0.0
His
2.128HisAla: 2.128 ± 0.892
0.0HisCys: 0.0 ± 0.0
0.426HisAsp: 0.426 ± 0.226
0.0HisGlu: 0.0 ± 0.0
0.0HisPhe: 0.0 ± 0.0
1.277HisGly: 1.277 ± 0.679
0.426HisHis: 0.426 ± 0.226
2.128HisIle: 2.128 ± 1.132
2.128HisLys: 2.128 ± 1.132
2.128HisLeu: 2.128 ± 1.132
1.702HisMet: 1.702 ± 0.231
0.0HisAsn: 0.0 ± 0.0
0.426HisPro: 0.426 ± 0.226
0.0HisGln: 0.0 ± 0.0
1.277HisArg: 1.277 ± 0.004
0.851HisSer: 0.851 ± 0.453
1.702HisThr: 1.702 ± 0.906
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
1.702HisTyr: 1.702 ± 0.444
0.0HisXaa: 0.0 ± 0.0
Ile
6.383IleAla: 6.383 ± 0.697
0.851IleCys: 0.851 ± 0.453
5.106IleAsp: 5.106 ± 0.018
3.83IleGlu: 3.83 ± 0.688
0.426IlePhe: 0.426 ± 0.448
3.83IleGly: 3.83 ± 0.661
0.426IleHis: 0.426 ± 0.226
3.83IleIle: 3.83 ± 0.661
3.404IleLys: 3.404 ± 0.462
3.83IleLeu: 3.83 ± 1.363
0.0IleMet: 0.0 ± 0.0
4.255IleAsn: 4.255 ± 2.459
2.979IlePro: 2.979 ± 1.114
0.851IleGln: 0.851 ± 0.453
1.702IleArg: 1.702 ± 0.231
10.213IleSer: 10.213 ± 2.663
3.404IleThr: 3.404 ± 0.213
4.681IleVal: 4.681 ± 0.209
1.702IleTrp: 1.702 ± 0.231
1.702IleTyr: 1.702 ± 0.444
0.0IleXaa: 0.0 ± 0.0
Lys
3.404LysAla: 3.404 ± 1.811
0.426LysCys: 0.426 ± 0.226
3.404LysAsp: 3.404 ± 1.136
1.277LysGlu: 1.277 ± 0.679
3.83LysPhe: 3.83 ± 0.688
2.553LysGly: 2.553 ± 1.358
0.851LysHis: 0.851 ± 0.453
1.277LysIle: 1.277 ± 0.67
2.128LysLys: 2.128 ± 1.132
5.532LysLeu: 5.532 ± 1.78
1.277LysMet: 1.277 ± 0.679
1.702LysAsn: 1.702 ± 0.231
2.553LysPro: 2.553 ± 1.358
1.277LysGln: 1.277 ± 0.004
2.553LysArg: 2.553 ± 0.009
2.128LysSer: 2.128 ± 1.132
1.277LysThr: 1.277 ± 0.004
5.532LysVal: 5.532 ± 2.268
0.0LysTrp: 0.0 ± 0.0
4.255LysTyr: 4.255 ± 0.915
0.0LysXaa: 0.0 ± 0.0
Leu
6.809LeuAla: 6.809 ± 1.776
1.277LeuCys: 1.277 ± 0.679
3.83LeuAsp: 3.83 ± 0.013
6.383LeuGlu: 6.383 ± 1.372
3.404LeuPhe: 3.404 ± 0.462
4.681LeuGly: 4.681 ± 0.209
2.979LeuHis: 2.979 ± 0.91
2.979LeuIle: 2.979 ± 0.235
4.681LeuLys: 4.681 ± 1.141
7.66LeuLeu: 7.66 ± 0.701
1.702LeuMet: 1.702 ± 0.266
2.979LeuAsn: 2.979 ± 0.91
4.255LeuPro: 4.255 ± 3.134
3.404LeuGln: 3.404 ± 1.811
6.383LeuArg: 6.383 ± 1.372
5.532LeuSer: 5.532 ± 0.431
5.532LeuThr: 5.532 ± 0.431
3.404LeuVal: 3.404 ± 0.462
0.0LeuTrp: 0.0 ± 0.0
1.277LeuTyr: 1.277 ± 0.679
0.0LeuXaa: 0.0 ± 0.0
Met
2.979MetAla: 2.979 ± 0.235
0.851MetCys: 0.851 ± 0.453
0.851MetAsp: 0.851 ± 0.453
0.426MetGlu: 0.426 ± 0.448
0.851MetPhe: 0.851 ± 0.897
3.83MetGly: 3.83 ± 1.363
0.0MetHis: 0.0 ± 0.0
3.404MetIle: 3.404 ± 1.136
0.426MetLys: 0.426 ± 0.226
0.851MetLeu: 0.851 ± 0.222
0.426MetMet: 0.426 ± 0.226
1.702MetAsn: 1.702 ± 0.231
0.426MetPro: 0.426 ± 0.226
0.851MetGln: 0.851 ± 0.222
1.702MetArg: 1.702 ± 0.444
1.702MetSer: 1.702 ± 0.231
2.128MetThr: 2.128 ± 0.892
1.277MetVal: 1.277 ± 0.679
0.426MetTrp: 0.426 ± 0.226
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.553AsnAla: 2.553 ± 0.684
1.702AsnCys: 1.702 ± 0.444
2.553AsnAsp: 2.553 ± 0.009
1.702AsnGlu: 1.702 ± 0.231
4.681AsnPhe: 4.681 ± 1.141
2.979AsnGly: 2.979 ± 0.439
0.426AsnHis: 0.426 ± 0.226
3.404AsnIle: 3.404 ± 0.213
1.702AsnLys: 1.702 ± 0.231
3.83AsnLeu: 3.83 ± 0.688
0.851AsnMet: 0.851 ± 0.222
2.979AsnAsn: 2.979 ± 0.235
1.702AsnPro: 1.702 ± 1.793
0.851AsnGln: 0.851 ± 0.222
2.128AsnArg: 2.128 ± 0.892
2.979AsnSer: 2.979 ± 1.789
4.681AsnThr: 4.681 ± 0.209
4.681AsnVal: 4.681 ± 0.883
0.426AsnTrp: 0.426 ± 0.226
1.277AsnTyr: 1.277 ± 0.679
0.0AsnXaa: 0.0 ± 0.0
Pro
4.255ProAla: 4.255 ± 1.785
0.0ProCys: 0.0 ± 0.0
2.553ProAsp: 2.553 ± 0.684
1.702ProGlu: 1.702 ± 0.906
4.255ProPhe: 4.255 ± 0.435
2.553ProGly: 2.553 ± 0.684
0.426ProHis: 0.426 ± 0.226
3.83ProIle: 3.83 ± 2.011
1.277ProLys: 1.277 ± 0.679
5.957ProLeu: 5.957 ± 0.204
0.0ProMet: 0.0 ± 0.0
0.851ProAsn: 0.851 ± 0.222
1.702ProPro: 1.702 ± 1.119
2.128ProGln: 2.128 ± 1.567
1.702ProArg: 1.702 ± 0.444
2.979ProSer: 2.979 ± 0.439
3.404ProThr: 3.404 ± 2.237
5.106ProVal: 5.106 ± 1.332
1.702ProTrp: 1.702 ± 0.444
2.979ProTyr: 2.979 ± 0.439
0.0ProXaa: 0.0 ± 0.0
Gln
1.277GlnAla: 1.277 ± 0.679
0.426GlnCys: 0.426 ± 0.226
1.277GlnAsp: 1.277 ± 0.004
0.851GlnGlu: 0.851 ± 0.222
0.0GlnPhe: 0.0 ± 0.0
2.128GlnGly: 2.128 ± 0.457
0.426GlnHis: 0.426 ± 0.226
1.702GlnIle: 1.702 ± 0.444
0.426GlnLys: 0.426 ± 0.226
2.553GlnLeu: 2.553 ± 0.666
0.851GlnMet: 0.851 ± 0.222
0.851GlnAsn: 0.851 ± 0.453
1.277GlnPro: 1.277 ± 0.67
0.851GlnGln: 0.851 ± 0.222
1.277GlnArg: 1.277 ± 0.004
2.979GlnSer: 2.979 ± 1.114
0.0GlnThr: 0.0 ± 0.0
2.553GlnVal: 2.553 ± 0.684
0.426GlnTrp: 0.426 ± 0.226
0.851GlnTyr: 0.851 ± 0.453
0.0GlnXaa: 0.0 ± 0.0
Arg
4.681ArgAla: 4.681 ± 1.141
0.851ArgCys: 0.851 ± 0.453
2.128ArgAsp: 2.128 ± 0.218
0.851ArgGlu: 0.851 ± 0.453
1.702ArgPhe: 1.702 ± 0.444
4.681ArgGly: 4.681 ± 0.209
0.851ArgHis: 0.851 ± 0.222
3.404ArgIle: 3.404 ± 0.213
2.553ArgLys: 2.553 ± 1.358
1.702ArgLeu: 1.702 ± 0.444
1.702ArgMet: 1.702 ± 0.444
0.0ArgAsn: 0.0 ± 0.0
2.553ArgPro: 2.553 ± 0.666
1.277ArgGln: 1.277 ± 0.67
2.128ArgArg: 2.128 ± 0.457
4.681ArgSer: 4.681 ± 0.209
2.553ArgThr: 2.553 ± 0.684
3.83ArgVal: 3.83 ± 0.013
0.851ArgTrp: 0.851 ± 0.453
3.83ArgTyr: 3.83 ± 1.336
0.0ArgXaa: 0.0 ± 0.0
Ser
11.064SerAla: 11.064 ± 2.211
1.702SerCys: 1.702 ± 0.231
4.255SerAsp: 4.255 ± 2.459
3.404SerGlu: 3.404 ± 1.811
3.404SerPhe: 3.404 ± 0.213
5.957SerGly: 5.957 ± 1.554
1.277SerHis: 1.277 ± 0.679
6.383SerIle: 6.383 ± 2.677
3.83SerLys: 3.83 ± 0.013
7.66SerLeu: 7.66 ± 0.027
2.128SerMet: 2.128 ± 0.792
3.83SerAsn: 3.83 ± 1.363
5.532SerPro: 5.532 ± 0.431
2.553SerGln: 2.553 ± 2.015
2.553SerArg: 2.553 ± 0.009
7.234SerSer: 7.234 ± 2.899
5.106SerThr: 5.106 ± 2.006
6.383SerVal: 6.383 ± 1.327
1.277SerTrp: 1.277 ± 0.67
2.979SerTyr: 2.979 ± 0.439
0.0SerXaa: 0.0 ± 0.0
Thr
3.83ThrAla: 3.83 ± 0.661
0.426ThrCys: 0.426 ± 0.226
4.681ThrAsp: 4.681 ± 0.466
0.851ThrGlu: 0.851 ± 0.453
3.404ThrPhe: 3.404 ± 0.213
5.532ThrGly: 5.532 ± 0.244
1.702ThrHis: 1.702 ± 0.906
5.532ThrIle: 5.532 ± 0.244
2.128ThrLys: 2.128 ± 0.457
2.553ThrLeu: 2.553 ± 0.666
2.128ThrMet: 2.128 ± 0.218
2.553ThrAsn: 2.553 ± 0.666
4.255ThrPro: 4.255 ± 1.11
1.277ThrGln: 1.277 ± 0.679
1.702ThrArg: 1.702 ± 0.231
6.809ThrSer: 6.809 ± 1.776
4.681ThrThr: 4.681 ± 2.233
4.255ThrVal: 4.255 ± 1.785
0.426ThrTrp: 0.426 ± 0.226
3.404ThrTyr: 3.404 ± 0.888
0.0ThrXaa: 0.0 ± 0.0
Val
8.936ValAla: 8.936 ± 1.318
2.128ValCys: 2.128 ± 0.457
3.404ValAsp: 3.404 ± 0.213
3.83ValGlu: 3.83 ± 0.013
2.128ValPhe: 2.128 ± 0.218
7.234ValGly: 7.234 ± 1.15
1.702ValHis: 1.702 ± 0.231
3.83ValIle: 3.83 ± 0.661
4.681ValLys: 4.681 ± 0.466
5.106ValLeu: 5.106 ± 0.018
1.702ValMet: 1.702 ± 0.906
5.532ValAsn: 5.532 ± 1.594
2.979ValPro: 2.979 ± 1.114
1.277ValGln: 1.277 ± 0.679
4.681ValArg: 4.681 ± 0.209
8.085ValSer: 8.085 ± 0.422
4.681ValThr: 4.681 ± 0.466
3.404ValVal: 3.404 ± 0.213
1.702ValTrp: 1.702 ± 0.231
2.553ValTyr: 2.553 ± 0.666
0.0ValXaa: 0.0 ± 0.0
Trp
1.702TrpAla: 1.702 ± 0.444
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.851TrpGlu: 0.851 ± 0.222
1.277TrpPhe: 1.277 ± 0.004
0.426TrpGly: 0.426 ± 0.226
0.851TrpHis: 0.851 ± 0.222
0.426TrpIle: 0.426 ± 0.226
0.851TrpLys: 0.851 ± 0.453
0.851TrpLeu: 0.851 ± 0.222
0.0TrpMet: 0.0 ± 0.0
1.702TrpAsn: 1.702 ± 0.906
0.426TrpPro: 0.426 ± 0.226
0.0TrpGln: 0.0 ± 0.0
0.426TrpArg: 0.426 ± 0.448
1.277TrpSer: 1.277 ± 0.67
0.851TrpThr: 0.851 ± 0.222
1.277TrpVal: 1.277 ± 0.679
0.0TrpTrp: 0.0 ± 0.0
0.426TrpTyr: 0.426 ± 0.226
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.553TyrAla: 2.553 ± 0.684
1.277TyrCys: 1.277 ± 0.004
3.83TyrAsp: 3.83 ± 0.661
2.553TyrGlu: 2.553 ± 0.009
0.851TyrPhe: 0.851 ± 0.453
2.128TyrGly: 2.128 ± 0.457
0.0TyrHis: 0.0 ± 0.0
2.128TyrIle: 2.128 ± 0.457
0.851TyrLys: 0.851 ± 0.222
3.404TyrLeu: 3.404 ± 0.888
1.702TyrMet: 1.702 ± 0.231
2.979TyrAsn: 2.979 ± 0.439
1.277TyrPro: 1.277 ± 0.004
1.277TyrGln: 1.277 ± 0.004
2.979TyrArg: 2.979 ± 0.439
4.255TyrSer: 4.255 ± 1.785
2.979TyrThr: 2.979 ± 0.91
3.404TyrVal: 3.404 ± 0.888
0.426TyrTrp: 0.426 ± 0.226
0.851TyrTyr: 0.851 ± 0.897
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2351 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski