Amino acid dipepetide frequency for Thauera terpenica 58Eu

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.402AlaAla: 17.402 ± 0.188	1.338AlaCys: 1.338 ± 0.037	7.061AlaAsp: 7.061 ± 0.087	7.705AlaGlu: 7.705 ± 0.092	4.094AlaPhe: 4.094 ± 0.067	10.223AlaGly: 10.223 ± 0.108	2.84AlaHis: 2.84 ± 0.053	5.513AlaIle: 5.513 ± 0.073	3.155AlaLys: 3.155 ± 0.073	15.715AlaLeu: 15.715 ± 0.157	3.342AlaMet: 3.342 ± 0.053	2.793AlaAsn: 2.793 ± 0.056	5.441AlaPro: 5.441 ± 0.085	5.313AlaGln: 5.313 ± 0.064	9.9AlaArg: 9.9 ± 0.115	6.573AlaSer: 6.573 ± 0.089	5.551AlaThr: 5.551 ± 0.069	8.799AlaVal: 8.799 ± 0.089	1.778AlaTrp: 1.778 ± 0.042	2.518AlaTyr: 2.518 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.217CysAla: 1.217 ± 0.035	0.134CysCys: 0.134 ± 0.01	0.567CysAsp: 0.567 ± 0.021	0.557CysGlu: 0.557 ± 0.024	0.325CysPhe: 0.325 ± 0.014	1.007CysGly: 1.007 ± 0.028	0.312CysHis: 0.312 ± 0.019	0.428CysIle: 0.428 ± 0.019	0.236CysLys: 0.236 ± 0.012	0.874CysLeu: 0.874 ± 0.031	0.181CysMet: 0.181 ± 0.012	0.25CysAsn: 0.25 ± 0.014	0.504CysPro: 0.504 ± 0.021	0.252CysGln: 0.252 ± 0.014	0.691CysArg: 0.691 ± 0.027	0.543CysSer: 0.543 ± 0.021	0.468CysThr: 0.468 ± 0.022	0.711CysVal: 0.711 ± 0.024	0.137CysTrp: 0.137 ± 0.01	0.222CysTyr: 0.222 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.262AspAla: 7.262 ± 0.081	0.511AspCys: 0.511 ± 0.024	3.001AspAsp: 3.001 ± 0.054	3.84AspGlu: 3.84 ± 0.059	2.264AspPhe: 2.264 ± 0.046	4.76AspGly: 4.76 ± 0.111	1.162AspHis: 1.162 ± 0.037	2.689AspIle: 2.689 ± 0.057	1.83AspLys: 1.83 ± 0.045	5.31AspLeu: 5.31 ± 0.068	1.276AspMet: 1.276 ± 0.033	1.242AspAsn: 1.242 ± 0.03	2.82AspPro: 2.82 ± 0.05	1.588AspGln: 1.588 ± 0.037	3.492AspArg: 3.492 ± 0.059	2.571AspSer: 2.571 ± 0.051	2.669AspThr: 2.669 ± 0.049	3.812AspVal: 3.812 ± 0.059	1.028AspTrp: 1.028 ± 0.029	1.531AspTyr: 1.531 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	7.65GluAla: 7.65 ± 0.084	0.475GluCys: 0.475 ± 0.021	2.765GluAsp: 2.765 ± 0.045	2.836GluGlu: 2.836 ± 0.057	1.886GluPhe: 1.886 ± 0.044	4.207GluGly: 4.207 ± 0.059	1.681GluHis: 1.681 ± 0.036	3.169GluIle: 3.169 ± 0.061	1.876GluLys: 1.876 ± 0.044	7.207GluLeu: 7.207 ± 0.084	1.371GluMet: 1.371 ± 0.034	1.316GluAsn: 1.316 ± 0.033	2.536GluPro: 2.536 ± 0.057	2.729GluGln: 2.729 ± 0.052	5.518GluArg: 5.518 ± 0.069	2.695GluSer: 2.695 ± 0.051	2.689GluThr: 2.689 ± 0.043	4.584GluVal: 4.584 ± 0.057	0.752GluTrp: 0.752 ± 0.029	1.132GluTyr: 1.132 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.466PheAla: 4.466 ± 0.069	0.41PheCys: 0.41 ± 0.021	2.517PheAsp: 2.517 ± 0.044	2.327PheGlu: 2.327 ± 0.045	1.415PhePhe: 1.415 ± 0.04	3.415PheGly: 3.415 ± 0.053	0.776PheHis: 0.776 ± 0.026	1.738PheIle: 1.738 ± 0.038	1.041PheLys: 1.041 ± 0.034	3.1PheLeu: 3.1 ± 0.053	0.825PheMet: 0.825 ± 0.028	1.109PheAsn: 1.109 ± 0.034	1.448PhePro: 1.448 ± 0.032	0.979PheGln: 0.979 ± 0.03	2.195PheArg: 2.195 ± 0.046	2.183PheSer: 2.183 ± 0.045	1.726PheThr: 1.726 ± 0.033	2.936PheVal: 2.936 ± 0.056	0.533PheTrp: 0.533 ± 0.021	0.864PheTyr: 0.864 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	8.856GlyAla: 8.856 ± 0.105	0.897GlyCys: 0.897 ± 0.028	4.015GlyAsp: 4.015 ± 0.058	5.211GlyGlu: 5.211 ± 0.071	3.348GlyPhe: 3.348 ± 0.054	6.651GlyGly: 6.651 ± 0.109	1.782GlyHis: 1.782 ± 0.036	4.005GlyIle: 4.005 ± 0.066	3.157GlyLys: 3.157 ± 0.058	9.05GlyLeu: 9.05 ± 0.092	2.303GlyMet: 2.303 ± 0.049	1.95GlyAsn: 1.95 ± 0.049	2.593GlyPro: 2.593 ± 0.047	2.948GlyGln: 2.948 ± 0.058	5.83GlyArg: 5.83 ± 0.066	4.431GlySer: 4.431 ± 0.096	3.734GlyThr: 3.734 ± 0.059	6.5GlyVal: 6.5 ± 0.084	1.333GlyTrp: 1.333 ± 0.032	2.09GlyTyr: 2.09 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.959HisAla: 2.959 ± 0.05	0.315HisCys: 0.315 ± 0.016	1.308HisAsp: 1.308 ± 0.03	1.256HisGlu: 1.256 ± 0.033	0.996HisPhe: 0.996 ± 0.03	2.13HisGly: 2.13 ± 0.045	0.663HisHis: 0.663 ± 0.023	1.053HisIle: 1.053 ± 0.03	0.618HisLys: 0.618 ± 0.022	2.406HisLeu: 2.406 ± 0.043	0.511HisMet: 0.511 ± 0.026	0.528HisAsn: 0.528 ± 0.022	1.513HisPro: 1.513 ± 0.039	0.717HisGln: 0.717 ± 0.024	1.565HisArg: 1.565 ± 0.042	1.114HisSer: 1.114 ± 0.033	1.101HisThr: 1.101 ± 0.032	1.527HisVal: 1.527 ± 0.043	0.386HisTrp: 0.386 ± 0.018	0.718HisTyr: 0.718 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.382IleAla: 6.382 ± 0.084	0.43IleCys: 0.43 ± 0.018	3.438IleAsp: 3.438 ± 0.057	3.671IleGlu: 3.671 ± 0.058	1.423IlePhe: 1.423 ± 0.035	4.404IleGly: 4.404 ± 0.062	1.006IleHis: 1.006 ± 0.028	1.958IleIle: 1.958 ± 0.044	1.555IleLys: 1.555 ± 0.036	3.755IleLeu: 3.755 ± 0.061	0.858IleMet: 0.858 ± 0.029	1.433IleAsn: 1.433 ± 0.038	2.074IlePro: 2.074 ± 0.039	1.277IleGln: 1.277 ± 0.031	2.985IleArg: 2.985 ± 0.053	2.567IleSer: 2.567 ± 0.047	2.517IleThr: 2.517 ± 0.043	3.776IleVal: 3.776 ± 0.051	0.468IleTrp: 0.468 ± 0.021	0.987IleTyr: 0.987 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.848LysAla: 3.848 ± 0.072	0.185LysCys: 0.185 ± 0.012	1.58LysAsp: 1.58 ± 0.041	1.47LysGlu: 1.47 ± 0.041	0.836LysPhe: 0.836 ± 0.027	2.32LysGly: 2.32 ± 0.046	0.717LysHis: 0.717 ± 0.024	1.385LysIle: 1.385 ± 0.039	1.114LysLys: 1.114 ± 0.03	3.445LysLeu: 3.445 ± 0.058	0.769LysMet: 0.769 ± 0.026	0.81LysAsn: 0.81 ± 0.026	1.842LysPro: 1.842 ± 0.043	1.141LysGln: 1.141 ± 0.034	2.288LysArg: 2.288 ± 0.047	1.595LysSer: 1.595 ± 0.043	1.653LysThr: 1.653 ± 0.038	2.409LysVal: 2.409 ± 0.055	0.331LysTrp: 0.331 ± 0.014	0.601LysTyr: 0.601 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	15.432LeuAla: 15.432 ± 0.134	1.045LeuCys: 1.045 ± 0.028	6.4LeuAsp: 6.4 ± 0.076	6.37LeuGlu: 6.37 ± 0.075	3.764LeuPhe: 3.764 ± 0.051	8.945LeuGly: 8.945 ± 0.108	2.46LeuHis: 2.46 ± 0.046	5.147LeuIle: 5.147 ± 0.07	3.502LeuLys: 3.502 ± 0.064	11.82LeuLeu: 11.82 ± 0.142	2.613LeuMet: 2.613 ± 0.053	2.773LeuAsn: 2.773 ± 0.05	6.144LeuPro: 6.144 ± 0.081	3.945LeuGln: 3.945 ± 0.067	8.219LeuArg: 8.219 ± 0.107	6.74LeuSer: 6.74 ± 0.085	5.191LeuThr: 5.191 ± 0.063	7.722LeuVal: 7.722 ± 0.093	1.251LeuTrp: 1.251 ± 0.042	2.112LeuTyr: 2.112 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.878MetAla: 2.878 ± 0.051	0.193MetCys: 0.193 ± 0.014	1.132MetAsp: 1.132 ± 0.03	1.183MetGlu: 1.183 ± 0.03	0.757MetPhe: 0.757 ± 0.028	1.771MetGly: 1.771 ± 0.047	0.537MetHis: 0.537 ± 0.021	1.151MetIle: 1.151 ± 0.029	1.036MetLys: 1.036 ± 0.032	2.869MetLeu: 2.869 ± 0.051	0.699MetMet: 0.699 ± 0.025	0.854MetAsn: 0.854 ± 0.027	1.406MetPro: 1.406 ± 0.038	1.032MetGln: 1.032 ± 0.027	1.811MetArg: 1.811 ± 0.037	1.689MetSer: 1.689 ± 0.037	1.388MetThr: 1.388 ± 0.036	1.682MetVal: 1.682 ± 0.037	0.231MetTrp: 0.231 ± 0.013	0.374MetTyr: 0.374 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.063AsnAla: 3.063 ± 0.054	0.274AsnCys: 0.274 ± 0.015	1.221AsnAsp: 1.221 ± 0.035	1.29AsnGlu: 1.29 ± 0.036	0.919AsnPhe: 0.919 ± 0.026	1.983AsnGly: 1.983 ± 0.05	0.523AsnHis: 0.523 ± 0.02	1.234AsnIle: 1.234 ± 0.038	0.827AsnLys: 0.827 ± 0.029	2.677AsnLeu: 2.677 ± 0.045	0.581AsnMet: 0.581 ± 0.022	0.692AsnAsn: 0.692 ± 0.029	1.728AsnPro: 1.728 ± 0.034	0.798AsnGln: 0.798 ± 0.03	1.733AsnArg: 1.733 ± 0.043	1.088AsnSer: 1.088 ± 0.033	1.416AsnThr: 1.416 ± 0.043	1.764AsnVal: 1.764 ± 0.036	0.427AsnTrp: 0.427 ± 0.018	0.672AsnTyr: 0.672 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	6.683ProAla: 6.683 ± 0.092	0.378ProCys: 0.378 ± 0.019	2.988ProAsp: 2.988 ± 0.051	3.523ProGlu: 3.523 ± 0.058	1.74ProPhe: 1.74 ± 0.04	4.052ProGly: 4.052 ± 0.063	1.073ProHis: 1.073 ± 0.035	1.985ProIle: 1.985 ± 0.042	1.286ProLys: 1.286 ± 0.034	5.048ProLeu: 5.048 ± 0.076	1.202ProMet: 1.202 ± 0.031	1.181ProAsn: 1.181 ± 0.031	2.432ProPro: 2.432 ± 0.055	1.833ProGln: 1.833 ± 0.041	2.891ProArg: 2.891 ± 0.049	2.523ProSer: 2.523 ± 0.049	2.354ProThr: 2.354 ± 0.042	3.763ProVal: 3.763 ± 0.053	0.697ProTrp: 0.697 ± 0.026	1.053ProTyr: 1.053 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	5.127GlnAla: 5.127 ± 0.073	0.287GlnCys: 0.287 ± 0.017	1.577GlnAsp: 1.577 ± 0.038	1.57GlnGlu: 1.57 ± 0.037	1.153GlnPhe: 1.153 ± 0.032	2.771GlnGly: 2.771 ± 0.05	0.959GlnHis: 0.959 ± 0.029	1.778GlnIle: 1.778 ± 0.039	0.995GlnLys: 0.995 ± 0.03	4.142GlnLeu: 4.142 ± 0.068	0.911GlnMet: 0.911 ± 0.024	0.759GlnAsn: 0.759 ± 0.025	1.898GlnPro: 1.898 ± 0.037	1.695GlnGln: 1.695 ± 0.052	3.362GlnArg: 3.362 ± 0.053	1.739GlnSer: 1.739 ± 0.04	1.767GlnThr: 1.767 ± 0.038	2.704GlnVal: 2.704 ± 0.043	0.575GlnTrp: 0.575 ± 0.022	0.703GlnTyr: 0.703 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	8.419ArgAla: 8.419 ± 0.102	0.661ArgCys: 0.661 ± 0.027	3.892ArgAsp: 3.892 ± 0.063	4.699ArgGlu: 4.699 ± 0.064	3.065ArgPhe: 3.065 ± 0.051	4.703ArgGly: 4.703 ± 0.064	2.025ArgHis: 2.025 ± 0.043	3.95ArgIle: 3.95 ± 0.065	2.325ArgLys: 2.325 ± 0.049	8.848ArgLeu: 8.848 ± 0.125	2.012ArgMet: 2.012 ± 0.046	1.958ArgAsn: 1.958 ± 0.038	3.201ArgPro: 3.201 ± 0.062	2.872ArgGln: 2.872 ± 0.054	5.644ArgArg: 5.644 ± 0.091	3.908ArgSer: 3.908 ± 0.06	3.162ArgThr: 3.162 ± 0.057	5.276ArgVal: 5.276 ± 0.069	1.107ArgTrp: 1.107 ± 0.033	1.972ArgTyr: 1.972 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	7.085SerAla: 7.085 ± 0.086	0.493SerCys: 0.493 ± 0.023	2.673SerAsp: 2.673 ± 0.044	2.701SerGlu: 2.701 ± 0.06	2.121SerPhe: 2.121 ± 0.039	5.121SerGly: 5.121 ± 0.073	1.202SerHis: 1.202 ± 0.029	2.542SerIle: 2.542 ± 0.043	1.431SerLys: 1.431 ± 0.04	5.769SerLeu: 5.769 ± 0.079	1.424SerMet: 1.424 ± 0.033	1.356SerAsn: 1.356 ± 0.036	2.718SerPro: 2.718 ± 0.044	1.67SerGln: 1.67 ± 0.039	3.633SerArg: 3.633 ± 0.054	3.005SerSer: 3.005 ± 0.057	2.879SerThr: 2.879 ± 0.045	3.876SerVal: 3.876 ± 0.064	0.75SerTrp: 0.75 ± 0.024	1.198SerTyr: 1.198 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	5.534ThrAla: 5.534 ± 0.065	0.406ThrCys: 0.406 ± 0.018	2.52ThrAsp: 2.52 ± 0.052	2.593ThrGlu: 2.593 ± 0.052	1.511ThrPhe: 1.511 ± 0.038	4.005ThrGly: 4.005 ± 0.068	1.185ThrHis: 1.185 ± 0.034	2.075ThrIle: 2.075 ± 0.041	1.084ThrLys: 1.084 ± 0.034	6.327ThrLeu: 6.327 ± 0.081	1.026ThrMet: 1.026 ± 0.028	1.112ThrAsn: 1.112 ± 0.034	3.143ThrPro: 3.143 ± 0.049	1.726ThrGln: 1.726 ± 0.04	3.437ThrArg: 3.437 ± 0.053	2.345ThrSer: 2.345 ± 0.045	2.463ThrThr: 2.463 ± 0.047	3.892ThrVal: 3.892 ± 0.066	0.599ThrTrp: 0.599 ± 0.024	0.995ThrTyr: 0.995 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	8.93ValAla: 8.93 ± 0.102	0.773ValCys: 0.773 ± 0.029	4.194ValAsp: 4.194 ± 0.06	4.491ValGlu: 4.491 ± 0.06	2.937ValPhe: 2.937 ± 0.052	5.431ValGly: 5.431 ± 0.067	1.612ValHis: 1.612 ± 0.035	3.67ValIle: 3.67 ± 0.056	2.204ValLys: 2.204 ± 0.046	8.71ValLeu: 8.71 ± 0.095	1.928ValMet: 1.928 ± 0.046	1.831ValAsn: 1.831 ± 0.053	3.499ValPro: 3.499 ± 0.056	2.437ValGln: 2.437 ± 0.04	5.375ValArg: 5.375 ± 0.07	4.435ValSer: 4.435 ± 0.064	3.519ValThr: 3.519 ± 0.062	6.161ValVal: 6.161 ± 0.092	0.944ValTrp: 0.944 ± 0.031	1.442ValTyr: 1.442 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.286TrpAla: 1.286 ± 0.034	0.162TrpCys: 0.162 ± 0.011	0.611TrpAsp: 0.611 ± 0.024	0.627TrpGlu: 0.627 ± 0.025	0.521TrpPhe: 0.521 ± 0.023	0.872TrpGly: 0.872 ± 0.034	0.353TrpHis: 0.353 ± 0.018	0.668TrpIle: 0.668 ± 0.025	0.471TrpLys: 0.471 ± 0.02	2.067TrpLeu: 2.067 ± 0.043	0.416TrpMet: 0.416 ± 0.022	0.394TrpAsn: 0.394 ± 0.018	0.649TrpPro: 0.649 ± 0.025	0.695TrpGln: 0.695 ± 0.027	1.222TrpArg: 1.222 ± 0.036	0.769TrpSer: 0.769 ± 0.025	0.603TrpThr: 0.603 ± 0.025	1.021TrpVal: 1.021 ± 0.031	0.239TrpTrp: 0.239 ± 0.015	0.287TrpTyr: 0.287 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.574TyrAla: 2.574 ± 0.049	0.249TyrCys: 0.249 ± 0.015	1.199TyrAsp: 1.199 ± 0.04	1.155TyrGlu: 1.155 ± 0.032	0.928TyrPhe: 0.928 ± 0.03	1.915TyrGly: 1.915 ± 0.046	0.516TyrHis: 0.516 ± 0.022	0.825TyrIle: 0.825 ± 0.022	0.597TyrLys: 0.597 ± 0.021	2.455TyrLeu: 2.455 ± 0.045	0.423TyrMet: 0.423 ± 0.019	0.571TyrAsn: 0.571 ± 0.022	1.096TyrPro: 1.096 ± 0.027	0.826TyrGln: 0.826 ± 0.032	1.91TyrArg: 1.91 ± 0.037	1.135TyrSer: 1.135 ± 0.032	1.127TyrThr: 1.127 ± 0.029	1.608TyrVal: 1.608 ± 0.036	0.364TyrTrp: 0.364 ± 0.018	0.629TyrTyr: 0.629 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3813 proteins (1232099 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---