Amino acid dipepetide frequency for Streptomyces uncialis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.093AlaAla: 21.093 ± 0.144	0.972AlaCys: 0.972 ± 0.018	8.71AlaAsp: 8.71 ± 0.071	8.429AlaGlu: 8.429 ± 0.087	3.465AlaPhe: 3.465 ± 0.039	13.359AlaGly: 13.359 ± 0.1	2.839AlaHis: 2.839 ± 0.042	3.144AlaIle: 3.144 ± 0.044	2.57AlaLys: 2.57 ± 0.045	14.868AlaLeu: 14.868 ± 0.122	2.392AlaMet: 2.392 ± 0.035	1.681AlaAsn: 1.681 ± 0.032	7.782AlaPro: 7.782 ± 0.093	3.455AlaGln: 3.455 ± 0.044	11.275AlaArg: 11.275 ± 0.096	5.634AlaSer: 5.634 ± 0.051	7.139AlaThr: 7.139 ± 0.067	12.551AlaVal: 12.551 ± 0.092	1.74AlaTrp: 1.74 ± 0.029	2.654AlaTyr: 2.654 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.091CysAla: 1.091 ± 0.023	0.088CysCys: 0.088 ± 0.006	0.482CysAsp: 0.482 ± 0.014	0.388CysGlu: 0.388 ± 0.014	0.196CysPhe: 0.196 ± 0.011	0.967CysGly: 0.967 ± 0.02	0.183CysHis: 0.183 ± 0.008	0.116CysIle: 0.116 ± 0.007	0.102CysLys: 0.102 ± 0.006	0.703CysLeu: 0.703 ± 0.02	0.107CysMet: 0.107 ± 0.007	0.119CysAsn: 0.119 ± 0.007	0.477CysPro: 0.477 ± 0.016	0.139CysGln: 0.139 ± 0.008	0.619CysArg: 0.619 ± 0.019	0.382CysSer: 0.382 ± 0.015	0.417CysThr: 0.417 ± 0.015	0.717CysVal: 0.717 ± 0.019	0.114CysTrp: 0.114 ± 0.008	0.134CysTyr: 0.134 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.675AspAla: 7.675 ± 0.063	0.406AspCys: 0.406 ± 0.016	3.764AspAsp: 3.764 ± 0.045	3.889AspGlu: 3.889 ± 0.051	1.598AspPhe: 1.598 ± 0.029	6.994AspGly: 6.994 ± 0.063	1.506AspHis: 1.506 ± 0.032	1.985AspIle: 1.985 ± 0.037	1.13AspLys: 1.13 ± 0.027	6.262AspLeu: 6.262 ± 0.064	0.846AspMet: 0.846 ± 0.018	0.895AspAsn: 0.895 ± 0.022	4.947AspPro: 4.947 ± 0.05	1.524AspGln: 1.524 ± 0.025	5.364AspArg: 5.364 ± 0.055	2.62AspSer: 2.62 ± 0.036	3.638AspThr: 3.638 ± 0.049	4.329AspVal: 4.329 ± 0.046	1.036AspTrp: 1.036 ± 0.024	0.991AspTyr: 0.991 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	6.854GluAla: 6.854 ± 0.079	0.363GluCys: 0.363 ± 0.014	2.733GluAsp: 2.733 ± 0.039	3.198GluGlu: 3.198 ± 0.05	1.403GluPhe: 1.403 ± 0.026	4.199GluGly: 4.199 ± 0.048	1.475GluHis: 1.475 ± 0.03	2.146GluIle: 2.146 ± 0.038	1.249GluLys: 1.249 ± 0.03	6.86GluLeu: 6.86 ± 0.073	0.842GluMet: 0.842 ± 0.021	0.955GluAsn: 0.955 ± 0.022	3.403GluPro: 3.403 ± 0.039	2.008GluGln: 2.008 ± 0.034	5.808GluArg: 5.808 ± 0.058	2.532GluSer: 2.532 ± 0.036	2.584GluThr: 2.584 ± 0.038	4.535GluVal: 4.535 ± 0.052	0.79GluTrp: 0.79 ± 0.019	1.124GluTyr: 1.124 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.565PheAla: 3.565 ± 0.042	0.261PheCys: 0.261 ± 0.012	1.937PheAsp: 1.937 ± 0.033	1.368PheGlu: 1.368 ± 0.028	0.786PhePhe: 0.786 ± 0.019	2.957PheGly: 2.957 ± 0.039	0.626PheHis: 0.626 ± 0.018	0.668PheIle: 0.668 ± 0.018	0.455PheLys: 0.455 ± 0.016	2.615PheLeu: 2.615 ± 0.041	0.373PheMet: 0.373 ± 0.014	0.514PheAsn: 0.514 ± 0.016	1.401PhePro: 1.401 ± 0.029	0.653PheGln: 0.653 ± 0.017	1.905PheArg: 1.905 ± 0.03	1.381PheSer: 1.381 ± 0.029	1.999PheThr: 1.999 ± 0.031	2.211PheVal: 2.211 ± 0.033	0.41PheTrp: 0.41 ± 0.013	0.51PheTyr: 0.51 ± 0.016	0.0PheXaa: 0.0 ± 0.001
Gly	11.91GlyAla: 11.91 ± 0.096	0.801GlyCys: 0.801 ± 0.02	5.54GlyAsp: 5.54 ± 0.051	5.176GlyGlu: 5.176 ± 0.045	2.937GlyPhe: 2.937 ± 0.046	9.434GlyGly: 9.434 ± 0.105	2.448GlyHis: 2.448 ± 0.041	3.284GlyIle: 3.284 ± 0.044	2.247GlyLys: 2.247 ± 0.041	9.484GlyLeu: 9.484 ± 0.081	2.005GlyMet: 2.005 ± 0.032	1.673GlyAsn: 1.673 ± 0.035	6.17GlyPro: 6.17 ± 0.073	2.606GlyGln: 2.606 ± 0.043	8.156GlyArg: 8.156 ± 0.06	5.523GlySer: 5.523 ± 0.06	7.124GlyThr: 7.124 ± 0.064	7.797GlyVal: 7.797 ± 0.061	1.777GlyTrp: 1.777 ± 0.033	2.236GlyTyr: 2.236 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.622HisAla: 2.622 ± 0.037	0.21HisCys: 0.21 ± 0.01	1.405HisAsp: 1.405 ± 0.027	1.19HisGlu: 1.19 ± 0.025	0.606HisPhe: 0.606 ± 0.018	2.463HisGly: 2.463 ± 0.036	0.715HisHis: 0.715 ± 0.021	0.657HisIle: 0.657 ± 0.018	0.334HisLys: 0.334 ± 0.014	2.309HisLeu: 2.309 ± 0.032	0.346HisMet: 0.346 ± 0.013	0.346HisAsn: 0.346 ± 0.013	1.929HisPro: 1.929 ± 0.035	0.695HisGln: 0.695 ± 0.018	2.115HisArg: 2.115 ± 0.034	1.014HisSer: 1.014 ± 0.023	1.412HisThr: 1.412 ± 0.026	1.588HisVal: 1.588 ± 0.028	0.385HisTrp: 0.385 ± 0.014	0.458HisTyr: 0.458 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.622IleAla: 4.622 ± 0.051	0.257IleCys: 0.257 ± 0.012	2.163IleAsp: 2.163 ± 0.036	1.88IleGlu: 1.88 ± 0.033	0.616IlePhe: 0.616 ± 0.018	3.533IleGly: 3.533 ± 0.044	0.585IleHis: 0.585 ± 0.018	0.827IleIle: 0.827 ± 0.022	0.648IleLys: 0.648 ± 0.02	2.198IleLeu: 2.198 ± 0.04	0.417IleMet: 0.417 ± 0.015	0.6IleAsn: 0.6 ± 0.016	1.637IlePro: 1.637 ± 0.029	0.658IleGln: 0.658 ± 0.018	2.218IleArg: 2.218 ± 0.036	1.55IleSer: 1.55 ± 0.026	2.189IleThr: 2.189 ± 0.039	2.681IleVal: 2.681 ± 0.035	0.333IleTrp: 0.333 ± 0.012	0.423IleTyr: 0.423 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.658LysAla: 2.658 ± 0.043	0.098LysCys: 0.098 ± 0.007	1.292LysAsp: 1.292 ± 0.027	1.098LysGlu: 1.098 ± 0.029	0.397LysPhe: 0.397 ± 0.014	1.731LysGly: 1.731 ± 0.038	0.386LysHis: 0.386 ± 0.014	0.72LysIle: 0.72 ± 0.021	0.768LysLys: 0.768 ± 0.028	1.832LysLeu: 1.832 ± 0.034	0.329LysMet: 0.329 ± 0.014	0.473LysAsn: 0.473 ± 0.018	1.19LysPro: 1.19 ± 0.024	0.573LysGln: 0.573 ± 0.018	1.407LysArg: 1.407 ± 0.029	1.038LysSer: 1.038 ± 0.025	1.064LysThr: 1.064 ± 0.025	1.756LysVal: 1.756 ± 0.037	0.213LysTrp: 0.213 ± 0.009	0.414LysTyr: 0.414 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.302LeuAla: 15.302 ± 0.107	0.822LeuCys: 0.822 ± 0.02	6.914LeuAsp: 6.914 ± 0.062	4.505LeuGlu: 4.505 ± 0.056	2.582LeuPhe: 2.582 ± 0.038	9.491LeuGly: 9.491 ± 0.071	2.161LeuHis: 2.161 ± 0.029	3.281LeuIle: 3.281 ± 0.051	1.852LeuLys: 1.852 ± 0.031	11.453LeuLeu: 11.453 ± 0.117	1.683LeuMet: 1.683 ± 0.032	1.549LeuAsn: 1.549 ± 0.029	6.458LeuPro: 6.458 ± 0.059	1.981LeuGln: 1.981 ± 0.036	9.108LeuArg: 9.108 ± 0.078	5.277LeuSer: 5.277 ± 0.061	7.305LeuThr: 7.305 ± 0.059	8.817LeuVal: 8.817 ± 0.082	1.325LeuTrp: 1.325 ± 0.028	1.747LeuTyr: 1.747 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.217MetAla: 2.217 ± 0.029	0.127MetCys: 0.127 ± 0.007	0.885MetAsp: 0.885 ± 0.02	0.733MetGlu: 0.733 ± 0.02	0.466MetPhe: 0.466 ± 0.015	1.285MetGly: 1.285 ± 0.025	0.313MetHis: 0.313 ± 0.012	0.672MetIle: 0.672 ± 0.019	0.377MetLys: 0.377 ± 0.012	1.668MetLeu: 1.668 ± 0.03	0.282MetMet: 0.282 ± 0.009	0.402MetAsn: 0.402 ± 0.013	1.132MetPro: 1.132 ± 0.023	0.362MetGln: 0.362 ± 0.014	1.463MetArg: 1.463 ± 0.027	1.363MetSer: 1.363 ± 0.022	1.522MetThr: 1.522 ± 0.03	1.238MetVal: 1.238 ± 0.027	0.211MetTrp: 0.211 ± 0.009	0.317MetTyr: 0.317 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.056AsnAla: 2.056 ± 0.031	0.155AsnCys: 0.155 ± 0.008	0.866AsnAsp: 0.866 ± 0.023	0.721AsnGlu: 0.721 ± 0.02	0.43AsnPhe: 0.43 ± 0.016	1.723AsnGly: 1.723 ± 0.034	0.358AsnHis: 0.358 ± 0.014	0.623AsnIle: 0.623 ± 0.018	0.362AsnLys: 0.362 ± 0.015	1.512AsnLeu: 1.512 ± 0.028	0.266AsnMet: 0.266 ± 0.011	0.389AsnAsn: 0.389 ± 0.018	1.261AsnPro: 1.261 ± 0.025	0.46AsnGln: 0.46 ± 0.014	1.201AsnArg: 1.201 ± 0.024	0.845AsnSer: 0.845 ± 0.021	1.072AsnThr: 1.072 ± 0.026	1.236AsnVal: 1.236 ± 0.025	0.25AsnTrp: 0.25 ± 0.011	0.34AsnTyr: 0.34 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	9.059ProAla: 9.059 ± 0.09	0.34ProCys: 0.34 ± 0.011	4.957ProAsp: 4.957 ± 0.053	4.198ProGlu: 4.198 ± 0.043	1.525ProPhe: 1.525 ± 0.029	7.925ProGly: 7.925 ± 0.101	1.454ProHis: 1.454 ± 0.03	1.16ProIle: 1.16 ± 0.023	1.059ProLys: 1.059 ± 0.029	5.569ProLeu: 5.569 ± 0.059	1.008ProMet: 1.008 ± 0.018	0.786ProAsn: 0.786 ± 0.021	3.993ProPro: 3.993 ± 0.074	1.605ProGln: 1.605 ± 0.031	4.484ProArg: 4.484 ± 0.052	3.214ProSer: 3.214 ± 0.046	3.26ProThr: 3.26 ± 0.046	5.922ProVal: 5.922 ± 0.058	0.938ProTrp: 0.938 ± 0.021	1.393ProTyr: 1.393 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.273GlnAla: 3.273 ± 0.044	0.14GlnCys: 0.14 ± 0.008	1.408GlnAsp: 1.408 ± 0.026	1.369GlnGlu: 1.369 ± 0.029	0.595GlnPhe: 0.595 ± 0.019	2.265GlnGly: 2.265 ± 0.036	0.634GlnHis: 0.634 ± 0.016	0.977GlnIle: 0.977 ± 0.02	0.487GlnLys: 0.487 ± 0.017	2.835GlnLeu: 2.835 ± 0.042	0.422GlnMet: 0.422 ± 0.013	0.444GlnAsn: 0.444 ± 0.014	1.532GlnPro: 1.532 ± 0.034	1.032GlnGln: 1.032 ± 0.028	2.411GlnArg: 2.411 ± 0.035	1.144GlnSer: 1.144 ± 0.023	1.168GlnThr: 1.168 ± 0.025	2.226GlnVal: 2.226 ± 0.033	0.401GlnTrp: 0.401 ± 0.015	0.538GlnTyr: 0.538 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	10.729ArgAla: 10.729 ± 0.092	0.599ArgCys: 0.599 ± 0.017	4.73ArgAsp: 4.73 ± 0.048	4.849ArgGlu: 4.849 ± 0.061	2.464ArgPhe: 2.464 ± 0.036	6.367ArgGly: 6.367 ± 0.057	2.131ArgHis: 2.131 ± 0.032	3.188ArgIle: 3.188 ± 0.033	1.558ArgLys: 1.558 ± 0.03	8.985ArgLeu: 8.985 ± 0.077	1.818ArgMet: 1.818 ± 0.028	1.324ArgAsn: 1.324 ± 0.026	5.357ArgPro: 5.357 ± 0.06	2.146ArgGln: 2.146 ± 0.033	7.795ArgArg: 7.795 ± 0.079	4.271ArgSer: 4.271 ± 0.043	6.101ArgThr: 6.101 ± 0.058	6.468ArgVal: 6.468 ± 0.062	1.464ArgTrp: 1.464 ± 0.031	1.917ArgTyr: 1.917 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	6.709SerAla: 6.709 ± 0.057	0.404SerCys: 0.404 ± 0.014	2.639SerAsp: 2.639 ± 0.036	2.249SerGlu: 2.249 ± 0.037	1.46SerPhe: 1.46 ± 0.026	6.26SerGly: 6.26 ± 0.067	0.982SerHis: 0.982 ± 0.021	1.263SerIle: 1.263 ± 0.025	0.901SerLys: 0.901 ± 0.023	4.826SerLeu: 4.826 ± 0.053	1.012SerMet: 1.012 ± 0.021	0.792SerAsn: 0.792 ± 0.019	3.208SerPro: 3.208 ± 0.043	1.114SerGln: 1.114 ± 0.022	3.777SerArg: 3.777 ± 0.05	2.627SerSer: 2.627 ± 0.039	2.942SerThr: 2.942 ± 0.046	4.381SerVal: 4.381 ± 0.047	0.866SerTrp: 0.866 ± 0.023	1.146SerTyr: 1.146 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	9.41ThrAla: 9.41 ± 0.081	0.42ThrCys: 0.42 ± 0.015	3.749ThrAsp: 3.749 ± 0.046	3.348ThrGlu: 3.348 ± 0.048	1.567ThrPhe: 1.567 ± 0.025	7.492ThrGly: 7.492 ± 0.076	1.284ThrHis: 1.284 ± 0.02	1.547ThrIle: 1.547 ± 0.031	1.063ThrLys: 1.063 ± 0.024	5.989ThrLeu: 5.989 ± 0.05	0.933ThrMet: 0.933 ± 0.021	0.917ThrAsn: 0.917 ± 0.023	4.386ThrPro: 4.386 ± 0.06	1.238ThrGln: 1.238 ± 0.024	4.226ThrArg: 4.226 ± 0.049	3.022ThrSer: 3.022 ± 0.037	3.889ThrThr: 3.889 ± 0.052	6.43ThrVal: 6.43 ± 0.068	0.862ThrTrp: 0.862 ± 0.02	1.298ThrTyr: 1.298 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	10.631ValAla: 10.631 ± 0.093	0.754ValCys: 0.754 ± 0.02	4.94ValAsp: 4.94 ± 0.048	4.566ValGlu: 4.566 ± 0.048	2.382ValPhe: 2.382 ± 0.038	6.623ValGly: 6.623 ± 0.066	1.968ValHis: 1.968 ± 0.028	2.807ValIle: 2.807 ± 0.044	1.598ValLys: 1.598 ± 0.037	9.827ValLeu: 9.827 ± 0.083	1.434ValMet: 1.434 ± 0.029	1.561ValAsn: 1.561 ± 0.03	5.722ValPro: 5.722 ± 0.057	1.951ValGln: 1.951 ± 0.031	7.673ValArg: 7.673 ± 0.066	4.27ValSer: 4.27 ± 0.048	6.026ValThr: 6.026 ± 0.063	7.936ValVal: 7.936 ± 0.082	1.188ValTrp: 1.188 ± 0.024	1.52ValTyr: 1.52 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.643TrpAla: 1.643 ± 0.031	0.148TrpCys: 0.148 ± 0.01	0.848TrpAsp: 0.848 ± 0.023	0.722TrpGlu: 0.722 ± 0.017	0.52TrpPhe: 0.52 ± 0.015	1.073TrpGly: 1.073 ± 0.021	0.365TrpHis: 0.365 ± 0.012	0.508TrpIle: 0.508 ± 0.016	0.334TrpLys: 0.334 ± 0.012	1.737TrpLeu: 1.737 ± 0.031	0.271TrpMet: 0.271 ± 0.012	0.39TrpAsn: 0.39 ± 0.012	0.808TrpPro: 0.808 ± 0.021	0.534TrpGln: 0.534 ± 0.017	1.39TrpArg: 1.39 ± 0.028	0.95TrpSer: 0.95 ± 0.022	1.078TrpThr: 1.078 ± 0.025	0.986TrpVal: 0.986 ± 0.023	0.328TrpTrp: 0.328 ± 0.011	0.339TrpTyr: 0.339 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.633TyrAla: 2.633 ± 0.034	0.173TyrCys: 0.173 ± 0.009	1.437TyrAsp: 1.437 ± 0.032	1.189TyrGlu: 1.189 ± 0.028	0.601TyrPhe: 0.601 ± 0.017	2.185TyrGly: 2.185 ± 0.034	0.386TyrHis: 0.386 ± 0.014	0.463TyrIle: 0.463 ± 0.016	0.344TyrLys: 0.344 ± 0.014	2.079TyrLeu: 2.079 ± 0.035	0.25TyrMet: 0.25 ± 0.012	0.317TyrAsn: 0.317 ± 0.013	1.057TyrPro: 1.057 ± 0.024	0.565TyrGln: 0.565 ± 0.016	1.863TyrArg: 1.863 ± 0.03	0.905TyrSer: 0.905 ± 0.021	1.142TyrThr: 1.142 ± 0.025	1.573TyrVal: 1.573 ± 0.029	0.341TyrTrp: 0.341 ± 0.013	0.384TyrTyr: 0.384 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6725 proteins (2184566 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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