Amino acid dipepetide frequency for Pseudoalteromonas phenolica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.84AlaAla: 6.84 ± 0.089	0.968AlaCys: 0.968 ± 0.028	4.443AlaAsp: 4.443 ± 0.059	5.509AlaGlu: 5.509 ± 0.064	3.681AlaPhe: 3.681 ± 0.053	5.321AlaGly: 5.321 ± 0.062	1.815AlaHis: 1.815 ± 0.04	5.867AlaIle: 5.867 ± 0.073	5.397AlaLys: 5.397 ± 0.066	9.673AlaLeu: 9.673 ± 0.095	2.386AlaMet: 2.386 ± 0.046	3.94AlaAsn: 3.94 ± 0.056	2.846AlaPro: 2.846 ± 0.057	4.265AlaGln: 4.265 ± 0.067	3.124AlaArg: 3.124 ± 0.054	5.212AlaSer: 5.212 ± 0.053	4.079AlaThr: 4.079 ± 0.056	5.329AlaVal: 5.329 ± 0.072	0.937AlaTrp: 0.937 ± 0.026	2.509AlaTyr: 2.509 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.809CysAla: 0.809 ± 0.023	0.152CysCys: 0.152 ± 0.012	0.619CysAsp: 0.619 ± 0.022	0.618CysGlu: 0.618 ± 0.024	0.498CysPhe: 0.498 ± 0.019	0.746CysGly: 0.746 ± 0.029	0.326CysHis: 0.326 ± 0.016	0.604CysIle: 0.604 ± 0.023	0.515CysLys: 0.515 ± 0.018	0.995CysLeu: 0.995 ± 0.027	0.212CysMet: 0.212 ± 0.013	0.399CysAsn: 0.399 ± 0.017	0.383CysPro: 0.383 ± 0.017	0.464CysGln: 0.464 ± 0.019	0.371CysArg: 0.371 ± 0.017	0.704CysSer: 0.704 ± 0.022	0.432CysThr: 0.432 ± 0.018	0.61CysVal: 0.61 ± 0.023	0.104CysTrp: 0.104 ± 0.008	0.338CysTyr: 0.338 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.463AspAla: 4.463 ± 0.062	0.467AspCys: 0.467 ± 0.02	3.109AspAsp: 3.109 ± 0.06	4.049AspGlu: 4.049 ± 0.069	2.686AspPhe: 2.686 ± 0.047	3.565AspGly: 3.565 ± 0.069	1.007AspHis: 1.007 ± 0.031	4.251AspIle: 4.251 ± 0.065	3.817AspLys: 3.817 ± 0.058	5.326AspLeu: 5.326 ± 0.073	1.364AspMet: 1.364 ± 0.028	2.769AspAsn: 2.769 ± 0.049	1.803AspPro: 1.803 ± 0.042	1.685AspGln: 1.685 ± 0.037	1.784AspArg: 1.784 ± 0.039	3.325AspSer: 3.325 ± 0.057	2.865AspThr: 2.865 ± 0.048	3.796AspVal: 3.796 ± 0.059	0.781AspTrp: 0.781 ± 0.022	2.156AspTyr: 2.156 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	5.142GluAla: 5.142 ± 0.077	0.498GluCys: 0.498 ± 0.02	2.869GluAsp: 2.869 ± 0.057	3.649GluGlu: 3.649 ± 0.068	2.896GluPhe: 2.896 ± 0.046	3.429GluGly: 3.429 ± 0.052	1.803GluHis: 1.803 ± 0.037	4.033GluIle: 4.033 ± 0.055	4.128GluLys: 4.128 ± 0.054	7.547GluLeu: 7.547 ± 0.085	1.487GluMet: 1.487 ± 0.031	3.047GluAsn: 3.047 ± 0.05	1.912GluPro: 1.912 ± 0.04	5.118GluGln: 5.118 ± 0.071	2.934GluArg: 2.934 ± 0.052	3.866GluSer: 3.866 ± 0.058	3.066GluThr: 3.066 ± 0.044	4.408GluVal: 4.408 ± 0.063	0.615GluTrp: 0.615 ± 0.019	1.959GluTyr: 1.959 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.067PheAla: 4.067 ± 0.053	0.53PheCys: 0.53 ± 0.021	3.074PheAsp: 3.074 ± 0.048	3.03PheGlu: 3.03 ± 0.043	1.813PhePhe: 1.813 ± 0.035	2.999PheGly: 2.999 ± 0.044	0.784PheHis: 0.784 ± 0.024	3.147PheIle: 3.147 ± 0.05	2.684PheLys: 2.684 ± 0.051	3.625PheLeu: 3.625 ± 0.056	1.03PheMet: 1.03 ± 0.028	2.61PheAsn: 2.61 ± 0.042	1.283PhePro: 1.283 ± 0.029	1.244PheGln: 1.244 ± 0.032	1.324PheArg: 1.324 ± 0.03	3.889PheSer: 3.889 ± 0.059	2.602PheThr: 2.602 ± 0.044	2.946PheVal: 2.946 ± 0.044	0.532PheTrp: 0.532 ± 0.023	1.596PheTyr: 1.596 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	4.714GlyAla: 4.714 ± 0.077	0.782GlyCys: 0.782 ± 0.022	3.384GlyAsp: 3.384 ± 0.055	4.302GlyGlu: 4.302 ± 0.064	3.37GlyPhe: 3.37 ± 0.055	4.199GlyGly: 4.199 ± 0.07	1.473GlyHis: 1.473 ± 0.038	4.119GlyIle: 4.119 ± 0.059	3.957GlyLys: 3.957 ± 0.057	6.623GlyLeu: 6.623 ± 0.081	1.633GlyMet: 1.633 ± 0.035	2.593GlyAsn: 2.593 ± 0.052	1.487GlyPro: 1.487 ± 0.031	2.742GlyGln: 2.742 ± 0.055	2.572GlyArg: 2.572 ± 0.045	3.832GlySer: 3.832 ± 0.056	3.129GlyThr: 3.129 ± 0.052	4.645GlyVal: 4.645 ± 0.069	0.769GlyTrp: 0.769 ± 0.022	2.448GlyTyr: 2.448 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.612HisAla: 1.612 ± 0.033	0.315HisCys: 0.315 ± 0.016	1.146HisAsp: 1.146 ± 0.036	1.256HisGlu: 1.256 ± 0.027	1.225HisPhe: 1.225 ± 0.03	1.489HisGly: 1.489 ± 0.038	0.685HisHis: 0.685 ± 0.025	1.573HisIle: 1.573 ± 0.039	1.232HisLys: 1.232 ± 0.03	2.357HisLeu: 2.357 ± 0.044	0.438HisMet: 0.438 ± 0.019	1.067HisAsn: 1.067 ± 0.031	1.011HisPro: 1.011 ± 0.027	1.127HisGln: 1.127 ± 0.03	0.875HisArg: 0.875 ± 0.024	1.532HisSer: 1.532 ± 0.037	1.234HisThr: 1.234 ± 0.034	1.27HisVal: 1.27 ± 0.03	0.328HisTrp: 0.328 ± 0.016	0.937HisTyr: 0.937 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.274IleAla: 6.274 ± 0.078	0.706IleCys: 0.706 ± 0.024	4.228IleAsp: 4.228 ± 0.051	5.102IleGlu: 5.102 ± 0.064	2.386IlePhe: 2.386 ± 0.047	4.161IleGly: 4.161 ± 0.058	1.236IleHis: 1.236 ± 0.029	3.501IleIle: 3.501 ± 0.06	4.025IleLys: 4.025 ± 0.061	5.23IleLeu: 5.23 ± 0.065	1.237IleMet: 1.237 ± 0.032	3.552IleAsn: 3.552 ± 0.054	2.269IlePro: 2.269 ± 0.043	2.165IleGln: 2.165 ± 0.045	2.447IleArg: 2.447 ± 0.044	4.957IleSer: 4.957 ± 0.061	3.799IleThr: 3.799 ± 0.051	3.796IleVal: 3.796 ± 0.061	0.646IleTrp: 0.646 ± 0.02	1.815IleTyr: 1.815 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	5.401LysAla: 5.401 ± 0.059	0.361LysCys: 0.361 ± 0.019	3.071LysAsp: 3.071 ± 0.043	3.582LysGlu: 3.582 ± 0.061	2.023LysPhe: 2.023 ± 0.034	3.4LysGly: 3.4 ± 0.05	1.633LysHis: 1.633 ± 0.037	3.266LysIle: 3.266 ± 0.051	3.525LysLys: 3.525 ± 0.055	6.4LysLeu: 6.4 ± 0.074	1.329LysMet: 1.329 ± 0.022	2.626LysAsn: 2.626 ± 0.042	2.586LysPro: 2.586 ± 0.047	4.024LysGln: 4.024 ± 0.064	2.848LysArg: 2.848 ± 0.045	3.887LysSer: 3.887 ± 0.06	3.335LysThr: 3.335 ± 0.05	4.323LysVal: 4.323 ± 0.061	0.561LysTrp: 0.561 ± 0.019	1.719LysTyr: 1.719 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	9.575LeuAla: 9.575 ± 0.099	1.098LeuCys: 1.098 ± 0.03	5.951LeuAsp: 5.951 ± 0.082	6.577LeuGlu: 6.577 ± 0.084	4.609LeuPhe: 4.609 ± 0.062	6.42LeuGly: 6.42 ± 0.074	1.987LeuHis: 1.987 ± 0.037	6.398LeuIle: 6.398 ± 0.084	6.525LeuLys: 6.525 ± 0.069	10.731LeuLeu: 10.731 ± 0.137	2.516LeuMet: 2.516 ± 0.046	5.593LeuAsn: 5.593 ± 0.065	4.417LeuPro: 4.417 ± 0.057	4.014LeuGln: 4.014 ± 0.065	3.76LeuArg: 3.76 ± 0.055	8.627LeuSer: 8.627 ± 0.096	6.16LeuThr: 6.16 ± 0.076	6.745LeuVal: 6.745 ± 0.086	0.937LeuTrp: 0.937 ± 0.029	2.802LeuTyr: 2.802 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.226MetAla: 2.226 ± 0.04	0.181MetCys: 0.181 ± 0.01	1.027MetAsp: 1.027 ± 0.026	0.996MetGlu: 0.996 ± 0.025	0.882MetPhe: 0.882 ± 0.025	1.48MetGly: 1.48 ± 0.032	0.508MetHis: 0.508 ± 0.02	1.31MetIle: 1.31 ± 0.033	1.339MetLys: 1.339 ± 0.034	2.622MetLeu: 2.622 ± 0.046	0.693MetMet: 0.693 ± 0.025	1.04MetAsn: 1.04 ± 0.028	1.151MetPro: 1.151 ± 0.029	1.292MetGln: 1.292 ± 0.03	1.084MetArg: 1.084 ± 0.031	1.894MetSer: 1.894 ± 0.038	1.506MetThr: 1.506 ± 0.035	1.452MetVal: 1.452 ± 0.03	0.208MetTrp: 0.208 ± 0.011	0.558MetTyr: 0.558 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.886AsnAla: 3.886 ± 0.053	0.46AsnCys: 0.46 ± 0.017	2.672AsnAsp: 2.672 ± 0.049	2.99AsnGlu: 2.99 ± 0.047	1.849AsnPhe: 1.849 ± 0.036	3.023AsnGly: 3.023 ± 0.056	1.093AsnHis: 1.093 ± 0.029	3.186AsnIle: 3.186 ± 0.049	2.994AsnLys: 2.994 ± 0.047	4.724AsnLeu: 4.724 ± 0.067	1.074AsnMet: 1.074 ± 0.026	2.552AsnAsn: 2.552 ± 0.045	2.014AsnPro: 2.014 ± 0.038	2.358AsnGln: 2.358 ± 0.041	1.921AsnArg: 1.921 ± 0.035	3.029AsnSer: 3.029 ± 0.054	2.84AsnThr: 2.84 ± 0.051	2.73AsnVal: 2.73 ± 0.042	0.635AsnTrp: 0.635 ± 0.022	1.637AsnTyr: 1.637 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	2.756ProAla: 2.756 ± 0.051	0.311ProCys: 0.311 ± 0.016	2.104ProAsp: 2.104 ± 0.038	3.051ProGlu: 3.051 ± 0.05	1.712ProPhe: 1.712 ± 0.038	1.967ProGly: 1.967 ± 0.039	0.811ProHis: 0.811 ± 0.027	2.439ProIle: 2.439 ± 0.042	2.176ProLys: 2.176 ± 0.045	3.777ProLeu: 3.777 ± 0.047	0.863ProMet: 0.863 ± 0.025	1.832ProAsn: 1.832 ± 0.035	0.868ProPro: 0.868 ± 0.029	1.471ProGln: 1.471 ± 0.038	1.117ProArg: 1.117 ± 0.033	2.466ProSer: 2.466 ± 0.049	1.873ProThr: 1.873 ± 0.036	2.665ProVal: 2.665 ± 0.052	0.481ProTrp: 0.481 ± 0.018	1.222ProTyr: 1.222 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	4.624GlnAla: 4.624 ± 0.07	0.404GlnCys: 0.404 ± 0.017	2.238GlnAsp: 2.238 ± 0.043	2.291GlnGlu: 2.291 ± 0.044	2.188GlnPhe: 2.188 ± 0.046	3.138GlnGly: 3.138 ± 0.051	1.24GlnHis: 1.24 ± 0.034	2.807GlnIle: 2.807 ± 0.047	2.543GlnLys: 2.543 ± 0.047	5.761GlnLeu: 5.761 ± 0.082	0.985GlnMet: 0.985 ± 0.025	2.083GlnAsn: 2.083 ± 0.038	1.653GlnPro: 1.653 ± 0.035	3.446GlnGln: 3.446 ± 0.083	1.904GlnArg: 1.904 ± 0.041	3.402GlnSer: 3.402 ± 0.054	2.656GlnThr: 2.656 ± 0.048	3.458GlnVal: 3.458 ± 0.054	0.589GlnTrp: 0.589 ± 0.019	1.502GlnTyr: 1.502 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	3.102ArgAla: 3.102 ± 0.052	0.347ArgCys: 0.347 ± 0.015	2.128ArgAsp: 2.128 ± 0.04	2.432ArgGlu: 2.432 ± 0.05	2.168ArgPhe: 2.168 ± 0.039	2.217ArgGly: 2.217 ± 0.043	0.916ArgHis: 0.916 ± 0.024	2.6ArgIle: 2.6 ± 0.046	2.202ArgLys: 2.202 ± 0.042	4.429ArgLeu: 4.429 ± 0.059	0.899ArgMet: 0.899 ± 0.026	1.67ArgAsn: 1.67 ± 0.033	1.313ArgPro: 1.313 ± 0.034	1.785ArgGln: 1.785 ± 0.036	1.709ArgArg: 1.709 ± 0.038	2.256ArgSer: 2.256 ± 0.044	1.896ArgThr: 1.896 ± 0.035	2.878ArgVal: 2.878 ± 0.05	0.493ArgTrp: 0.493 ± 0.019	1.508ArgTyr: 1.508 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	5.503SerAla: 5.503 ± 0.07	0.642SerCys: 0.642 ± 0.022	3.941SerAsp: 3.941 ± 0.066	4.725SerGlu: 4.725 ± 0.064	3.287SerPhe: 3.287 ± 0.054	4.74SerGly: 4.74 ± 0.075	1.637SerHis: 1.637 ± 0.039	4.372SerIle: 4.372 ± 0.062	4.008SerLys: 4.008 ± 0.06	7.432SerLeu: 7.432 ± 0.081	1.593SerMet: 1.593 ± 0.033	3.178SerAsn: 3.178 ± 0.049	2.368SerPro: 2.368 ± 0.044	3.405SerGln: 3.405 ± 0.05	2.525SerArg: 2.525 ± 0.045	4.792SerSer: 4.792 ± 0.079	3.33SerThr: 3.33 ± 0.059	4.549SerVal: 4.549 ± 0.056	0.762SerTrp: 0.762 ± 0.022	2.293SerTyr: 2.293 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.341ThrAla: 4.341 ± 0.059	0.481ThrCys: 0.481 ± 0.021	2.941ThrAsp: 2.941 ± 0.048	3.405ThrGlu: 3.405 ± 0.053	2.26ThrPhe: 2.26 ± 0.044	3.764ThrGly: 3.764 ± 0.054	1.35ThrHis: 1.35 ± 0.031	3.177ThrIle: 3.177 ± 0.046	2.64ThrLys: 2.64 ± 0.042	6.414ThrLeu: 6.414 ± 0.076	1.069ThrMet: 1.069 ± 0.032	2.154ThrAsn: 2.154 ± 0.042	2.598ThrPro: 2.598 ± 0.048	2.865ThrGln: 2.865 ± 0.05	2.027ThrArg: 2.027 ± 0.044	3.485ThrSer: 3.485 ± 0.055	2.758ThrThr: 2.758 ± 0.056	3.56ThrVal: 3.56 ± 0.056	0.625ThrTrp: 0.625 ± 0.02	1.583ThrTyr: 1.583 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	5.735ValAla: 5.735 ± 0.073	0.7ValCys: 0.7 ± 0.023	3.793ValAsp: 3.793 ± 0.057	4.608ValGlu: 4.608 ± 0.06	3.022ValPhe: 3.022 ± 0.045	3.975ValGly: 3.975 ± 0.064	1.22ValHis: 1.22 ± 0.036	4.513ValIle: 4.513 ± 0.06	3.987ValLys: 3.987 ± 0.051	6.649ValLeu: 6.649 ± 0.078	1.727ValMet: 1.727 ± 0.035	3.242ValAsn: 3.242 ± 0.053	2.32ValPro: 2.32 ± 0.044	2.26ValGln: 2.26 ± 0.039	2.47ValArg: 2.47 ± 0.043	5.042ValSer: 5.042 ± 0.065	3.883ValThr: 3.883 ± 0.058	4.648ValVal: 4.648 ± 0.07	0.715ValTrp: 0.715 ± 0.021	1.931ValTyr: 1.931 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.708TrpAla: 0.708 ± 0.021	0.114TrpCys: 0.114 ± 0.008	0.541TrpAsp: 0.541 ± 0.02	0.478TrpGlu: 0.478 ± 0.018	0.551TrpPhe: 0.551 ± 0.021	0.651TrpGly: 0.651 ± 0.022	0.403TrpHis: 0.403 ± 0.017	0.536TrpIle: 0.536 ± 0.02	0.392TrpLys: 0.392 ± 0.018	1.588TrpLeu: 1.588 ± 0.035	0.291TrpMet: 0.291 ± 0.016	0.383TrpAsn: 0.383 ± 0.019	0.458TrpPro: 0.458 ± 0.02	1.215TrpGln: 1.215 ± 0.036	0.591TrpArg: 0.591 ± 0.022	0.7TrpSer: 0.7 ± 0.025	0.422TrpThr: 0.422 ± 0.019	0.772TrpVal: 0.772 ± 0.024	0.165TrpTrp: 0.165 ± 0.012	0.372TrpTyr: 0.372 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.361TyrAla: 2.361 ± 0.047	0.38TyrCys: 0.38 ± 0.016	1.791TyrAsp: 1.791 ± 0.037	1.754TyrGlu: 1.754 ± 0.035	1.703TyrPhe: 1.703 ± 0.04	2.089TyrGly: 2.089 ± 0.035	0.777TyrHis: 0.777 ± 0.024	1.832TyrIle: 1.832 ± 0.037	1.816TyrLys: 1.816 ± 0.033	3.54TyrLeu: 3.54 ± 0.054	0.625TyrMet: 0.625 ± 0.022	1.337TyrAsn: 1.337 ± 0.034	1.222TyrPro: 1.222 ± 0.025	1.969TyrGln: 1.969 ± 0.042	1.564TyrArg: 1.564 ± 0.031	2.185TyrSer: 2.185 ± 0.044	1.633TyrThr: 1.633 ± 0.034	1.859TyrVal: 1.859 ± 0.037	0.445TyrTrp: 0.445 ± 0.018	1.147TyrTyr: 1.147 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4164 proteins (1416653 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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