Amino acid dipepetide frequency for Beihai tombus-like virus 4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.17AlaAla: 5.17 ± 3.47
0.739AlaCys: 0.739 ± 0.56
3.693AlaAsp: 3.693 ± 1.667
5.17AlaGlu: 5.17 ± 1.624
1.477AlaPhe: 1.477 ± 0.71
11.078AlaGly: 11.078 ± 4.19
0.739AlaHis: 0.739 ± 0.511
4.431AlaIle: 4.431 ± 0.728
2.954AlaLys: 2.954 ± 1.219
6.647AlaLeu: 6.647 ± 3.045
2.216AlaMet: 2.216 ± 1.022
0.739AlaAsn: 0.739 ± 0.56
3.693AlaPro: 3.693 ± 0.422
3.693AlaGln: 3.693 ± 1.352
5.908AlaArg: 5.908 ± 1.552
2.954AlaSer: 2.954 ± 0.969
3.693AlaThr: 3.693 ± 0.915
8.863AlaVal: 8.863 ± 1.513
0.0AlaTrp: 0.0 ± 0.0
1.477AlaTyr: 1.477 ± 1.54
0.0AlaXaa: 0.0 ± 0.0
Cys
0.739CysAla: 0.739 ± 0.56
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.739CysGlu: 0.739 ± 0.77
0.0CysPhe: 0.0 ± 0.0
0.739CysGly: 0.739 ± 0.511
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
2.954CysLeu: 2.954 ± 1.165
0.739CysMet: 0.739 ± 0.77
0.739CysAsn: 0.739 ± 0.56
0.0CysPro: 0.0 ± 0.0
0.739CysGln: 0.739 ± 0.511
0.739CysArg: 0.739 ± 0.511
1.477CysSer: 1.477 ± 1.022
1.477CysThr: 1.477 ± 0.61
2.216CysVal: 2.216 ± 0.215
0.0CysTrp: 0.0 ± 0.0
0.739CysTyr: 0.739 ± 0.511
0.0CysXaa: 0.0 ± 0.0
Asp
4.431AspAla: 4.431 ± 1.585
0.739AspCys: 0.739 ± 0.511
2.216AspAsp: 2.216 ± 0.942
2.954AspGlu: 2.954 ± 0.969
0.0AspPhe: 0.0 ± 0.0
5.17AspGly: 5.17 ± 3.579
2.216AspHis: 2.216 ± 0.215
2.954AspIle: 2.954 ± 1.165
2.216AspLys: 2.216 ± 1.534
2.954AspLeu: 2.954 ± 0.969
1.477AspMet: 1.477 ± 0.61
2.216AspAsn: 2.216 ± 1.021
2.954AspPro: 2.954 ± 0.334
2.216AspGln: 2.216 ± 0.215
2.216AspArg: 2.216 ± 1.021
3.693AspSer: 3.693 ± 0.915
1.477AspThr: 1.477 ± 0.71
3.693AspVal: 3.693 ± 1.131
1.477AspTrp: 1.477 ± 1.022
2.216AspTyr: 2.216 ± 1.021
0.0AspXaa: 0.0 ± 0.0
Glu
2.954GluAla: 2.954 ± 0.969
1.477GluCys: 1.477 ± 0.582
2.216GluAsp: 2.216 ± 1.37
4.431GluGlu: 4.431 ± 0.728
3.693GluPhe: 3.693 ± 1.884
3.693GluGly: 3.693 ± 3.849
3.693GluHis: 3.693 ± 1.884
2.954GluIle: 2.954 ± 0.334
2.954GluLys: 2.954 ± 1.219
5.908GluLeu: 5.908 ± 1.125
2.954GluMet: 2.954 ± 0.498
5.908GluAsn: 5.908 ± 1.938
6.647GluPro: 6.647 ± 1.716
4.431GluGln: 4.431 ± 1.346
5.908GluArg: 5.908 ± 2.367
4.431GluSer: 4.431 ± 0.934
2.216GluThr: 2.216 ± 0.215
4.431GluVal: 4.431 ± 1.585
0.739GluTrp: 0.739 ± 0.77
1.477GluTyr: 1.477 ± 0.61
0.0GluXaa: 0.0 ± 0.0
Phe
0.739PheAla: 0.739 ± 0.511
1.477PheCys: 1.477 ± 0.582
3.693PheAsp: 3.693 ± 1.48
2.954PheGlu: 2.954 ± 0.969
1.477PhePhe: 1.477 ± 0.61
0.0PheGly: 0.0 ± 0.0
0.739PheHis: 0.739 ± 0.56
1.477PheIle: 1.477 ± 1.121
2.216PheLys: 2.216 ± 0.821
1.477PheLeu: 1.477 ± 0.61
0.739PheMet: 0.739 ± 0.77
1.477PheAsn: 1.477 ± 1.022
0.739PhePro: 0.739 ± 0.56
2.216PheGln: 2.216 ± 0.942
1.477PheArg: 1.477 ± 0.61
1.477PheSer: 1.477 ± 0.582
2.954PheThr: 2.954 ± 1.165
2.954PheVal: 2.954 ± 1.165
0.0PheTrp: 0.0 ± 0.0
1.477PheTyr: 1.477 ± 1.022
0.0PheXaa: 0.0 ± 0.0
Gly
7.386GlyAla: 7.386 ± 1.989
2.216GlyCys: 2.216 ± 0.821
7.386GlyAsp: 7.386 ± 0.3
8.124GlyGlu: 8.124 ± 1.336
2.954GlyPhe: 2.954 ± 0.969
5.908GlyGly: 5.908 ± 1.275
0.0GlyHis: 0.0 ± 0.0
4.431GlyIle: 4.431 ± 1.346
2.216GlyLys: 2.216 ± 0.942
6.647GlyLeu: 6.647 ± 0.891
3.693GlyMet: 3.693 ± 1.352
2.216GlyAsn: 2.216 ± 0.821
1.477GlyPro: 1.477 ± 0.61
0.739GlyGln: 0.739 ± 0.511
3.693GlyArg: 3.693 ± 0.837
5.908GlySer: 5.908 ± 4.045
2.954GlyThr: 2.954 ± 1.487
8.863GlyVal: 8.863 ± 2.91
1.477GlyTrp: 1.477 ± 0.71
2.216GlyTyr: 2.216 ± 1.022
0.0GlyXaa: 0.0 ± 0.0
His
2.216HisAla: 2.216 ± 0.215
0.739HisCys: 0.739 ± 0.77
0.739HisAsp: 0.739 ± 0.77
0.739HisGlu: 0.739 ± 0.511
0.0HisPhe: 0.0 ± 0.0
1.477HisGly: 1.477 ± 1.022
0.739HisHis: 0.739 ± 0.77
0.739HisIle: 0.739 ± 0.511
2.216HisLys: 2.216 ± 0.942
2.216HisLeu: 2.216 ± 1.022
0.739HisMet: 0.739 ± 0.56
0.739HisAsn: 0.739 ± 0.56
1.477HisPro: 1.477 ± 1.54
0.0HisGln: 0.0 ± 0.0
1.477HisArg: 1.477 ± 0.71
0.739HisSer: 0.739 ± 0.511
0.739HisThr: 0.739 ± 0.56
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.739HisTyr: 0.739 ± 0.511
0.0HisXaa: 0.0 ± 0.0
Ile
3.693IleAla: 3.693 ± 1.131
0.739IleCys: 0.739 ± 0.77
5.17IleAsp: 5.17 ± 1.121
2.954IleGlu: 2.954 ± 0.334
2.216IlePhe: 2.216 ± 1.534
1.477IleGly: 1.477 ± 1.121
0.739IleHis: 0.739 ± 0.511
1.477IleIle: 1.477 ± 1.022
2.216IleLys: 2.216 ± 1.37
3.693IleLeu: 3.693 ± 0.915
2.216IleMet: 2.216 ± 0.942
4.431IleAsn: 4.431 ± 0.728
2.954IlePro: 2.954 ± 0.969
1.477IleGln: 1.477 ± 0.582
5.17IleArg: 5.17 ± 0.234
4.431IleSer: 4.431 ± 1.747
6.647IleThr: 6.647 ± 1.716
0.739IleVal: 0.739 ± 0.56
0.0IleTrp: 0.0 ± 0.0
1.477IleTyr: 1.477 ± 1.022
0.0IleXaa: 0.0 ± 0.0
Lys
3.693LysAla: 3.693 ± 1.867
0.0LysCys: 0.0 ± 0.0
2.954LysAsp: 2.954 ± 2.045
1.477LysGlu: 1.477 ± 0.582
1.477LysPhe: 1.477 ± 1.022
3.693LysGly: 3.693 ± 1.687
2.216LysHis: 2.216 ± 1.37
3.693LysIle: 3.693 ± 1.687
1.477LysLys: 1.477 ± 1.022
3.693LysLeu: 3.693 ± 0.422
1.477LysMet: 1.477 ± 1.022
2.954LysAsn: 2.954 ± 0.334
3.693LysPro: 3.693 ± 1.352
3.693LysGln: 3.693 ± 0.837
5.908LysArg: 5.908 ± 1.552
2.216LysSer: 2.216 ± 0.215
1.477LysThr: 1.477 ± 0.61
2.954LysVal: 2.954 ± 1.399
0.739LysTrp: 0.739 ± 0.56
2.216LysTyr: 2.216 ± 0.942
0.0LysXaa: 0.0 ± 0.0
Leu
4.431LeuAla: 4.431 ± 1.585
0.739LeuCys: 0.739 ± 0.56
1.477LeuAsp: 1.477 ± 0.582
8.124LeuGlu: 8.124 ± 1.075
0.739LeuPhe: 0.739 ± 0.56
8.863LeuGly: 8.863 ± 1.412
0.0LeuHis: 0.0 ± 0.0
7.386LeuIle: 7.386 ± 1.381
5.17LeuLys: 5.17 ± 1.856
8.124LeuLeu: 8.124 ± 1.049
2.954LeuMet: 2.954 ± 0.591
5.17LeuAsn: 5.17 ± 0.69
2.216LeuPro: 2.216 ± 0.942
2.216LeuGln: 2.216 ± 0.215
4.431LeuArg: 4.431 ± 1.169
5.17LeuSer: 5.17 ± 2.131
4.431LeuThr: 4.431 ± 1.169
2.216LeuVal: 2.216 ± 0.215
0.739LeuTrp: 0.739 ± 0.511
2.954LeuTyr: 2.954 ± 0.591
0.0LeuXaa: 0.0 ± 0.0
Met
2.954MetAla: 2.954 ± 1.487
0.739MetCys: 0.739 ± 0.511
0.0MetAsp: 0.0 ± 0.0
3.693MetGlu: 3.693 ± 1.687
0.739MetPhe: 0.739 ± 0.56
2.954MetGly: 2.954 ± 1.224
0.739MetHis: 0.739 ± 0.77
0.739MetIle: 0.739 ± 0.77
0.739MetLys: 0.739 ± 0.511
3.693MetLeu: 3.693 ± 1.131
0.739MetMet: 0.739 ± 0.511
2.216MetAsn: 2.216 ± 1.534
0.0MetPro: 0.0 ± 0.0
0.739MetGln: 0.739 ± 0.56
2.954MetArg: 2.954 ± 0.969
4.431MetSer: 4.431 ± 1.455
0.739MetThr: 0.739 ± 0.511
0.739MetVal: 0.739 ± 0.56
1.477MetTrp: 1.477 ± 1.022
1.477MetTyr: 1.477 ± 0.61
0.0MetXaa: 0.0 ± 0.0
Asn
4.431AsnAla: 4.431 ± 1.169
0.0AsnCys: 0.0 ± 0.0
2.216AsnAsp: 2.216 ± 0.821
5.17AsnGlu: 5.17 ± 1.319
2.216AsnPhe: 2.216 ± 1.021
4.431AsnGly: 4.431 ± 0.728
0.0AsnHis: 0.0 ± 0.0
2.216AsnIle: 2.216 ± 1.021
2.216AsnLys: 2.216 ± 1.022
2.954AsnLeu: 2.954 ± 0.591
2.216AsnMet: 2.216 ± 0.821
2.954AsnAsn: 2.954 ± 0.591
2.216AsnPro: 2.216 ± 1.534
2.216AsnGln: 2.216 ± 0.215
3.693AsnArg: 3.693 ± 1.667
1.477AsnSer: 1.477 ± 1.121
5.17AsnThr: 5.17 ± 2.043
2.216AsnVal: 2.216 ± 0.821
0.739AsnTrp: 0.739 ± 0.56
2.954AsnTyr: 2.954 ± 0.969
0.0AsnXaa: 0.0 ± 0.0
Pro
5.908ProAla: 5.908 ± 2.8
1.477ProCys: 1.477 ± 0.61
2.954ProAsp: 2.954 ± 1.224
3.693ProGlu: 3.693 ± 1.867
2.216ProPhe: 2.216 ± 1.021
0.0ProGly: 0.0 ± 0.0
0.0ProHis: 0.0 ± 0.0
2.954ProIle: 2.954 ± 0.969
2.216ProLys: 2.216 ± 0.821
3.693ProLeu: 3.693 ± 0.722
0.0ProMet: 0.0 ± 0.0
3.693ProAsn: 3.693 ± 0.422
0.739ProPro: 0.739 ± 0.56
0.739ProGln: 0.739 ± 0.56
3.693ProArg: 3.693 ± 1.687
0.739ProSer: 0.739 ± 0.511
2.954ProThr: 2.954 ± 0.591
4.431ProVal: 4.431 ± 1.346
2.216ProTrp: 2.216 ± 0.942
0.739ProTyr: 0.739 ± 0.56
0.0ProXaa: 0.0 ± 0.0
Gln
4.431GlnAla: 4.431 ± 1.641
0.739GlnCys: 0.739 ± 0.511
0.739GlnAsp: 0.739 ± 0.511
3.693GlnGlu: 3.693 ± 1.48
2.216GlnPhe: 2.216 ± 0.821
2.216GlnGly: 2.216 ± 0.215
0.739GlnHis: 0.739 ± 0.511
0.0GlnIle: 0.0 ± 0.0
2.216GlnLys: 2.216 ± 1.534
2.216GlnLeu: 2.216 ± 1.534
0.739GlnMet: 0.739 ± 0.77
0.739GlnAsn: 0.739 ± 0.56
0.739GlnPro: 0.739 ± 0.511
1.477GlnGln: 1.477 ± 0.61
2.216GlnArg: 2.216 ± 0.942
3.693GlnSer: 3.693 ± 2.001
1.477GlnThr: 1.477 ± 0.71
2.216GlnVal: 2.216 ± 1.022
0.0GlnTrp: 0.0 ± 0.0
0.739GlnTyr: 0.739 ± 0.511
0.0GlnXaa: 0.0 ± 0.0
Arg
4.431ArgAla: 4.431 ± 0.43
0.739ArgCys: 0.739 ± 0.511
1.477ArgAsp: 1.477 ± 0.61
5.908ArgGlu: 5.908 ± 2.01
1.477ArgPhe: 1.477 ± 1.022
6.647ArgGly: 6.647 ± 1.924
1.477ArgHis: 1.477 ± 1.121
3.693ArgIle: 3.693 ± 0.837
5.908ArgLys: 5.908 ± 2.01
4.431ArgLeu: 4.431 ± 0.728
2.954ArgMet: 2.954 ± 1.271
3.693ArgAsn: 3.693 ± 2.042
3.693ArgPro: 3.693 ± 0.422
1.477ArgGln: 1.477 ± 1.022
5.17ArgArg: 5.17 ± 3.47
5.908ArgSer: 5.908 ± 1.44
2.954ArgThr: 2.954 ± 0.969
5.17ArgVal: 5.17 ± 0.994
0.739ArgTrp: 0.739 ± 0.77
2.954ArgTyr: 2.954 ± 1.165
0.0ArgXaa: 0.0 ± 0.0
Ser
4.431SerAla: 4.431 ± 1.585
0.0SerCys: 0.0 ± 0.0
3.693SerAsp: 3.693 ± 0.915
2.954SerGlu: 2.954 ± 1.419
0.739SerPhe: 0.739 ± 0.511
8.863SerGly: 8.863 ± 2.015
2.216SerHis: 2.216 ± 0.215
3.693SerIle: 3.693 ± 2.084
5.17SerLys: 5.17 ± 2.33
5.17SerLeu: 5.17 ± 1.185
1.477SerMet: 1.477 ± 0.574
2.954SerAsn: 2.954 ± 1.542
2.954SerPro: 2.954 ± 0.334
1.477SerGln: 1.477 ± 0.582
5.908SerArg: 5.908 ± 2.977
3.693SerSer: 3.693 ± 0.915
3.693SerThr: 3.693 ± 0.422
0.739SerVal: 0.739 ± 0.511
0.0SerTrp: 0.0 ± 0.0
3.693SerTyr: 3.693 ± 1.567
0.0SerXaa: 0.0 ± 0.0
Thr
1.477ThrAla: 1.477 ± 0.71
0.0ThrCys: 0.0 ± 0.0
2.216ThrAsp: 2.216 ± 1.021
2.216ThrGlu: 2.216 ± 1.021
1.477ThrPhe: 1.477 ± 1.121
4.431ThrGly: 4.431 ± 1.585
2.216ThrHis: 2.216 ± 0.215
1.477ThrIle: 1.477 ± 0.71
2.216ThrLys: 2.216 ± 0.942
3.693ThrLeu: 3.693 ± 1.48
2.216ThrMet: 2.216 ± 0.942
2.954ThrAsn: 2.954 ± 0.591
4.431ThrPro: 4.431 ± 0.728
0.739ThrGln: 0.739 ± 0.56
2.954ThrArg: 2.954 ± 0.591
4.431ThrSer: 4.431 ± 1.585
6.647ThrThr: 6.647 ± 3.481
2.954ThrVal: 2.954 ± 0.334
2.954ThrTrp: 2.954 ± 0.591
2.954ThrTyr: 2.954 ± 0.334
0.0ThrXaa: 0.0 ± 0.0
Val
8.863ValAla: 8.863 ± 2.906
0.739ValCys: 0.739 ± 0.511
2.954ValAsp: 2.954 ± 1.419
4.431ValGlu: 4.431 ± 1.346
3.693ValPhe: 3.693 ± 1.48
7.386ValGly: 7.386 ± 1.381
0.0ValHis: 0.0 ± 0.0
5.908ValIle: 5.908 ± 1.275
4.431ValLys: 4.431 ± 1.829
2.216ValLeu: 2.216 ± 0.942
0.739ValMet: 0.739 ± 0.77
4.431ValAsn: 4.431 ± 0.728
4.431ValPro: 4.431 ± 0.43
2.216ValGln: 2.216 ± 0.942
3.693ValArg: 3.693 ± 1.667
2.216ValSer: 2.216 ± 1.022
1.477ValThr: 1.477 ± 0.582
4.431ValVal: 4.431 ± 1.585
2.216ValTrp: 2.216 ± 1.021
2.216ValTyr: 2.216 ± 1.534
0.0ValXaa: 0.0 ± 0.0
Trp
0.739TrpAla: 0.739 ± 0.77
0.0TrpCys: 0.0 ± 0.0
0.739TrpAsp: 0.739 ± 0.511
1.477TrpGlu: 1.477 ± 0.61
0.739TrpPhe: 0.739 ± 0.511
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
2.216TrpIle: 2.216 ± 1.021
0.739TrpLys: 0.739 ± 0.56
1.477TrpLeu: 1.477 ± 0.71
1.477TrpMet: 1.477 ± 0.582
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
1.477TrpArg: 1.477 ± 0.71
2.216TrpSer: 2.216 ± 1.534
0.0TrpThr: 0.0 ± 0.0
2.954TrpVal: 2.954 ± 0.591
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.216TyrAla: 2.216 ± 1.021
0.739TyrCys: 0.739 ± 0.56
2.954TyrAsp: 2.954 ± 2.242
2.216TyrGlu: 2.216 ± 1.022
2.216TyrPhe: 2.216 ± 0.942
1.477TyrGly: 1.477 ± 0.582
0.0TyrHis: 0.0 ± 0.0
1.477TyrIle: 1.477 ± 0.582
2.216TyrLys: 2.216 ± 1.534
3.693TyrLeu: 3.693 ± 1.567
0.0TyrMet: 0.0 ± 0.0
1.477TyrAsn: 1.477 ± 0.61
0.0TyrPro: 0.0 ± 0.0
0.739TyrGln: 0.739 ± 0.511
2.954TyrArg: 2.954 ± 1.224
2.216TyrSer: 2.216 ± 0.821
1.477TyrThr: 1.477 ± 0.61
5.908TyrVal: 5.908 ± 2.152
0.739TyrTrp: 0.739 ± 0.77
2.954TyrTyr: 2.954 ± 1.224
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1355 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski