Amino acid dipepetide frequency for Paludifilum halophilum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.039AlaAla: 7.039 ± 0.106	0.718AlaCys: 0.718 ± 0.027	4.241AlaAsp: 4.241 ± 0.071	5.74AlaGlu: 5.74 ± 0.084	3.196AlaPhe: 3.196 ± 0.062	6.827AlaGly: 6.827 ± 0.091	1.384AlaHis: 1.384 ± 0.037	4.421AlaIle: 4.421 ± 0.083	3.538AlaLys: 3.538 ± 0.061	7.667AlaLeu: 7.667 ± 0.09	2.083AlaMet: 2.083 ± 0.046	1.906AlaAsn: 1.906 ± 0.046	2.543AlaPro: 2.543 ± 0.05	2.35AlaGln: 2.35 ± 0.051	4.466AlaArg: 4.466 ± 0.073	4.105AlaSer: 4.105 ± 0.068	3.23AlaThr: 3.23 ± 0.059	6.997AlaVal: 6.997 ± 0.102	0.93AlaTrp: 0.93 ± 0.03	2.275AlaTyr: 2.275 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.493CysAla: 0.493 ± 0.02	0.105CysCys: 0.105 ± 0.011	0.456CysAsp: 0.456 ± 0.022	0.446CysGlu: 0.446 ± 0.022	0.368CysPhe: 0.368 ± 0.02	0.812CysGly: 0.812 ± 0.029	0.222CysHis: 0.222 ± 0.017	0.44CysIle: 0.44 ± 0.018	0.277CysLys: 0.277 ± 0.016	0.795CysLeu: 0.795 ± 0.03	0.178CysMet: 0.178 ± 0.014	0.251CysAsn: 0.251 ± 0.015	0.474CysPro: 0.474 ± 0.023	0.257CysGln: 0.257 ± 0.016	0.673CysArg: 0.673 ± 0.026	0.554CysSer: 0.554 ± 0.025	0.411CysThr: 0.411 ± 0.021	0.447CysVal: 0.447 ± 0.019	0.115CysTrp: 0.115 ± 0.01	0.255CysTyr: 0.255 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.611AspAla: 3.611 ± 0.059	0.434AspCys: 0.434 ± 0.019	2.551AspAsp: 2.551 ± 0.053	4.218AspGlu: 4.218 ± 0.072	2.187AspPhe: 2.187 ± 0.044	4.08AspGly: 4.08 ± 0.074	1.398AspHis: 1.398 ± 0.034	2.94AspIle: 2.94 ± 0.058	2.076AspLys: 2.076 ± 0.049	5.581AspLeu: 5.581 ± 0.07	1.208AspMet: 1.208 ± 0.035	1.274AspAsn: 1.274 ± 0.043	3.29AspPro: 3.29 ± 0.061	2.445AspGln: 2.445 ± 0.054	4.505AspArg: 4.505 ± 0.061	2.868AspSer: 2.868 ± 0.05	2.505AspThr: 2.505 ± 0.049	3.723AspVal: 3.723 ± 0.062	0.979AspTrp: 0.979 ± 0.036	1.807AspTyr: 1.807 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	6.234GluAla: 6.234 ± 0.097	0.47GluCys: 0.47 ± 0.023	3.825GluAsp: 3.825 ± 0.063	8.078GluGlu: 8.078 ± 0.132	1.776GluPhe: 1.776 ± 0.044	5.553GluGly: 5.553 ± 0.08	1.407GluHis: 1.407 ± 0.044	4.322GluIle: 4.322 ± 0.071	5.767GluLys: 5.767 ± 0.093	6.282GluLeu: 6.282 ± 0.082	2.264GluMet: 2.264 ± 0.053	2.634GluAsn: 2.634 ± 0.059	2.64GluPro: 2.64 ± 0.05	3.339GluGln: 3.339 ± 0.061	5.052GluArg: 5.052 ± 0.093	3.747GluSer: 3.747 ± 0.062	4.001GluThr: 4.001 ± 0.063	5.53GluVal: 5.53 ± 0.085	1.23GluTrp: 1.23 ± 0.034	1.936GluTyr: 1.936 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	2.825PheAla: 2.825 ± 0.056	0.353PheCys: 0.353 ± 0.018	2.152PheAsp: 2.152 ± 0.044	2.215PheGlu: 2.215 ± 0.051	2.062PhePhe: 2.062 ± 0.063	3.134PheGly: 3.134 ± 0.071	1.089PheHis: 1.089 ± 0.028	2.377PheIle: 2.377 ± 0.061	1.362PheLys: 1.362 ± 0.035	4.26PheLeu: 4.26 ± 0.08	0.882PheMet: 0.882 ± 0.033	1.185PheAsn: 1.185 ± 0.038	1.925PhePro: 1.925 ± 0.04	1.578PheGln: 1.578 ± 0.041	2.467PheArg: 2.467 ± 0.046	2.84PheSer: 2.84 ± 0.054	2.137PheThr: 2.137 ± 0.044	2.709PheVal: 2.709 ± 0.049	0.503PheTrp: 0.503 ± 0.023	1.393PheTyr: 1.393 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	5.63GlyAla: 5.63 ± 0.091	0.793GlyCys: 0.793 ± 0.031	3.991GlyAsp: 3.991 ± 0.061	5.81GlyGlu: 5.81 ± 0.082	3.325GlyPhe: 3.325 ± 0.061	6.17GlyGly: 6.17 ± 0.09	1.565GlyHis: 1.565 ± 0.041	5.379GlyIle: 5.379 ± 0.083	4.832GlyLys: 4.832 ± 0.066	7.455GlyLeu: 7.455 ± 0.11	2.559GlyMet: 2.559 ± 0.055	2.453GlyAsn: 2.453 ± 0.061	2.401GlyPro: 2.401 ± 0.051	2.447GlyGln: 2.447 ± 0.04	4.626GlyArg: 4.626 ± 0.068	4.581GlySer: 4.581 ± 0.07	4.37GlyThr: 4.37 ± 0.068	6.204GlyVal: 6.204 ± 0.082	1.381GlyTrp: 1.381 ± 0.043	2.715GlyTyr: 2.715 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.416HisAla: 1.416 ± 0.035	0.239HisCys: 0.239 ± 0.016	0.955HisAsp: 0.955 ± 0.036	1.187HisGlu: 1.187 ± 0.034	0.982HisPhe: 0.982 ± 0.031	1.555HisGly: 1.555 ± 0.043	0.739HisHis: 0.739 ± 0.029	1.287HisIle: 1.287 ± 0.04	0.718HisLys: 0.718 ± 0.024	2.54HisLeu: 2.54 ± 0.061	0.524HisMet: 0.524 ± 0.022	0.576HisAsn: 0.576 ± 0.022	1.699HisPro: 1.699 ± 0.043	0.94HisGln: 0.94 ± 0.032	1.856HisArg: 1.856 ± 0.043	1.262HisSer: 1.262 ± 0.034	1.152HisThr: 1.152 ± 0.033	1.436HisVal: 1.436 ± 0.036	0.337HisTrp: 0.337 ± 0.019	0.757HisTyr: 0.757 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	4.937IleAla: 4.937 ± 0.084	0.533IleCys: 0.533 ± 0.021	3.4IleAsp: 3.4 ± 0.068	3.614IleGlu: 3.614 ± 0.058	2.116IlePhe: 2.116 ± 0.051	5.088IleGly: 5.088 ± 0.079	1.666IleHis: 1.666 ± 0.038	2.91IleIle: 2.91 ± 0.058	2.241IleLys: 2.241 ± 0.052	5.911IleLeu: 5.911 ± 0.094	1.152IleMet: 1.152 ± 0.039	1.736IleAsn: 1.736 ± 0.038	3.337IlePro: 3.337 ± 0.063	2.605IleGln: 2.605 ± 0.051	4.837IleArg: 4.837 ± 0.077	3.612IleSer: 3.612 ± 0.062	3.099IleThr: 3.099 ± 0.064	3.914IleVal: 3.914 ± 0.065	0.681IleTrp: 0.681 ± 0.027	1.706IleTyr: 1.706 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.049LysAla: 4.049 ± 0.071	0.238LysCys: 0.238 ± 0.017	2.77LysAsp: 2.77 ± 0.057	5.365LysGlu: 5.365 ± 0.086	1.04LysPhe: 1.04 ± 0.033	4.284LysGly: 4.284 ± 0.067	0.995LysHis: 0.995 ± 0.033	2.666LysIle: 2.666 ± 0.058	4.472LysLys: 4.472 ± 0.081	3.982LysLeu: 3.982 ± 0.054	1.499LysMet: 1.499 ± 0.038	2.065LysAsn: 2.065 ± 0.048	2.215LysPro: 2.215 ± 0.049	2.217LysGln: 2.217 ± 0.054	3.656LysArg: 3.656 ± 0.055	2.544LysSer: 2.544 ± 0.046	2.881LysThr: 2.881 ± 0.045	3.788LysVal: 3.788 ± 0.068	0.709LysTrp: 0.709 ± 0.026	1.355LysTyr: 1.355 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	7.913LeuAla: 7.913 ± 0.108	0.829LeuCys: 0.829 ± 0.029	5.267LeuAsp: 5.267 ± 0.082	6.7LeuGlu: 6.7 ± 0.089	4.592LeuPhe: 4.592 ± 0.084	6.885LeuGly: 6.885 ± 0.089	2.111LeuHis: 2.111 ± 0.049	6.107LeuIle: 6.107 ± 0.095	5.521LeuLys: 5.521 ± 0.074	10.185LeuLeu: 10.185 ± 0.172	2.395LeuMet: 2.395 ± 0.054	3.47LeuAsn: 3.47 ± 0.058	4.622LeuPro: 4.622 ± 0.079	3.46LeuGln: 3.46 ± 0.053	5.491LeuArg: 5.491 ± 0.084	6.901LeuSer: 6.901 ± 0.089	5.308LeuThr: 5.308 ± 0.067	6.622LeuVal: 6.622 ± 0.095	1.138LeuTrp: 1.138 ± 0.035	2.878LeuTyr: 2.878 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.307MetAla: 2.307 ± 0.051	0.125MetCys: 0.125 ± 0.012	1.69MetAsp: 1.69 ± 0.044	2.263MetGlu: 2.263 ± 0.052	0.826MetPhe: 0.826 ± 0.028	2.115MetGly: 2.115 ± 0.052	0.417MetHis: 0.417 ± 0.018	1.872MetIle: 1.872 ± 0.04	1.946MetLys: 1.946 ± 0.044	2.2MetLeu: 2.2 ± 0.054	0.862MetMet: 0.862 ± 0.032	1.193MetAsn: 1.193 ± 0.034	1.01MetPro: 1.01 ± 0.036	0.8MetGln: 0.8 ± 0.029	1.422MetArg: 1.422 ± 0.036	1.432MetSer: 1.432 ± 0.033	1.508MetThr: 1.508 ± 0.038	2.077MetVal: 2.077 ± 0.045	0.21MetTrp: 0.21 ± 0.014	0.584MetTyr: 0.584 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.155AsnAla: 2.155 ± 0.051	0.226AsnCys: 0.226 ± 0.013	1.465AsnAsp: 1.465 ± 0.041	1.982AsnGlu: 1.982 ± 0.048	0.907AsnPhe: 0.907 ± 0.03	2.517AsnGly: 2.517 ± 0.06	0.88AsnHis: 0.88 ± 0.029	1.857AsnIle: 1.857 ± 0.038	1.409AsnLys: 1.409 ± 0.041	2.95AsnLeu: 2.95 ± 0.049	0.772AsnMet: 0.772 ± 0.03	0.993AsnAsn: 0.993 ± 0.038	2.179AsnPro: 2.179 ± 0.051	1.516AsnGln: 1.516 ± 0.047	2.993AsnArg: 2.993 ± 0.055	1.455AsnSer: 1.455 ± 0.044	1.542AsnThr: 1.542 ± 0.04	1.996AsnVal: 1.996 ± 0.046	0.424AsnTrp: 0.424 ± 0.02	0.887AsnTyr: 0.887 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	3.097ProAla: 3.097 ± 0.063	0.307ProCys: 0.307 ± 0.015	3.24ProAsp: 3.24 ± 0.052	4.296ProGlu: 4.296 ± 0.077	2.094ProPhe: 2.094 ± 0.05	3.708ProGly: 3.708 ± 0.063	1.046ProHis: 1.046 ± 0.031	2.389ProIle: 2.389 ± 0.053	1.94ProLys: 1.94 ± 0.05	4.265ProLeu: 4.265 ± 0.067	1.091ProMet: 1.091 ± 0.033	1.243ProAsn: 1.243 ± 0.035	1.824ProPro: 1.824 ± 0.052	1.451ProGln: 1.451 ± 0.039	2.355ProArg: 2.355 ± 0.051	2.856ProSer: 2.856 ± 0.05	1.998ProThr: 1.998 ± 0.046	4.013ProVal: 4.013 ± 0.062	0.616ProTrp: 0.616 ± 0.025	1.499ProTyr: 1.499 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.237GlnAla: 3.237 ± 0.058	0.217GlnCys: 0.217 ± 0.017	1.564GlnAsp: 1.564 ± 0.036	2.799GlnGlu: 2.799 ± 0.063	1.211GlnPhe: 1.211 ± 0.038	2.651GlnGly: 2.651 ± 0.053	0.686GlnHis: 0.686 ± 0.026	2.008GlnIle: 2.008 ± 0.05	2.276GlnLys: 2.276 ± 0.051	3.732GlnLeu: 3.732 ± 0.064	1.146GlnMet: 1.146 ± 0.033	1.165GlnAsn: 1.165 ± 0.032	1.836GlnPro: 1.836 ± 0.049	1.654GlnGln: 1.654 ± 0.068	2.37GlnArg: 2.37 ± 0.053	2.124GlnSer: 2.124 ± 0.044	2.065GlnThr: 2.065 ± 0.041	2.92GlnVal: 2.92 ± 0.058	0.604GlnTrp: 0.604 ± 0.025	1.139GlnTyr: 1.139 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.766ArgAla: 3.766 ± 0.063	0.531ArgCys: 0.531 ± 0.023	3.255ArgAsp: 3.255 ± 0.053	5.864ArgGlu: 5.864 ± 0.094	2.899ArgPhe: 2.899 ± 0.058	4.318ArgGly: 4.318 ± 0.074	1.371ArgHis: 1.371 ± 0.041	4.319ArgIle: 4.319 ± 0.075	3.9ArgLys: 3.9 ± 0.068	7.105ArgLeu: 7.105 ± 0.104	2.252ArgMet: 2.252 ± 0.045	1.984ArgAsn: 1.984 ± 0.042	2.484ArgPro: 2.484 ± 0.046	2.526ArgGln: 2.526 ± 0.046	4.959ArgArg: 4.959 ± 0.089	3.697ArgSer: 3.697 ± 0.067	2.962ArgThr: 2.962 ± 0.047	4.97ArgVal: 4.97 ± 0.066	1.124ArgTrp: 1.124 ± 0.037	2.305ArgTyr: 2.305 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	4.076SerAla: 4.076 ± 0.062	0.456SerCys: 0.456 ± 0.023	3.097SerAsp: 3.097 ± 0.061	3.702SerGlu: 3.702 ± 0.06	2.831SerPhe: 2.831 ± 0.058	5.174SerGly: 5.174 ± 0.074	1.313SerHis: 1.313 ± 0.037	3.401SerIle: 3.401 ± 0.06	2.5SerLys: 2.5 ± 0.049	6.258SerLeu: 6.258 ± 0.085	1.542SerMet: 1.542 ± 0.039	1.536SerAsn: 1.536 ± 0.038	2.94SerPro: 2.94 ± 0.057	1.855SerGln: 1.855 ± 0.041	3.97SerArg: 3.97 ± 0.061	3.597SerSer: 3.597 ± 0.081	2.734SerThr: 2.734 ± 0.053	4.339SerVal: 4.339 ± 0.062	0.803SerTrp: 0.803 ± 0.028	1.757SerTyr: 1.757 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	4.443ThrAla: 4.443 ± 0.068	0.423ThrCys: 0.423 ± 0.021	2.892ThrAsp: 2.892 ± 0.062	3.387ThrGlu: 3.387 ± 0.063	2.169ThrPhe: 2.169 ± 0.049	4.94ThrGly: 4.94 ± 0.065	1.105ThrHis: 1.105 ± 0.029	2.846ThrIle: 2.846 ± 0.065	1.906ThrLys: 1.906 ± 0.046	5.244ThrLeu: 5.244 ± 0.076	1.258ThrMet: 1.258 ± 0.036	1.36ThrAsn: 1.36 ± 0.033	2.657ThrPro: 2.657 ± 0.054	1.462ThrGln: 1.462 ± 0.039	2.928ThrArg: 2.928 ± 0.053	2.732ThrSer: 2.732 ± 0.052	2.462ThrThr: 2.462 ± 0.06	4.645ThrVal: 4.645 ± 0.066	0.639ThrTrp: 0.639 ± 0.028	1.652ThrTyr: 1.652 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	5.53ValAla: 5.53 ± 0.067	0.659ValCys: 0.659 ± 0.027	4.431ValAsp: 4.431 ± 0.069	5.504ValGlu: 5.504 ± 0.077	2.939ValPhe: 2.939 ± 0.052	5.353ValGly: 5.353 ± 0.064	1.691ValHis: 1.691 ± 0.04	4.859ValIle: 4.859 ± 0.067	3.94ValLys: 3.94 ± 0.061	7.348ValLeu: 7.348 ± 0.088	1.917ValMet: 1.917 ± 0.043	2.455ValAsn: 2.455 ± 0.047	3.277ValPro: 3.277 ± 0.054	2.759ValGln: 2.759 ± 0.049	4.485ValArg: 4.485 ± 0.074	4.626ValSer: 4.626 ± 0.072	4.4ValThr: 4.4 ± 0.074	5.668ValVal: 5.668 ± 0.09	0.918ValTrp: 0.918 ± 0.03	2.194ValTyr: 2.194 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.852TrpAla: 0.852 ± 0.032	0.093TrpCys: 0.093 ± 0.01	0.692TrpAsp: 0.692 ± 0.027	1.008TrpGlu: 1.008 ± 0.032	0.606TrpPhe: 0.606 ± 0.026	0.988TrpGly: 0.988 ± 0.034	0.242TrpHis: 0.242 ± 0.016	1.04TrpIle: 1.04 ± 0.036	0.913TrpLys: 0.913 ± 0.026	1.453TrpLeu: 1.453 ± 0.042	0.575TrpMet: 0.575 ± 0.025	0.639TrpAsn: 0.639 ± 0.023	0.407TrpPro: 0.407 ± 0.022	0.427TrpGln: 0.427 ± 0.023	0.776TrpArg: 0.776 ± 0.029	0.791TrpSer: 0.791 ± 0.03	0.745TrpThr: 0.745 ± 0.027	1.101TrpVal: 1.101 ± 0.033	0.252TrpTrp: 0.252 ± 0.019	0.417TrpTyr: 0.417 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.044TyrAla: 2.044 ± 0.047	0.28TyrCys: 0.28 ± 0.016	1.747TyrAsp: 1.747 ± 0.044	1.911TyrGlu: 1.911 ± 0.047	1.323TyrPhe: 1.323 ± 0.035	2.536TyrGly: 2.536 ± 0.052	0.833TyrHis: 0.833 ± 0.028	1.655TyrIle: 1.655 ± 0.045	1.255TyrLys: 1.255 ± 0.033	3.181TyrLeu: 3.181 ± 0.056	0.699TyrMet: 0.699 ± 0.024	0.987TyrAsn: 0.987 ± 0.032	1.564TyrPro: 1.564 ± 0.041	1.314TyrGln: 1.314 ± 0.036	2.703TyrArg: 2.703 ± 0.049	1.56TyrSer: 1.56 ± 0.037	1.639TyrThr: 1.639 ± 0.043	1.854TyrVal: 1.854 ± 0.044	0.424TyrTrp: 0.424 ± 0.021	1.165TyrTyr: 1.165 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3615 proteins (1049894 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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