Amino acid dipepetide frequency for Sphingomonas melonis TY

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.81AlaAla: 21.81 ± 0.245	1.096AlaCys: 1.096 ± 0.034	8.59AlaAsp: 8.59 ± 0.113	7.222AlaGlu: 7.222 ± 0.102	4.485AlaPhe: 4.485 ± 0.067	12.231AlaGly: 12.231 ± 0.113	2.536AlaHis: 2.536 ± 0.052	7.214AlaIle: 7.214 ± 0.093	4.072AlaLys: 4.072 ± 0.082	14.4AlaLeu: 14.4 ± 0.145	4.055AlaMet: 4.055 ± 0.066	3.185AlaAsn: 3.185 ± 0.055	7.055AlaPro: 7.055 ± 0.113	4.664AlaGln: 4.664 ± 0.065	10.336AlaArg: 10.336 ± 0.13	6.574AlaSer: 6.574 ± 0.078	7.899AlaThr: 7.899 ± 0.092	9.378AlaVal: 9.378 ± 0.106	1.792AlaTrp: 1.792 ± 0.036	2.662AlaTyr: 2.662 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.972CysAla: 0.972 ± 0.03	0.084CysCys: 0.084 ± 0.008	0.51CysAsp: 0.51 ± 0.022	0.346CysGlu: 0.346 ± 0.02	0.261CysPhe: 0.261 ± 0.016	0.821CysGly: 0.821 ± 0.031	0.184CysHis: 0.184 ± 0.012	0.343CysIle: 0.343 ± 0.017	0.153CysLys: 0.153 ± 0.011	0.638CysLeu: 0.638 ± 0.024	0.128CysMet: 0.128 ± 0.011	0.154CysAsn: 0.154 ± 0.012	0.405CysPro: 0.405 ± 0.018	0.187CysGln: 0.187 ± 0.013	0.571CysArg: 0.571 ± 0.024	0.402CysSer: 0.402 ± 0.02	0.393CysThr: 0.393 ± 0.022	0.515CysVal: 0.515 ± 0.021	0.121CysTrp: 0.121 ± 0.008	0.16CysTyr: 0.16 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	9.213AspAla: 9.213 ± 0.105	0.429AspCys: 0.429 ± 0.018	3.659AspAsp: 3.659 ± 0.059	3.111AspGlu: 3.111 ± 0.058	1.929AspPhe: 1.929 ± 0.045	6.039AspGly: 6.039 ± 0.079	1.367AspHis: 1.367 ± 0.036	2.617AspIle: 2.617 ± 0.051	1.541AspLys: 1.541 ± 0.042	5.953AspLeu: 5.953 ± 0.071	1.337AspMet: 1.337 ± 0.035	1.211AspAsn: 1.211 ± 0.033	3.94AspPro: 3.94 ± 0.068	1.899AspGln: 1.899 ± 0.04	5.442AspArg: 5.442 ± 0.076	2.149AspSer: 2.149 ± 0.042	3.247AspThr: 3.247 ± 0.051	4.422AspVal: 4.422 ± 0.059	1.181AspTrp: 1.181 ± 0.031	1.68AspTyr: 1.68 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.439GluAla: 7.439 ± 0.108	0.269GluCys: 0.269 ± 0.017	2.466GluAsp: 2.466 ± 0.048	2.338GluGlu: 2.338 ± 0.056	1.177GluPhe: 1.177 ± 0.035	4.167GluGly: 4.167 ± 0.052	1.045GluHis: 1.045 ± 0.033	2.328GluIle: 2.328 ± 0.049	1.448GluLys: 1.448 ± 0.04	4.289GluLeu: 4.289 ± 0.072	1.165GluMet: 1.165 ± 0.034	1.032GluAsn: 1.032 ± 0.036	2.358GluPro: 2.358 ± 0.055	1.88GluGln: 1.88 ± 0.039	4.824GluArg: 4.824 ± 0.081	1.902GluSer: 1.902 ± 0.048	2.905GluThr: 2.905 ± 0.049	3.34GluVal: 3.34 ± 0.052	0.639GluTrp: 0.639 ± 0.025	0.81GluTyr: 0.81 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.91PheAla: 4.91 ± 0.066	0.287PheCys: 0.287 ± 0.014	2.742PheAsp: 2.742 ± 0.052	1.678PheGlu: 1.678 ± 0.038	1.165PhePhe: 1.165 ± 0.034	3.518PheGly: 3.518 ± 0.06	0.619PheHis: 0.619 ± 0.023	1.168PheIle: 1.168 ± 0.034	0.759PheLys: 0.759 ± 0.029	2.863PheLeu: 2.863 ± 0.059	0.646PheMet: 0.646 ± 0.024	0.942PheAsn: 0.942 ± 0.029	1.416PhePro: 1.416 ± 0.031	0.877PheGln: 0.877 ± 0.027	2.21PheArg: 2.21 ± 0.041	1.72PheSer: 1.72 ± 0.043	1.999PheThr: 1.999 ± 0.043	2.691PheVal: 2.691 ± 0.052	0.466PheTrp: 0.466 ± 0.019	0.828PheTyr: 0.828 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	10.363GlyAla: 10.363 ± 0.112	0.818GlyCys: 0.818 ± 0.027	5.246GlyAsp: 5.246 ± 0.069	4.483GlyGlu: 4.483 ± 0.067	3.515GlyPhe: 3.515 ± 0.052	8.308GlyGly: 8.308 ± 0.109	1.822GlyHis: 1.822 ± 0.045	4.621GlyIle: 4.621 ± 0.055	2.956GlyLys: 2.956 ± 0.057	8.621GlyLeu: 8.621 ± 0.109	2.233GlyMet: 2.233 ± 0.047	2.195GlyAsn: 2.195 ± 0.052	3.673GlyPro: 3.673 ± 0.052	3.099GlyGln: 3.099 ± 0.052	6.965GlyArg: 6.965 ± 0.081	4.603GlySer: 4.603 ± 0.072	5.291GlyThr: 5.291 ± 0.079	6.741GlyVal: 6.741 ± 0.083	1.729GlyTrp: 1.729 ± 0.042	2.42GlyTyr: 2.42 ± 0.047	0.003GlyXaa: 0.003 ± 0.002
His	2.62HisAla: 2.62 ± 0.051	0.182HisCys: 0.182 ± 0.011	1.395HisAsp: 1.395 ± 0.038	0.916HisGlu: 0.916 ± 0.029	0.741HisPhe: 0.741 ± 0.025	1.974HisGly: 1.974 ± 0.045	0.567HisHis: 0.567 ± 0.024	0.873HisIle: 0.873 ± 0.031	0.367HisLys: 0.367 ± 0.017	1.882HisLeu: 1.882 ± 0.042	0.389HisMet: 0.389 ± 0.018	0.442HisAsn: 0.442 ± 0.02	1.286HisPro: 1.286 ± 0.037	0.576HisGln: 0.576 ± 0.022	1.562HisArg: 1.562 ± 0.036	0.744HisSer: 0.744 ± 0.027	0.783HisThr: 0.783 ± 0.028	1.535HisVal: 1.535 ± 0.04	0.365HisTrp: 0.365 ± 0.02	0.541HisTyr: 0.541 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	8.478IleAla: 8.478 ± 0.104	0.357IleCys: 0.357 ± 0.02	4.127IleAsp: 4.127 ± 0.061	3.059IleGlu: 3.059 ± 0.057	1.237IlePhe: 1.237 ± 0.035	5.184IleGly: 5.184 ± 0.076	0.854IleHis: 0.854 ± 0.028	1.57IleIle: 1.57 ± 0.042	1.047IleLys: 1.047 ± 0.033	3.666IleLeu: 3.666 ± 0.057	0.694IleMet: 0.694 ± 0.024	1.224IleAsn: 1.224 ± 0.04	2.092IlePro: 2.092 ± 0.046	1.114IleGln: 1.114 ± 0.033	3.1IleArg: 3.1 ± 0.051	1.971IleSer: 1.971 ± 0.045	2.472IleThr: 2.472 ± 0.051	4.476IleVal: 4.476 ± 0.069	0.533IleTrp: 0.533 ± 0.02	0.875IleTyr: 0.875 ± 0.028	0.001IleXaa: 0.001 ± 0.001
Lys	3.894LysAla: 3.894 ± 0.071	0.107LysCys: 0.107 ± 0.009	1.457LysAsp: 1.457 ± 0.039	0.959LysGlu: 0.959 ± 0.034	0.644LysPhe: 0.644 ± 0.024	2.441LysGly: 2.441 ± 0.05	0.453LysHis: 0.453 ± 0.023	1.185LysIle: 1.185 ± 0.04	0.865LysLys: 0.865 ± 0.035	2.727LysLeu: 2.727 ± 0.052	0.639LysMet: 0.639 ± 0.025	0.597LysAsn: 0.597 ± 0.022	1.891LysPro: 1.891 ± 0.045	0.824LysGln: 0.824 ± 0.029	2.088LysArg: 2.088 ± 0.039	1.347LysSer: 1.347 ± 0.035	1.691LysThr: 1.691 ± 0.037	1.999LysVal: 1.999 ± 0.048	0.3LysTrp: 0.3 ± 0.017	0.508LysTyr: 0.508 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.408LeuAla: 14.408 ± 0.143	0.714LeuCys: 0.714 ± 0.026	6.369LeuAsp: 6.369 ± 0.071	4.047LeuGlu: 4.047 ± 0.068	3.489LeuPhe: 3.489 ± 0.063	8.175LeuGly: 8.175 ± 0.088	1.853LeuHis: 1.853 ± 0.044	4.59LeuIle: 4.59 ± 0.069	2.756LeuLys: 2.756 ± 0.051	9.017LeuLeu: 9.017 ± 0.123	2.014LeuMet: 2.014 ± 0.044	2.201LeuAsn: 2.201 ± 0.048	5.829LeuPro: 5.829 ± 0.081	2.394LeuGln: 2.394 ± 0.054	7.033LeuArg: 7.033 ± 0.085	5.732LeuSer: 5.732 ± 0.071	6.058LeuThr: 6.058 ± 0.07	7.171LeuVal: 7.171 ± 0.09	1.258LeuTrp: 1.258 ± 0.036	1.981LeuTyr: 1.981 ± 0.042	0.001LeuXaa: 0.001 ± 0.001
Met	3.121MetAla: 3.121 ± 0.052	0.144MetCys: 0.144 ± 0.012	1.026MetAsp: 1.026 ± 0.031	0.897MetGlu: 0.897 ± 0.024	0.613MetPhe: 0.613 ± 0.024	1.772MetGly: 1.772 ± 0.037	0.437MetHis: 0.437 ± 0.019	1.26MetIle: 1.26 ± 0.035	0.766MetLys: 0.766 ± 0.025	2.505MetLeu: 2.505 ± 0.052	0.619MetMet: 0.619 ± 0.024	0.58MetAsn: 0.58 ± 0.023	1.494MetPro: 1.494 ± 0.037	0.671MetGln: 0.671 ± 0.02	1.803MetArg: 1.803 ± 0.038	1.272MetSer: 1.272 ± 0.033	1.915MetThr: 1.915 ± 0.038	1.553MetVal: 1.553 ± 0.034	0.205MetTrp: 0.205 ± 0.013	0.279MetTyr: 0.279 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.188AsnAla: 3.188 ± 0.054	0.209AsnCys: 0.209 ± 0.016	1.383AsnAsp: 1.383 ± 0.036	0.924AsnGlu: 0.924 ± 0.029	0.811AsnPhe: 0.811 ± 0.03	2.43AsnGly: 2.43 ± 0.049	0.441AsnHis: 0.441 ± 0.021	1.086AsnIle: 1.086 ± 0.034	0.565AsnLys: 0.565 ± 0.021	2.359AsnLeu: 2.359 ± 0.05	0.438AsnMet: 0.438 ± 0.019	0.675AsnAsn: 0.675 ± 0.032	1.673AsnPro: 1.673 ± 0.039	0.734AsnGln: 0.734 ± 0.028	1.764AsnArg: 1.764 ± 0.046	1.043AsnSer: 1.043 ± 0.034	1.256AsnThr: 1.256 ± 0.035	1.874AsnVal: 1.874 ± 0.045	0.392AsnTrp: 0.392 ± 0.017	0.699AsnTyr: 0.699 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	7.982ProAla: 7.982 ± 0.126	0.324ProCys: 0.324 ± 0.015	3.886ProAsp: 3.886 ± 0.058	3.038ProGlu: 3.038 ± 0.052	1.904ProPhe: 1.904 ± 0.037	4.78ProGly: 4.78 ± 0.062	1.058ProHis: 1.058 ± 0.03	2.575ProIle: 2.575 ± 0.055	1.456ProLys: 1.456 ± 0.036	5.014ProLeu: 5.014 ± 0.08	1.157ProMet: 1.157 ± 0.028	1.283ProAsn: 1.283 ± 0.038	2.859ProPro: 2.859 ± 0.077	1.819ProGln: 1.819 ± 0.039	3.371ProArg: 3.371 ± 0.052	2.621ProSer: 2.621 ± 0.044	2.969ProThr: 2.969 ± 0.055	4.591ProVal: 4.591 ± 0.073	0.703ProTrp: 0.703 ± 0.026	1.149ProTyr: 1.149 ± 0.032	0.004ProXaa: 0.004 ± 0.002
Gln	4.577GlnAla: 4.577 ± 0.07	0.202GlnCys: 0.202 ± 0.013	1.462GlnAsp: 1.462 ± 0.035	1.083GlnGlu: 1.083 ± 0.033	1.042GlnPhe: 1.042 ± 0.029	2.577GlnGly: 2.577 ± 0.044	0.59GlnHis: 0.59 ± 0.025	1.586GlnIle: 1.586 ± 0.04	0.731GlnLys: 0.731 ± 0.028	3.034GlnLeu: 3.034 ± 0.049	0.797GlnMet: 0.797 ± 0.028	0.777GlnAsn: 0.777 ± 0.026	1.942GlnPro: 1.942 ± 0.044	1.198GlnGln: 1.198 ± 0.044	2.748GlnArg: 2.748 ± 0.057	1.622GlnSer: 1.622 ± 0.042	1.826GlnThr: 1.826 ± 0.043	2.247GlnVal: 2.247 ± 0.047	0.431GlnTrp: 0.431 ± 0.017	0.64GlnTyr: 0.64 ± 0.026	0.001GlnXaa: 0.001 ± 0.001
Arg	9.421ArgAla: 9.421 ± 0.118	0.512ArgCys: 0.512 ± 0.024	4.819ArgAsp: 4.819 ± 0.07	3.662ArgGlu: 3.662 ± 0.061	3.183ArgPhe: 3.183 ± 0.055	5.591ArgGly: 5.591 ± 0.074	1.788ArgHis: 1.788 ± 0.048	4.267ArgIle: 4.267 ± 0.064	1.712ArgLys: 1.712 ± 0.042	8.407ArgLeu: 8.407 ± 0.105	1.968ArgMet: 1.968 ± 0.039	1.824ArgAsn: 1.824 ± 0.037	3.946ArgPro: 3.946 ± 0.055	2.563ArgGln: 2.563 ± 0.043	6.363ArgArg: 6.363 ± 0.098	3.689ArgSer: 3.689 ± 0.063	3.975ArgThr: 3.975 ± 0.057	5.358ArgVal: 5.358 ± 0.072	1.328ArgTrp: 1.328 ± 0.037	2.083ArgTyr: 2.083 ± 0.042	0.001ArgXaa: 0.001 ± 0.001
Ser	6.174SerAla: 6.174 ± 0.089	0.346SerCys: 0.346 ± 0.019	2.934SerAsp: 2.934 ± 0.055	2.1SerGlu: 2.1 ± 0.047	1.907SerPhe: 1.907 ± 0.047	5.036SerGly: 5.036 ± 0.059	0.903SerHis: 0.903 ± 0.031	2.5SerIle: 2.5 ± 0.058	1.239SerLys: 1.239 ± 0.04	4.699SerLeu: 4.699 ± 0.07	1.014SerMet: 1.014 ± 0.031	1.325SerAsn: 1.325 ± 0.038	2.687SerPro: 2.687 ± 0.048	1.434SerGln: 1.434 ± 0.03	3.267SerArg: 3.267 ± 0.058	2.453SerSer: 2.453 ± 0.059	2.73SerThr: 2.73 ± 0.053	3.715SerVal: 3.715 ± 0.056	0.699SerTrp: 0.699 ± 0.029	1.28SerTyr: 1.28 ± 0.035	0.001SerXaa: 0.001 ± 0.001
Thr	7.428ThrAla: 7.428 ± 0.09	0.394ThrCys: 0.394 ± 0.023	3.313ThrAsp: 3.313 ± 0.051	2.169ThrGlu: 2.169 ± 0.041	1.893ThrPhe: 1.893 ± 0.043	5.658ThrGly: 5.658 ± 0.081	1.005ThrHis: 1.005 ± 0.033	3.352ThrIle: 3.352 ± 0.052	1.339ThrLys: 1.339 ± 0.039	6.409ThrLeu: 6.409 ± 0.078	1.235ThrMet: 1.235 ± 0.032	1.35ThrAsn: 1.35 ± 0.04	4.051ThrPro: 4.051 ± 0.064	1.739ThrGln: 1.739 ± 0.041	4.038ThrArg: 4.038 ± 0.061	2.655ThrSer: 2.655 ± 0.051	3.324ThrThr: 3.324 ± 0.075	4.537ThrVal: 4.537 ± 0.063	0.672ThrTrp: 0.672 ± 0.022	1.299ThrTyr: 1.299 ± 0.039	0.001ThrXaa: 0.001 ± 0.001
Val	10.881ValAla: 10.881 ± 0.11	0.526ValCys: 0.526 ± 0.019	4.568ValAsp: 4.568 ± 0.063	4.265ValGlu: 4.265 ± 0.066	2.224ValPhe: 2.224 ± 0.044	5.826ValGly: 5.826 ± 0.093	1.37ValHis: 1.37 ± 0.036	3.543ValIle: 3.543 ± 0.063	1.933ValLys: 1.933 ± 0.044	6.795ValLeu: 6.795 ± 0.088	1.663ValMet: 1.663 ± 0.039	1.861ValAsn: 1.861 ± 0.049	4.196ValPro: 4.196 ± 0.054	2.083ValGln: 2.083 ± 0.04	5.523ValArg: 5.523 ± 0.081	4.009ValSer: 4.009 ± 0.055	5.077ValThr: 5.077 ± 0.07	5.909ValVal: 5.909 ± 0.071	0.879ValTrp: 0.879 ± 0.028	1.415ValTyr: 1.415 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.423TrpAla: 1.423 ± 0.036	0.128TrpCys: 0.128 ± 0.012	0.76TrpAsp: 0.76 ± 0.029	0.49TrpGlu: 0.49 ± 0.022	0.542TrpPhe: 0.542 ± 0.02	0.982TrpGly: 0.982 ± 0.033	0.371TrpHis: 0.371 ± 0.017	0.673TrpIle: 0.673 ± 0.029	0.386TrpLys: 0.386 ± 0.018	1.727TrpLeu: 1.727 ± 0.04	0.351TrpMet: 0.351 ± 0.016	0.426TrpAsn: 0.426 ± 0.018	0.737TrpPro: 0.737 ± 0.026	0.662TrpGln: 0.662 ± 0.024	1.443TrpArg: 1.443 ± 0.041	0.865TrpSer: 0.865 ± 0.029	0.908TrpThr: 0.908 ± 0.029	0.847TrpVal: 0.847 ± 0.027	0.282TrpTrp: 0.282 ± 0.015	0.315TrpTyr: 0.315 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.949TyrAla: 2.949 ± 0.054	0.217TyrCys: 0.217 ± 0.014	1.653TyrAsp: 1.653 ± 0.041	1.035TyrGlu: 1.035 ± 0.031	0.744TyrPhe: 0.744 ± 0.029	2.191TyrGly: 2.191 ± 0.05	0.476TyrHis: 0.476 ± 0.018	0.781TyrIle: 0.781 ± 0.03	0.527TyrLys: 0.527 ± 0.023	2.084TyrLeu: 2.084 ± 0.055	0.388TyrMet: 0.388 ± 0.018	0.658TyrAsn: 0.658 ± 0.03	1.009TyrPro: 1.009 ± 0.034	0.697TyrGln: 0.697 ± 0.025	2.009TyrArg: 2.009 ± 0.045	1.069TyrSer: 1.069 ± 0.035	1.144TyrThr: 1.144 ± 0.031	1.648TyrVal: 1.648 ± 0.033	0.344TyrTrp: 0.344 ± 0.014	0.632TyrTyr: 0.632 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.003XaaGly: 0.003 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.003XaaLeu: 0.003 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.003XaaPro: 0.003 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3680 proteins (1186662 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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