Amino acid dipepetide frequency for Streptococcus phage Javan636

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.295AlaAla: 3.295 ± 1.218
0.253AlaCys: 0.253 ± 0.13
4.14AlaAsp: 4.14 ± 0.559
5.154AlaGlu: 5.154 ± 0.664
3.211AlaPhe: 3.211 ± 0.671
4.647AlaGly: 4.647 ± 1.109
0.845AlaHis: 0.845 ± 0.276
6.759AlaIle: 6.759 ± 1.19
6.421AlaLys: 6.421 ± 0.82
5.492AlaLeu: 5.492 ± 0.653
2.366AlaMet: 2.366 ± 0.577
4.224AlaAsn: 4.224 ± 0.583
1.859AlaPro: 1.859 ± 0.612
2.366AlaGln: 2.366 ± 0.468
2.788AlaArg: 2.788 ± 0.412
5.069AlaSer: 5.069 ± 1.551
5.154AlaThr: 5.154 ± 0.949
3.633AlaVal: 3.633 ± 0.901
0.76AlaTrp: 0.76 ± 0.253
2.112AlaTyr: 2.112 ± 0.464
0.0AlaXaa: 0.0 ± 0.0
Cys
0.338CysAla: 0.338 ± 0.18
0.0CysCys: 0.0 ± 0.0
0.338CysAsp: 0.338 ± 0.163
0.338CysGlu: 0.338 ± 0.145
0.169CysPhe: 0.169 ± 0.115
0.169CysGly: 0.169 ± 0.139
0.0CysHis: 0.0 ± 0.0
0.084CysIle: 0.084 ± 0.081
0.338CysLys: 0.338 ± 0.18
0.422CysLeu: 0.422 ± 0.199
0.253CysMet: 0.253 ± 0.142
0.338CysAsn: 0.338 ± 0.154
0.084CysPro: 0.084 ± 0.088
0.0CysGln: 0.0 ± 0.0
0.253CysArg: 0.253 ± 0.155
0.169CysSer: 0.169 ± 0.134
0.169CysThr: 0.169 ± 0.124
0.084CysVal: 0.084 ± 0.076
0.084CysTrp: 0.084 ± 0.087
0.591CysTyr: 0.591 ± 0.307
0.0CysXaa: 0.0 ± 0.0
Asp
4.393AspAla: 4.393 ± 0.683
0.338AspCys: 0.338 ± 0.17
3.802AspAsp: 3.802 ± 0.679
3.886AspGlu: 3.886 ± 0.725
3.548AspPhe: 3.548 ± 0.674
5.238AspGly: 5.238 ± 0.913
0.338AspHis: 0.338 ± 0.153
3.886AspIle: 3.886 ± 0.651
6.421AspLys: 6.421 ± 0.729
6.759AspLeu: 6.759 ± 0.914
0.845AspMet: 0.845 ± 0.249
3.802AspAsn: 3.802 ± 0.697
1.859AspPro: 1.859 ± 0.416
1.605AspGln: 1.605 ± 0.475
2.366AspArg: 2.366 ± 0.434
3.464AspSer: 3.464 ± 0.58
3.717AspThr: 3.717 ± 0.628
3.126AspVal: 3.126 ± 0.564
0.591AspTrp: 0.591 ± 0.296
3.548AspTyr: 3.548 ± 0.588
0.0AspXaa: 0.0 ± 0.0
Glu
4.647GluAla: 4.647 ± 0.879
0.422GluCys: 0.422 ± 0.181
4.055GluAsp: 4.055 ± 0.753
5.492GluGlu: 5.492 ± 0.899
2.788GluPhe: 2.788 ± 0.42
3.126GluGly: 3.126 ± 0.63
1.098GluHis: 1.098 ± 0.275
7.435GluIle: 7.435 ± 0.904
6.844GluLys: 6.844 ± 1.44
6.252GluLeu: 6.252 ± 0.969
3.211GluMet: 3.211 ± 0.488
5.323GluAsn: 5.323 ± 0.786
1.69GluPro: 1.69 ± 0.428
2.957GluGln: 2.957 ± 0.552
3.211GluArg: 3.211 ± 0.564
3.211GluSer: 3.211 ± 0.512
3.548GluThr: 3.548 ± 0.669
4.816GluVal: 4.816 ± 0.738
0.929GluTrp: 0.929 ± 0.323
1.943GluTyr: 1.943 ± 0.458
0.0GluXaa: 0.0 ± 0.0
Phe
2.366PheAla: 2.366 ± 0.439
0.169PheCys: 0.169 ± 0.112
3.717PheAsp: 3.717 ± 0.511
3.548PheGlu: 3.548 ± 0.615
1.098PhePhe: 1.098 ± 0.349
3.38PheGly: 3.38 ± 0.782
0.676PheHis: 0.676 ± 0.247
2.535PheIle: 2.535 ± 0.432
3.38PheLys: 3.38 ± 0.599
3.211PheLeu: 3.211 ± 0.566
1.014PheMet: 1.014 ± 0.364
2.957PheAsn: 2.957 ± 0.583
0.929PhePro: 0.929 ± 0.295
0.76PheGln: 0.76 ± 0.289
1.352PheArg: 1.352 ± 0.384
2.535PheSer: 2.535 ± 0.447
3.211PheThr: 3.211 ± 0.437
1.859PheVal: 1.859 ± 0.435
0.591PheTrp: 0.591 ± 0.341
1.774PheTyr: 1.774 ± 0.376
0.0PheXaa: 0.0 ± 0.0
Gly
4.309GlyAla: 4.309 ± 1.118
0.169GlyCys: 0.169 ± 0.13
3.211GlyAsp: 3.211 ± 0.529
2.873GlyGlu: 2.873 ± 0.531
2.873GlyPhe: 2.873 ± 0.474
4.224GlyGly: 4.224 ± 0.931
1.183GlyHis: 1.183 ± 0.281
4.985GlyIle: 4.985 ± 1.128
5.323GlyLys: 5.323 ± 0.738
4.985GlyLeu: 4.985 ± 0.879
2.112GlyMet: 2.112 ± 0.628
3.38GlyAsn: 3.38 ± 0.492
1.098GlyPro: 1.098 ± 0.665
2.028GlyGln: 2.028 ± 0.644
1.943GlyArg: 1.943 ± 0.429
5.069GlySer: 5.069 ± 0.978
5.999GlyThr: 5.999 ± 0.988
4.478GlyVal: 4.478 ± 0.653
0.676GlyTrp: 0.676 ± 0.243
1.943GlyTyr: 1.943 ± 0.404
0.0GlyXaa: 0.0 ± 0.0
His
0.845HisAla: 0.845 ± 0.251
0.084HisCys: 0.084 ± 0.079
1.014HisAsp: 1.014 ± 0.24
0.845HisGlu: 0.845 ± 0.293
0.253HisPhe: 0.253 ± 0.176
0.676HisGly: 0.676 ± 0.191
0.338HisHis: 0.338 ± 0.219
1.098HisIle: 1.098 ± 0.297
1.014HisLys: 1.014 ± 0.343
0.591HisLeu: 0.591 ± 0.251
0.253HisMet: 0.253 ± 0.151
1.014HisAsn: 1.014 ± 0.29
0.507HisPro: 0.507 ± 0.221
0.338HisGln: 0.338 ± 0.13
0.084HisArg: 0.084 ± 0.071
0.845HisSer: 0.845 ± 0.239
1.014HisThr: 1.014 ± 0.284
0.929HisVal: 0.929 ± 0.253
0.169HisTrp: 0.169 ± 0.13
0.845HisTyr: 0.845 ± 0.245
0.0HisXaa: 0.0 ± 0.0
Ile
5.914IleAla: 5.914 ± 1.092
0.253IleCys: 0.253 ± 0.151
5.745IleAsp: 5.745 ± 0.727
6.168IleGlu: 6.168 ± 0.823
1.859IlePhe: 1.859 ± 0.341
4.309IleGly: 4.309 ± 0.992
0.76IleHis: 0.76 ± 0.225
4.9IleIle: 4.9 ± 0.631
6.59IleLys: 6.59 ± 0.635
3.971IleLeu: 3.971 ± 0.538
1.436IleMet: 1.436 ± 0.359
4.985IleAsn: 4.985 ± 0.779
2.45IlePro: 2.45 ± 0.482
2.704IleGln: 2.704 ± 0.345
2.112IleArg: 2.112 ± 0.39
5.914IleSer: 5.914 ± 0.785
4.562IleThr: 4.562 ± 0.673
3.971IleVal: 3.971 ± 0.593
0.338IleTrp: 0.338 ± 0.157
2.619IleTyr: 2.619 ± 0.434
0.0IleXaa: 0.0 ± 0.0
Lys
7.773LysAla: 7.773 ± 0.784
0.169LysCys: 0.169 ± 0.115
4.816LysAsp: 4.816 ± 0.772
7.181LysGlu: 7.181 ± 1.155
3.38LysPhe: 3.38 ± 0.633
5.154LysGly: 5.154 ± 0.733
0.676LysHis: 0.676 ± 0.255
6.844LysIle: 6.844 ± 0.732
7.519LysLys: 7.519 ± 1.082
7.097LysLeu: 7.097 ± 0.901
2.535LysMet: 2.535 ± 0.439
5.323LysAsn: 5.323 ± 0.688
2.704LysPro: 2.704 ± 0.503
3.717LysGln: 3.717 ± 0.624
3.464LysArg: 3.464 ± 0.588
5.492LysSer: 5.492 ± 0.613
4.731LysThr: 4.731 ± 0.587
5.576LysVal: 5.576 ± 0.764
1.521LysTrp: 1.521 ± 0.449
3.042LysTyr: 3.042 ± 0.525
0.0LysXaa: 0.0 ± 0.0
Leu
5.238LeuAla: 5.238 ± 0.555
0.507LeuCys: 0.507 ± 0.181
5.154LeuAsp: 5.154 ± 0.703
6.421LeuGlu: 6.421 ± 0.787
2.535LeuPhe: 2.535 ± 0.49
5.323LeuGly: 5.323 ± 0.709
1.352LeuHis: 1.352 ± 0.349
5.576LeuIle: 5.576 ± 0.739
6.928LeuLys: 6.928 ± 1.093
5.914LeuLeu: 5.914 ± 0.786
1.774LeuMet: 1.774 ± 0.528
5.238LeuAsn: 5.238 ± 0.597
2.281LeuPro: 2.281 ± 0.379
2.366LeuGln: 2.366 ± 0.446
3.38LeuArg: 3.38 ± 0.628
5.83LeuSer: 5.83 ± 0.695
5.661LeuThr: 5.661 ± 0.79
4.562LeuVal: 4.562 ± 0.464
0.591LeuTrp: 0.591 ± 0.316
2.281LeuTyr: 2.281 ± 0.404
0.0LeuXaa: 0.0 ± 0.0
Met
2.45MetAla: 2.45 ± 0.684
0.169MetCys: 0.169 ± 0.111
1.352MetAsp: 1.352 ± 0.328
1.183MetGlu: 1.183 ± 0.327
1.014MetPhe: 1.014 ± 0.342
0.845MetGly: 0.845 ± 0.293
0.169MetHis: 0.169 ± 0.102
1.183MetIle: 1.183 ± 0.375
2.788MetLys: 2.788 ± 0.536
2.197MetLeu: 2.197 ± 0.426
0.253MetMet: 0.253 ± 0.147
1.352MetAsn: 1.352 ± 0.316
0.676MetPro: 0.676 ± 0.255
1.521MetGln: 1.521 ± 0.353
1.267MetArg: 1.267 ± 0.376
1.098MetSer: 1.098 ± 0.264
2.028MetThr: 2.028 ± 0.395
1.267MetVal: 1.267 ± 0.293
0.507MetTrp: 0.507 ± 0.231
1.098MetTyr: 1.098 ± 0.34
0.0MetXaa: 0.0 ± 0.0
Asn
3.633AsnAla: 3.633 ± 0.564
0.084AsnCys: 0.084 ± 0.091
2.366AsnAsp: 2.366 ± 0.471
4.562AsnGlu: 4.562 ± 0.719
2.704AsnPhe: 2.704 ± 0.459
3.971AsnGly: 3.971 ± 0.536
0.845AsnHis: 0.845 ± 0.208
4.224AsnIle: 4.224 ± 0.59
4.9AsnLys: 4.9 ± 0.561
5.154AsnLeu: 5.154 ± 0.617
1.014AsnMet: 1.014 ± 0.247
2.873AsnAsn: 2.873 ± 0.483
2.45AsnPro: 2.45 ± 0.474
3.38AsnGln: 3.38 ± 0.482
2.366AsnArg: 2.366 ± 0.514
3.886AsnSer: 3.886 ± 0.512
3.295AsnThr: 3.295 ± 0.442
4.055AsnVal: 4.055 ± 0.54
1.352AsnTrp: 1.352 ± 0.32
3.042AsnTyr: 3.042 ± 0.487
0.0AsnXaa: 0.0 ± 0.0
Pro
2.028ProAla: 2.028 ± 0.463
0.0ProCys: 0.0 ± 0.0
2.197ProAsp: 2.197 ± 0.446
2.45ProGlu: 2.45 ± 0.419
1.352ProPhe: 1.352 ± 0.393
0.591ProGly: 0.591 ± 0.203
0.253ProHis: 0.253 ± 0.141
1.521ProIle: 1.521 ± 0.384
2.028ProLys: 2.028 ± 0.434
1.774ProLeu: 1.774 ± 0.439
0.676ProMet: 0.676 ± 0.186
1.859ProAsn: 1.859 ± 0.4
0.76ProPro: 0.76 ± 0.188
1.014ProGln: 1.014 ± 0.297
0.929ProArg: 0.929 ± 0.33
2.45ProSer: 2.45 ± 0.363
2.197ProThr: 2.197 ± 0.461
2.028ProVal: 2.028 ± 0.504
0.253ProTrp: 0.253 ± 0.174
1.436ProTyr: 1.436 ± 0.307
0.0ProXaa: 0.0 ± 0.0
Gln
2.873GlnAla: 2.873 ± 0.713
0.253GlnCys: 0.253 ± 0.124
1.605GlnAsp: 1.605 ± 0.309
2.788GlnGlu: 2.788 ± 0.638
1.436GlnPhe: 1.436 ± 0.354
2.704GlnGly: 2.704 ± 0.995
0.169GlnHis: 0.169 ± 0.153
2.45GlnIle: 2.45 ± 0.393
3.38GlnLys: 3.38 ± 0.554
3.126GlnLeu: 3.126 ± 0.708
0.676GlnMet: 0.676 ± 0.288
2.197GlnAsn: 2.197 ± 0.438
0.929GlnPro: 0.929 ± 0.328
1.69GlnGln: 1.69 ± 0.385
0.929GlnArg: 0.929 ± 0.298
2.957GlnSer: 2.957 ± 0.507
1.352GlnThr: 1.352 ± 0.368
2.112GlnVal: 2.112 ± 0.405
0.676GlnTrp: 0.676 ± 0.22
2.028GlnTyr: 2.028 ± 0.44
0.0GlnXaa: 0.0 ± 0.0
Arg
2.45ArgAla: 2.45 ± 0.353
0.253ArgCys: 0.253 ± 0.139
2.028ArgAsp: 2.028 ± 0.418
3.126ArgGlu: 3.126 ± 0.608
1.183ArgPhe: 1.183 ± 0.309
1.436ArgGly: 1.436 ± 0.391
0.676ArgHis: 0.676 ± 0.295
2.028ArgIle: 2.028 ± 0.353
3.633ArgLys: 3.633 ± 0.671
3.211ArgLeu: 3.211 ± 0.586
1.014ArgMet: 1.014 ± 0.282
2.281ArgAsn: 2.281 ± 0.427
1.267ArgPro: 1.267 ± 0.357
1.521ArgGln: 1.521 ± 0.309
1.859ArgArg: 1.859 ± 0.47
1.436ArgSer: 1.436 ± 0.315
3.211ArgThr: 3.211 ± 0.484
2.366ArgVal: 2.366 ± 0.455
0.507ArgTrp: 0.507 ± 0.198
2.028ArgTyr: 2.028 ± 0.434
0.0ArgXaa: 0.0 ± 0.0
Ser
5.661SerAla: 5.661 ± 1.292
0.253SerCys: 0.253 ± 0.147
5.492SerAsp: 5.492 ± 0.679
4.647SerGlu: 4.647 ± 0.803
2.788SerPhe: 2.788 ± 0.428
4.478SerGly: 4.478 ± 0.991
0.845SerHis: 0.845 ± 0.182
4.055SerIle: 4.055 ± 0.6
5.492SerLys: 5.492 ± 0.744
4.562SerLeu: 4.562 ± 0.467
1.521SerMet: 1.521 ± 0.541
3.464SerAsn: 3.464 ± 0.545
1.352SerPro: 1.352 ± 0.316
2.619SerGln: 2.619 ± 0.614
2.112SerArg: 2.112 ± 0.393
5.323SerSer: 5.323 ± 0.928
4.985SerThr: 4.985 ± 0.841
4.14SerVal: 4.14 ± 0.779
0.76SerTrp: 0.76 ± 0.297
2.028SerTyr: 2.028 ± 0.429
0.0SerXaa: 0.0 ± 0.0
Thr
5.069ThrAla: 5.069 ± 0.982
0.253ThrCys: 0.253 ± 0.127
5.069ThrAsp: 5.069 ± 0.656
4.393ThrGlu: 4.393 ± 0.75
3.126ThrPhe: 3.126 ± 0.51
5.154ThrGly: 5.154 ± 0.965
1.183ThrHis: 1.183 ± 0.342
6.168ThrIle: 6.168 ± 1.043
5.661ThrLys: 5.661 ± 0.692
5.069ThrLeu: 5.069 ± 0.777
0.591ThrMet: 0.591 ± 0.458
3.126ThrAsn: 3.126 ± 0.63
1.774ThrPro: 1.774 ± 0.377
2.535ThrGln: 2.535 ± 0.528
1.69ThrArg: 1.69 ± 0.399
4.055ThrSer: 4.055 ± 0.903
4.816ThrThr: 4.816 ± 0.523
4.9ThrVal: 4.9 ± 0.847
0.591ThrTrp: 0.591 ± 0.23
2.535ThrTyr: 2.535 ± 0.56
0.0ThrXaa: 0.0 ± 0.0
Val
4.055ValAla: 4.055 ± 0.818
0.169ValCys: 0.169 ± 0.121
4.562ValAsp: 4.562 ± 0.694
4.985ValGlu: 4.985 ± 0.843
2.957ValPhe: 2.957 ± 0.378
4.14ValGly: 4.14 ± 0.667
0.591ValHis: 0.591 ± 0.281
3.126ValIle: 3.126 ± 0.537
5.154ValLys: 5.154 ± 0.646
4.055ValLeu: 4.055 ± 0.478
1.774ValMet: 1.774 ± 0.356
3.717ValAsn: 3.717 ± 0.515
1.943ValPro: 1.943 ± 0.369
1.69ValGln: 1.69 ± 0.398
2.197ValArg: 2.197 ± 0.399
4.816ValSer: 4.816 ± 0.465
4.562ValThr: 4.562 ± 0.513
5.238ValVal: 5.238 ± 0.821
0.507ValTrp: 0.507 ± 0.223
1.521ValTyr: 1.521 ± 0.393
0.0ValXaa: 0.0 ± 0.0
Trp
0.845TrpAla: 0.845 ± 0.315
0.084TrpCys: 0.084 ± 0.079
0.084TrpAsp: 0.084 ± 0.079
1.014TrpGlu: 1.014 ± 0.349
0.676TrpPhe: 0.676 ± 0.23
1.183TrpGly: 1.183 ± 0.295
0.169TrpHis: 0.169 ± 0.118
0.845TrpIle: 0.845 ± 0.298
1.352TrpLys: 1.352 ± 0.319
1.183TrpLeu: 1.183 ± 0.529
0.169TrpMet: 0.169 ± 0.127
0.676TrpAsn: 0.676 ± 0.232
0.0TrpPro: 0.0 ± 0.0
0.253TrpGln: 0.253 ± 0.152
0.507TrpArg: 0.507 ± 0.21
0.76TrpSer: 0.76 ± 0.254
1.183TrpThr: 1.183 ± 0.366
0.422TrpVal: 0.422 ± 0.165
0.253TrpTrp: 0.253 ± 0.15
0.507TrpTyr: 0.507 ± 0.216
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.366TyrAla: 2.366 ± 0.449
0.338TyrCys: 0.338 ± 0.231
2.788TyrAsp: 2.788 ± 0.528
1.943TyrGlu: 1.943 ± 0.489
2.112TyrPhe: 2.112 ± 0.478
2.112TyrGly: 2.112 ± 0.372
0.591TyrHis: 0.591 ± 0.198
1.859TyrIle: 1.859 ± 0.392
3.548TyrLys: 3.548 ± 0.568
3.886TyrLeu: 3.886 ± 0.511
0.845TyrMet: 0.845 ± 0.251
2.028TyrAsn: 2.028 ± 0.441
1.183TyrPro: 1.183 ± 0.344
1.267TyrGln: 1.267 ± 0.332
2.704TyrArg: 2.704 ± 0.536
2.197TyrSer: 2.197 ± 0.473
2.366TyrThr: 2.366 ± 0.459
2.281TyrVal: 2.281 ± 0.405
0.507TyrTrp: 0.507 ± 0.2
1.436TyrTyr: 1.436 ± 0.373
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 62 proteins (11837 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski