Amino acid dipepetide frequency for Pedobacter glucosidilyticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.57AlaAla: 5.57 ± 0.1	0.716AlaCys: 0.716 ± 0.027	4.104AlaAsp: 4.104 ± 0.072	4.159AlaGlu: 4.159 ± 0.07	3.646AlaPhe: 3.646 ± 0.055	4.935AlaGly: 4.935 ± 0.084	1.241AlaHis: 1.241 ± 0.032	5.793AlaIle: 5.793 ± 0.082	5.373AlaLys: 5.373 ± 0.088	7.064AlaLeu: 7.064 ± 0.088	1.572AlaMet: 1.572 ± 0.039	3.946AlaAsn: 3.946 ± 0.085	2.103AlaPro: 2.103 ± 0.048	3.193AlaGln: 3.193 ± 0.057	2.134AlaArg: 2.134 ± 0.047	4.557AlaSer: 4.557 ± 0.074	4.037AlaThr: 4.037 ± 0.087	4.575AlaVal: 4.575 ± 0.066	0.708AlaTrp: 0.708 ± 0.027	2.962AlaTyr: 2.962 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.492CysAla: 0.492 ± 0.021	0.126CysCys: 0.126 ± 0.01	0.393CysAsp: 0.393 ± 0.021	0.401CysGlu: 0.401 ± 0.02	0.415CysPhe: 0.415 ± 0.023	0.602CysGly: 0.602 ± 0.023	0.174CysHis: 0.174 ± 0.013	0.613CysIle: 0.613 ± 0.027	0.55CysLys: 0.55 ± 0.023	0.782CysLeu: 0.782 ± 0.03	0.155CysMet: 0.155 ± 0.012	0.391CysAsn: 0.391 ± 0.019	0.339CysPro: 0.339 ± 0.02	0.231CysGln: 0.231 ± 0.016	0.238CysArg: 0.238 ± 0.016	0.513CysSer: 0.513 ± 0.021	0.377CysThr: 0.377 ± 0.021	0.395CysVal: 0.395 ± 0.017	0.074CysTrp: 0.074 ± 0.009	0.302CysTyr: 0.302 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.926AspAla: 3.926 ± 0.069	0.375AspCys: 0.375 ± 0.019	2.751AspAsp: 2.751 ± 0.064	3.607AspGlu: 3.607 ± 0.074	3.535AspPhe: 3.535 ± 0.064	3.641AspGly: 3.641 ± 0.077	0.807AspHis: 0.807 ± 0.026	4.435AspIle: 4.435 ± 0.069	4.24AspLys: 4.24 ± 0.076	5.16AspLeu: 5.16 ± 0.074	1.071AspMet: 1.071 ± 0.03	2.585AspAsn: 2.585 ± 0.06	1.623AspPro: 1.623 ± 0.044	1.398AspGln: 1.398 ± 0.033	1.819AspArg: 1.819 ± 0.04	2.662AspSer: 2.662 ± 0.05	2.385AspThr: 2.385 ± 0.053	3.404AspVal: 3.404 ± 0.055	0.763AspTrp: 0.763 ± 0.027	2.574AspTyr: 2.574 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	4.356GluAla: 4.356 ± 0.075	0.321GluCys: 0.321 ± 0.016	3.1GluAsp: 3.1 ± 0.063	4.527GluGlu: 4.527 ± 0.088	2.624GluPhe: 2.624 ± 0.051	3.452GluGly: 3.452 ± 0.069	1.109GluHis: 1.109 ± 0.03	5.06GluIle: 5.06 ± 0.074	5.136GluLys: 5.136 ± 0.082	5.726GluLeu: 5.726 ± 0.082	1.318GluMet: 1.318 ± 0.036	3.821GluAsn: 3.821 ± 0.057	1.594GluPro: 1.594 ± 0.042	2.572GluGln: 2.572 ± 0.053	2.392GluArg: 2.392 ± 0.048	2.912GluSer: 2.912 ± 0.049	3.084GluThr: 3.084 ± 0.06	4.041GluVal: 4.041 ± 0.068	0.631GluTrp: 0.631 ± 0.024	1.902GluTyr: 1.902 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.453PheAla: 3.453 ± 0.062	0.436PheCys: 0.436 ± 0.021	3.007PheAsp: 3.007 ± 0.058	2.889PheGlu: 2.889 ± 0.054	2.652PhePhe: 2.652 ± 0.057	3.475PheGly: 3.475 ± 0.064	0.835PheHis: 0.835 ± 0.027	4.091PheIle: 4.091 ± 0.074	4.006PheLys: 4.006 ± 0.066	4.798PheLeu: 4.798 ± 0.079	1.132PheMet: 1.132 ± 0.035	3.54PheAsn: 3.54 ± 0.072	1.757PhePro: 1.757 ± 0.034	1.497PheGln: 1.497 ± 0.038	1.75PheArg: 1.75 ± 0.045	3.886PheSer: 3.886 ± 0.066	3.309PheThr: 3.309 ± 0.061	2.783PheVal: 2.783 ± 0.052	0.621PheTrp: 0.621 ± 0.027	2.195PheTyr: 2.195 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	4.552GlyAla: 4.552 ± 0.078	0.571GlyCys: 0.571 ± 0.026	3.26GlyAsp: 3.26 ± 0.07	3.367GlyGlu: 3.367 ± 0.048	3.854GlyPhe: 3.854 ± 0.062	4.664GlyGly: 4.664 ± 0.107	1.08GlyHis: 1.08 ± 0.034	5.24GlyIle: 5.24 ± 0.079	5.19GlyLys: 5.19 ± 0.072	6.315GlyLeu: 6.315 ± 0.093	1.486GlyMet: 1.486 ± 0.037	3.721GlyAsn: 3.721 ± 0.075	1.531GlyPro: 1.531 ± 0.043	1.854GlyGln: 1.854 ± 0.044	2.32GlyArg: 2.32 ± 0.051	4.087GlySer: 4.087 ± 0.07	3.994GlyThr: 3.994 ± 0.101	4.238GlyVal: 4.238 ± 0.071	0.816GlyTrp: 0.816 ± 0.032	2.832GlyTyr: 2.832 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.113HisAla: 1.113 ± 0.033	0.179HisCys: 0.179 ± 0.013	0.896HisAsp: 0.896 ± 0.03	0.986HisGlu: 0.986 ± 0.029	1.108HisPhe: 1.108 ± 0.035	1.068HisGly: 1.068 ± 0.032	0.609HisHis: 0.609 ± 0.022	1.453HisIle: 1.453 ± 0.045	1.126HisLys: 1.126 ± 0.034	1.928HisLeu: 1.928 ± 0.04	0.305HisMet: 0.305 ± 0.017	0.813HisAsn: 0.813 ± 0.028	1.074HisPro: 1.074 ± 0.033	1.155HisGln: 1.155 ± 0.035	0.625HisArg: 0.625 ± 0.025	0.912HisSer: 0.912 ± 0.026	0.863HisThr: 0.863 ± 0.027	0.968HisVal: 0.968 ± 0.032	0.248HisTrp: 0.248 ± 0.015	0.869HisTyr: 0.869 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.137IleAla: 6.137 ± 0.084	0.737IleCys: 0.737 ± 0.028	4.278IleAsp: 4.278 ± 0.069	4.589IleGlu: 4.589 ± 0.071	3.587IlePhe: 3.587 ± 0.068	4.997IleGly: 4.997 ± 0.071	1.478IleHis: 1.478 ± 0.038	6.364IleIle: 6.364 ± 0.103	6.139IleLys: 6.139 ± 0.075	7.034IleLeu: 7.034 ± 0.103	1.333IleMet: 1.333 ± 0.035	4.976IleAsn: 4.976 ± 0.082	3.134IlePro: 3.134 ± 0.056	2.62IleGln: 2.62 ± 0.047	2.713IleArg: 2.713 ± 0.049	5.554IleSer: 5.554 ± 0.075	4.672IleThr: 4.672 ± 0.079	4.191IleVal: 4.191 ± 0.066	0.782IleTrp: 0.782 ± 0.03	2.808IleTyr: 2.808 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	5.793LysAla: 5.793 ± 0.092	0.328LysCys: 0.328 ± 0.018	4.46LysAsp: 4.46 ± 0.07	5.761LysGlu: 5.761 ± 0.091	3.002LysPhe: 3.002 ± 0.054	4.657LysGly: 4.657 ± 0.074	1.424LysHis: 1.424 ± 0.034	5.975LysIle: 5.975 ± 0.076	6.006LysLys: 6.006 ± 0.093	6.874LysLeu: 6.874 ± 0.084	1.799LysMet: 1.799 ± 0.046	4.864LysAsn: 4.864 ± 0.064	2.873LysPro: 2.873 ± 0.055	3.196LysGln: 3.196 ± 0.065	2.758LysArg: 2.758 ± 0.053	4.418LysSer: 4.418 ± 0.066	4.31LysThr: 4.31 ± 0.066	4.686LysVal: 4.686 ± 0.078	0.823LysTrp: 0.823 ± 0.03	2.971LysTyr: 2.971 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	7.163LeuAla: 7.163 ± 0.085	0.721LeuCys: 0.721 ± 0.029	4.87LeuAsp: 4.87 ± 0.058	5.495LeuGlu: 5.495 ± 0.087	4.721LeuPhe: 4.721 ± 0.085	5.914LeuGly: 5.914 ± 0.083	1.642LeuHis: 1.642 ± 0.045	7.209LeuIle: 7.209 ± 0.101	8.538LeuLys: 8.538 ± 0.104	9.085LeuLeu: 9.085 ± 0.134	2.084LeuMet: 2.084 ± 0.047	6.402LeuAsn: 6.402 ± 0.102	3.857LeuPro: 3.857 ± 0.051	3.614LeuGln: 3.614 ± 0.061	3.475LeuArg: 3.475 ± 0.057	7.069LeuSer: 7.069 ± 0.088	5.238LeuThr: 5.238 ± 0.079	5.466LeuVal: 5.466 ± 0.072	0.938LeuTrp: 0.938 ± 0.034	3.284LeuTyr: 3.284 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.632MetAla: 1.632 ± 0.04	0.131MetCys: 0.131 ± 0.012	1.045MetAsp: 1.045 ± 0.031	1.143MetGlu: 1.143 ± 0.038	0.802MetPhe: 0.802 ± 0.029	1.397MetGly: 1.397 ± 0.037	0.382MetHis: 0.382 ± 0.018	1.468MetIle: 1.468 ± 0.042	1.901MetLys: 1.901 ± 0.033	2.062MetLeu: 2.062 ± 0.051	0.664MetMet: 0.664 ± 0.023	1.173MetAsn: 1.173 ± 0.032	0.901MetPro: 0.901 ± 0.029	0.867MetGln: 0.867 ± 0.03	0.839MetArg: 0.839 ± 0.026	1.211MetSer: 1.211 ± 0.034	0.912MetThr: 0.912 ± 0.031	1.34MetVal: 1.34 ± 0.036	0.172MetTrp: 0.172 ± 0.011	0.598MetTyr: 0.598 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.992AsnAla: 3.992 ± 0.07	0.465AsnCys: 0.465 ± 0.022	2.683AsnAsp: 2.683 ± 0.062	2.946AsnGlu: 2.946 ± 0.054	3.313AsnPhe: 3.313 ± 0.074	4.027AsnGly: 4.027 ± 0.08	1.203AsnHis: 1.203 ± 0.031	4.916AsnIle: 4.916 ± 0.089	4.139AsnLys: 4.139 ± 0.064	5.877AsnLeu: 5.877 ± 0.084	1.121AsnMet: 1.121 ± 0.031	3.765AsnAsn: 3.765 ± 0.08	3.019AsnPro: 3.019 ± 0.059	2.694AsnGln: 2.694 ± 0.055	2.204AsnArg: 2.204 ± 0.045	3.494AsnSer: 3.494 ± 0.075	3.501AsnThr: 3.501 ± 0.066	2.946AsnVal: 2.946 ± 0.061	0.866AsnTrp: 0.866 ± 0.034	2.823AsnTyr: 2.823 ± 0.05	0.0AsnXaa: 0.0 ± 0.0
Pro	2.653ProAla: 2.653 ± 0.058	0.22ProCys: 0.22 ± 0.015	2.237ProAsp: 2.237 ± 0.042	2.717ProGlu: 2.717 ± 0.052	1.97ProPhe: 1.97 ± 0.039	2.173ProGly: 2.173 ± 0.049	0.74ProHis: 0.74 ± 0.027	2.543ProIle: 2.543 ± 0.053	2.428ProLys: 2.428 ± 0.048	3.32ProLeu: 3.32 ± 0.05	0.66ProMet: 0.66 ± 0.026	2.064ProAsn: 2.064 ± 0.044	0.838ProPro: 0.838 ± 0.031	1.515ProGln: 1.515 ± 0.036	0.978ProArg: 0.978 ± 0.037	2.236ProSer: 2.236 ± 0.055	1.979ProThr: 1.979 ± 0.044	2.643ProVal: 2.643 ± 0.047	0.372ProTrp: 0.372 ± 0.019	1.471ProTyr: 1.471 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.797GlnAla: 2.797 ± 0.048	0.16GlnCys: 0.16 ± 0.012	2.098GlnAsp: 2.098 ± 0.042	2.732GlnGlu: 2.732 ± 0.055	1.79GlnPhe: 1.79 ± 0.038	1.843GlnGly: 1.843 ± 0.042	0.832GlnHis: 0.832 ± 0.029	2.884GlnIle: 2.884 ± 0.052	3.145GlnLys: 3.145 ± 0.057	3.869GlnLeu: 3.869 ± 0.063	0.774GlnMet: 0.774 ± 0.025	2.404GlnAsn: 2.404 ± 0.053	1.265GlnPro: 1.265 ± 0.036	2.142GlnGln: 2.142 ± 0.053	1.336GlnArg: 1.336 ± 0.036	1.947GlnSer: 1.947 ± 0.046	2.16GlnThr: 2.16 ± 0.043	2.411GlnVal: 2.411 ± 0.047	0.385GlnTrp: 0.385 ± 0.019	1.478GlnTyr: 1.478 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	2.189ArgAla: 2.189 ± 0.05	0.194ArgCys: 0.194 ± 0.013	1.724ArgAsp: 1.724 ± 0.043	2.051ArgGlu: 2.051 ± 0.045	2.036ArgPhe: 2.036 ± 0.045	2.13ArgGly: 2.13 ± 0.048	0.526ArgHis: 0.526 ± 0.023	2.865ArgIle: 2.865 ± 0.047	2.722ArgLys: 2.722 ± 0.056	3.567ArgLeu: 3.567 ± 0.055	0.847ArgMet: 0.847 ± 0.03	2.222ArgAsn: 2.222 ± 0.049	1.189ArgPro: 1.189 ± 0.04	1.142ArgGln: 1.142 ± 0.03	1.336ArgArg: 1.336 ± 0.037	1.954ArgSer: 1.954 ± 0.047	1.877ArgThr: 1.877 ± 0.039	2.288ArgVal: 2.288 ± 0.047	0.484ArgTrp: 0.484 ± 0.025	1.594ArgTyr: 1.594 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	4.243SerAla: 4.243 ± 0.072	0.552SerCys: 0.552 ± 0.023	2.882SerAsp: 2.882 ± 0.055	3.008SerGlu: 3.008 ± 0.049	3.945SerPhe: 3.945 ± 0.078	4.713SerGly: 4.713 ± 0.094	1.046SerHis: 1.046 ± 0.03	4.925SerIle: 4.925 ± 0.067	4.399SerLys: 4.399 ± 0.064	6.59SerLeu: 6.59 ± 0.081	1.148SerMet: 1.148 ± 0.03	3.519SerAsn: 3.519 ± 0.069	2.132SerPro: 2.132 ± 0.051	2.058SerGln: 2.058 ± 0.048	2.214SerArg: 2.214 ± 0.052	4.406SerSer: 4.406 ± 0.073	3.578SerThr: 3.578 ± 0.071	3.725SerVal: 3.725 ± 0.066	0.76SerTrp: 0.76 ± 0.026	2.839SerTyr: 2.839 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.4ThrAla: 4.4 ± 0.086	0.365ThrCys: 0.365 ± 0.02	3.013ThrAsp: 3.013 ± 0.053	3.084ThrGlu: 3.084 ± 0.048	2.872ThrPhe: 2.872 ± 0.057	4.278ThrGly: 4.278 ± 0.087	1.022ThrHis: 1.022 ± 0.036	4.224ThrIle: 4.224 ± 0.085	3.423ThrLys: 3.423 ± 0.054	5.56ThrLeu: 5.56 ± 0.096	0.886ThrMet: 0.886 ± 0.028	2.995ThrAsn: 2.995 ± 0.065	2.385ThrPro: 2.385 ± 0.05	2.123ThrGln: 2.123 ± 0.043	1.665ThrArg: 1.665 ± 0.048	3.711ThrSer: 3.711 ± 0.079	3.242ThrThr: 3.242 ± 0.067	3.477ThrVal: 3.477 ± 0.069	0.601ThrTrp: 0.601 ± 0.025	2.29ThrTyr: 2.29 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	4.396ValAla: 4.396 ± 0.062	0.529ValCys: 0.529 ± 0.022	3.149ValAsp: 3.149 ± 0.06	3.444ValGlu: 3.444 ± 0.059	3.281ValPhe: 3.281 ± 0.06	3.63ValGly: 3.63 ± 0.068	0.908ValHis: 0.908 ± 0.03	4.607ValIle: 4.607 ± 0.067	4.822ValLys: 4.822 ± 0.065	6.029ValLeu: 6.029 ± 0.069	1.292ValMet: 1.292 ± 0.038	3.774ValAsn: 3.774 ± 0.065	2.113ValPro: 2.113 ± 0.051	1.803ValGln: 1.803 ± 0.043	2.034ValArg: 2.034 ± 0.052	4.131ValSer: 4.131 ± 0.069	3.23ValThr: 3.23 ± 0.067	3.931ValVal: 3.931 ± 0.065	0.705ValTrp: 0.705 ± 0.027	2.463ValTyr: 2.463 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.797TrpAla: 0.797 ± 0.033	0.101TrpCys: 0.101 ± 0.01	0.665TrpAsp: 0.665 ± 0.026	0.701TrpGlu: 0.701 ± 0.027	0.628TrpPhe: 0.628 ± 0.026	0.778TrpGly: 0.778 ± 0.03	0.24TrpHis: 0.24 ± 0.014	0.76TrpIle: 0.76 ± 0.031	0.85TrpLys: 0.85 ± 0.029	1.15TrpLeu: 1.15 ± 0.032	0.307TrpMet: 0.307 ± 0.016	0.679TrpAsn: 0.679 ± 0.027	0.367TrpPro: 0.367 ± 0.022	0.507TrpGln: 0.507 ± 0.021	0.481TrpArg: 0.481 ± 0.02	0.607TrpSer: 0.607 ± 0.028	0.558TrpThr: 0.558 ± 0.023	0.681TrpVal: 0.681 ± 0.028	0.172TrpTrp: 0.172 ± 0.013	0.425TrpTyr: 0.425 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.733TyrAla: 2.733 ± 0.051	0.338TyrCys: 0.338 ± 0.02	2.145TyrAsp: 2.145 ± 0.048	2.068TyrGlu: 2.068 ± 0.048	2.329TyrPhe: 2.329 ± 0.045	2.601TyrGly: 2.601 ± 0.055	1.0TyrHis: 1.0 ± 0.028	2.699TyrIle: 2.699 ± 0.055	2.845TyrLys: 2.845 ± 0.053	3.994TyrLeu: 3.994 ± 0.066	0.686TyrMet: 0.686 ± 0.025	2.337TyrAsn: 2.337 ± 0.044	1.666TyrPro: 1.666 ± 0.04	2.272TyrGln: 2.272 ± 0.05	1.624TyrArg: 1.624 ± 0.039	2.414TyrSer: 2.414 ± 0.045	2.313TyrThr: 2.313 ± 0.052	2.083TyrVal: 2.083 ± 0.041	0.533TyrTrp: 0.533 ± 0.023	1.854TyrTyr: 1.854 ± 0.045	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3311 proteins (1165797 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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