Amino acid dipepetide frequency for Agrococcus pavilionensis RW1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.444AlaAla: 22.444 ± 0.276
0.692AlaCys: 0.692 ± 0.032
8.487AlaAsp: 8.487 ± 0.113
9.65AlaGlu: 9.65 ± 0.13
3.982AlaPhe: 3.982 ± 0.07
12.602AlaGly: 12.602 ± 0.147
2.596AlaHis: 2.596 ± 0.057
6.964AlaIle: 6.964 ± 0.104
2.651AlaLys: 2.651 ± 0.07
15.883AlaLeu: 15.883 ± 0.196
3.295AlaMet: 3.295 ± 0.059
2.064AlaAsn: 2.064 ± 0.053
7.259AlaPro: 7.259 ± 0.108
3.861AlaGln: 3.861 ± 0.083
10.568AlaArg: 10.568 ± 0.147
7.914AlaSer: 7.914 ± 0.095
7.427AlaThr: 7.427 ± 0.115
11.872AlaVal: 11.872 ± 0.156
2.248AlaTrp: 2.248 ± 0.053
2.185AlaTyr: 2.185 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.622CysAla: 0.622 ± 0.031
0.045CysCys: 0.045 ± 0.007
0.309CysAsp: 0.309 ± 0.021
0.286CysGlu: 0.286 ± 0.019
0.174CysPhe: 0.174 ± 0.014
0.533CysGly: 0.533 ± 0.027
0.115CysHis: 0.115 ± 0.013
0.194CysIle: 0.194 ± 0.017
0.048CysLys: 0.048 ± 0.008
0.401CysLeu: 0.401 ± 0.023
0.066CysMet: 0.066 ± 0.009
0.108CysAsn: 0.108 ± 0.012
0.266CysPro: 0.266 ± 0.02
0.111CysGln: 0.111 ± 0.011
0.313CysArg: 0.313 ± 0.02
0.316CysSer: 0.316 ± 0.017
0.284CysThr: 0.284 ± 0.019
0.422CysVal: 0.422 ± 0.021
0.064CysTrp: 0.064 ± 0.009
0.072CysTyr: 0.072 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
10.675AspAla: 10.675 ± 0.136
0.22AspCys: 0.22 ± 0.016
4.572AspAsp: 4.572 ± 0.077
5.146AspGlu: 5.146 ± 0.095
1.613AspPhe: 1.613 ± 0.041
6.051AspGly: 6.051 ± 0.094
1.108AspHis: 1.108 ± 0.038
2.004AspIle: 2.004 ± 0.046
0.731AspLys: 0.731 ± 0.032
5.498AspLeu: 5.498 ± 0.073
0.817AspMet: 0.817 ± 0.032
0.667AspAsn: 0.667 ± 0.03
3.973AspPro: 3.973 ± 0.067
1.228AspGln: 1.228 ± 0.041
5.032AspArg: 5.032 ± 0.088
2.201AspSer: 2.201 ± 0.057
2.235AspThr: 2.235 ± 0.047
5.395AspVal: 5.395 ± 0.073
0.968AspTrp: 0.968 ± 0.031
1.051AspTyr: 1.051 ± 0.03
0.0AspXaa: 0.0 ± 0.0
Glu
8.939GluAla: 8.939 ± 0.13
0.28GluCys: 0.28 ± 0.018
2.526GluAsp: 2.526 ± 0.06
3.421GluGlu: 3.421 ± 0.075
1.453GluPhe: 1.453 ± 0.045
4.99GluGly: 4.99 ± 0.078
2.038GluHis: 2.038 ± 0.047
2.609GluIle: 2.609 ± 0.058
0.905GluLys: 0.905 ± 0.04
7.935GluLeu: 7.935 ± 0.106
0.959GluMet: 0.959 ± 0.033
0.737GluAsn: 0.737 ± 0.031
4.185GluPro: 4.185 ± 0.097
2.861GluGln: 2.861 ± 0.07
8.002GluArg: 8.002 ± 0.116
3.043GluSer: 3.043 ± 0.062
3.042GluThr: 3.042 ± 0.071
4.945GluVal: 4.945 ± 0.079
0.949GluTrp: 0.949 ± 0.035
0.903GluTyr: 0.903 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
4.131PheAla: 4.131 ± 0.079
0.132PheCys: 0.132 ± 0.012
2.286PheAsp: 2.286 ± 0.048
2.088PheGlu: 2.088 ± 0.053
0.853PhePhe: 0.853 ± 0.033
3.193PheGly: 3.193 ± 0.066
0.533PheHis: 0.533 ± 0.028
0.999PheIle: 0.999 ± 0.039
0.406PheLys: 0.406 ± 0.02
2.461PheLeu: 2.461 ± 0.065
0.404PheMet: 0.404 ± 0.023
0.525PheAsn: 0.525 ± 0.023
1.225PhePro: 1.225 ± 0.042
0.761PheGln: 0.761 ± 0.032
1.61PheArg: 1.61 ± 0.047
1.425PheSer: 1.425 ± 0.045
1.645PheThr: 1.645 ± 0.048
2.528PheVal: 2.528 ± 0.059
0.364PheTrp: 0.364 ± 0.024
0.529PheTyr: 0.529 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
12.066GlyAla: 12.066 ± 0.157
0.559GlyCys: 0.559 ± 0.028
5.414GlyAsp: 5.414 ± 0.092
5.742GlyGlu: 5.742 ± 0.086
3.181GlyPhe: 3.181 ± 0.071
7.88GlyGly: 7.88 ± 0.132
1.863GlyHis: 1.863 ± 0.055
4.76GlyIle: 4.76 ± 0.079
1.95GlyLys: 1.95 ± 0.061
8.875GlyLeu: 8.875 ± 0.119
2.098GlyMet: 2.098 ± 0.051
1.342GlyAsn: 1.342 ± 0.051
3.785GlyPro: 3.785 ± 0.067
2.464GlyGln: 2.464 ± 0.054
6.829GlyArg: 6.829 ± 0.09
5.326GlySer: 5.326 ± 0.088
5.093GlyThr: 5.093 ± 0.09
7.854GlyVal: 7.854 ± 0.095
1.625GlyTrp: 1.625 ± 0.045
1.913GlyTyr: 1.913 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
2.732HisAla: 2.732 ± 0.06
0.137HisCys: 0.137 ± 0.011
1.427HisAsp: 1.427 ± 0.041
1.38HisGlu: 1.38 ± 0.04
0.509HisPhe: 0.509 ± 0.024
2.31HisGly: 2.31 ± 0.055
0.581HisHis: 0.581 ± 0.03
0.701HisIle: 0.701 ± 0.029
0.251HisLys: 0.251 ± 0.017
2.091HisLeu: 2.091 ± 0.056
0.321HisMet: 0.321 ± 0.018
0.309HisAsn: 0.309 ± 0.019
1.521HisPro: 1.521 ± 0.036
0.43HisGln: 0.43 ± 0.021
1.861HisArg: 1.861 ± 0.052
0.927HisSer: 0.927 ± 0.033
0.816HisThr: 0.816 ± 0.031
1.902HisVal: 1.902 ± 0.045
0.333HisTrp: 0.333 ± 0.018
0.398HisTyr: 0.398 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
7.701IleAla: 7.701 ± 0.106
0.204IleCys: 0.204 ± 0.016
3.503IleAsp: 3.503 ± 0.065
3.384IleGlu: 3.384 ± 0.067
1.004IlePhe: 1.004 ± 0.037
4.672IleGly: 4.672 ± 0.081
0.692IleHis: 0.692 ± 0.028
1.511IleIle: 1.511 ± 0.047
0.656IleLys: 0.656 ± 0.036
3.232IleLeu: 3.232 ± 0.081
0.636IleMet: 0.636 ± 0.032
0.693IleAsn: 0.693 ± 0.029
1.966IlePro: 1.966 ± 0.052
0.841IleGln: 0.841 ± 0.033
2.689IleArg: 2.689 ± 0.057
1.854IleSer: 1.854 ± 0.05
2.327IleThr: 2.327 ± 0.06
4.802IleVal: 4.802 ± 0.093
0.47IleTrp: 0.47 ± 0.02
0.592IleTyr: 0.592 ± 0.026
0.0IleXaa: 0.0 ± 0.0
Lys
2.272LysAla: 2.272 ± 0.062
0.053LysCys: 0.053 ± 0.008
0.852LysAsp: 0.852 ± 0.034
0.86LysGlu: 0.86 ± 0.034
0.309LysPhe: 0.309 ± 0.02
1.407LysGly: 1.407 ± 0.049
0.49LysHis: 0.49 ± 0.024
0.581LysIle: 0.581 ± 0.029
0.521LysLys: 0.521 ± 0.032
1.606LysLeu: 1.606 ± 0.044
0.28LysMet: 0.28 ± 0.021
0.318LysAsn: 0.318 ± 0.02
1.112LysPro: 1.112 ± 0.042
0.716LysGln: 0.716 ± 0.031
1.696LysArg: 1.696 ± 0.051
0.913LysSer: 0.913 ± 0.037
0.985LysThr: 0.985 ± 0.041
1.399LysVal: 1.399 ± 0.051
0.202LysTrp: 0.202 ± 0.015
0.308LysTyr: 0.308 ± 0.017
0.0LysXaa: 0.0 ± 0.0
Leu
16.097LeuAla: 16.097 ± 0.177
0.456LeuCys: 0.456 ± 0.026
7.041LeuAsp: 7.041 ± 0.099
7.447LeuGlu: 7.447 ± 0.114
2.472LeuPhe: 2.472 ± 0.066
9.834LeuGly: 9.834 ± 0.139
1.924LeuHis: 1.924 ± 0.046
3.79LeuIle: 3.79 ± 0.074
1.476LeuLys: 1.476 ± 0.045
10.704LeuLeu: 10.704 ± 0.151
1.591LeuMet: 1.591 ± 0.046
1.312LeuAsn: 1.312 ± 0.041
5.696LeuPro: 5.696 ± 0.088
2.819LeuGln: 2.819 ± 0.058
8.023LeuArg: 8.023 ± 0.104
5.018LeuSer: 5.018 ± 0.082
5.344LeuThr: 5.344 ± 0.083
9.831LeuVal: 9.831 ± 0.126
1.237LeuTrp: 1.237 ± 0.041
1.317LeuTyr: 1.317 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
2.416MetAla: 2.416 ± 0.05
0.108MetCys: 0.108 ± 0.011
0.796MetAsp: 0.796 ± 0.029
0.739MetGlu: 0.739 ± 0.029
0.467MetPhe: 0.467 ± 0.026
1.394MetGly: 1.394 ± 0.043
0.459MetHis: 0.459 ± 0.022
0.786MetIle: 0.786 ± 0.029
0.301MetLys: 0.301 ± 0.019
2.422MetLeu: 2.422 ± 0.062
0.29MetMet: 0.29 ± 0.018
0.362MetAsn: 0.362 ± 0.021
1.337MetPro: 1.337 ± 0.039
0.717MetGln: 0.717 ± 0.027
1.809MetArg: 1.809 ± 0.044
1.257MetSer: 1.257 ± 0.05
1.599MetThr: 1.599 ± 0.04
1.305MetVal: 1.305 ± 0.042
0.187MetTrp: 0.187 ± 0.015
0.246MetTyr: 0.246 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.072AsnAla: 2.072 ± 0.052
0.078AsnCys: 0.078 ± 0.009
0.881AsnAsp: 0.881 ± 0.035
0.831AsnGlu: 0.831 ± 0.033
0.447AsnPhe: 0.447 ± 0.025
1.433AsnGly: 1.433 ± 0.062
0.305AsnHis: 0.305 ± 0.02
0.603AsnIle: 0.603 ± 0.025
0.276AsnLys: 0.276 ± 0.021
1.455AsnLeu: 1.455 ± 0.041
0.249AsnMet: 0.249 ± 0.019
0.328AsnAsn: 0.328 ± 0.022
1.319AsnPro: 1.319 ± 0.046
0.433AsnGln: 0.433 ± 0.026
1.123AsnArg: 1.123 ± 0.038
0.628AsnSer: 0.628 ± 0.027
0.714AsnThr: 0.714 ± 0.034
1.283AsnVal: 1.283 ± 0.038
0.238AsnTrp: 0.238 ± 0.016
0.306AsnTyr: 0.306 ± 0.019
0.0AsnXaa: 0.0 ± 0.0
Pro
7.566ProAla: 7.566 ± 0.123
0.188ProCys: 0.188 ± 0.016
3.765ProAsp: 3.765 ± 0.074
4.204ProGlu: 4.204 ± 0.088
1.625ProPhe: 1.625 ± 0.05
5.245ProGly: 5.245 ± 0.084
1.15ProHis: 1.15 ± 0.041
2.298ProIle: 2.298 ± 0.063
0.967ProLys: 0.967 ± 0.039
4.956ProLeu: 4.956 ± 0.075
1.035ProMet: 1.035 ± 0.034
0.844ProAsn: 0.844 ± 0.029
2.412ProPro: 2.412 ± 0.067
1.501ProGln: 1.501 ± 0.045
3.482ProArg: 3.482 ± 0.069
3.104ProSer: 3.104 ± 0.07
3.224ProThr: 3.224 ± 0.073
4.882ProVal: 4.882 ± 0.085
0.934ProTrp: 0.934 ± 0.038
0.926ProTyr: 0.926 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
3.775GlnAla: 3.775 ± 0.072
0.105GlnCys: 0.105 ± 0.01
1.12GlnAsp: 1.12 ± 0.036
1.345GlnGlu: 1.345 ± 0.043
0.769GlnPhe: 0.769 ± 0.03
2.113GlnGly: 2.113 ± 0.051
0.769GlnHis: 0.769 ± 0.027
1.178GlnIle: 1.178 ± 0.041
0.454GlnLys: 0.454 ± 0.022
3.633GlnLeu: 3.633 ± 0.078
0.466GlnMet: 0.466 ± 0.023
0.451GlnAsn: 0.451 ± 0.025
1.82GlnPro: 1.82 ± 0.056
1.433GlnGln: 1.433 ± 0.047
2.925GlnArg: 2.925 ± 0.063
1.507GlnSer: 1.507 ± 0.039
1.189GlnThr: 1.189 ± 0.039
2.4GlnVal: 2.4 ± 0.058
0.473GlnTrp: 0.473 ± 0.024
0.509GlnTyr: 0.509 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
10.713ArgAla: 10.713 ± 0.136
0.36ArgCys: 0.36 ± 0.023
4.778ArgAsp: 4.778 ± 0.078
5.429ArgGlu: 5.429 ± 0.1
2.65ArgPhe: 2.65 ± 0.045
6.017ArgGly: 6.017 ± 0.085
1.689ArgHis: 1.689 ± 0.053
4.182ArgIle: 4.182 ± 0.071
1.4ArgLys: 1.4 ± 0.042
8.326ArgLeu: 8.326 ± 0.137
2.118ArgMet: 2.118 ± 0.049
1.068ArgAsn: 1.068 ± 0.039
3.991ArgPro: 3.991 ± 0.087
2.218ArgGln: 2.218 ± 0.05
7.242ArgArg: 7.242 ± 0.109
4.54ArgSer: 4.54 ± 0.081
3.807ArgThr: 3.807 ± 0.067
6.688ArgVal: 6.688 ± 0.097
1.376ArgTrp: 1.376 ± 0.041
1.486ArgTyr: 1.486 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
6.952SerAla: 6.952 ± 0.098
0.251SerCys: 0.251 ± 0.023
2.604SerAsp: 2.604 ± 0.049
2.556SerGlu: 2.556 ± 0.054
1.722SerPhe: 1.722 ± 0.051
5.169SerGly: 5.169 ± 0.099
1.015SerHis: 1.015 ± 0.036
2.645SerIle: 2.645 ± 0.058
1.041SerLys: 1.041 ± 0.037
5.252SerLeu: 5.252 ± 0.086
1.287SerMet: 1.287 ± 0.041
0.903SerAsn: 0.903 ± 0.031
2.88SerPro: 2.88 ± 0.075
1.282SerGln: 1.282 ± 0.041
3.823SerArg: 3.823 ± 0.069
3.204SerSer: 3.204 ± 0.057
3.384SerThr: 3.384 ± 0.069
4.163SerVal: 4.163 ± 0.064
0.887SerTrp: 0.887 ± 0.033
0.91SerTyr: 0.91 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
7.109ThrAla: 7.109 ± 0.102
0.229ThrCys: 0.229 ± 0.018
3.108ThrAsp: 3.108 ± 0.065
2.811ThrGlu: 2.811 ± 0.056
1.498ThrPhe: 1.498 ± 0.049
5.537ThrGly: 5.537 ± 0.083
1.067ThrHis: 1.067 ± 0.036
2.754ThrIle: 2.754 ± 0.062
0.946ThrLys: 0.946 ± 0.035
5.317ThrLeu: 5.317 ± 0.073
1.01ThrMet: 1.01 ± 0.034
0.881ThrAsn: 0.881 ± 0.035
3.227ThrPro: 3.227 ± 0.072
1.289ThrGln: 1.289 ± 0.038
3.415ThrArg: 3.415 ± 0.063
2.704ThrSer: 2.704 ± 0.055
3.283ThrThr: 3.283 ± 0.086
4.973ThrVal: 4.973 ± 0.097
0.762ThrTrp: 0.762 ± 0.028
0.936ThrTyr: 0.936 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
12.416ValAla: 12.416 ± 0.132
0.436ValCys: 0.436 ± 0.022
5.948ValAsp: 5.948 ± 0.08
5.829ValGlu: 5.829 ± 0.095
2.33ValPhe: 2.33 ± 0.056
7.38ValGly: 7.38 ± 0.113
1.887ValHis: 1.887 ± 0.051
3.611ValIle: 3.611 ± 0.078
1.407ValLys: 1.407 ± 0.042
9.646ValLeu: 9.646 ± 0.115
1.44ValMet: 1.44 ± 0.045
1.446ValAsn: 1.446 ± 0.042
4.805ValPro: 4.805 ± 0.076
2.415ValGln: 2.415 ± 0.058
6.64ValArg: 6.64 ± 0.108
4.263ValSer: 4.263 ± 0.077
4.919ValThr: 4.919 ± 0.089
9.124ValVal: 9.124 ± 0.127
1.098ValTrp: 1.098 ± 0.037
1.225ValTyr: 1.225 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
1.741TrpAla: 1.741 ± 0.05
0.1TrpCys: 0.1 ± 0.011
0.683TrpAsp: 0.683 ± 0.029
0.606TrpGlu: 0.606 ± 0.027
0.51TrpPhe: 0.51 ± 0.028
1.114TrpGly: 1.114 ± 0.04
0.393TrpHis: 0.393 ± 0.025
0.757TrpIle: 0.757 ± 0.027
0.229TrpLys: 0.229 ± 0.016
1.998TrpLeu: 1.998 ± 0.059
0.384TrpMet: 0.384 ± 0.02
0.327TrpAsn: 0.327 ± 0.02
0.708TrpPro: 0.708 ± 0.032
0.619TrpGln: 0.619 ± 0.027
1.434TrpArg: 1.434 ± 0.041
0.905TrpSer: 0.905 ± 0.031
0.764TrpThr: 0.764 ± 0.028
1.181TrpVal: 1.181 ± 0.037
0.371TrpTrp: 0.371 ± 0.021
0.236TrpTyr: 0.236 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.205TyrAla: 2.205 ± 0.052
0.117TyrCys: 0.117 ± 0.01
1.081TyrAsp: 1.081 ± 0.037
0.963TyrGlu: 0.963 ± 0.035
0.529TyrPhe: 0.529 ± 0.025
1.747TyrGly: 1.747 ± 0.051
0.265TyrHis: 0.265 ± 0.018
0.503TyrIle: 0.503 ± 0.027
0.265TyrLys: 0.265 ± 0.014
1.739TyrLeu: 1.739 ± 0.044
0.252TyrMet: 0.252 ± 0.018
0.316TyrAsn: 0.316 ± 0.023
0.817TyrPro: 0.817 ± 0.029
0.435TyrGln: 0.435 ± 0.024
1.564TyrArg: 1.564 ± 0.039
0.882TyrSer: 0.882 ± 0.037
0.774TyrThr: 0.774 ± 0.031
1.316TyrVal: 1.316 ± 0.038
0.275TyrTrp: 0.275 ± 0.019
0.345TyrTyr: 0.345 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2776 proteins (872884 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski