Amino acid dipepetide frequency for Mycobacterium sp. ITM-2016-00318

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.806AlaAla: 18.806 ± 0.188	0.976AlaCys: 0.976 ± 0.026	8.466AlaAsp: 8.466 ± 0.076	7.786AlaGlu: 7.786 ± 0.082	3.572AlaPhe: 3.572 ± 0.047	11.167AlaGly: 11.167 ± 0.09	2.427AlaHis: 2.427 ± 0.043	5.408AlaIle: 5.408 ± 0.052	3.305AlaLys: 3.305 ± 0.056	12.614AlaLeu: 12.614 ± 0.112	3.018AlaMet: 3.018 ± 0.043	2.609AlaAsn: 2.609 ± 0.038	6.111AlaPro: 6.111 ± 0.085	3.74AlaGln: 3.74 ± 0.051	8.123AlaArg: 8.123 ± 0.083	6.115AlaSer: 6.115 ± 0.061	6.965AlaThr: 6.965 ± 0.071	11.492AlaVal: 11.492 ± 0.098	1.614AlaTrp: 1.614 ± 0.036	2.319AlaTyr: 2.319 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.063CysAla: 1.063 ± 0.026	0.102CysCys: 0.102 ± 0.008	0.546CysAsp: 0.546 ± 0.016	0.47CysGlu: 0.47 ± 0.019	0.24CysPhe: 0.24 ± 0.012	0.935CysGly: 0.935 ± 0.022	0.178CysHis: 0.178 ± 0.012	0.294CysIle: 0.294 ± 0.013	0.133CysLys: 0.133 ± 0.009	0.687CysLeu: 0.687 ± 0.018	0.149CysMet: 0.149 ± 0.01	0.178CysAsn: 0.178 ± 0.01	0.478CysPro: 0.478 ± 0.017	0.223CysGln: 0.223 ± 0.011	0.588CysArg: 0.588 ± 0.018	0.486CysSer: 0.486 ± 0.018	0.495CysThr: 0.495 ± 0.017	0.668CysVal: 0.668 ± 0.024	0.127CysTrp: 0.127 ± 0.01	0.188CysTyr: 0.188 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.872AspAla: 7.872 ± 0.082	0.503AspCys: 0.503 ± 0.018	4.886AspAsp: 4.886 ± 0.062	4.443AspGlu: 4.443 ± 0.053	1.893AspPhe: 1.893 ± 0.036	6.073AspGly: 6.073 ± 0.071	1.416AspHis: 1.416 ± 0.03	2.797AspIle: 2.797 ± 0.043	1.471AspLys: 1.471 ± 0.034	6.005AspLeu: 6.005 ± 0.062	1.13AspMet: 1.13 ± 0.027	1.344AspAsn: 1.344 ± 0.026	4.374AspPro: 4.374 ± 0.051	1.679AspGln: 1.679 ± 0.033	4.667AspArg: 4.667 ± 0.05	2.928AspSer: 2.928 ± 0.041	3.188AspThr: 3.188 ± 0.045	5.604AspVal: 5.604 ± 0.053	1.025AspTrp: 1.025 ± 0.026	1.438AspTyr: 1.438 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	6.387GluAla: 6.387 ± 0.077	0.395GluCys: 0.395 ± 0.017	2.684GluAsp: 2.684 ± 0.041	2.759GluGlu: 2.759 ± 0.054	1.897GluPhe: 1.897 ± 0.035	3.632GluGly: 3.632 ± 0.044	1.546GluHis: 1.546 ± 0.029	2.752GluIle: 2.752 ± 0.041	1.64GluLys: 1.64 ± 0.035	6.543GluLeu: 6.543 ± 0.068	1.199GluMet: 1.199 ± 0.027	1.241GluAsn: 1.241 ± 0.031	3.189GluPro: 3.189 ± 0.051	2.188GluGln: 2.188 ± 0.037	4.523GluArg: 4.523 ± 0.061	2.867GluSer: 2.867 ± 0.048	2.84GluThr: 2.84 ± 0.043	4.58GluVal: 4.58 ± 0.057	0.793GluTrp: 0.793 ± 0.024	1.17GluTyr: 1.17 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	3.998PheAla: 3.998 ± 0.051	0.342PheCys: 0.342 ± 0.015	2.648PheAsp: 2.648 ± 0.043	1.7PheGlu: 1.7 ± 0.032	1.076PhePhe: 1.076 ± 0.028	3.534PheGly: 3.534 ± 0.047	0.628PheHis: 0.628 ± 0.02	1.151PheIle: 1.151 ± 0.028	0.565PheLys: 0.565 ± 0.018	2.538PheLeu: 2.538 ± 0.04	0.53PheMet: 0.53 ± 0.02	0.812PheAsn: 0.812 ± 0.021	1.445PhePro: 1.445 ± 0.032	0.656PheGln: 0.656 ± 0.019	1.746PheArg: 1.746 ± 0.032	1.813PheSer: 1.813 ± 0.035	2.101PheThr: 2.101 ± 0.031	2.715PheVal: 2.715 ± 0.046	0.452PheTrp: 0.452 ± 0.018	0.724PheTyr: 0.724 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.84GlyAla: 9.84 ± 0.08	0.779GlyCys: 0.779 ± 0.02	5.25GlyAsp: 5.25 ± 0.061	4.66GlyGlu: 4.66 ± 0.047	3.09GlyPhe: 3.09 ± 0.046	7.845GlyGly: 7.845 ± 0.104	2.036GlyHis: 2.036 ± 0.04	4.135GlyIle: 4.135 ± 0.051	2.386GlyLys: 2.386 ± 0.042	8.336GlyLeu: 8.336 ± 0.079	2.21GlyMet: 2.21 ± 0.036	2.031GlyAsn: 2.031 ± 0.049	4.365GlyPro: 4.365 ± 0.059	2.72GlyGln: 2.72 ± 0.046	6.177GlyArg: 6.177 ± 0.072	5.176GlySer: 5.176 ± 0.065	5.195GlyThr: 5.195 ± 0.063	7.638GlyVal: 7.638 ± 0.067	1.675GlyTrp: 1.675 ± 0.036	2.369GlyTyr: 2.369 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.366HisAla: 2.366 ± 0.037	0.213HisCys: 0.213 ± 0.013	1.361HisAsp: 1.361 ± 0.031	1.137HisGlu: 1.137 ± 0.028	0.684HisPhe: 0.684 ± 0.021	2.046HisGly: 2.046 ± 0.034	0.641HisHis: 0.641 ± 0.023	0.969HisIle: 0.969 ± 0.025	0.414HisLys: 0.414 ± 0.015	2.096HisLeu: 2.096 ± 0.041	0.347HisMet: 0.347 ± 0.016	0.476HisAsn: 0.476 ± 0.018	1.554HisPro: 1.554 ± 0.029	0.596HisGln: 0.596 ± 0.019	1.824HisArg: 1.824 ± 0.038	1.082HisSer: 1.082 ± 0.028	1.195HisThr: 1.195 ± 0.024	1.651HisVal: 1.651 ± 0.032	0.39HisTrp: 0.39 ± 0.015	0.532HisTyr: 0.532 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	6.561IleAla: 6.561 ± 0.066	0.418IleCys: 0.418 ± 0.015	3.56IleAsp: 3.56 ± 0.045	2.791IleGlu: 2.791 ± 0.044	1.112IlePhe: 1.112 ± 0.028	4.7IleGly: 4.7 ± 0.056	0.775IleHis: 0.775 ± 0.023	1.588IleIle: 1.588 ± 0.036	1.012IleLys: 1.012 ± 0.026	3.1IleLeu: 3.1 ± 0.04	0.623IleMet: 0.623 ± 0.019	1.17IleAsn: 1.17 ± 0.03	2.453IlePro: 2.453 ± 0.04	0.953IleGln: 0.953 ± 0.024	2.709IleArg: 2.709 ± 0.045	2.374IleSer: 2.374 ± 0.039	2.746IleThr: 2.746 ± 0.043	3.901IleVal: 3.901 ± 0.045	0.497IleTrp: 0.497 ± 0.018	0.808IleTyr: 0.808 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	2.981LysAla: 2.981 ± 0.048	0.128LysCys: 0.128 ± 0.008	1.254LysAsp: 1.254 ± 0.031	1.164LysGlu: 1.164 ± 0.031	0.688LysPhe: 0.688 ± 0.021	1.74LysGly: 1.74 ± 0.034	0.521LysHis: 0.521 ± 0.021	1.087LysIle: 1.087 ± 0.027	0.769LysLys: 0.769 ± 0.028	2.366LysLeu: 2.366 ± 0.039	0.538LysMet: 0.538 ± 0.019	0.564LysAsn: 0.564 ± 0.019	1.678LysPro: 1.678 ± 0.031	0.829LysGln: 0.829 ± 0.023	1.845LysArg: 1.845 ± 0.04	1.4LysSer: 1.4 ± 0.029	1.478LysThr: 1.478 ± 0.032	2.096LysVal: 2.096 ± 0.04	0.338LysTrp: 0.338 ± 0.013	0.499LysTyr: 0.499 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	13.51LeuAla: 13.51 ± 0.097	0.835LeuCys: 0.835 ± 0.022	6.368LeuAsp: 6.368 ± 0.066	4.557LeuGlu: 4.557 ± 0.057	2.789LeuPhe: 2.789 ± 0.041	8.35LeuGly: 8.35 ± 0.075	2.04LeuHis: 2.04 ± 0.033	4.231LeuIle: 4.231 ± 0.064	1.996LeuLys: 1.996 ± 0.034	9.519LeuLeu: 9.519 ± 0.085	1.834LeuMet: 1.834 ± 0.033	2.205LeuAsn: 2.205 ± 0.038	5.547LeuPro: 5.547 ± 0.064	2.458LeuGln: 2.458 ± 0.037	7.328LeuArg: 7.328 ± 0.069	5.582LeuSer: 5.582 ± 0.06	6.188LeuThr: 6.188 ± 0.059	8.246LeuVal: 8.246 ± 0.083	1.205LeuTrp: 1.205 ± 0.03	1.751LeuTyr: 1.751 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.78MetAla: 2.78 ± 0.038	0.2MetCys: 0.2 ± 0.013	0.97MetAsp: 0.97 ± 0.023	0.772MetGlu: 0.772 ± 0.02	0.687MetPhe: 0.687 ± 0.021	1.549MetGly: 1.549 ± 0.031	0.447MetHis: 0.447 ± 0.019	0.922MetIle: 0.922 ± 0.023	0.516MetLys: 0.516 ± 0.018	2.094MetLeu: 2.094 ± 0.035	0.467MetMet: 0.467 ± 0.018	0.549MetAsn: 0.549 ± 0.019	1.295MetPro: 1.295 ± 0.029	0.576MetGln: 0.576 ± 0.017	1.699MetArg: 1.699 ± 0.034	1.582MetSer: 1.582 ± 0.03	1.958MetThr: 1.958 ± 0.033	1.718MetVal: 1.718 ± 0.032	0.3MetTrp: 0.3 ± 0.014	0.376MetTyr: 0.376 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.716AsnAla: 2.716 ± 0.038	0.195AsnCys: 0.195 ± 0.011	1.345AsnAsp: 1.345 ± 0.035	1.145AsnGlu: 1.145 ± 0.029	0.695AsnPhe: 0.695 ± 0.02	2.198AsnGly: 2.198 ± 0.039	0.461AsnHis: 0.461 ± 0.016	0.99AsnIle: 0.99 ± 0.026	0.526AsnLys: 0.526 ± 0.017	2.08AsnLeu: 2.08 ± 0.038	0.461AsnMet: 0.461 ± 0.018	0.645AsnAsn: 0.645 ± 0.028	1.774AsnPro: 1.774 ± 0.029	0.676AsnGln: 0.676 ± 0.022	1.676AsnArg: 1.676 ± 0.033	1.218AsnSer: 1.218 ± 0.026	1.405AsnThr: 1.405 ± 0.039	1.919AsnVal: 1.919 ± 0.031	0.419AsnTrp: 0.419 ± 0.015	0.58AsnTyr: 0.58 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	6.67ProAla: 6.67 ± 0.08	0.317ProCys: 0.317 ± 0.014	4.425ProAsp: 4.425 ± 0.057	3.684ProGlu: 3.684 ± 0.048	1.694ProPhe: 1.694 ± 0.032	5.369ProGly: 5.369 ± 0.07	1.162ProHis: 1.162 ± 0.028	2.251ProIle: 2.251 ± 0.037	1.384ProLys: 1.384 ± 0.032	4.866ProLeu: 4.866 ± 0.055	1.321ProMet: 1.321 ± 0.027	1.39ProAsn: 1.39 ± 0.03	3.823ProPro: 3.823 ± 0.095	1.801ProGln: 1.801 ± 0.035	3.357ProArg: 3.357 ± 0.051	3.254ProSer: 3.254 ± 0.05	3.453ProThr: 3.453 ± 0.041	5.001ProVal: 5.001 ± 0.06	0.845ProTrp: 0.845 ± 0.024	1.193ProTyr: 1.193 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.447GlnAla: 3.447 ± 0.046	0.216GlnCys: 0.216 ± 0.012	1.2GlnAsp: 1.2 ± 0.027	1.191GlnGlu: 1.191 ± 0.03	0.993GlnPhe: 0.993 ± 0.023	1.964GlnGly: 1.964 ± 0.034	0.679GlnHis: 0.679 ± 0.017	1.46GlnIle: 1.46 ± 0.03	0.733GlnLys: 0.733 ± 0.022	3.357GlnLeu: 3.357 ± 0.044	0.683GlnMet: 0.683 ± 0.022	0.646GlnAsn: 0.646 ± 0.018	1.742GlnPro: 1.742 ± 0.039	1.297GlnGln: 1.297 ± 0.031	2.737GlnArg: 2.737 ± 0.046	1.499GlnSer: 1.499 ± 0.032	1.603GlnThr: 1.603 ± 0.035	2.352GlnVal: 2.352 ± 0.038	0.587GlnTrp: 0.587 ± 0.019	0.636GlnTyr: 0.636 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	7.859ArgAla: 7.859 ± 0.08	0.623ArgCys: 0.623 ± 0.022	4.395ArgAsp: 4.395 ± 0.055	3.986ArgGlu: 3.986 ± 0.043	2.461ArgPhe: 2.461 ± 0.04	5.122ArgGly: 5.122 ± 0.062	1.699ArgHis: 1.699 ± 0.037	3.537ArgIle: 3.537 ± 0.048	1.775ArgLys: 1.775 ± 0.031	7.419ArgLeu: 7.419 ± 0.08	1.812ArgMet: 1.812 ± 0.033	1.696ArgAsn: 1.696 ± 0.034	3.793ArgPro: 3.793 ± 0.05	2.246ArgGln: 2.246 ± 0.041	6.443ArgArg: 6.443 ± 0.083	4.053ArgSer: 4.053 ± 0.056	4.133ArgThr: 4.133 ± 0.055	5.377ArgVal: 5.377 ± 0.056	1.357ArgTrp: 1.357 ± 0.03	1.901ArgTyr: 1.901 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.965SerAla: 6.965 ± 0.058	0.419SerCys: 0.419 ± 0.016	3.446SerAsp: 3.446 ± 0.049	2.792SerGlu: 2.792 ± 0.052	1.719SerPhe: 1.719 ± 0.031	5.613SerGly: 5.613 ± 0.061	1.109SerHis: 1.109 ± 0.026	2.191SerIle: 2.191 ± 0.036	1.256SerLys: 1.256 ± 0.03	4.805SerLeu: 4.805 ± 0.053	1.452SerMet: 1.452 ± 0.03	1.164SerAsn: 1.164 ± 0.027	3.158SerPro: 3.158 ± 0.041	1.558SerGln: 1.558 ± 0.027	3.848SerArg: 3.848 ± 0.05	3.293SerSer: 3.293 ± 0.056	3.438SerThr: 3.438 ± 0.045	4.633SerVal: 4.633 ± 0.052	0.888SerTrp: 0.888 ± 0.028	1.213SerTyr: 1.213 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	7.623ThrAla: 7.623 ± 0.07	0.422ThrCys: 0.422 ± 0.015	3.79ThrAsp: 3.79 ± 0.05	3.208ThrGlu: 3.208 ± 0.045	1.871ThrPhe: 1.871 ± 0.034	5.725ThrGly: 5.725 ± 0.06	1.144ThrHis: 1.144 ± 0.026	2.546ThrIle: 2.546 ± 0.04	1.403ThrLys: 1.403 ± 0.031	5.462ThrLeu: 5.462 ± 0.063	1.295ThrMet: 1.295 ± 0.028	1.335ThrAsn: 1.335 ± 0.029	3.76ThrPro: 3.76 ± 0.058	1.483ThrGln: 1.483 ± 0.031	3.578ThrArg: 3.578 ± 0.055	3.319ThrSer: 3.319 ± 0.045	3.896ThrThr: 3.896 ± 0.068	5.775ThrVal: 5.775 ± 0.061	0.862ThrTrp: 0.862 ± 0.023	1.334ThrTyr: 1.334 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	11.285ValAla: 11.285 ± 0.091	0.733ValCys: 0.733 ± 0.023	5.908ValAsp: 5.908 ± 0.062	4.787ValGlu: 4.787 ± 0.052	2.669ValPhe: 2.669 ± 0.037	7.199ValGly: 7.199 ± 0.065	1.808ValHis: 1.808 ± 0.033	4.122ValIle: 4.122 ± 0.055	1.88ValLys: 1.88 ± 0.038	8.711ValLeu: 8.711 ± 0.085	1.713ValMet: 1.713 ± 0.036	2.172ValAsn: 2.172 ± 0.038	4.564ValPro: 4.564 ± 0.06	2.063ValGln: 2.063 ± 0.034	5.733ValArg: 5.733 ± 0.061	4.777ValSer: 4.777 ± 0.057	5.416ValThr: 5.416 ± 0.06	8.511ValVal: 8.511 ± 0.089	1.035ValTrp: 1.035 ± 0.025	1.574ValTyr: 1.574 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.511TrpAla: 1.511 ± 0.032	0.172TrpCys: 0.172 ± 0.01	0.815TrpAsp: 0.815 ± 0.021	0.667TrpGlu: 0.667 ± 0.019	0.539TrpPhe: 0.539 ± 0.019	1.032TrpGly: 1.032 ± 0.024	0.389TrpHis: 0.389 ± 0.016	0.659TrpIle: 0.659 ± 0.019	0.354TrpLys: 0.354 ± 0.014	1.719TrpLeu: 1.719 ± 0.033	0.352TrpMet: 0.352 ± 0.016	0.422TrpAsn: 0.422 ± 0.017	0.879TrpPro: 0.879 ± 0.025	0.605TrpGln: 0.605 ± 0.02	1.279TrpArg: 1.279 ± 0.029	0.963TrpSer: 0.963 ± 0.023	0.921TrpThr: 0.921 ± 0.024	1.132TrpVal: 1.132 ± 0.025	0.342TrpTrp: 0.342 ± 0.015	0.345TrpTyr: 0.345 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.392TyrAla: 2.392 ± 0.041	0.242TyrCys: 0.242 ± 0.012	1.413TyrAsp: 1.413 ± 0.032	1.127TyrGlu: 1.127 ± 0.03	0.806TyrPhe: 0.806 ± 0.02	2.119TyrGly: 2.119 ± 0.039	0.469TyrHis: 0.469 ± 0.014	0.757TyrIle: 0.757 ± 0.025	0.442TyrLys: 0.442 ± 0.018	2.225TyrLeu: 2.225 ± 0.04	0.322TyrMet: 0.322 ± 0.014	0.476TyrAsn: 0.476 ± 0.017	1.279TyrPro: 1.279 ± 0.031	0.677TyrGln: 0.677 ± 0.021	1.807TyrArg: 1.807 ± 0.034	1.18TyrSer: 1.18 ± 0.024	1.219TyrThr: 1.219 ± 0.031	1.651TyrVal: 1.651 ± 0.034	0.346TyrTrp: 0.346 ± 0.013	0.52TyrTyr: 0.52 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6184 proteins (1695395 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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