Amino acid dipepetide frequency for Boudabousia marimammalium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.712AlaAla: 13.712 ± 0.256
0.837AlaCys: 0.837 ± 0.042
6.048AlaAsp: 6.048 ± 0.121
7.813AlaGlu: 7.813 ± 0.145
3.465AlaPhe: 3.465 ± 0.096
9.263AlaGly: 9.263 ± 0.151
2.049AlaHis: 2.049 ± 0.062
5.59AlaIle: 5.59 ± 0.13
4.349AlaLys: 4.349 ± 0.107
11.196AlaLeu: 11.196 ± 0.169
2.506AlaMet: 2.506 ± 0.073
2.933AlaAsn: 2.933 ± 0.072
4.581AlaPro: 4.581 ± 0.112
4.953AlaGln: 4.953 ± 0.114
6.195AlaArg: 6.195 ± 0.143
6.128AlaSer: 6.128 ± 0.112
6.384AlaThr: 6.384 ± 0.139
8.405AlaVal: 8.405 ± 0.135
1.533AlaTrp: 1.533 ± 0.066
2.328AlaTyr: 2.328 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.813CysAla: 0.813 ± 0.04
0.076CysCys: 0.076 ± 0.011
0.393CysAsp: 0.393 ± 0.029
0.484CysGlu: 0.484 ± 0.032
0.261CysPhe: 0.261 ± 0.024
0.7CysGly: 0.7 ± 0.037
0.154CysHis: 0.154 ± 0.018
0.307CysIle: 0.307 ± 0.027
0.188CysLys: 0.188 ± 0.019
0.582CysLeu: 0.582 ± 0.031
0.123CysMet: 0.123 ± 0.015
0.18CysAsn: 0.18 ± 0.02
0.4CysPro: 0.4 ± 0.027
0.207CysGln: 0.207 ± 0.021
0.346CysArg: 0.346 ± 0.027
0.46CysSer: 0.46 ± 0.03
0.424CysThr: 0.424 ± 0.027
0.551CysVal: 0.551 ± 0.036
0.076CysTrp: 0.076 ± 0.013
0.177CysTyr: 0.177 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
5.597AspAla: 5.597 ± 0.119
0.367AspCys: 0.367 ± 0.031
2.804AspAsp: 2.804 ± 0.089
4.094AspGlu: 4.094 ± 0.108
2.021AspPhe: 2.021 ± 0.06
4.44AspGly: 4.44 ± 0.124
1.023AspHis: 1.023 ± 0.05
2.611AspIle: 2.611 ± 0.07
1.933AspLys: 1.933 ± 0.069
5.681AspLeu: 5.681 ± 0.13
1.124AspMet: 1.124 ± 0.048
1.483AspAsn: 1.483 ± 0.056
3.158AspPro: 3.158 ± 0.081
2.015AspGln: 2.015 ± 0.061
3.05AspArg: 3.05 ± 0.071
3.606AspSer: 3.606 ± 0.085
2.871AspThr: 2.871 ± 0.068
3.943AspVal: 3.943 ± 0.099
0.929AspTrp: 0.929 ± 0.04
1.649AspTyr: 1.649 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
7.225GluAla: 7.225 ± 0.148
0.363GluCys: 0.363 ± 0.025
3.634GluAsp: 3.634 ± 0.095
4.084GluGlu: 4.084 ± 0.116
1.757GluPhe: 1.757 ± 0.055
4.698GluGly: 4.698 ± 0.09
1.383GluHis: 1.383 ± 0.053
3.906GluIle: 3.906 ± 0.097
2.616GluLys: 2.616 ± 0.09
6.764GluLeu: 6.764 ± 0.12
1.49GluMet: 1.49 ± 0.055
2.172GluAsn: 2.172 ± 0.068
3.003GluPro: 3.003 ± 0.117
2.713GluGln: 2.713 ± 0.081
3.885GluArg: 3.885 ± 0.099
3.55GluSer: 3.55 ± 0.092
3.697GluThr: 3.697 ± 0.094
4.899GluVal: 4.899 ± 0.103
0.767GluTrp: 0.767 ± 0.037
1.461GluTyr: 1.461 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
3.695PheAla: 3.695 ± 0.084
0.253PheCys: 0.253 ± 0.023
2.175PheAsp: 2.175 ± 0.065
1.677PheGlu: 1.677 ± 0.058
1.338PhePhe: 1.338 ± 0.056
2.901PheGly: 2.901 ± 0.081
0.633PheHis: 0.633 ± 0.032
1.591PheIle: 1.591 ± 0.062
1.126PheLys: 1.126 ± 0.044
3.059PheLeu: 3.059 ± 0.093
0.741PheMet: 0.741 ± 0.04
1.159PheAsn: 1.159 ± 0.054
1.556PhePro: 1.556 ± 0.059
0.994PheGln: 0.994 ± 0.045
1.584PheArg: 1.584 ± 0.058
2.449PheSer: 2.449 ± 0.071
2.38PheThr: 2.38 ± 0.075
2.724PheVal: 2.724 ± 0.068
0.506PheTrp: 0.506 ± 0.032
0.837PheTyr: 0.837 ± 0.038
0.0PheXaa: 0.0 ± 0.0
Gly
7.81GlyAla: 7.81 ± 0.149
0.54GlyCys: 0.54 ± 0.034
3.965GlyAsp: 3.965 ± 0.102
4.914GlyGlu: 4.914 ± 0.095
3.063GlyPhe: 3.063 ± 0.078
5.901GlyGly: 5.901 ± 0.13
1.611GlyHis: 1.611 ± 0.062
4.462GlyIle: 4.462 ± 0.099
3.742GlyLys: 3.742 ± 0.09
7.646GlyLeu: 7.646 ± 0.132
2.064GlyMet: 2.064 ± 0.063
2.289GlyAsn: 2.289 ± 0.076
2.951GlyPro: 2.951 ± 0.088
2.99GlyGln: 2.99 ± 0.082
4.652GlyArg: 4.652 ± 0.094
5.002GlySer: 5.002 ± 0.107
4.719GlyThr: 4.719 ± 0.106
6.513GlyVal: 6.513 ± 0.129
1.357GlyTrp: 1.357 ± 0.055
2.229GlyTyr: 2.229 ± 0.07
0.0GlyXaa: 0.0 ± 0.0
His
1.976HisAla: 1.976 ± 0.061
0.184HisCys: 0.184 ± 0.019
1.183HisAsp: 1.183 ± 0.051
1.176HisGlu: 1.176 ± 0.046
0.661HisPhe: 0.661 ± 0.04
1.615HisGly: 1.615 ± 0.051
0.523HisHis: 0.523 ± 0.034
0.826HisIle: 0.826 ± 0.041
0.586HisLys: 0.586 ± 0.034
2.177HisLeu: 2.177 ± 0.067
0.38HisMet: 0.38 ± 0.026
0.621HisAsn: 0.621 ± 0.035
1.394HisPro: 1.394 ± 0.059
0.759HisGln: 0.759 ± 0.033
1.295HisArg: 1.295 ± 0.053
1.183HisSer: 1.183 ± 0.052
1.113HisThr: 1.113 ± 0.046
1.386HisVal: 1.386 ± 0.059
0.281HisTrp: 0.281 ± 0.022
0.61HisTyr: 0.61 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
6.042IleAla: 6.042 ± 0.12
0.48IleCys: 0.48 ± 0.032
3.346IleAsp: 3.346 ± 0.08
3.176IleGlu: 3.176 ± 0.082
1.825IlePhe: 1.825 ± 0.076
4.181IleGly: 4.181 ± 0.093
0.975IleHis: 0.975 ± 0.044
2.851IleIle: 2.851 ± 0.096
1.799IleLys: 1.799 ± 0.062
4.563IleLeu: 4.563 ± 0.111
1.219IleMet: 1.219 ± 0.045
1.6IleAsn: 1.6 ± 0.058
2.994IlePro: 2.994 ± 0.068
1.429IleGln: 1.429 ± 0.056
2.827IleArg: 2.827 ± 0.085
3.783IleSer: 3.783 ± 0.087
3.247IleThr: 3.247 ± 0.078
4.464IleVal: 4.464 ± 0.108
0.698IleTrp: 0.698 ± 0.04
1.288IleTyr: 1.288 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
4.123LysAla: 4.123 ± 0.106
0.177LysCys: 0.177 ± 0.018
2.01LysAsp: 2.01 ± 0.074
2.224LysGlu: 2.224 ± 0.072
1.072LysPhe: 1.072 ± 0.048
2.242LysGly: 2.242 ± 0.069
0.843LysHis: 0.843 ± 0.037
2.108LysIle: 2.108 ± 0.074
1.615LysLys: 1.615 ± 0.079
3.757LysLeu: 3.757 ± 0.093
1.074LysMet: 1.074 ± 0.046
1.308LysAsn: 1.308 ± 0.057
1.905LysPro: 1.905 ± 0.069
1.731LysGln: 1.731 ± 0.061
2.285LysArg: 2.285 ± 0.078
2.211LysSer: 2.211 ± 0.065
2.399LysThr: 2.399 ± 0.075
2.968LysVal: 2.968 ± 0.094
0.473LysTrp: 0.473 ± 0.031
0.979LysTyr: 0.979 ± 0.042
0.0LysXaa: 0.0 ± 0.0
Leu
11.608LeuAla: 11.608 ± 0.152
0.711LeuCys: 0.711 ± 0.037
5.588LeuAsp: 5.588 ± 0.109
5.716LeuGlu: 5.716 ± 0.132
3.113LeuPhe: 3.113 ± 0.092
8.275LeuGly: 8.275 ± 0.155
1.878LeuHis: 1.878 ± 0.059
5.294LeuIle: 5.294 ± 0.132
3.478LeuLys: 3.478 ± 0.088
10.007LeuLeu: 10.007 ± 0.194
2.147LeuMet: 2.147 ± 0.072
2.934LeuAsn: 2.934 ± 0.082
5.288LeuPro: 5.288 ± 0.109
3.294LeuGln: 3.294 ± 0.086
6.027LeuArg: 6.027 ± 0.125
7.155LeuSer: 7.155 ± 0.122
6.228LeuThr: 6.228 ± 0.103
8.065LeuVal: 8.065 ± 0.148
1.228LeuTrp: 1.228 ± 0.053
2.065LeuTyr: 2.065 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
2.432MetAla: 2.432 ± 0.072
0.149MetCys: 0.149 ± 0.018
1.036MetAsp: 1.036 ± 0.044
1.191MetGlu: 1.191 ± 0.051
0.722MetPhe: 0.722 ± 0.037
1.68MetGly: 1.68 ± 0.063
0.409MetHis: 0.409 ± 0.031
1.217MetIle: 1.217 ± 0.043
0.929MetLys: 0.929 ± 0.041
2.281MetLeu: 2.281 ± 0.073
0.545MetMet: 0.545 ± 0.038
0.793MetAsn: 0.793 ± 0.035
1.18MetPro: 1.18 ± 0.048
0.703MetGln: 0.703 ± 0.04
1.572MetArg: 1.572 ± 0.055
1.677MetSer: 1.677 ± 0.055
1.557MetThr: 1.557 ± 0.049
1.926MetVal: 1.926 ± 0.061
0.242MetTrp: 0.242 ± 0.022
0.408MetTyr: 0.408 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
2.782AsnAla: 2.782 ± 0.089
0.218AsnCys: 0.218 ± 0.019
1.463AsnAsp: 1.463 ± 0.053
1.643AsnGlu: 1.643 ± 0.06
0.921AsnPhe: 0.921 ± 0.045
2.397AsnGly: 2.397 ± 0.086
0.651AsnHis: 0.651 ± 0.035
1.44AsnIle: 1.44 ± 0.055
0.88AsnLys: 0.88 ± 0.051
3.387AsnLeu: 3.387 ± 0.075
0.674AsnMet: 0.674 ± 0.038
0.932AsnAsn: 0.932 ± 0.053
2.346AsnPro: 2.346 ± 0.068
1.468AsnGln: 1.468 ± 0.06
1.745AsnArg: 1.745 ± 0.054
1.784AsnSer: 1.784 ± 0.064
1.658AsnThr: 1.658 ± 0.062
1.926AsnVal: 1.926 ± 0.063
0.575AsnTrp: 0.575 ± 0.041
0.958AsnTyr: 0.958 ± 0.052
0.0AsnXaa: 0.0 ± 0.0
Pro
5.746ProAla: 5.746 ± 0.135
0.274ProCys: 0.274 ± 0.023
2.977ProAsp: 2.977 ± 0.088
4.323ProGlu: 4.323 ± 0.093
1.49ProPhe: 1.49 ± 0.053
3.867ProGly: 3.867 ± 0.104
1.035ProHis: 1.035 ± 0.039
2.359ProIle: 2.359 ± 0.066
1.745ProLys: 1.745 ± 0.056
4.444ProLeu: 4.444 ± 0.082
0.906ProMet: 0.906 ± 0.041
1.494ProAsn: 1.494 ± 0.055
1.669ProPro: 1.669 ± 0.062
2.151ProGln: 2.151 ± 0.067
2.559ProArg: 2.559 ± 0.082
3.282ProSer: 3.282 ± 0.095
3.139ProThr: 3.139 ± 0.109
4.283ProVal: 4.283 ± 0.102
0.72ProTrp: 0.72 ± 0.041
1.237ProTyr: 1.237 ± 0.056
0.0ProXaa: 0.0 ± 0.0
Gln
4.594GlnAla: 4.594 ± 0.1
0.221GlnCys: 0.221 ± 0.024
1.565GlnAsp: 1.565 ± 0.058
1.976GlnGlu: 1.976 ± 0.059
1.059GlnPhe: 1.059 ± 0.04
2.466GlnGly: 2.466 ± 0.075
0.754GlnHis: 0.754 ± 0.035
2.57GlnIle: 2.57 ± 0.065
1.396GlnLys: 1.396 ± 0.058
4.609GlnLeu: 4.609 ± 0.149
0.994GlnMet: 0.994 ± 0.043
1.219GlnAsn: 1.219 ± 0.05
1.835GlnPro: 1.835 ± 0.062
2.01GlnGln: 2.01 ± 0.084
2.426GlnArg: 2.426 ± 0.069
2.231GlnSer: 2.231 ± 0.073
1.879GlnThr: 1.879 ± 0.065
3.411GlnVal: 3.411 ± 0.077
0.633GlnTrp: 0.633 ± 0.037
0.968GlnTyr: 0.968 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
5.754ArgAla: 5.754 ± 0.121
0.408ArgCys: 0.408 ± 0.031
3.014ArgAsp: 3.014 ± 0.086
3.978ArgGlu: 3.978 ± 0.097
1.989ArgPhe: 1.989 ± 0.063
4.023ArgGly: 4.023 ± 0.107
1.267ArgHis: 1.267 ± 0.064
3.374ArgIle: 3.374 ± 0.079
2.359ArgLys: 2.359 ± 0.065
5.763ArgLeu: 5.763 ± 0.116
1.492ArgMet: 1.492 ± 0.064
1.762ArgAsn: 1.762 ± 0.065
2.722ArgPro: 2.722 ± 0.087
2.384ArgGln: 2.384 ± 0.072
4.207ArgArg: 4.207 ± 0.109
3.468ArgSer: 3.468 ± 0.078
3.275ArgThr: 3.275 ± 0.079
4.535ArgVal: 4.535 ± 0.098
0.91ArgTrp: 0.91 ± 0.039
1.608ArgTyr: 1.608 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
7.114SerAla: 7.114 ± 0.121
0.365SerCys: 0.365 ± 0.028
3.273SerAsp: 3.273 ± 0.073
3.857SerGlu: 3.857 ± 0.092
2.451SerPhe: 2.451 ± 0.076
5.759SerGly: 5.759 ± 0.113
1.256SerHis: 1.256 ± 0.048
2.843SerIle: 2.843 ± 0.074
2.086SerLys: 2.086 ± 0.07
6.572SerLeu: 6.572 ± 0.134
1.351SerMet: 1.351 ± 0.053
1.684SerAsn: 1.684 ± 0.053
3.15SerPro: 3.15 ± 0.083
2.484SerGln: 2.484 ± 0.079
3.72SerArg: 3.72 ± 0.097
4.269SerSer: 4.269 ± 0.108
3.79SerThr: 3.79 ± 0.081
5.037SerVal: 5.037 ± 0.108
0.899SerTrp: 0.899 ± 0.039
1.71SerTyr: 1.71 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
6.282ThrAla: 6.282 ± 0.122
0.394ThrCys: 0.394 ± 0.025
3.148ThrAsp: 3.148 ± 0.087
3.848ThrGlu: 3.848 ± 0.092
1.926ThrPhe: 1.926 ± 0.067
5.136ThrGly: 5.136 ± 0.104
1.167ThrHis: 1.167 ± 0.05
3.277ThrIle: 3.277 ± 0.082
2.136ThrLys: 2.136 ± 0.063
5.765ThrLeu: 5.765 ± 0.098
1.18ThrMet: 1.18 ± 0.045
1.61ThrAsn: 1.61 ± 0.055
3.669ThrPro: 3.669 ± 0.091
2.173ThrGln: 2.173 ± 0.068
2.88ThrArg: 2.88 ± 0.077
3.364ThrSer: 3.364 ± 0.092
3.374ThrThr: 3.374 ± 0.088
5.835ThrVal: 5.835 ± 0.129
0.841ThrTrp: 0.841 ± 0.042
1.619ThrTyr: 1.619 ± 0.057
0.0ThrXaa: 0.0 ± 0.0
Val
9.066ValAla: 9.066 ± 0.158
0.575ValCys: 0.575 ± 0.033
4.667ValAsp: 4.667 ± 0.112
5.66ValGlu: 5.66 ± 0.119
2.797ValPhe: 2.797 ± 0.084
5.802ValGly: 5.802 ± 0.11
1.481ValHis: 1.481 ± 0.047
4.431ValIle: 4.431 ± 0.088
3.342ValLys: 3.342 ± 0.096
7.471ValLeu: 7.471 ± 0.148
1.801ValMet: 1.801 ± 0.059
2.419ValAsn: 2.419 ± 0.068
3.991ValPro: 3.991 ± 0.087
2.546ValGln: 2.546 ± 0.068
4.274ValArg: 4.274 ± 0.096
5.649ValSer: 5.649 ± 0.112
5.283ValThr: 5.283 ± 0.096
6.678ValVal: 6.678 ± 0.123
0.93ValTrp: 0.93 ± 0.042
1.654ValTyr: 1.654 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
1.396TrpAla: 1.396 ± 0.057
0.102TrpCys: 0.102 ± 0.014
0.726TrpAsp: 0.726 ± 0.037
0.83TrpGlu: 0.83 ± 0.043
0.528TrpPhe: 0.528 ± 0.037
1.025TrpGly: 1.025 ± 0.044
0.314TrpHis: 0.314 ± 0.024
0.726TrpIle: 0.726 ± 0.044
0.562TrpLys: 0.562 ± 0.036
1.624TrpLeu: 1.624 ± 0.061
0.419TrpMet: 0.419 ± 0.027
0.579TrpAsn: 0.579 ± 0.039
0.62TrpPro: 0.62 ± 0.036
0.623TrpGln: 0.623 ± 0.031
0.889TrpArg: 0.889 ± 0.042
0.824TrpSer: 0.824 ± 0.038
0.832TrpThr: 0.832 ± 0.043
1.094TrpVal: 1.094 ± 0.044
0.333TrpTrp: 0.333 ± 0.024
0.307TrpTyr: 0.307 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.501TyrAla: 2.501 ± 0.067
0.208TyrCys: 0.208 ± 0.018
1.383TyrAsp: 1.383 ± 0.06
1.405TyrGlu: 1.405 ± 0.048
0.919TyrPhe: 0.919 ± 0.039
2.049TyrGly: 2.049 ± 0.06
0.525TyrHis: 0.525 ± 0.034
1.005TyrIle: 1.005 ± 0.043
0.635TyrLys: 0.635 ± 0.035
2.75TyrLeu: 2.75 ± 0.074
0.419TyrMet: 0.419 ± 0.03
0.677TyrAsn: 0.677 ± 0.037
1.288TyrPro: 1.288 ± 0.049
1.187TyrGln: 1.187 ± 0.053
1.874TyrArg: 1.874 ± 0.069
1.595TyrSer: 1.595 ± 0.06
1.375TyrThr: 1.375 ± 0.058
1.874TyrVal: 1.874 ± 0.054
0.424TyrTrp: 0.424 ± 0.028
0.688TyrTyr: 0.688 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1518 proteins (537412 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski