Amino acid dipepetide frequency for Gordonia phage Syleon

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.873AlaAla: 12.873 ± 1.346
0.772AlaCys: 0.772 ± 0.202
7.037AlaAsp: 7.037 ± 0.512
7.681AlaGlu: 7.681 ± 0.67
2.918AlaPhe: 2.918 ± 0.331
8.582AlaGly: 8.582 ± 0.791
1.931AlaHis: 1.931 ± 0.296
4.935AlaIle: 4.935 ± 0.462
6.179AlaLys: 6.179 ± 0.624
9.569AlaLeu: 9.569 ± 0.809
2.918AlaMet: 2.918 ± 0.41
3.476AlaAsn: 3.476 ± 0.378
4.077AlaPro: 4.077 ± 0.345
3.562AlaGln: 3.562 ± 0.49
6.694AlaArg: 6.694 ± 0.594
5.321AlaSer: 5.321 ± 0.485
6.008AlaThr: 6.008 ± 0.447
6.608AlaVal: 6.608 ± 0.6
1.674AlaTrp: 1.674 ± 0.245
2.532AlaTyr: 2.532 ± 0.306
0.0AlaXaa: 0.0 ± 0.0
Cys
0.944CysAla: 0.944 ± 0.197
0.257CysCys: 0.257 ± 0.104
0.558CysAsp: 0.558 ± 0.181
0.386CysGlu: 0.386 ± 0.163
0.215CysPhe: 0.215 ± 0.1
1.416CysGly: 1.416 ± 0.303
0.215CysHis: 0.215 ± 0.108
0.3CysIle: 0.3 ± 0.14
0.3CysLys: 0.3 ± 0.119
0.429CysLeu: 0.429 ± 0.154
0.172CysMet: 0.172 ± 0.085
0.472CysAsn: 0.472 ± 0.152
0.343CysPro: 0.343 ± 0.112
0.386CysGln: 0.386 ± 0.137
0.815CysArg: 0.815 ± 0.179
0.429CysSer: 0.429 ± 0.118
0.644CysThr: 0.644 ± 0.167
0.515CysVal: 0.515 ± 0.181
0.257CysTrp: 0.257 ± 0.118
0.386CysTyr: 0.386 ± 0.13
0.0CysXaa: 0.0 ± 0.0
Asp
7.209AspAla: 7.209 ± 0.58
0.472AspCys: 0.472 ± 0.132
5.149AspAsp: 5.149 ± 0.529
5.021AspGlu: 5.021 ± 0.437
1.931AspPhe: 1.931 ± 0.276
5.879AspGly: 5.879 ± 0.457
1.244AspHis: 1.244 ± 0.213
2.961AspIle: 2.961 ± 0.422
2.274AspLys: 2.274 ± 0.29
5.064AspLeu: 5.064 ± 0.463
1.287AspMet: 1.287 ± 0.263
1.888AspAsn: 1.888 ± 0.311
3.948AspPro: 3.948 ± 0.422
2.231AspGln: 2.231 ± 0.351
3.605AspArg: 3.605 ± 0.422
3.905AspSer: 3.905 ± 0.302
3.004AspThr: 3.004 ± 0.483
4.72AspVal: 4.72 ± 0.449
1.459AspTrp: 1.459 ± 0.243
2.746AspTyr: 2.746 ± 0.438
0.0AspXaa: 0.0 ± 0.0
Glu
7.467GluAla: 7.467 ± 0.618
0.601GluCys: 0.601 ± 0.158
4.034GluAsp: 4.034 ± 0.458
3.304GluGlu: 3.304 ± 0.406
2.832GluPhe: 2.832 ± 0.404
3.905GluGly: 3.905 ± 0.436
2.017GluHis: 2.017 ± 0.331
2.703GluIle: 2.703 ± 0.343
2.06GluLys: 2.06 ± 0.328
6.308GluLeu: 6.308 ± 0.566
1.674GluMet: 1.674 ± 0.24
1.931GluAsn: 1.931 ± 0.279
3.218GluPro: 3.218 ± 0.41
2.961GluGln: 2.961 ± 0.454
4.162GluArg: 4.162 ± 0.47
3.304GluSer: 3.304 ± 0.347
3.776GluThr: 3.776 ± 0.403
4.806GluVal: 4.806 ± 0.496
1.588GluTrp: 1.588 ± 0.23
1.845GluTyr: 1.845 ± 0.275
0.0GluXaa: 0.0 ± 0.0
Phe
2.403PheAla: 2.403 ± 0.357
0.386PheCys: 0.386 ± 0.132
2.146PheAsp: 2.146 ± 0.369
3.004PheGlu: 3.004 ± 0.319
0.772PhePhe: 0.772 ± 0.218
2.832PheGly: 2.832 ± 0.362
1.03PheHis: 1.03 ± 0.175
1.33PheIle: 1.33 ± 0.227
1.202PheLys: 1.202 ± 0.219
2.532PheLeu: 2.532 ± 0.343
1.287PheMet: 1.287 ± 0.25
1.159PheAsn: 1.159 ± 0.222
1.802PhePro: 1.802 ± 0.304
0.901PheGln: 0.901 ± 0.174
1.974PheArg: 1.974 ± 0.24
2.146PheSer: 2.146 ± 0.388
2.274PheThr: 2.274 ± 0.333
2.231PheVal: 2.231 ± 0.271
0.772PheTrp: 0.772 ± 0.181
0.901PheTyr: 0.901 ± 0.214
0.0PheXaa: 0.0 ± 0.0
Gly
7.08GlyAla: 7.08 ± 0.902
0.729GlyCys: 0.729 ± 0.207
5.106GlyAsp: 5.106 ± 0.655
4.248GlyGlu: 4.248 ± 0.453
3.004GlyPhe: 3.004 ± 0.406
7.81GlyGly: 7.81 ± 1.472
1.459GlyHis: 1.459 ± 0.281
3.819GlyIle: 3.819 ± 0.389
4.291GlyLys: 4.291 ± 0.397
6.909GlyLeu: 6.909 ± 0.445
2.188GlyMet: 2.188 ± 0.306
2.918GlyAsn: 2.918 ± 0.384
3.347GlyPro: 3.347 ± 0.447
2.532GlyGln: 2.532 ± 0.314
5.278GlyArg: 5.278 ± 0.499
5.536GlySer: 5.536 ± 0.616
4.549GlyThr: 4.549 ± 0.544
7.08GlyVal: 7.08 ± 0.588
1.373GlyTrp: 1.373 ± 0.234
3.347GlyTyr: 3.347 ± 0.357
0.0GlyXaa: 0.0 ± 0.0
His
1.502HisAla: 1.502 ± 0.298
0.172HisCys: 0.172 ± 0.089
0.772HisAsp: 0.772 ± 0.194
1.202HisGlu: 1.202 ± 0.254
0.729HisPhe: 0.729 ± 0.157
1.373HisGly: 1.373 ± 0.275
0.558HisHis: 0.558 ± 0.19
1.03HisIle: 1.03 ± 0.224
0.729HisLys: 0.729 ± 0.159
1.802HisLeu: 1.802 ± 0.326
0.729HisMet: 0.729 ± 0.171
0.987HisAsn: 0.987 ± 0.235
1.33HisPro: 1.33 ± 0.279
0.3HisGln: 0.3 ± 0.114
1.373HisArg: 1.373 ± 0.227
1.03HisSer: 1.03 ± 0.227
1.03HisThr: 1.03 ± 0.202
2.06HisVal: 2.06 ± 0.252
0.257HisTrp: 0.257 ± 0.086
1.159HisTyr: 1.159 ± 0.196
0.0HisXaa: 0.0 ± 0.0
Ile
5.106IleAla: 5.106 ± 0.553
0.558IleCys: 0.558 ± 0.171
3.09IleAsp: 3.09 ± 0.337
2.875IleGlu: 2.875 ± 0.304
0.944IlePhe: 0.944 ± 0.198
3.605IleGly: 3.605 ± 0.499
0.772IleHis: 0.772 ± 0.197
1.244IleIle: 1.244 ± 0.203
1.845IleLys: 1.845 ± 0.303
2.918IleLeu: 2.918 ± 0.404
1.03IleMet: 1.03 ± 0.232
1.33IleAsn: 1.33 ± 0.242
2.832IlePro: 2.832 ± 0.394
1.716IleGln: 1.716 ± 0.263
3.09IleArg: 3.09 ± 0.357
2.489IleSer: 2.489 ± 0.389
3.304IleThr: 3.304 ± 0.508
3.175IleVal: 3.175 ± 0.389
0.601IleTrp: 0.601 ± 0.176
1.073IleTyr: 1.073 ± 0.214
0.0IleXaa: 0.0 ± 0.0
Lys
5.493LysAla: 5.493 ± 0.476
0.429LysCys: 0.429 ± 0.143
2.36LysAsp: 2.36 ± 0.335
2.489LysGlu: 2.489 ± 0.463
1.502LysPhe: 1.502 ± 0.261
3.605LysGly: 3.605 ± 0.391
1.459LysHis: 1.459 ± 0.274
1.502LysIle: 1.502 ± 0.207
2.274LysLys: 2.274 ± 0.346
3.647LysLeu: 3.647 ± 0.348
1.33LysMet: 1.33 ± 0.231
1.373LysAsn: 1.373 ± 0.297
3.047LysPro: 3.047 ± 0.522
1.416LysGln: 1.416 ± 0.259
3.39LysArg: 3.39 ± 0.426
3.004LysSer: 3.004 ± 0.412
2.06LysThr: 2.06 ± 0.334
2.703LysVal: 2.703 ± 0.308
0.815LysTrp: 0.815 ± 0.215
1.073LysTyr: 1.073 ± 0.204
0.0LysXaa: 0.0 ± 0.0
Leu
8.453LeuAla: 8.453 ± 0.665
0.858LeuCys: 0.858 ± 0.215
5.45LeuAsp: 5.45 ± 0.565
4.549LeuGlu: 4.549 ± 0.411
2.532LeuPhe: 2.532 ± 0.327
6.694LeuGly: 6.694 ± 0.633
1.845LeuHis: 1.845 ± 0.309
3.733LeuIle: 3.733 ± 0.362
4.034LeuLys: 4.034 ± 0.43
7.724LeuLeu: 7.724 ± 0.577
1.759LeuMet: 1.759 ± 0.228
2.703LeuAsn: 2.703 ± 0.324
4.205LeuPro: 4.205 ± 0.398
2.017LeuGln: 2.017 ± 0.29
6.05LeuArg: 6.05 ± 0.532
5.836LeuSer: 5.836 ± 0.417
5.45LeuThr: 5.45 ± 0.475
6.093LeuVal: 6.093 ± 0.501
1.845LeuTrp: 1.845 ± 0.284
1.974LeuTyr: 1.974 ± 0.304
0.0LeuXaa: 0.0 ± 0.0
Met
2.618MetAla: 2.618 ± 0.383
0.215MetCys: 0.215 ± 0.097
0.987MetAsp: 0.987 ± 0.191
0.815MetGlu: 0.815 ± 0.179
0.858MetPhe: 0.858 ± 0.163
1.888MetGly: 1.888 ± 0.257
0.172MetHis: 0.172 ± 0.094
0.944MetIle: 0.944 ± 0.2
1.116MetLys: 1.116 ± 0.23
2.06MetLeu: 2.06 ± 0.28
0.215MetMet: 0.215 ± 0.083
0.687MetAsn: 0.687 ± 0.162
1.588MetPro: 1.588 ± 0.23
0.772MetGln: 0.772 ± 0.157
2.017MetArg: 2.017 ± 0.299
2.532MetSer: 2.532 ± 0.334
2.146MetThr: 2.146 ± 0.311
0.944MetVal: 0.944 ± 0.212
0.472MetTrp: 0.472 ± 0.126
0.558MetTyr: 0.558 ± 0.159
0.0MetXaa: 0.0 ± 0.0
Asn
3.433AsnAla: 3.433 ± 0.412
0.129AsnCys: 0.129 ± 0.074
1.974AsnAsp: 1.974 ± 0.296
2.446AsnGlu: 2.446 ± 0.261
1.073AsnPhe: 1.073 ± 0.222
3.433AsnGly: 3.433 ± 0.415
0.772AsnHis: 0.772 ± 0.151
1.287AsnIle: 1.287 ± 0.214
1.159AsnLys: 1.159 ± 0.188
3.175AsnLeu: 3.175 ± 0.312
0.386AsnMet: 0.386 ± 0.113
1.073AsnAsn: 1.073 ± 0.246
2.317AsnPro: 2.317 ± 0.301
0.987AsnGln: 0.987 ± 0.219
2.403AsnArg: 2.403 ± 0.392
1.716AsnSer: 1.716 ± 0.255
1.759AsnThr: 1.759 ± 0.288
2.017AsnVal: 2.017 ± 0.314
0.601AsnTrp: 0.601 ± 0.148
0.944AsnTyr: 0.944 ± 0.19
0.0AsnXaa: 0.0 ± 0.0
Pro
5.536ProAla: 5.536 ± 0.502
0.386ProCys: 0.386 ± 0.148
4.892ProAsp: 4.892 ± 0.534
3.862ProGlu: 3.862 ± 0.477
1.931ProPhe: 1.931 ± 0.274
4.077ProGly: 4.077 ± 0.448
0.687ProHis: 0.687 ± 0.172
2.103ProIle: 2.103 ± 0.236
2.875ProLys: 2.875 ± 0.418
3.39ProLeu: 3.39 ± 0.381
1.03ProMet: 1.03 ± 0.195
1.845ProAsn: 1.845 ± 0.244
2.017ProPro: 2.017 ± 0.323
1.159ProGln: 1.159 ± 0.215
2.188ProArg: 2.188 ± 0.402
2.618ProSer: 2.618 ± 0.377
2.789ProThr: 2.789 ± 0.401
4.077ProVal: 4.077 ± 0.466
1.502ProTrp: 1.502 ± 0.273
1.373ProTyr: 1.373 ± 0.244
0.0ProXaa: 0.0 ± 0.0
Gln
3.862GlnAla: 3.862 ± 0.585
0.3GlnCys: 0.3 ± 0.098
1.802GlnAsp: 1.802 ± 0.299
2.317GlnGlu: 2.317 ± 0.374
1.588GlnPhe: 1.588 ± 0.228
2.274GlnGly: 2.274 ± 0.269
0.729GlnHis: 0.729 ± 0.151
1.845GlnIle: 1.845 ± 0.272
1.416GlnLys: 1.416 ± 0.219
3.261GlnLeu: 3.261 ± 0.369
1.073GlnMet: 1.073 ± 0.213
0.858GlnAsn: 0.858 ± 0.262
1.287GlnPro: 1.287 ± 0.224
1.545GlnGln: 1.545 ± 0.249
1.674GlnArg: 1.674 ± 0.326
1.931GlnSer: 1.931 ± 0.269
1.416GlnThr: 1.416 ± 0.269
2.446GlnVal: 2.446 ± 0.328
0.815GlnTrp: 0.815 ± 0.176
1.244GlnTyr: 1.244 ± 0.233
0.0GlnXaa: 0.0 ± 0.0
Arg
6.136ArgAla: 6.136 ± 0.553
0.558ArgCys: 0.558 ± 0.2
4.248ArgAsp: 4.248 ± 0.392
4.978ArgGlu: 4.978 ± 0.489
1.845ArgPhe: 1.845 ± 0.316
4.034ArgGly: 4.034 ± 0.431
0.944ArgHis: 0.944 ± 0.233
3.519ArgIle: 3.519 ± 0.409
3.562ArgLys: 3.562 ± 0.413
5.493ArgLeu: 5.493 ± 0.489
1.588ArgMet: 1.588 ± 0.25
1.674ArgAsn: 1.674 ± 0.329
2.575ArgPro: 2.575 ± 0.36
2.317ArgGln: 2.317 ± 0.357
3.991ArgArg: 3.991 ± 0.41
3.605ArgSer: 3.605 ± 0.402
3.991ArgThr: 3.991 ± 0.42
5.364ArgVal: 5.364 ± 0.526
1.287ArgTrp: 1.287 ± 0.212
1.416ArgTyr: 1.416 ± 0.237
0.0ArgXaa: 0.0 ± 0.0
Ser
5.793SerAla: 5.793 ± 0.498
0.472SerCys: 0.472 ± 0.159
4.205SerAsp: 4.205 ± 0.404
3.733SerGlu: 3.733 ± 0.43
2.103SerPhe: 2.103 ± 0.314
5.149SerGly: 5.149 ± 0.687
1.202SerHis: 1.202 ± 0.24
2.703SerIle: 2.703 ± 0.4
2.575SerLys: 2.575 ± 0.407
5.278SerLeu: 5.278 ± 0.414
1.116SerMet: 1.116 ± 0.207
1.845SerAsn: 1.845 ± 0.261
3.261SerPro: 3.261 ± 0.388
1.759SerGln: 1.759 ± 0.343
2.918SerArg: 2.918 ± 0.351
5.364SerSer: 5.364 ± 0.797
2.832SerThr: 2.832 ± 0.429
4.806SerVal: 4.806 ± 0.519
1.33SerTrp: 1.33 ± 0.281
1.716SerTyr: 1.716 ± 0.354
0.0SerXaa: 0.0 ± 0.0
Thr
5.621ThrAla: 5.621 ± 0.573
0.515ThrCys: 0.515 ± 0.152
3.218ThrAsp: 3.218 ± 0.333
3.605ThrGlu: 3.605 ± 0.396
2.446ThrPhe: 2.446 ± 0.342
6.136ThrGly: 6.136 ± 0.679
0.815ThrHis: 0.815 ± 0.187
3.004ThrIle: 3.004 ± 0.415
1.974ThrLys: 1.974 ± 0.309
4.849ThrLeu: 4.849 ± 0.459
1.03ThrMet: 1.03 ± 0.216
2.146ThrAsn: 2.146 ± 0.309
3.476ThrPro: 3.476 ± 0.447
2.575ThrGln: 2.575 ± 0.315
3.133ThrArg: 3.133 ± 0.307
2.66ThrSer: 2.66 ± 0.406
3.39ThrThr: 3.39 ± 0.541
4.892ThrVal: 4.892 ± 0.442
0.858ThrTrp: 0.858 ± 0.206
1.759ThrTyr: 1.759 ± 0.329
0.0ThrXaa: 0.0 ± 0.0
Val
8.711ValAla: 8.711 ± 0.73
1.073ValCys: 1.073 ± 0.265
5.407ValAsp: 5.407 ± 0.53
4.935ValGlu: 4.935 ± 0.446
2.317ValPhe: 2.317 ± 0.331
5.75ValGly: 5.75 ± 0.487
1.33ValHis: 1.33 ± 0.234
3.004ValIle: 3.004 ± 0.315
3.433ValLys: 3.433 ± 0.37
5.364ValLeu: 5.364 ± 0.401
1.545ValMet: 1.545 ± 0.244
2.489ValAsn: 2.489 ± 0.28
3.905ValPro: 3.905 ± 0.476
2.36ValGln: 2.36 ± 0.298
4.291ValArg: 4.291 ± 0.429
3.733ValSer: 3.733 ± 0.466
4.892ValThr: 4.892 ± 0.425
6.222ValVal: 6.222 ± 0.462
1.588ValTrp: 1.588 ± 0.26
1.974ValTyr: 1.974 ± 0.297
0.0ValXaa: 0.0 ± 0.0
Trp
2.146TrpAla: 2.146 ± 0.292
0.3TrpCys: 0.3 ± 0.103
1.545TrpAsp: 1.545 ± 0.232
1.202TrpGlu: 1.202 ± 0.201
0.644TrpPhe: 0.644 ± 0.166
1.159TrpGly: 1.159 ± 0.241
0.3TrpHis: 0.3 ± 0.118
0.987TrpIle: 0.987 ± 0.189
0.644TrpLys: 0.644 ± 0.18
1.802TrpLeu: 1.802 ± 0.295
0.429TrpMet: 0.429 ± 0.147
1.159TrpAsn: 1.159 ± 0.226
0.772TrpPro: 0.772 ± 0.161
0.901TrpGln: 0.901 ± 0.155
1.588TrpArg: 1.588 ± 0.228
1.287TrpSer: 1.287 ± 0.311
0.901TrpThr: 0.901 ± 0.178
1.631TrpVal: 1.631 ± 0.277
0.644TrpTrp: 0.644 ± 0.187
0.429TrpTyr: 0.429 ± 0.136
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.961TyrAla: 2.961 ± 0.306
0.257TyrCys: 0.257 ± 0.142
2.017TyrAsp: 2.017 ± 0.314
1.845TyrGlu: 1.845 ± 0.355
0.901TyrPhe: 0.901 ± 0.178
3.004TyrGly: 3.004 ± 0.321
0.644TyrHis: 0.644 ± 0.19
0.644TyrIle: 0.644 ± 0.144
1.03TyrLys: 1.03 ± 0.191
2.231TyrLeu: 2.231 ± 0.377
0.772TyrMet: 0.772 ± 0.173
1.073TyrAsn: 1.073 ± 0.192
0.987TyrPro: 0.987 ± 0.222
1.287TyrGln: 1.287 ± 0.222
2.489TyrArg: 2.489 ± 0.381
1.759TyrSer: 1.759 ± 0.302
1.888TyrThr: 1.888 ± 0.315
1.931TyrVal: 1.931 ± 0.29
0.729TyrTrp: 0.729 ± 0.189
1.202TyrTyr: 1.202 ± 0.212
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 138 proteins (23305 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski