Amino acid dipepetide frequency for Thiosulfativibrio zosterae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.767AlaAla: 7.767 ± 0.147
0.798AlaCys: 0.798 ± 0.038
4.624AlaAsp: 4.624 ± 0.072
6.033AlaGlu: 6.033 ± 0.097
3.746AlaPhe: 3.746 ± 0.085
5.777AlaGly: 5.777 ± 0.188
1.849AlaHis: 1.849 ± 0.059
5.787AlaIle: 5.787 ± 0.097
5.48AlaLys: 5.48 ± 0.12
10.649AlaLeu: 10.649 ± 0.155
2.793AlaMet: 2.793 ± 0.071
3.685AlaAsn: 3.685 ± 0.071
3.022AlaPro: 3.022 ± 0.08
5.16AlaGln: 5.16 ± 0.086
3.246AlaArg: 3.246 ± 0.084
5.063AlaSer: 5.063 ± 0.082
4.509AlaThr: 4.509 ± 0.153
5.732AlaVal: 5.732 ± 0.097
1.207AlaTrp: 1.207 ± 0.046
2.53AlaTyr: 2.53 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.55CysAla: 0.55 ± 0.028
0.084CysCys: 0.084 ± 0.012
0.472CysAsp: 0.472 ± 0.027
0.54CysGlu: 0.54 ± 0.028
0.319CysPhe: 0.319 ± 0.02
0.662CysGly: 0.662 ± 0.032
0.299CysHis: 0.299 ± 0.022
0.429CysIle: 0.429 ± 0.025
0.379CysLys: 0.379 ± 0.027
0.847CysLeu: 0.847 ± 0.038
0.146CysMet: 0.146 ± 0.014
0.247CysAsn: 0.247 ± 0.017
0.421CysPro: 0.421 ± 0.026
0.509CysGln: 0.509 ± 0.029
0.362CysArg: 0.362 ± 0.022
0.465CysSer: 0.465 ± 0.025
0.323CysThr: 0.323 ± 0.022
0.517CysVal: 0.517 ± 0.028
0.075CysTrp: 0.075 ± 0.01
0.219CysTyr: 0.219 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
4.961AspAla: 4.961 ± 0.091
0.459AspCys: 0.459 ± 0.024
2.798AspAsp: 2.798 ± 0.205
3.703AspGlu: 3.703 ± 0.088
2.839AspPhe: 2.839 ± 0.122
3.443AspGly: 3.443 ± 0.183
0.969AspHis: 0.969 ± 0.038
3.686AspIle: 3.686 ± 0.076
2.85AspLys: 2.85 ± 0.061
6.207AspLeu: 6.207 ± 0.092
1.43AspMet: 1.43 ± 0.044
2.035AspAsn: 2.035 ± 0.091
1.929AspPro: 1.929 ± 0.043
2.207AspGln: 2.207 ± 0.073
1.997AspArg: 1.997 ± 0.059
2.814AspSer: 2.814 ± 0.071
2.699AspThr: 2.699 ± 0.102
3.226AspVal: 3.226 ± 0.068
0.99AspTrp: 0.99 ± 0.041
2.086AspTyr: 2.086 ± 0.086
0.0AspXaa: 0.0 ± 0.0
Glu
6.033GluAla: 6.033 ± 0.103
0.389GluCys: 0.389 ± 0.022
2.894GluAsp: 2.894 ± 0.061
3.427GluGlu: 3.427 ± 0.09
2.528GluPhe: 2.528 ± 0.072
3.585GluGly: 3.585 ± 0.073
1.496GluHis: 1.496 ± 0.054
4.049GluIle: 4.049 ± 0.087
4.018GluLys: 4.018 ± 0.096
6.285GluLeu: 6.285 ± 0.116
1.946GluMet: 1.946 ± 0.055
2.841GluAsn: 2.841 ± 0.077
1.976GluPro: 1.976 ± 0.053
3.562GluGln: 3.562 ± 0.083
2.736GluArg: 2.736 ± 0.07
3.644GluSer: 3.644 ± 0.072
3.571GluThr: 3.571 ± 0.087
4.913GluVal: 4.913 ± 0.097
0.683GluTrp: 0.683 ± 0.033
1.56GluTyr: 1.56 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
3.693PheAla: 3.693 ± 0.079
0.421PheCys: 0.421 ± 0.025
2.637PheAsp: 2.637 ± 0.058
3.074PheGlu: 3.074 ± 0.086
1.772PhePhe: 1.772 ± 0.058
2.956PheGly: 2.956 ± 0.075
0.802PheHis: 0.802 ± 0.035
2.606PheIle: 2.606 ± 0.067
2.685PheLys: 2.685 ± 0.066
3.832PheLeu: 3.832 ± 0.093
1.102PheMet: 1.102 ± 0.044
2.189PheAsn: 2.189 ± 0.086
1.363PhePro: 1.363 ± 0.043
1.563PheGln: 1.563 ± 0.046
1.287PheArg: 1.287 ± 0.044
2.972PheSer: 2.972 ± 0.058
2.132PheThr: 2.132 ± 0.145
2.758PheVal: 2.758 ± 0.077
0.627PheTrp: 0.627 ± 0.032
1.476PheTyr: 1.476 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
4.876GlyAla: 4.876 ± 0.115
0.739GlyCys: 0.739 ± 0.032
3.447GlyAsp: 3.447 ± 0.15
3.915GlyGlu: 3.915 ± 0.087
3.341GlyPhe: 3.341 ± 0.074
4.151GlyGly: 4.151 ± 0.108
1.571GlyHis: 1.571 ± 0.061
4.422GlyIle: 4.422 ± 0.084
3.876GlyLys: 3.876 ± 0.082
7.533GlyLeu: 7.533 ± 0.121
1.934GlyMet: 1.934 ± 0.056
2.279GlyAsn: 2.279 ± 0.06
1.477GlyPro: 1.477 ± 0.049
3.293GlyGln: 3.293 ± 0.073
2.76GlyArg: 2.76 ± 0.073
3.614GlySer: 3.614 ± 0.103
3.379GlyThr: 3.379 ± 0.359
4.82GlyVal: 4.82 ± 0.093
0.904GlyTrp: 0.904 ± 0.038
2.425GlyTyr: 2.425 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
1.82HisAla: 1.82 ± 0.058
0.218HisCys: 0.218 ± 0.017
1.047HisAsp: 1.047 ± 0.038
1.212HisGlu: 1.212 ± 0.043
1.189HisPhe: 1.189 ± 0.042
1.351HisGly: 1.351 ± 0.046
0.792HisHis: 0.792 ± 0.037
1.314HisIle: 1.314 ± 0.043
1.098HisLys: 1.098 ± 0.037
2.779HisLeu: 2.779 ± 0.067
0.505HisMet: 0.505 ± 0.027
0.923HisAsn: 0.923 ± 0.032
1.403HisPro: 1.403 ± 0.053
1.361HisGln: 1.361 ± 0.047
0.962HisArg: 0.962 ± 0.034
1.295HisSer: 1.295 ± 0.046
1.055HisThr: 1.055 ± 0.039
0.945HisVal: 0.945 ± 0.042
0.37HisTrp: 0.37 ± 0.023
0.843HisTyr: 0.843 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
5.83IleAla: 5.83 ± 0.119
0.554IleCys: 0.554 ± 0.026
4.06IleAsp: 4.06 ± 0.074
4.843IleGlu: 4.843 ± 0.092
2.265IlePhe: 2.265 ± 0.061
4.2IleGly: 4.2 ± 0.087
1.466IleHis: 1.466 ± 0.045
3.581IleIle: 3.581 ± 0.088
3.775IleLys: 3.775 ± 0.072
6.02IleLeu: 6.02 ± 0.115
1.451IleMet: 1.451 ± 0.049
3.007IleAsn: 3.007 ± 0.064
2.536IlePro: 2.536 ± 0.059
3.083IleGln: 3.083 ± 0.073
2.518IleArg: 2.518 ± 0.066
4.128IleSer: 4.128 ± 0.128
3.694IleThr: 3.694 ± 0.19
3.68IleVal: 3.68 ± 0.087
0.686IleTrp: 0.686 ± 0.031
1.676IleTyr: 1.676 ± 0.046
0.0IleXaa: 0.0 ± 0.0
Lys
5.361LysAla: 5.361 ± 0.108
0.278LysCys: 0.278 ± 0.023
2.948LysAsp: 2.948 ± 0.065
3.148LysGlu: 3.148 ± 0.081
1.684LysPhe: 1.684 ± 0.051
3.403LysGly: 3.403 ± 0.075
1.334LysHis: 1.334 ± 0.044
3.639LysIle: 3.639 ± 0.077
3.175LysLys: 3.175 ± 0.083
5.656LysLeu: 5.656 ± 0.113
1.8LysMet: 1.8 ± 0.052
2.705LysAsn: 2.705 ± 0.073
2.835LysPro: 2.835 ± 0.067
3.127LysGln: 3.127 ± 0.085
2.495LysArg: 2.495 ± 0.075
3.583LysSer: 3.583 ± 0.087
4.044LysThr: 4.044 ± 0.105
4.307LysVal: 4.307 ± 0.085
0.512LysTrp: 0.512 ± 0.03
1.208LysTyr: 1.208 ± 0.04
0.0LysXaa: 0.0 ± 0.0
Leu
10.326LeuAla: 10.326 ± 0.14
0.707LeuCys: 0.707 ± 0.032
5.81LeuAsp: 5.81 ± 0.099
6.702LeuGlu: 6.702 ± 0.108
4.083LeuPhe: 4.083 ± 0.088
7.185LeuGly: 7.185 ± 0.134
1.951LeuHis: 1.951 ± 0.053
6.551LeuIle: 6.551 ± 0.12
7.232LeuLys: 7.232 ± 0.139
10.562LeuLeu: 10.562 ± 0.201
3.115LeuMet: 3.115 ± 0.076
5.312LeuAsn: 5.312 ± 0.091
4.969LeuPro: 4.969 ± 0.107
4.927LeuGln: 4.927 ± 0.104
3.978LeuArg: 3.978 ± 0.089
7.99LeuSer: 7.99 ± 0.104
6.132LeuThr: 6.132 ± 0.084
7.211LeuVal: 7.211 ± 0.118
1.169LeuTrp: 1.169 ± 0.044
2.521LeuTyr: 2.521 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
2.778MetAla: 2.778 ± 0.065
0.145MetCys: 0.145 ± 0.014
1.475MetAsp: 1.475 ± 0.042
1.279MetGlu: 1.279 ± 0.043
0.789MetPhe: 0.789 ± 0.034
2.026MetGly: 2.026 ± 0.072
0.552MetHis: 0.552 ± 0.03
1.732MetIle: 1.732 ± 0.05
1.536MetLys: 1.536 ± 0.051
2.542MetLeu: 2.542 ± 0.064
0.93MetMet: 0.93 ± 0.04
1.33MetAsn: 1.33 ± 0.055
1.44MetPro: 1.44 ± 0.047
1.562MetGln: 1.562 ± 0.053
1.207MetArg: 1.207 ± 0.038
2.134MetSer: 2.134 ± 0.064
1.777MetThr: 1.777 ± 0.056
1.861MetVal: 1.861 ± 0.055
0.178MetTrp: 0.178 ± 0.014
0.445MetTyr: 0.445 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
4.12AsnAla: 4.12 ± 0.088
0.323AsnCys: 0.323 ± 0.023
2.316AsnAsp: 2.316 ± 0.171
2.472AsnGlu: 2.472 ± 0.054
1.754AsnPhe: 1.754 ± 0.088
2.654AsnGly: 2.654 ± 0.064
1.143AsnHis: 1.143 ± 0.041
2.849AsnIle: 2.849 ± 0.067
2.021AsnLys: 2.021 ± 0.063
4.871AsnLeu: 4.871 ± 0.074
1.024AsnMet: 1.024 ± 0.068
1.864AsnAsn: 1.864 ± 0.057
2.548AsnPro: 2.548 ± 0.073
2.808AsnGln: 2.808 ± 0.064
1.98AsnArg: 1.98 ± 0.07
2.429AsnSer: 2.429 ± 0.058
2.275AsnThr: 2.275 ± 0.058
2.154AsnVal: 2.154 ± 0.049
0.564AsnTrp: 0.564 ± 0.027
1.335AsnTyr: 1.335 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
3.143ProAla: 3.143 ± 0.078
0.283ProCys: 0.283 ± 0.019
2.24ProAsp: 2.24 ± 0.055
3.476ProGlu: 3.476 ± 0.079
1.772ProPhe: 1.772 ± 0.052
2.449ProGly: 2.449 ± 0.072
0.824ProHis: 0.824 ± 0.032
2.749ProIle: 2.749 ± 0.075
2.611ProLys: 2.611 ± 0.069
4.105ProLeu: 4.105 ± 0.084
1.188ProMet: 1.188 ± 0.045
2.066ProAsn: 2.066 ± 0.064
1.193ProPro: 1.193 ± 0.042
1.975ProGln: 1.975 ± 0.052
1.121ProArg: 1.121 ± 0.038
2.394ProSer: 2.394 ± 0.072
2.066ProThr: 2.066 ± 0.051
3.013ProVal: 3.013 ± 0.067
0.501ProTrp: 0.501 ± 0.024
1.275ProTyr: 1.275 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
6.008GlnAla: 6.008 ± 0.111
0.298GlnCys: 0.298 ± 0.019
2.468GlnAsp: 2.468 ± 0.07
2.587GlnGlu: 2.587 ± 0.06
1.941GlnPhe: 1.941 ± 0.051
3.27GlnGly: 3.27 ± 0.07
1.186GlnHis: 1.186 ± 0.043
3.208GlnIle: 3.208 ± 0.067
3.344GlnLys: 3.344 ± 0.095
5.513GlnLeu: 5.513 ± 0.123
1.381GlnMet: 1.381 ± 0.043
2.468GlnAsn: 2.468 ± 0.069
2.078GlnPro: 2.078 ± 0.055
3.497GlnGln: 3.497 ± 0.112
2.203GlnArg: 2.203 ± 0.066
3.053GlnSer: 3.053 ± 0.079
3.426GlnThr: 3.426 ± 0.073
3.915GlnVal: 3.915 ± 0.077
0.595GlnTrp: 0.595 ± 0.026
1.27GlnTyr: 1.27 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
3.047ArgAla: 3.047 ± 0.078
0.314ArgCys: 0.314 ± 0.02
1.89ArgAsp: 1.89 ± 0.047
2.26ArgGlu: 2.26 ± 0.064
2.058ArgPhe: 2.058 ± 0.054
2.209ArgGly: 2.209 ± 0.07
1.04ArgHis: 1.04 ± 0.038
2.682ArgIle: 2.682 ± 0.07
2.118ArgLys: 2.118 ± 0.054
4.891ArgLeu: 4.891 ± 0.096
1.113ArgMet: 1.113 ± 0.039
1.734ArgAsn: 1.734 ± 0.05
1.56ArgPro: 1.56 ± 0.059
2.091ArgGln: 2.091 ± 0.06
1.765ArgArg: 1.765 ± 0.062
2.109ArgSer: 2.109 ± 0.063
1.806ArgThr: 1.806 ± 0.048
2.765ArgVal: 2.765 ± 0.069
0.611ArgTrp: 0.611 ± 0.032
1.467ArgTyr: 1.467 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
5.277SerAla: 5.277 ± 0.105
0.476SerCys: 0.476 ± 0.025
3.135SerAsp: 3.135 ± 0.052
3.7SerGlu: 3.7 ± 0.074
2.872SerPhe: 2.872 ± 0.135
4.467SerGly: 4.467 ± 0.104
1.495SerHis: 1.495 ± 0.043
3.851SerIle: 3.851 ± 0.07
3.115SerLys: 3.115 ± 0.073
7.039SerLeu: 7.039 ± 0.107
1.717SerMet: 1.717 ± 0.05
2.573SerAsn: 2.573 ± 0.141
2.415SerPro: 2.415 ± 0.052
3.369SerGln: 3.369 ± 0.086
2.298SerArg: 2.298 ± 0.061
3.822SerSer: 3.822 ± 0.083
3.066SerThr: 3.066 ± 0.143
4.149SerVal: 4.149 ± 0.072
0.686SerTrp: 0.686 ± 0.029
1.8SerTyr: 1.8 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
4.727ThrAla: 4.727 ± 0.133
0.406ThrCys: 0.406 ± 0.023
3.039ThrAsp: 3.039 ± 0.217
3.256ThrGlu: 3.256 ± 0.06
2.143ThrPhe: 2.143 ± 0.055
3.938ThrGly: 3.938 ± 0.128
1.415ThrHis: 1.415 ± 0.048
3.112ThrIle: 3.112 ± 0.273
2.214ThrLys: 2.214 ± 0.07
7.092ThrLeu: 7.092 ± 0.098
1.066ThrMet: 1.066 ± 0.043
1.879ThrAsn: 1.879 ± 0.085
3.124ThrPro: 3.124 ± 0.069
3.686ThrGln: 3.686 ± 0.079
1.932ThrArg: 1.932 ± 0.053
2.909ThrSer: 2.909 ± 0.116
2.932ThrThr: 2.932 ± 0.171
3.594ThrVal: 3.594 ± 0.3
0.59ThrTrp: 0.59 ± 0.027
1.639ThrTyr: 1.639 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
5.941ValAla: 5.941 ± 0.138
0.597ValCys: 0.597 ± 0.032
3.916ValAsp: 3.916 ± 0.203
4.143ValGlu: 4.143 ± 0.075
2.894ValPhe: 2.894 ± 0.076
4.266ValGly: 4.266 ± 0.078
1.267ValHis: 1.267 ± 0.043
4.537ValIle: 4.537 ± 0.085
3.875ValLys: 3.875 ± 0.084
7.033ValLeu: 7.033 ± 0.118
2.072ValMet: 2.072 ± 0.06
2.897ValAsn: 2.897 ± 0.057
2.375ValPro: 2.375 ± 0.068
2.704ValGln: 2.704 ± 0.069
2.654ValArg: 2.654 ± 0.069
4.538ValSer: 4.538 ± 0.08
3.922ValThr: 3.922 ± 0.116
5.033ValVal: 5.033 ± 0.117
0.78ValTrp: 0.78 ± 0.035
1.844ValTyr: 1.844 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
0.838TrpAla: 0.838 ± 0.032
0.101TrpCys: 0.101 ± 0.011
0.496TrpAsp: 0.496 ± 0.024
0.527TrpGlu: 0.527 ± 0.025
0.571TrpPhe: 0.571 ± 0.028
0.714TrpGly: 0.714 ± 0.028
0.322TrpHis: 0.322 ± 0.02
0.774TrpIle: 0.774 ± 0.036
0.521TrpLys: 0.521 ± 0.028
1.71TrpLeu: 1.71 ± 0.055
0.424TrpMet: 0.424 ± 0.023
0.413TrpAsn: 0.413 ± 0.021
0.461TrpPro: 0.461 ± 0.022
1.092TrpGln: 1.092 ± 0.042
0.577TrpArg: 0.577 ± 0.028
0.698TrpSer: 0.698 ± 0.037
0.491TrpThr: 0.491 ± 0.025
1.136TrpVal: 1.136 ± 0.036
0.142TrpTrp: 0.142 ± 0.013
0.287TrpTyr: 0.287 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.365TyrAla: 2.365 ± 0.06
0.274TyrCys: 0.274 ± 0.019
1.612TyrAsp: 1.612 ± 0.044
1.839TyrGlu: 1.839 ± 0.051
1.385TyrPhe: 1.385 ± 0.043
2.046TyrGly: 2.046 ± 0.05
0.712TyrHis: 0.712 ± 0.027
1.496TyrIle: 1.496 ± 0.045
1.32TyrLys: 1.32 ± 0.038
3.269TyrLeu: 3.269 ± 0.079
0.58TyrMet: 0.58 ± 0.029
1.056TyrAsn: 1.056 ± 0.038
1.318TyrPro: 1.318 ± 0.047
2.134TyrGln: 2.134 ± 0.058
1.452TyrArg: 1.452 ± 0.044
1.668TyrSer: 1.668 ± 0.051
1.398TyrThr: 1.398 ± 0.123
1.556TyrVal: 1.556 ± 0.043
0.426TyrTrp: 0.426 ± 0.022
0.886TyrTyr: 0.886 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2362 proteins (802121 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski