Amino acid dipepetide frequency for Leucosporidium creatinivorum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.264AlaAla: 11.264 ± 0.087	1.057AlaCys: 1.057 ± 0.018	4.108AlaAsp: 4.108 ± 0.033	6.259AlaGlu: 6.259 ± 0.045	3.592AlaPhe: 3.592 ± 0.033	6.832AlaGly: 6.832 ± 0.047	1.917AlaHis: 1.917 ± 0.023	3.891AlaIle: 3.891 ± 0.034	4.11AlaLys: 4.11 ± 0.04	9.603AlaLeu: 9.603 ± 0.063	1.87AlaMet: 1.87 ± 0.022	2.47AlaAsn: 2.47 ± 0.022	7.231AlaPro: 7.231 ± 0.079	3.517AlaGln: 3.517 ± 0.037	5.948AlaArg: 5.948 ± 0.041	9.409AlaSer: 9.409 ± 0.065	5.959AlaThr: 5.959 ± 0.048	5.734AlaVal: 5.734 ± 0.037	1.238AlaTrp: 1.238 ± 0.019	2.089AlaTyr: 2.089 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	0.882CysAla: 0.882 ± 0.015	0.223CysCys: 0.223 ± 0.008	0.536CysAsp: 0.536 ± 0.012	0.538CysGlu: 0.538 ± 0.01	0.476CysPhe: 0.476 ± 0.012	0.804CysGly: 0.804 ± 0.02	0.229CysHis: 0.229 ± 0.007	0.531CysIle: 0.531 ± 0.011	0.438CysLys: 0.438 ± 0.014	1.084CysLeu: 1.084 ± 0.017	0.204CysMet: 0.204 ± 0.008	0.277CysAsn: 0.277 ± 0.009	0.633CysPro: 0.633 ± 0.014	0.324CysGln: 0.324 ± 0.011	0.676CysArg: 0.676 ± 0.014	0.987CysSer: 0.987 ± 0.021	0.704CysThr: 0.704 ± 0.017	0.639CysVal: 0.639 ± 0.013	0.194CysTrp: 0.194 ± 0.007	0.293CysTyr: 0.293 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.43AspAla: 4.43 ± 0.036	0.486AspCys: 0.486 ± 0.012	3.972AspAsp: 3.972 ± 0.045	4.644AspGlu: 4.644 ± 0.048	1.918AspPhe: 1.918 ± 0.02	3.834AspGly: 3.834 ± 0.035	1.013AspHis: 1.013 ± 0.016	1.98AspIle: 1.98 ± 0.022	1.919AspLys: 1.919 ± 0.024	5.112AspLeu: 5.112 ± 0.035	0.842AspMet: 0.842 ± 0.012	1.127AspAsn: 1.127 ± 0.016	3.245AspPro: 3.245 ± 0.029	1.499AspGln: 1.499 ± 0.019	2.636AspArg: 2.636 ± 0.027	4.127AspSer: 4.127 ± 0.038	2.231AspThr: 2.231 ± 0.025	3.292AspVal: 3.292 ± 0.031	0.89AspTrp: 0.89 ± 0.014	1.329AspTyr: 1.329 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	6.157GluAla: 6.157 ± 0.048	0.538GluCys: 0.538 ± 0.011	4.189GluAsp: 4.189 ± 0.037	7.713GluGlu: 7.713 ± 0.076	1.622GluPhe: 1.622 ± 0.02	5.648GluGly: 5.648 ± 0.046	1.284GluHis: 1.284 ± 0.019	2.461GluIle: 2.461 ± 0.027	3.575GluLys: 3.575 ± 0.037	5.993GluLeu: 5.993 ± 0.045	1.529GluMet: 1.529 ± 0.018	1.357GluAsn: 1.357 ± 0.019	2.62GluPro: 2.62 ± 0.03	2.754GluGln: 2.754 ± 0.03	4.599GluArg: 4.599 ± 0.048	3.932GluSer: 3.932 ± 0.033	3.011GluThr: 3.011 ± 0.029	4.189GluVal: 4.189 ± 0.036	1.011GluTrp: 1.011 ± 0.015	1.249GluTyr: 1.249 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	3.673PheAla: 3.673 ± 0.029	0.494PheCys: 0.494 ± 0.011	2.163PheAsp: 2.163 ± 0.021	2.074PheGlu: 2.074 ± 0.025	1.511PhePhe: 1.511 ± 0.021	2.92PheGly: 2.92 ± 0.034	0.805PheHis: 0.805 ± 0.014	1.537PheIle: 1.537 ± 0.021	1.348PheLys: 1.348 ± 0.02	3.546PheLeu: 3.546 ± 0.038	0.535PheMet: 0.535 ± 0.012	1.182PheAsn: 1.182 ± 0.018	2.065PhePro: 2.065 ± 0.022	1.004PheGln: 1.004 ± 0.016	1.72PheArg: 1.72 ± 0.02	3.076PheSer: 3.076 ± 0.028	2.083PheThr: 2.083 ± 0.022	2.386PheVal: 2.386 ± 0.028	0.514PheTrp: 0.514 ± 0.014	0.914PheTyr: 0.914 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	7.142GlyAla: 7.142 ± 0.052	0.783GlyCys: 0.783 ± 0.015	3.468GlyAsp: 3.468 ± 0.029	4.911GlyGlu: 4.911 ± 0.038	2.672GlyPhe: 2.672 ± 0.026	8.214GlyGly: 8.214 ± 0.086	1.41GlyHis: 1.41 ± 0.019	2.888GlyIle: 2.888 ± 0.029	3.768GlyLys: 3.768 ± 0.038	6.208GlyLeu: 6.208 ± 0.044	1.527GlyMet: 1.527 ± 0.021	1.808GlyAsn: 1.808 ± 0.019	3.063GlyPro: 3.063 ± 0.028	2.296GlyGln: 2.296 ± 0.024	4.615GlyArg: 4.615 ± 0.037	6.183GlySer: 6.183 ± 0.044	3.654GlyThr: 3.654 ± 0.03	4.804GlyVal: 4.804 ± 0.039	1.331GlyTrp: 1.331 ± 0.019	1.841GlyTyr: 1.841 ± 0.026	0.0GlyXaa: 0.0 ± 0.0
His	1.82HisAla: 1.82 ± 0.02	0.25HisCys: 0.25 ± 0.008	1.041HisAsp: 1.041 ± 0.016	1.106HisGlu: 1.106 ± 0.017	0.883HisPhe: 0.883 ± 0.013	1.378HisGly: 1.378 ± 0.019	0.892HisHis: 0.892 ± 0.018	0.883HisIle: 0.883 ± 0.013	0.687HisLys: 0.687 ± 0.015	2.716HisLeu: 2.716 ± 0.026	0.274HisMet: 0.274 ± 0.008	0.541HisAsn: 0.541 ± 0.01	1.86HisPro: 1.86 ± 0.025	0.936HisGln: 0.936 ± 0.018	1.433HisArg: 1.433 ± 0.021	2.04HisSer: 2.04 ± 0.026	1.121HisThr: 1.121 ± 0.016	1.181HisVal: 1.181 ± 0.015	0.285HisTrp: 0.285 ± 0.008	0.603HisTyr: 0.603 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.032IleAla: 4.032 ± 0.039	0.519IleCys: 0.519 ± 0.012	2.237IleAsp: 2.237 ± 0.023	2.432IleGlu: 2.432 ± 0.029	1.588IlePhe: 1.588 ± 0.025	2.627IleGly: 2.627 ± 0.03	0.899IleHis: 0.899 ± 0.013	1.955IleIle: 1.955 ± 0.027	1.893IleLys: 1.893 ± 0.023	3.95IleLeu: 3.95 ± 0.042	0.682IleMet: 0.682 ± 0.014	1.305IleAsn: 1.305 ± 0.019	2.598IlePro: 2.598 ± 0.025	1.241IleGln: 1.241 ± 0.018	2.23IleArg: 2.23 ± 0.025	3.278IleSer: 3.278 ± 0.03	2.322IleThr: 2.322 ± 0.026	2.85IleVal: 2.85 ± 0.034	0.537IleTrp: 0.537 ± 0.012	1.044IleTyr: 1.044 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.541LysAla: 4.541 ± 0.039	0.382LysCys: 0.382 ± 0.01	2.295LysAsp: 2.295 ± 0.027	3.768LysGlu: 3.768 ± 0.036	1.078LysPhe: 1.078 ± 0.019	3.523LysGly: 3.523 ± 0.033	0.875LysHis: 0.875 ± 0.015	1.773LysIle: 1.773 ± 0.023	3.214LysLys: 3.214 ± 0.044	3.923LysLeu: 3.923 ± 0.036	0.902LysMet: 0.902 ± 0.015	1.147LysAsn: 1.147 ± 0.018	2.368LysPro: 2.368 ± 0.028	1.561LysGln: 1.561 ± 0.018	3.28LysArg: 3.28 ± 0.031	3.114LysSer: 3.114 ± 0.029	2.38LysThr: 2.38 ± 0.027	2.84LysVal: 2.84 ± 0.029	0.579LysTrp: 0.579 ± 0.01	0.907LysTyr: 0.907 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	9.991LeuAla: 9.991 ± 0.054	1.121LeuCys: 1.121 ± 0.016	5.199LeuAsp: 5.199 ± 0.037	5.993LeuGlu: 5.993 ± 0.039	3.517LeuPhe: 3.517 ± 0.032	6.69LeuGly: 6.69 ± 0.045	2.401LeuHis: 2.401 ± 0.023	3.731LeuIle: 3.731 ± 0.038	4.125LeuLys: 4.125 ± 0.038	10.082LeuLeu: 10.082 ± 0.077	1.536LeuMet: 1.536 ± 0.02	2.792LeuAsn: 2.792 ± 0.029	7.384LeuPro: 7.384 ± 0.049	3.521LeuGln: 3.521 ± 0.029	6.209LeuArg: 6.209 ± 0.047	8.78LeuSer: 8.78 ± 0.057	5.333LeuThr: 5.333 ± 0.043	6.168LeuVal: 6.168 ± 0.049	1.144LeuTrp: 1.144 ± 0.017	2.24LeuTyr: 2.24 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	1.895MetAla: 1.895 ± 0.019	0.184MetCys: 0.184 ± 0.006	1.027MetAsp: 1.027 ± 0.013	1.17MetGlu: 1.17 ± 0.017	0.52MetPhe: 0.52 ± 0.012	1.405MetGly: 1.405 ± 0.02	0.344MetHis: 0.344 ± 0.009	0.676MetIle: 0.676 ± 0.013	0.772MetLys: 0.772 ± 0.014	1.667MetLeu: 1.667 ± 0.022	0.453MetMet: 0.453 ± 0.01	0.489MetAsn: 0.489 ± 0.011	0.977MetPro: 0.977 ± 0.016	0.59MetGln: 0.59 ± 0.012	1.137MetArg: 1.137 ± 0.018	1.668MetSer: 1.668 ± 0.02	0.958MetThr: 0.958 ± 0.015	1.081MetVal: 1.081 ± 0.016	0.219MetTrp: 0.219 ± 0.008	0.384MetTyr: 0.384 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.613AsnAla: 2.613 ± 0.026	0.306AsnCys: 0.306 ± 0.009	1.389AsnAsp: 1.389 ± 0.018	1.501AsnGlu: 1.501 ± 0.019	0.991AsnPhe: 0.991 ± 0.016	2.241AsnGly: 2.241 ± 0.026	0.569AsnHis: 0.569 ± 0.012	1.187AsnIle: 1.187 ± 0.018	1.144AsnLys: 1.144 ± 0.02	2.763AsnLeu: 2.763 ± 0.029	0.446AsnMet: 0.446 ± 0.01	0.816AsnAsn: 0.816 ± 0.016	2.056AsnPro: 2.056 ± 0.023	0.816AsnGln: 0.816 ± 0.015	1.422AsnArg: 1.422 ± 0.019	2.403AsnSer: 2.403 ± 0.025	1.489AsnThr: 1.489 ± 0.021	1.742AsnVal: 1.742 ± 0.023	0.396AsnTrp: 0.396 ± 0.01	0.719AsnTyr: 0.719 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	6.644ProAla: 6.644 ± 0.063	0.459ProCys: 0.459 ± 0.012	2.41ProAsp: 2.41 ± 0.023	3.205ProGlu: 3.205 ± 0.029	2.469ProPhe: 2.469 ± 0.023	3.257ProGly: 3.257 ± 0.035	1.535ProHis: 1.535 ± 0.02	2.505ProIle: 2.505 ± 0.023	2.47ProLys: 2.47 ± 0.029	6.413ProLeu: 6.413 ± 0.04	0.814ProMet: 0.814 ± 0.013	1.892ProAsn: 1.892 ± 0.023	8.517ProPro: 8.517 ± 0.125	2.243ProGln: 2.243 ± 0.033	3.969ProArg: 3.969 ± 0.045	9.605ProSer: 9.605 ± 0.092	5.299ProThr: 5.299 ± 0.045	3.33ProVal: 3.33 ± 0.026	0.615ProTrp: 0.615 ± 0.012	1.443ProTyr: 1.443 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.592GlnAla: 3.592 ± 0.035	0.312GlnCys: 0.312 ± 0.009	1.599GlnAsp: 1.599 ± 0.02	2.163GlnGlu: 2.163 ± 0.025	0.975GlnPhe: 0.975 ± 0.016	2.329GlnGly: 2.329 ± 0.026	1.011GlnHis: 1.011 ± 0.019	1.372GlnIle: 1.372 ± 0.02	1.332GlnLys: 1.332 ± 0.017	3.636GlnLeu: 3.636 ± 0.027	0.641GlnMet: 0.641 ± 0.011	0.835GlnAsn: 0.835 ± 0.015	2.449GlnPro: 2.449 ± 0.035	2.713GlnGln: 2.713 ± 0.07	2.485GlnArg: 2.485 ± 0.024	2.481GlnSer: 2.481 ± 0.027	1.782GlnThr: 1.782 ± 0.021	2.029GlnVal: 2.029 ± 0.019	0.447GlnTrp: 0.447 ± 0.01	0.766GlnTyr: 0.766 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	5.666ArgAla: 5.666 ± 0.043	0.703ArgCys: 0.703 ± 0.014	2.955ArgAsp: 2.955 ± 0.033	4.254ArgGlu: 4.254 ± 0.039	2.134ArgPhe: 2.134 ± 0.023	4.212ArgGly: 4.212 ± 0.042	1.319ArgHis: 1.319 ± 0.016	2.52ArgIle: 2.52 ± 0.024	3.294ArgLys: 3.294 ± 0.029	5.967ArgLeu: 5.967 ± 0.046	1.247ArgMet: 1.247 ± 0.016	1.641ArgAsn: 1.641 ± 0.022	3.988ArgPro: 3.988 ± 0.04	2.233ArgGln: 2.233 ± 0.024	6.025ArgArg: 6.025 ± 0.061	5.487ArgSer: 5.487 ± 0.05	3.371ArgThr: 3.371 ± 0.031	3.436ArgVal: 3.436 ± 0.027	1.027ArgTrp: 1.027 ± 0.016	1.403ArgTyr: 1.403 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	9.056SerAla: 9.056 ± 0.066	0.877SerCys: 0.877 ± 0.021	3.8SerAsp: 3.8 ± 0.029	3.86SerGlu: 3.86 ± 0.027	3.606SerPhe: 3.606 ± 0.033	5.496SerGly: 5.496 ± 0.042	2.101SerHis: 2.101 ± 0.026	3.59SerIle: 3.59 ± 0.033	3.462SerLys: 3.462 ± 0.032	9.642SerLeu: 9.642 ± 0.062	1.382SerMet: 1.382 ± 0.019	2.733SerAsn: 2.733 ± 0.029	7.77SerPro: 7.77 ± 0.077	2.706SerGln: 2.706 ± 0.03	5.428SerArg: 5.428 ± 0.047	13.054SerSer: 13.054 ± 0.111	7.777SerThr: 7.777 ± 0.059	4.498SerVal: 4.498 ± 0.034	1.161SerTrp: 1.161 ± 0.016	2.07SerTyr: 2.07 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	5.63ThrAla: 5.63 ± 0.042	0.691ThrCys: 0.691 ± 0.021	2.37ThrAsp: 2.37 ± 0.024	2.867ThrGlu: 2.867 ± 0.025	2.339ThrPhe: 2.339 ± 0.025	3.82ThrGly: 3.82 ± 0.033	1.169ThrHis: 1.169 ± 0.017	2.673ThrIle: 2.673 ± 0.03	2.311ThrLys: 2.311 ± 0.026	6.149ThrLeu: 6.149 ± 0.04	0.9ThrMet: 0.9 ± 0.014	1.662ThrAsn: 1.662 ± 0.022	5.066ThrPro: 5.066 ± 0.046	1.566ThrGln: 1.566 ± 0.02	3.255ThrArg: 3.255 ± 0.029	6.909ThrSer: 6.909 ± 0.055	4.898ThrThr: 4.898 ± 0.057	3.281ThrVal: 3.281 ± 0.029	0.736ThrTrp: 0.736 ± 0.014	1.39ThrTyr: 1.39 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	5.904ValAla: 5.904 ± 0.041	0.767ValCys: 0.767 ± 0.016	3.633ValAsp: 3.633 ± 0.032	4.682ValGlu: 4.682 ± 0.037	2.207ValPhe: 2.207 ± 0.027	4.584ValGly: 4.584 ± 0.035	1.257ValHis: 1.257 ± 0.018	2.371ValIle: 2.371 ± 0.029	3.026ValLys: 3.026 ± 0.028	5.815ValLeu: 5.815 ± 0.042	1.106ValMet: 1.106 ± 0.016	1.697ValAsn: 1.697 ± 0.022	3.33ValPro: 3.33 ± 0.027	2.162ValGln: 2.162 ± 0.022	3.39ValArg: 3.39 ± 0.027	4.333ValSer: 4.333 ± 0.034	2.99ValThr: 2.99 ± 0.032	4.638ValVal: 4.638 ± 0.039	0.904ValTrp: 0.904 ± 0.015	1.438ValTyr: 1.438 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.133TrpAla: 1.133 ± 0.016	0.192TrpCys: 0.192 ± 0.007	0.784TrpAsp: 0.784 ± 0.015	1.012TrpGlu: 1.012 ± 0.015	0.464TrpPhe: 0.464 ± 0.011	0.962TrpGly: 0.962 ± 0.016	0.28TrpHis: 0.28 ± 0.008	0.693TrpIle: 0.693 ± 0.013	0.699TrpLys: 0.699 ± 0.013	1.28TrpLeu: 1.28 ± 0.019	0.332TrpMet: 0.332 ± 0.009	0.467TrpAsn: 0.467 ± 0.012	0.527TrpPro: 0.527 ± 0.01	0.436TrpGln: 0.436 ± 0.01	1.041TrpArg: 1.041 ± 0.018	1.219TrpSer: 1.219 ± 0.018	0.922TrpThr: 0.922 ± 0.016	0.806TrpVal: 0.806 ± 0.014	0.291TrpTrp: 0.291 ± 0.009	0.326TrpTyr: 0.326 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.033TyrAla: 2.033 ± 0.026	0.33TyrCys: 0.33 ± 0.009	1.35TyrAsp: 1.35 ± 0.019	1.283TyrGlu: 1.283 ± 0.017	0.987TyrPhe: 0.987 ± 0.016	1.81TyrGly: 1.81 ± 0.027	0.617TyrHis: 0.617 ± 0.012	1.001TyrIle: 1.001 ± 0.017	0.863TyrLys: 0.863 ± 0.016	2.408TyrLeu: 2.408 ± 0.026	0.391TyrMet: 0.391 ± 0.009	0.77TyrAsn: 0.77 ± 0.013	1.347TyrPro: 1.347 ± 0.018	0.833TyrGln: 0.833 ± 0.014	1.385TyrArg: 1.385 ± 0.019	1.985TyrSer: 1.985 ± 0.021	1.395TyrThr: 1.395 ± 0.019	1.311TyrVal: 1.311 ± 0.018	0.347TyrTrp: 0.347 ± 0.01	0.74TyrTyr: 0.74 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9828 proteins (4540455 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---