Amino acid dipepetide frequency for Marinobacterium georgiense DSM 11526

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.176AlaAla: 10.176 ± 0.122	1.146AlaCys: 1.146 ± 0.032	5.694AlaAsp: 5.694 ± 0.084	6.811AlaGlu: 6.811 ± 0.096	3.399AlaPhe: 3.399 ± 0.057	7.854AlaGly: 7.854 ± 0.098	1.891AlaHis: 1.891 ± 0.041	5.118AlaIle: 5.118 ± 0.071	2.859AlaLys: 2.859 ± 0.064	11.748AlaLeu: 11.748 ± 0.126	2.645AlaMet: 2.645 ± 0.054	2.641AlaAsn: 2.641 ± 0.05	3.528AlaPro: 3.528 ± 0.066	4.216AlaGln: 4.216 ± 0.063	6.092AlaArg: 6.092 ± 0.086	5.468AlaSer: 5.468 ± 0.077	4.457AlaThr: 4.457 ± 0.073	6.591AlaVal: 6.591 ± 0.091	1.227AlaTrp: 1.227 ± 0.032	2.203AlaTyr: 2.203 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.885CysAla: 0.885 ± 0.028	0.164CysCys: 0.164 ± 0.013	0.601CysAsp: 0.601 ± 0.028	0.625CysGlu: 0.625 ± 0.023	0.421CysPhe: 0.421 ± 0.019	0.987CysGly: 0.987 ± 0.032	0.34CysHis: 0.34 ± 0.019	0.554CysIle: 0.554 ± 0.022	0.331CysLys: 0.331 ± 0.019	1.072CysLeu: 1.072 ± 0.036	0.242CysMet: 0.242 ± 0.014	0.334CysAsn: 0.334 ± 0.018	0.515CysPro: 0.515 ± 0.022	0.426CysGln: 0.426 ± 0.021	0.69CysArg: 0.69 ± 0.029	0.73CysSer: 0.73 ± 0.029	0.523CysThr: 0.523 ± 0.023	0.639CysVal: 0.639 ± 0.023	0.153CysTrp: 0.153 ± 0.01	0.279CysTyr: 0.279 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.185AspAla: 5.185 ± 0.07	0.539AspCys: 0.539 ± 0.018	3.018AspAsp: 3.018 ± 0.075	3.952AspGlu: 3.952 ± 0.074	2.09AspPhe: 2.09 ± 0.045	4.05AspGly: 4.05 ± 0.083	1.226AspHis: 1.226 ± 0.03	3.167AspIle: 3.167 ± 0.055	1.96AspLys: 1.96 ± 0.04	6.021AspLeu: 6.021 ± 0.068	1.391AspMet: 1.391 ± 0.037	1.965AspAsn: 1.965 ± 0.041	2.688AspPro: 2.688 ± 0.05	2.641AspGln: 2.641 ± 0.045	3.39AspArg: 3.39 ± 0.064	3.239AspSer: 3.239 ± 0.058	2.91AspThr: 2.91 ± 0.058	3.508AspVal: 3.508 ± 0.06	0.965AspTrp: 0.965 ± 0.03	1.793AspTyr: 1.793 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.364GluAla: 6.364 ± 0.081	0.506GluCys: 0.506 ± 0.024	2.774GluAsp: 2.774 ± 0.054	3.691GluGlu: 3.691 ± 0.064	2.038GluPhe: 2.038 ± 0.046	4.256GluGly: 4.256 ± 0.074	1.787GluHis: 1.787 ± 0.041	3.487GluIle: 3.487 ± 0.056	2.506GluLys: 2.506 ± 0.053	7.825GluLeu: 7.825 ± 0.096	1.706GluMet: 1.706 ± 0.038	1.917GluAsn: 1.917 ± 0.045	2.692GluPro: 2.692 ± 0.071	4.678GluGln: 4.678 ± 0.091	4.731GluArg: 4.731 ± 0.081	3.456GluSer: 3.456 ± 0.049	3.162GluThr: 3.162 ± 0.048	4.514GluVal: 4.514 ± 0.068	0.834GluTrp: 0.834 ± 0.026	1.742GluTyr: 1.742 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.323PheAla: 3.323 ± 0.057	0.488PheCys: 0.488 ± 0.02	2.451PheAsp: 2.451 ± 0.047	2.324PheGlu: 2.324 ± 0.044	1.425PhePhe: 1.425 ± 0.044	3.06PheGly: 3.06 ± 0.052	0.779PheHis: 0.779 ± 0.022	2.104PheIle: 2.104 ± 0.047	1.322PheLys: 1.322 ± 0.033	3.202PheLeu: 3.202 ± 0.058	1.048PheMet: 1.048 ± 0.03	1.501PheAsn: 1.501 ± 0.038	1.375PhePro: 1.375 ± 0.031	1.115PheGln: 1.115 ± 0.027	2.016PheArg: 2.016 ± 0.042	2.873PheSer: 2.873 ± 0.05	1.999PheThr: 1.999 ± 0.049	2.386PheVal: 2.386 ± 0.049	0.51PheTrp: 0.51 ± 0.023	1.15PheTyr: 1.15 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	6.081GlyAla: 6.081 ± 0.098	0.972GlyCys: 0.972 ± 0.031	3.995GlyAsp: 3.995 ± 0.089	4.696GlyGlu: 4.696 ± 0.057	3.292GlyPhe: 3.292 ± 0.049	5.473GlyGly: 5.473 ± 0.115	1.776GlyHis: 1.776 ± 0.044	4.494GlyIle: 4.494 ± 0.072	3.115GlyLys: 3.115 ± 0.056	8.17GlyLeu: 8.17 ± 0.088	2.297GlyMet: 2.297 ± 0.044	2.502GlyAsn: 2.502 ± 0.072	2.286GlyPro: 2.286 ± 0.046	3.307GlyGln: 3.307 ± 0.055	4.584GlyArg: 4.584 ± 0.068	4.577GlySer: 4.577 ± 0.086	3.71GlyThr: 3.71 ± 0.087	5.655GlyVal: 5.655 ± 0.082	1.298GlyTrp: 1.298 ± 0.037	2.523GlyTyr: 2.523 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.006HisAla: 2.006 ± 0.047	0.332HisCys: 0.332 ± 0.018	1.271HisAsp: 1.271 ± 0.035	1.391HisGlu: 1.391 ± 0.04	1.057HisPhe: 1.057 ± 0.031	1.671HisGly: 1.671 ± 0.037	0.703HisHis: 0.703 ± 0.026	1.194HisIle: 1.194 ± 0.032	0.725HisLys: 0.725 ± 0.024	2.487HisLeu: 2.487 ± 0.048	0.565HisMet: 0.565 ± 0.021	0.778HisAsn: 0.778 ± 0.026	1.312HisPro: 1.312 ± 0.036	1.186HisGln: 1.186 ± 0.033	1.441HisArg: 1.441 ± 0.038	1.315HisSer: 1.315 ± 0.026	1.127HisThr: 1.127 ± 0.029	1.298HisVal: 1.298 ± 0.036	0.497HisTrp: 0.497 ± 0.022	0.863HisTyr: 0.863 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.449IleAla: 5.449 ± 0.077	0.659IleCys: 0.659 ± 0.023	3.706IleAsp: 3.706 ± 0.066	4.101IleGlu: 4.101 ± 0.065	1.718IlePhe: 1.718 ± 0.045	4.307IleGly: 4.307 ± 0.067	1.235IleHis: 1.235 ± 0.028	2.737IleIle: 2.737 ± 0.053	2.013IleLys: 2.013 ± 0.055	4.842IleLeu: 4.842 ± 0.079	1.201IleMet: 1.201 ± 0.032	2.296IleAsn: 2.296 ± 0.052	2.454IlePro: 2.454 ± 0.045	1.921IleGln: 1.921 ± 0.044	3.553IleArg: 3.553 ± 0.055	3.862IleSer: 3.862 ± 0.063	3.018IleThr: 3.018 ± 0.05	3.278IleVal: 3.278 ± 0.067	0.604IleTrp: 0.604 ± 0.026	1.314IleTyr: 1.314 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.716LysAla: 3.716 ± 0.072	0.229LysCys: 0.229 ± 0.015	1.722LysAsp: 1.722 ± 0.042	2.076LysGlu: 2.076 ± 0.052	0.873LysPhe: 0.873 ± 0.028	2.653LysGly: 2.653 ± 0.051	0.778LysHis: 0.778 ± 0.027	1.886LysIle: 1.886 ± 0.049	1.533LysLys: 1.533 ± 0.046	3.681LysLeu: 3.681 ± 0.048	0.886LysMet: 0.886 ± 0.031	1.106LysAsn: 1.106 ± 0.035	1.932LysPro: 1.932 ± 0.041	1.95LysGln: 1.95 ± 0.041	2.486LysArg: 2.486 ± 0.049	1.986LysSer: 1.986 ± 0.044	1.987LysThr: 1.987 ± 0.045	2.589LysVal: 2.589 ± 0.051	0.375LysTrp: 0.375 ± 0.019	0.82LysTyr: 0.82 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	11.419LeuAla: 11.419 ± 0.124	1.176LeuCys: 1.176 ± 0.031	6.336LeuAsp: 6.336 ± 0.075	7.322LeuGlu: 7.322 ± 0.097	4.15LeuPhe: 4.15 ± 0.074	7.89LeuGly: 7.89 ± 0.082	2.447LeuHis: 2.447 ± 0.045	6.204LeuIle: 6.204 ± 0.092	4.525LeuLys: 4.525 ± 0.066	13.348LeuLeu: 13.348 ± 0.21	2.968LeuMet: 2.968 ± 0.057	3.984LeuAsn: 3.984 ± 0.059	5.711LeuPro: 5.711 ± 0.076	5.432LeuGln: 5.432 ± 0.104	6.435LeuArg: 6.435 ± 0.088	7.823LeuSer: 7.823 ± 0.097	5.938LeuThr: 5.938 ± 0.075	7.44LeuVal: 7.44 ± 0.097	1.293LeuTrp: 1.293 ± 0.042	2.677LeuTyr: 2.677 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.708MetAla: 2.708 ± 0.048	0.176MetCys: 0.176 ± 0.012	1.292MetAsp: 1.292 ± 0.035	1.278MetGlu: 1.278 ± 0.035	0.782MetPhe: 0.782 ± 0.027	1.816MetGly: 1.816 ± 0.041	0.531MetHis: 0.531 ± 0.02	1.381MetIle: 1.381 ± 0.04	1.128MetLys: 1.128 ± 0.033	3.12MetLeu: 3.12 ± 0.052	0.676MetMet: 0.676 ± 0.024	0.958MetAsn: 0.958 ± 0.029	1.366MetPro: 1.366 ± 0.035	1.327MetGln: 1.327 ± 0.031	1.517MetArg: 1.517 ± 0.032	1.932MetSer: 1.932 ± 0.04	1.514MetThr: 1.514 ± 0.037	1.599MetVal: 1.599 ± 0.034	0.166MetTrp: 0.166 ± 0.012	0.405MetTyr: 0.405 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.022AsnAla: 3.022 ± 0.052	0.329AsnCys: 0.329 ± 0.015	1.811AsnAsp: 1.811 ± 0.057	1.863AsnGlu: 1.863 ± 0.041	1.078AsnPhe: 1.078 ± 0.031	2.701AsnGly: 2.701 ± 0.063	0.738AsnHis: 0.738 ± 0.03	1.933AsnIle: 1.933 ± 0.04	1.1AsnLys: 1.1 ± 0.037	3.522AsnLeu: 3.522 ± 0.049	0.77AsnMet: 0.77 ± 0.026	1.181AsnAsn: 1.181 ± 0.036	2.006AsnPro: 2.006 ± 0.045	1.387AsnGln: 1.387 ± 0.036	2.288AsnArg: 2.288 ± 0.046	1.936AsnSer: 1.936 ± 0.05	1.888AsnThr: 1.888 ± 0.046	1.862AsnVal: 1.862 ± 0.042	0.541AsnTrp: 0.541 ± 0.024	0.887AsnTyr: 0.887 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	4.512ProAla: 4.512 ± 0.07	0.368ProCys: 0.368 ± 0.018	3.227ProAsp: 3.227 ± 0.048	4.054ProGlu: 4.054 ± 0.074	1.694ProPhe: 1.694 ± 0.044	3.622ProGly: 3.622 ± 0.067	0.926ProHis: 0.926 ± 0.031	2.049ProIle: 2.049 ± 0.043	1.411ProLys: 1.411 ± 0.038	5.092ProLeu: 5.092 ± 0.072	1.053ProMet: 1.053 ± 0.03	1.317ProAsn: 1.317 ± 0.031	1.716ProPro: 1.716 ± 0.044	1.819ProGln: 1.819 ± 0.039	2.09ProArg: 2.09 ± 0.036	2.46ProSer: 2.46 ± 0.045	1.992ProThr: 1.992 ± 0.043	3.907ProVal: 3.907 ± 0.057	0.618ProTrp: 0.618 ± 0.024	1.048ProTyr: 1.048 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	5.112GlnAla: 5.112 ± 0.084	0.378GlnCys: 0.378 ± 0.019	1.959GlnAsp: 1.959 ± 0.041	2.526GlnGlu: 2.526 ± 0.048	1.403GlnPhe: 1.403 ± 0.037	3.215GlnGly: 3.215 ± 0.055	1.278GlnHis: 1.278 ± 0.033	2.354GlnIle: 2.354 ± 0.043	1.545GlnLys: 1.545 ± 0.039	6.204GlnLeu: 6.204 ± 0.1	1.2GlnMet: 1.2 ± 0.031	1.25GlnAsn: 1.25 ± 0.032	2.359GlnPro: 2.359 ± 0.054	3.655GlnGln: 3.655 ± 0.092	3.389GlnArg: 3.389 ± 0.058	2.584GlnSer: 2.584 ± 0.054	2.208GlnThr: 2.208 ± 0.048	3.427GlnVal: 3.427 ± 0.06	0.707GlnTrp: 0.707 ± 0.022	1.081GlnTyr: 1.081 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	5.082ArgAla: 5.082 ± 0.073	0.66ArgCys: 0.66 ± 0.026	3.282ArgAsp: 3.282 ± 0.054	4.231ArgGlu: 4.231 ± 0.072	2.808ArgPhe: 2.808 ± 0.046	3.599ArgGly: 3.599 ± 0.063	1.73ArgHis: 1.73 ± 0.034	3.788ArgIle: 3.788 ± 0.063	2.395ArgLys: 2.395 ± 0.049	7.71ArgLeu: 7.71 ± 0.111	1.703ArgMet: 1.703 ± 0.04	2.141ArgAsn: 2.141 ± 0.042	2.488ArgPro: 2.488 ± 0.05	3.413ArgGln: 3.413 ± 0.066	4.041ArgArg: 4.041 ± 0.078	3.477ArgSer: 3.477 ± 0.065	2.806ArgThr: 2.806 ± 0.054	4.297ArgVal: 4.297 ± 0.062	1.014ArgTrp: 1.014 ± 0.027	2.12ArgTyr: 2.12 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.835SerAla: 5.835 ± 0.07	0.655SerCys: 0.655 ± 0.031	3.406SerAsp: 3.406 ± 0.07	3.779SerGlu: 3.779 ± 0.054	2.353SerPhe: 2.353 ± 0.048	5.637SerGly: 5.637 ± 0.084	1.472SerHis: 1.472 ± 0.038	3.364SerIle: 3.364 ± 0.052	1.861SerLys: 1.861 ± 0.039	7.005SerLeu: 7.005 ± 0.094	1.553SerMet: 1.553 ± 0.033	1.882SerAsn: 1.882 ± 0.043	2.701SerPro: 2.701 ± 0.045	2.497SerGln: 2.497 ± 0.05	3.859SerArg: 3.859 ± 0.062	3.859SerSer: 3.859 ± 0.074	2.997SerThr: 2.997 ± 0.053	4.209SerVal: 4.209 ± 0.061	0.873SerTrp: 0.873 ± 0.028	1.622SerTyr: 1.622 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	4.988ThrAla: 4.988 ± 0.074	0.466ThrCys: 0.466 ± 0.02	3.003ThrAsp: 3.003 ± 0.058	3.295ThrGlu: 3.295 ± 0.058	1.773ThrPhe: 1.773 ± 0.043	4.645ThrGly: 4.645 ± 0.078	1.116ThrHis: 1.116 ± 0.034	2.326ThrIle: 2.326 ± 0.05	1.16ThrLys: 1.16 ± 0.033	6.885ThrLeu: 6.885 ± 0.081	0.886ThrMet: 0.886 ± 0.027	1.337ThrAsn: 1.337 ± 0.032	2.99ThrPro: 2.99 ± 0.052	1.99ThrGln: 1.99 ± 0.043	3.062ThrArg: 3.062 ± 0.057	2.817ThrSer: 2.817 ± 0.057	2.699ThrThr: 2.699 ± 0.054	3.443ThrVal: 3.443 ± 0.064	0.578ThrTrp: 0.578 ± 0.024	1.212ThrTyr: 1.212 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	6.674ValAla: 6.674 ± 0.089	0.795ValCys: 0.795 ± 0.028	3.98ValAsp: 3.98 ± 0.069	4.579ValGlu: 4.579 ± 0.061	2.494ValPhe: 2.494 ± 0.056	4.528ValGly: 4.528 ± 0.068	1.365ValHis: 1.365 ± 0.033	4.119ValIle: 4.119 ± 0.069	2.475ValLys: 2.475 ± 0.048	7.469ValLeu: 7.469 ± 0.095	1.954ValMet: 1.954 ± 0.041	2.359ValAsn: 2.359 ± 0.048	2.942ValPro: 2.942 ± 0.055	2.654ValGln: 2.654 ± 0.042	4.026ValArg: 4.026 ± 0.056	4.489ValSer: 4.489 ± 0.067	3.751ValThr: 3.751 ± 0.074	5.202ValVal: 5.202 ± 0.076	0.8ValTrp: 0.8 ± 0.026	1.683ValTyr: 1.683 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.976TrpAla: 0.976 ± 0.028	0.179TrpCys: 0.179 ± 0.011	0.611TrpAsp: 0.611 ± 0.025	0.578TrpGlu: 0.578 ± 0.024	0.572TrpPhe: 0.572 ± 0.021	0.825TrpGly: 0.825 ± 0.028	0.407TrpHis: 0.407 ± 0.02	0.726TrpIle: 0.726 ± 0.023	0.444TrpLys: 0.444 ± 0.02	2.113TrpLeu: 2.113 ± 0.056	0.39TrpMet: 0.39 ± 0.019	0.456TrpAsn: 0.456 ± 0.02	0.622TrpPro: 0.622 ± 0.025	0.92TrpGln: 0.92 ± 0.028	0.964TrpArg: 0.964 ± 0.03	0.824TrpSer: 0.824 ± 0.027	0.568TrpThr: 0.568 ± 0.021	0.922TrpVal: 0.922 ± 0.026	0.221TrpTrp: 0.221 ± 0.014	0.387TrpTyr: 0.387 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.252TyrAla: 2.252 ± 0.043	0.293TyrCys: 0.293 ± 0.016	1.56TyrAsp: 1.56 ± 0.046	1.497TyrGlu: 1.497 ± 0.032	1.032TyrPhe: 1.032 ± 0.028	2.014TyrGly: 2.014 ± 0.041	0.693TyrHis: 0.693 ± 0.024	1.282TyrIle: 1.282 ± 0.038	0.857TyrLys: 0.857 ± 0.029	3.004TyrLeu: 3.004 ± 0.054	0.538TyrMet: 0.538 ± 0.018	0.939TyrAsn: 0.939 ± 0.03	1.292TyrPro: 1.292 ± 0.034	1.299TyrGln: 1.299 ± 0.034	2.13TyrArg: 2.13 ± 0.05	1.712TyrSer: 1.712 ± 0.036	1.416TyrThr: 1.416 ± 0.043	1.569TyrVal: 1.569 ± 0.036	0.428TyrTrp: 0.428 ± 0.019	0.79TyrTyr: 0.79 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3706 proteins (1196020 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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