Amino acid dipepetide frequency for Leptospira phage LE1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.087AlaAla: 3.087 ± 0.535
0.661AlaCys: 0.661 ± 0.196
2.646AlaAsp: 2.646 ± 0.338
5.247AlaGlu: 5.247 ± 0.529
2.602AlaPhe: 2.602 ± 0.254
3.66AlaGly: 3.66 ± 0.371
1.058AlaHis: 1.058 ± 0.203
5.953AlaIle: 5.953 ± 0.506
6.041AlaLys: 6.041 ± 0.748
4.983AlaLeu: 4.983 ± 0.488
1.411AlaMet: 1.411 ± 0.23
2.998AlaAsn: 2.998 ± 0.304
1.631AlaPro: 1.631 ± 0.312
2.337AlaGln: 2.337 ± 0.313
2.998AlaArg: 2.998 ± 0.309
3.88AlaSer: 3.88 ± 0.374
3.175AlaThr: 3.175 ± 0.404
3.924AlaVal: 3.924 ± 0.493
0.794AlaTrp: 0.794 ± 0.178
1.896AlaTyr: 1.896 ± 0.248
0.0AlaXaa: 0.0 ± 0.0
Cys
0.309CysAla: 0.309 ± 0.1
0.044CysCys: 0.044 ± 0.042
0.529CysAsp: 0.529 ± 0.132
0.661CysGlu: 0.661 ± 0.184
0.485CysPhe: 0.485 ± 0.157
0.705CysGly: 0.705 ± 0.234
0.176CysHis: 0.176 ± 0.077
0.661CysIle: 0.661 ± 0.184
0.529CysLys: 0.529 ± 0.148
0.794CysLeu: 0.794 ± 0.201
0.088CysMet: 0.088 ± 0.053
0.529CysAsn: 0.529 ± 0.151
0.265CysPro: 0.265 ± 0.105
0.132CysGln: 0.132 ± 0.073
0.044CysArg: 0.044 ± 0.042
0.353CysSer: 0.353 ± 0.114
0.265CysThr: 0.265 ± 0.135
0.529CysVal: 0.529 ± 0.165
0.176CysTrp: 0.176 ± 0.074
0.353CysTyr: 0.353 ± 0.123
0.0CysXaa: 0.0 ± 0.0
Asp
3.307AspAla: 3.307 ± 0.414
0.485AspCys: 0.485 ± 0.158
2.69AspAsp: 2.69 ± 0.284
4.453AspGlu: 4.453 ± 0.433
3.219AspPhe: 3.219 ± 0.329
4.189AspGly: 4.189 ± 0.407
0.838AspHis: 0.838 ± 0.192
4.453AspIle: 4.453 ± 0.551
4.365AspLys: 4.365 ± 0.411
5.512AspLeu: 5.512 ± 0.441
0.882AspMet: 0.882 ± 0.186
1.984AspAsn: 1.984 ± 0.288
3.395AspPro: 3.395 ± 0.398
2.249AspGln: 2.249 ± 0.365
2.69AspArg: 2.69 ± 0.329
5.027AspSer: 5.027 ± 0.467
2.469AspThr: 2.469 ± 0.334
2.205AspVal: 2.205 ± 0.25
0.926AspTrp: 0.926 ± 0.22
1.587AspTyr: 1.587 ± 0.243
0.0AspXaa: 0.0 ± 0.0
Glu
4.277GluAla: 4.277 ± 0.418
0.485GluCys: 0.485 ± 0.141
3.88GluAsp: 3.88 ± 0.437
5.424GluGlu: 5.424 ± 0.605
5.159GluPhe: 5.159 ± 0.472
4.586GluGly: 4.586 ± 0.528
1.235GluHis: 1.235 ± 0.212
7.716GluIle: 7.716 ± 0.692
7.452GluLys: 7.452 ± 0.767
7.011GluLeu: 7.011 ± 0.506
1.411GluMet: 1.411 ± 0.245
4.233GluAsn: 4.233 ± 0.396
2.028GluPro: 2.028 ± 0.297
2.337GluGln: 2.337 ± 0.368
3.527GluArg: 3.527 ± 0.343
5.159GluSer: 5.159 ± 0.462
3.88GluThr: 3.88 ± 0.437
3.572GluVal: 3.572 ± 0.402
0.794GluTrp: 0.794 ± 0.196
2.778GluTyr: 2.778 ± 0.331
0.0GluXaa: 0.0 ± 0.0
Phe
2.734PheAla: 2.734 ± 0.4
0.617PheCys: 0.617 ± 0.226
2.954PheAsp: 2.954 ± 0.321
3.131PheGlu: 3.131 ± 0.367
2.337PhePhe: 2.337 ± 0.311
3.351PheGly: 3.351 ± 0.453
0.661PheHis: 0.661 ± 0.198
3.175PheIle: 3.175 ± 0.375
3.042PheLys: 3.042 ± 0.389
5.776PheLeu: 5.776 ± 0.631
0.75PheMet: 0.75 ± 0.162
2.381PheAsn: 2.381 ± 0.361
2.337PhePro: 2.337 ± 0.386
2.381PheGln: 2.381 ± 0.284
2.513PheArg: 2.513 ± 0.393
3.307PheSer: 3.307 ± 0.387
2.072PheThr: 2.072 ± 0.301
2.425PheVal: 2.425 ± 0.335
0.705PheTrp: 0.705 ± 0.21
1.499PheTyr: 1.499 ± 0.233
0.0PheXaa: 0.0 ± 0.0
Gly
3.572GlyAla: 3.572 ± 0.441
0.397GlyCys: 0.397 ± 0.112
3.087GlyAsp: 3.087 ± 0.377
4.894GlyGlu: 4.894 ± 0.479
3.88GlyPhe: 3.88 ± 0.388
4.718GlyGly: 4.718 ± 0.665
0.926GlyHis: 0.926 ± 0.181
4.938GlyIle: 4.938 ± 0.571
6.394GlyLys: 6.394 ± 0.59
4.894GlyLeu: 4.894 ± 0.494
1.676GlyMet: 1.676 ± 0.272
4.233GlyAsn: 4.233 ± 0.418
1.014GlyPro: 1.014 ± 0.22
2.028GlyGln: 2.028 ± 0.386
3.483GlyArg: 3.483 ± 0.384
5.115GlySer: 5.115 ± 0.518
3.439GlyThr: 3.439 ± 0.439
4.057GlyVal: 4.057 ± 0.449
1.323GlyTrp: 1.323 ± 0.273
2.513GlyTyr: 2.513 ± 0.362
0.0GlyXaa: 0.0 ± 0.0
His
0.309HisAla: 0.309 ± 0.121
0.22HisCys: 0.22 ± 0.096
0.617HisAsp: 0.617 ± 0.162
1.014HisGlu: 1.014 ± 0.244
0.882HisPhe: 0.882 ± 0.154
0.705HisGly: 0.705 ± 0.182
0.441HisHis: 0.441 ± 0.136
0.529HisIle: 0.529 ± 0.119
1.058HisLys: 1.058 ± 0.235
1.808HisLeu: 1.808 ± 0.352
0.176HisMet: 0.176 ± 0.079
1.014HisAsn: 1.014 ± 0.227
0.926HisPro: 0.926 ± 0.196
0.573HisGln: 0.573 ± 0.157
0.838HisArg: 0.838 ± 0.175
0.882HisSer: 0.882 ± 0.21
0.75HisThr: 0.75 ± 0.216
0.485HisVal: 0.485 ± 0.137
0.132HisTrp: 0.132 ± 0.08
0.838HisTyr: 0.838 ± 0.159
0.0HisXaa: 0.0 ± 0.0
Ile
4.983IleAla: 4.983 ± 0.382
0.617IleCys: 0.617 ± 0.134
5.776IleAsp: 5.776 ± 0.474
5.556IleGlu: 5.556 ± 0.538
2.557IlePhe: 2.557 ± 0.282
4.453IleGly: 4.453 ± 0.478
1.014IleHis: 1.014 ± 0.251
4.145IleIle: 4.145 ± 0.451
6.041IleLys: 6.041 ± 0.591
6.085IleLeu: 6.085 ± 0.685
1.323IleMet: 1.323 ± 0.192
2.954IleAsn: 2.954 ± 0.396
4.013IlePro: 4.013 ± 0.432
3.131IleGln: 3.131 ± 0.335
3.704IleArg: 3.704 ± 0.421
6.349IleSer: 6.349 ± 0.601
3.792IleThr: 3.792 ± 0.482
4.321IleVal: 4.321 ± 0.437
0.794IleTrp: 0.794 ± 0.18
2.205IleTyr: 2.205 ± 0.324
0.0IleXaa: 0.0 ± 0.0
Lys
6.394LysAla: 6.394 ± 0.694
0.441LysCys: 0.441 ± 0.129
5.071LysAsp: 5.071 ± 0.568
8.422LysGlu: 8.422 ± 0.914
3.792LysPhe: 3.792 ± 0.406
5.82LysGly: 5.82 ± 0.808
1.146LysHis: 1.146 ± 0.237
6.438LysIle: 6.438 ± 0.523
8.598LysLys: 8.598 ± 0.842
6.261LysLeu: 6.261 ± 0.601
1.764LysMet: 1.764 ± 0.31
4.674LysAsn: 4.674 ± 0.55
2.998LysPro: 2.998 ± 0.311
2.734LysGln: 2.734 ± 0.357
3.527LysArg: 3.527 ± 0.436
7.496LysSer: 7.496 ± 0.793
4.674LysThr: 4.674 ± 0.32
4.409LysVal: 4.409 ± 0.489
0.97LysTrp: 0.97 ± 0.222
3.219LysTyr: 3.219 ± 0.368
0.0LysXaa: 0.0 ± 0.0
Leu
5.776LeuAla: 5.776 ± 0.555
0.617LeuCys: 0.617 ± 0.19
5.909LeuAsp: 5.909 ± 0.712
6.702LeuGlu: 6.702 ± 0.644
3.88LeuPhe: 3.88 ± 0.415
5.335LeuGly: 5.335 ± 0.462
1.102LeuHis: 1.102 ± 0.234
5.115LeuIle: 5.115 ± 0.401
7.54LeuLys: 7.54 ± 0.623
7.055LeuLeu: 7.055 ± 0.635
1.984LeuMet: 1.984 ± 0.258
5.071LeuAsn: 5.071 ± 0.488
4.013LeuPro: 4.013 ± 0.403
2.557LeuGln: 2.557 ± 0.265
4.542LeuArg: 4.542 ± 0.448
7.011LeuSer: 7.011 ± 0.594
4.718LeuThr: 4.718 ± 0.442
4.233LeuVal: 4.233 ± 0.384
0.529LeuTrp: 0.529 ± 0.167
2.646LeuTyr: 2.646 ± 0.339
0.0LeuXaa: 0.0 ± 0.0
Met
1.631MetAla: 1.631 ± 0.295
0.176MetCys: 0.176 ± 0.095
0.794MetAsp: 0.794 ± 0.183
0.882MetGlu: 0.882 ± 0.237
0.794MetPhe: 0.794 ± 0.171
1.235MetGly: 1.235 ± 0.237
0.309MetHis: 0.309 ± 0.108
1.323MetIle: 1.323 ± 0.236
1.455MetLys: 1.455 ± 0.202
1.676MetLeu: 1.676 ± 0.243
0.176MetMet: 0.176 ± 0.107
1.102MetAsn: 1.102 ± 0.233
0.926MetPro: 0.926 ± 0.22
1.058MetGln: 1.058 ± 0.214
0.75MetArg: 0.75 ± 0.169
1.852MetSer: 1.852 ± 0.33
0.617MetThr: 0.617 ± 0.173
1.455MetVal: 1.455 ± 0.228
0.353MetTrp: 0.353 ± 0.137
0.573MetTyr: 0.573 ± 0.155
0.0MetXaa: 0.0 ± 0.0
Asn
3.616AsnAla: 3.616 ± 0.318
0.441AsnCys: 0.441 ± 0.174
2.513AsnAsp: 2.513 ± 0.29
2.866AsnGlu: 2.866 ± 0.311
2.161AsnPhe: 2.161 ± 0.328
4.189AsnGly: 4.189 ± 0.395
0.661AsnHis: 0.661 ± 0.163
3.66AsnIle: 3.66 ± 0.436
4.189AsnLys: 4.189 ± 0.506
4.586AsnLeu: 4.586 ± 0.516
0.661AsnMet: 0.661 ± 0.178
2.778AsnAsn: 2.778 ± 0.299
3.175AsnPro: 3.175 ± 0.387
2.602AsnGln: 2.602 ± 0.326
2.646AsnArg: 2.646 ± 0.314
3.351AsnSer: 3.351 ± 0.421
2.425AsnThr: 2.425 ± 0.377
2.91AsnVal: 2.91 ± 0.413
0.705AsnTrp: 0.705 ± 0.177
1.896AsnTyr: 1.896 ± 0.287
0.0AsnXaa: 0.0 ± 0.0
Pro
1.94ProAla: 1.94 ± 0.26
0.22ProCys: 0.22 ± 0.094
2.866ProAsp: 2.866 ± 0.392
3.395ProGlu: 3.395 ± 0.366
1.764ProPhe: 1.764 ± 0.28
2.954ProGly: 2.954 ± 0.463
0.617ProHis: 0.617 ± 0.177
2.778ProIle: 2.778 ± 0.407
4.233ProLys: 4.233 ± 0.486
3.131ProLeu: 3.131 ± 0.398
0.705ProMet: 0.705 ± 0.18
2.734ProAsn: 2.734 ± 0.367
1.852ProPro: 1.852 ± 0.325
0.617ProGln: 0.617 ± 0.154
1.543ProArg: 1.543 ± 0.347
2.91ProSer: 2.91 ± 0.373
2.822ProThr: 2.822 ± 0.387
1.984ProVal: 1.984 ± 0.311
0.265ProTrp: 0.265 ± 0.102
1.102ProTyr: 1.102 ± 0.217
0.0ProXaa: 0.0 ± 0.0
Gln
3.263GlnAla: 3.263 ± 0.374
0.132GlnCys: 0.132 ± 0.079
1.455GlnAsp: 1.455 ± 0.279
2.602GlnGlu: 2.602 ± 0.398
1.94GlnPhe: 1.94 ± 0.292
2.425GlnGly: 2.425 ± 0.374
0.485GlnHis: 0.485 ± 0.16
3.219GlnIle: 3.219 ± 0.409
3.968GlnLys: 3.968 ± 0.541
2.646GlnLeu: 2.646 ± 0.351
0.838GlnMet: 0.838 ± 0.211
1.631GlnAsn: 1.631 ± 0.256
0.705GlnPro: 0.705 ± 0.168
1.146GlnGln: 1.146 ± 0.278
1.764GlnArg: 1.764 ± 0.281
2.778GlnSer: 2.778 ± 0.363
2.072GlnThr: 2.072 ± 0.312
2.072GlnVal: 2.072 ± 0.286
0.441GlnTrp: 0.441 ± 0.149
1.191GlnTyr: 1.191 ± 0.201
0.0GlnXaa: 0.0 ± 0.0
Arg
3.307ArgAla: 3.307 ± 0.398
0.353ArgCys: 0.353 ± 0.123
3.087ArgAsp: 3.087 ± 0.299
4.013ArgGlu: 4.013 ± 0.387
2.425ArgPhe: 2.425 ± 0.273
2.337ArgGly: 2.337 ± 0.328
0.661ArgHis: 0.661 ± 0.17
4.277ArgIle: 4.277 ± 0.48
4.63ArgLys: 4.63 ± 0.452
4.233ArgLeu: 4.233 ± 0.535
0.661ArgMet: 0.661 ± 0.165
2.161ArgAsn: 2.161 ± 0.312
1.72ArgPro: 1.72 ± 0.255
1.146ArgGln: 1.146 ± 0.184
2.161ArgArg: 2.161 ± 0.377
2.91ArgSer: 2.91 ± 0.265
2.469ArgThr: 2.469 ± 0.31
2.337ArgVal: 2.337 ± 0.357
0.705ArgTrp: 0.705 ± 0.191
1.499ArgTyr: 1.499 ± 0.289
0.0ArgXaa: 0.0 ± 0.0
Ser
4.321SerAla: 4.321 ± 0.584
0.441SerCys: 0.441 ± 0.141
4.586SerAsp: 4.586 ± 0.49
6.129SerGlu: 6.129 ± 0.654
3.263SerPhe: 3.263 ± 0.396
5.82SerGly: 5.82 ± 0.707
1.014SerHis: 1.014 ± 0.183
5.291SerIle: 5.291 ± 0.403
6.658SerLys: 6.658 ± 0.659
6.702SerLeu: 6.702 ± 0.572
1.499SerMet: 1.499 ± 0.236
3.88SerAsn: 3.88 ± 0.44
2.822SerPro: 2.822 ± 0.378
4.145SerGln: 4.145 ± 0.465
2.734SerArg: 2.734 ± 0.377
4.145SerSer: 4.145 ± 0.471
3.483SerThr: 3.483 ± 0.443
4.409SerVal: 4.409 ± 0.583
0.705SerTrp: 0.705 ± 0.23
2.205SerTyr: 2.205 ± 0.258
0.0SerXaa: 0.0 ± 0.0
Thr
2.866ThrAla: 2.866 ± 0.416
0.353ThrCys: 0.353 ± 0.118
2.205ThrAsp: 2.205 ± 0.322
4.498ThrGlu: 4.498 ± 0.449
2.513ThrPhe: 2.513 ± 0.364
3.792ThrGly: 3.792 ± 0.457
0.75ThrHis: 0.75 ± 0.194
3.88ThrIle: 3.88 ± 0.367
4.233ThrLys: 4.233 ± 0.468
4.983ThrLeu: 4.983 ± 0.477
1.058ThrMet: 1.058 ± 0.212
2.381ThrAsn: 2.381 ± 0.378
2.866ThrPro: 2.866 ± 0.407
1.764ThrGln: 1.764 ± 0.274
1.279ThrArg: 1.279 ± 0.29
3.307ThrSer: 3.307 ± 0.435
2.293ThrThr: 2.293 ± 0.323
3.483ThrVal: 3.483 ± 0.452
0.882ThrTrp: 0.882 ± 0.204
1.499ThrTyr: 1.499 ± 0.253
0.0ThrXaa: 0.0 ± 0.0
Val
3.395ValAla: 3.395 ± 0.434
0.397ValCys: 0.397 ± 0.135
3.483ValAsp: 3.483 ± 0.356
4.453ValGlu: 4.453 ± 0.393
2.293ValPhe: 2.293 ± 0.357
3.439ValGly: 3.439 ± 0.377
0.573ValHis: 0.573 ± 0.152
3.307ValIle: 3.307 ± 0.38
4.894ValLys: 4.894 ± 0.523
3.66ValLeu: 3.66 ± 0.419
1.279ValMet: 1.279 ± 0.208
2.293ValAsn: 2.293 ± 0.276
2.249ValPro: 2.249 ± 0.387
2.116ValGln: 2.116 ± 0.315
3.131ValArg: 3.131 ± 0.396
4.806ValSer: 4.806 ± 0.448
3.263ValThr: 3.263 ± 0.454
2.469ValVal: 2.469 ± 0.384
0.441ValTrp: 0.441 ± 0.134
1.896ValTyr: 1.896 ± 0.293
0.0ValXaa: 0.0 ± 0.0
Trp
0.397TrpAla: 0.397 ± 0.123
0.088TrpCys: 0.088 ± 0.056
0.838TrpAsp: 0.838 ± 0.216
0.75TrpGlu: 0.75 ± 0.158
0.529TrpPhe: 0.529 ± 0.163
0.838TrpGly: 0.838 ± 0.174
0.176TrpHis: 0.176 ± 0.078
0.97TrpIle: 0.97 ± 0.207
0.97TrpLys: 0.97 ± 0.192
0.97TrpLeu: 0.97 ± 0.244
0.309TrpMet: 0.309 ± 0.128
1.014TrpAsn: 1.014 ± 0.236
0.353TrpPro: 0.353 ± 0.126
0.441TrpGln: 0.441 ± 0.146
0.794TrpArg: 0.794 ± 0.196
0.926TrpSer: 0.926 ± 0.179
0.573TrpThr: 0.573 ± 0.154
0.617TrpVal: 0.617 ± 0.178
0.088TrpTrp: 0.088 ± 0.062
0.705TrpTyr: 0.705 ± 0.183
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.499TyrAla: 1.499 ± 0.217
0.441TyrCys: 0.441 ± 0.147
1.94TyrAsp: 1.94 ± 0.292
1.852TyrGlu: 1.852 ± 0.237
1.676TyrPhe: 1.676 ± 0.272
2.028TyrGly: 2.028 ± 0.253
0.353TyrHis: 0.353 ± 0.12
1.984TyrIle: 1.984 ± 0.358
2.557TyrLys: 2.557 ± 0.403
3.572TyrLeu: 3.572 ± 0.384
0.441TyrMet: 0.441 ± 0.116
1.984TyrAsn: 1.984 ± 0.285
1.146TyrPro: 1.146 ± 0.239
1.279TyrGln: 1.279 ± 0.243
2.425TyrArg: 2.425 ± 0.319
2.734TyrSer: 2.734 ± 0.333
1.631TyrThr: 1.631 ± 0.242
1.94TyrVal: 1.94 ± 0.281
0.617TyrTrp: 0.617 ± 0.127
0.705TyrTyr: 0.705 ± 0.142
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 81 proteins (22680 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski