Amino acid dipepetide frequency for Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.006AlaAla: 9.006 ± 0.057	1.062AlaCys: 1.062 ± 0.015	4.285AlaAsp: 4.285 ± 0.027	5.291AlaGlu: 5.291 ± 0.043	3.117AlaPhe: 3.117 ± 0.027	5.679AlaGly: 5.679 ± 0.046	1.908AlaHis: 1.908 ± 0.023	4.295AlaIle: 4.295 ± 0.025	4.602AlaLys: 4.602 ± 0.04	7.553AlaLeu: 7.553 ± 0.044	2.091AlaMet: 2.091 ± 0.02	3.189AlaAsn: 3.189 ± 0.025	5.249AlaPro: 5.249 ± 0.05	3.707AlaGln: 3.707 ± 0.03	4.916AlaArg: 4.916 ± 0.036	7.243AlaSer: 7.243 ± 0.047	5.59AlaThr: 5.59 ± 0.037	5.261AlaVal: 5.261 ± 0.038	1.148AlaTrp: 1.148 ± 0.014	2.332AlaTyr: 2.332 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.93CysAla: 0.93 ± 0.014	0.239CysCys: 0.239 ± 0.007	0.632CysAsp: 0.632 ± 0.013	0.627CysGlu: 0.627 ± 0.011	0.51CysPhe: 0.51 ± 0.009	0.909CysGly: 0.909 ± 0.015	0.314CysHis: 0.314 ± 0.01	0.687CysIle: 0.687 ± 0.013	0.565CysLys: 0.565 ± 0.01	1.121CysLeu: 1.121 ± 0.018	0.291CysMet: 0.291 ± 0.007	0.448CysAsn: 0.448 ± 0.01	0.628CysPro: 0.628 ± 0.011	0.442CysGln: 0.442 ± 0.011	0.687CysArg: 0.687 ± 0.011	0.833CysSer: 0.833 ± 0.012	0.741CysThr: 0.741 ± 0.012	0.763CysVal: 0.763 ± 0.013	0.208CysTrp: 0.208 ± 0.005	0.354CysTyr: 0.354 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.059AspAla: 5.059 ± 0.031	0.613AspCys: 0.613 ± 0.011	4.443AspAsp: 4.443 ± 0.042	4.63AspGlu: 4.63 ± 0.039	2.182AspPhe: 2.182 ± 0.02	3.874AspGly: 3.874 ± 0.033	1.217AspHis: 1.217 ± 0.014	3.07AspIle: 3.07 ± 0.026	2.582AspLys: 2.582 ± 0.024	4.73AspLeu: 4.73 ± 0.029	1.497AspMet: 1.497 ± 0.016	1.935AspAsn: 1.935 ± 0.021	3.162AspPro: 3.162 ± 0.025	1.907AspGln: 1.907 ± 0.019	2.96AspArg: 2.96 ± 0.024	3.862AspSer: 3.862 ± 0.034	3.218AspThr: 3.218 ± 0.025	3.761AspVal: 3.761 ± 0.029	0.915AspTrp: 0.915 ± 0.015	1.651AspTyr: 1.651 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	5.684GluAla: 5.684 ± 0.051	0.637GluCys: 0.637 ± 0.012	4.468GluAsp: 4.468 ± 0.038	5.882GluGlu: 5.882 ± 0.066	1.894GluPhe: 1.894 ± 0.018	3.799GluGly: 3.799 ± 0.03	1.512GluHis: 1.512 ± 0.019	2.953GluIle: 2.953 ± 0.025	4.062GluLys: 4.062 ± 0.037	5.19GluLeu: 5.19 ± 0.037	1.543GluMet: 1.543 ± 0.017	2.216GluAsn: 2.216 ± 0.02	2.803GluPro: 2.803 ± 0.049	2.775GluGln: 2.775 ± 0.03	4.076GluArg: 4.076 ± 0.036	4.011GluSer: 4.011 ± 0.037	3.425GluThr: 3.425 ± 0.027	3.655GluVal: 3.655 ± 0.03	0.901GluTrp: 0.901 ± 0.012	1.734GluTyr: 1.734 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.097PheAla: 3.097 ± 0.029	0.521PheCys: 0.521 ± 0.01	2.305PheAsp: 2.305 ± 0.021	2.149PheGlu: 2.149 ± 0.022	1.557PhePhe: 1.557 ± 0.02	2.793PheGly: 2.793 ± 0.026	0.84PheHis: 0.84 ± 0.014	1.695PheIle: 1.695 ± 0.019	1.615PheLys: 1.615 ± 0.019	3.231PheLeu: 3.231 ± 0.032	0.768PheMet: 0.768 ± 0.011	1.472PheAsn: 1.472 ± 0.017	1.844PhePro: 1.844 ± 0.02	1.346PheGln: 1.346 ± 0.016	1.889PheArg: 1.889 ± 0.018	2.825PheSer: 2.825 ± 0.023	2.221PheThr: 2.221 ± 0.02	2.294PheVal: 2.294 ± 0.023	0.623PheTrp: 0.623 ± 0.012	1.062PheTyr: 1.062 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.346GlyAla: 5.346 ± 0.045	0.863GlyCys: 0.863 ± 0.014	3.513GlyAsp: 3.513 ± 0.028	3.696GlyGlu: 3.696 ± 0.027	2.703GlyPhe: 2.703 ± 0.023	5.92GlyGly: 5.92 ± 0.072	1.652GlyHis: 1.652 ± 0.021	3.411GlyIle: 3.411 ± 0.032	3.7GlyLys: 3.7 ± 0.029	5.646GlyLeu: 5.646 ± 0.04	1.726GlyMet: 1.726 ± 0.023	2.547GlyAsn: 2.547 ± 0.026	3.189GlyPro: 3.189 ± 0.029	2.492GlyGln: 2.492 ± 0.025	3.983GlyArg: 3.983 ± 0.032	5.221GlySer: 5.221 ± 0.038	3.977GlyThr: 3.977 ± 0.036	4.274GlyVal: 4.274 ± 0.033	1.157GlyTrp: 1.157 ± 0.017	2.132GlyTyr: 2.132 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.978HisAla: 1.978 ± 0.024	0.344HisCys: 0.344 ± 0.009	1.344HisAsp: 1.344 ± 0.016	1.412HisGlu: 1.412 ± 0.017	0.917HisPhe: 0.917 ± 0.013	1.675HisGly: 1.675 ± 0.018	0.874HisHis: 0.874 ± 0.017	1.231HisIle: 1.231 ± 0.017	1.003HisLys: 1.003 ± 0.014	2.182HisLeu: 2.182 ± 0.021	0.544HisMet: 0.544 ± 0.011	0.898HisAsn: 0.898 ± 0.014	1.606HisPro: 1.606 ± 0.019	1.011HisGln: 1.011 ± 0.015	1.48HisArg: 1.48 ± 0.018	1.783HisSer: 1.783 ± 0.022	1.405HisThr: 1.405 ± 0.018	1.514HisVal: 1.514 ± 0.017	0.357HisTrp: 0.357 ± 0.009	0.718HisTyr: 0.718 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.312IleAla: 4.312 ± 0.03	0.719IleCys: 0.719 ± 0.013	2.874IleAsp: 2.874 ± 0.026	2.917IleGlu: 2.917 ± 0.029	1.876IlePhe: 1.876 ± 0.021	3.094IleGly: 3.094 ± 0.029	1.182IleHis: 1.182 ± 0.014	2.411IleIle: 2.411 ± 0.027	2.321IleLys: 2.321 ± 0.018	4.264IleLeu: 4.264 ± 0.036	1.065IleMet: 1.065 ± 0.016	1.822IleAsn: 1.822 ± 0.021	2.991IlePro: 2.991 ± 0.023	1.904IleGln: 1.904 ± 0.021	2.701IleArg: 2.701 ± 0.025	3.629IleSer: 3.629 ± 0.025	3.028IleThr: 3.028 ± 0.025	3.109IleVal: 3.109 ± 0.022	0.679IleTrp: 0.679 ± 0.013	1.369IleTyr: 1.369 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.704LysAla: 4.704 ± 0.039	0.533LysCys: 0.533 ± 0.01	3.097LysAsp: 3.097 ± 0.029	3.828LysGlu: 3.828 ± 0.036	1.529LysPhe: 1.529 ± 0.016	3.19LysGly: 3.19 ± 0.03	1.226LysHis: 1.226 ± 0.016	2.38LysIle: 2.38 ± 0.021	3.97LysLys: 3.97 ± 0.049	4.303LysLeu: 4.303 ± 0.035	1.151LysMet: 1.151 ± 0.017	1.927LysAsn: 1.927 ± 0.02	3.016LysPro: 3.016 ± 0.029	2.074LysGln: 2.074 ± 0.022	3.64LysArg: 3.64 ± 0.033	3.579LysSer: 3.579 ± 0.033	3.124LysThr: 3.124 ± 0.028	2.911LysVal: 2.911 ± 0.026	0.726LysTrp: 0.726 ± 0.011	1.443LysTyr: 1.443 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	7.487LeuAla: 7.487 ± 0.053	1.152LeuCys: 1.152 ± 0.014	4.97LeuAsp: 4.97 ± 0.034	5.337LeuGlu: 5.337 ± 0.045	3.103LeuPhe: 3.103 ± 0.029	5.495LeuGly: 5.495 ± 0.04	2.21LeuHis: 2.21 ± 0.022	3.685LeuIle: 3.685 ± 0.029	4.284LeuLys: 4.284 ± 0.032	7.733LeuLeu: 7.733 ± 0.058	1.742LeuMet: 1.742 ± 0.019	3.134LeuAsn: 3.134 ± 0.027	5.37LeuPro: 5.37 ± 0.037	3.827LeuGln: 3.827 ± 0.036	5.497LeuArg: 5.497 ± 0.038	6.743LeuSer: 6.743 ± 0.042	4.655LeuThr: 4.655 ± 0.031	5.142LeuVal: 5.142 ± 0.043	1.119LeuTrp: 1.119 ± 0.015	2.32LeuTyr: 2.32 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.317MetAla: 2.317 ± 0.024	0.254MetCys: 0.254 ± 0.007	1.353MetAsp: 1.353 ± 0.014	1.356MetGlu: 1.356 ± 0.018	0.771MetPhe: 0.771 ± 0.014	1.533MetGly: 1.533 ± 0.019	0.525MetHis: 0.525 ± 0.01	0.978MetIle: 0.978 ± 0.014	1.118MetLys: 1.118 ± 0.016	1.93MetLeu: 1.93 ± 0.021	0.624MetMet: 0.624 ± 0.012	0.845MetAsn: 0.845 ± 0.014	1.408MetPro: 1.408 ± 0.017	0.975MetGln: 0.975 ± 0.015	1.369MetArg: 1.369 ± 0.016	2.026MetSer: 2.026 ± 0.022	1.35MetThr: 1.35 ± 0.015	1.384MetVal: 1.384 ± 0.018	0.288MetTrp: 0.288 ± 0.007	0.609MetTyr: 0.609 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.386AsnAla: 3.386 ± 0.03	0.43AsnCys: 0.43 ± 0.01	2.069AsnAsp: 2.069 ± 0.022	2.097AsnGlu: 2.097 ± 0.023	1.412AsnPhe: 1.412 ± 0.014	3.05AsnGly: 3.05 ± 0.029	0.856AsnHis: 0.856 ± 0.014	2.056AsnIle: 2.056 ± 0.022	1.803AsnLys: 1.803 ± 0.02	3.158AsnLeu: 3.158 ± 0.027	0.937AsnMet: 0.937 ± 0.016	1.645AsnAsn: 1.645 ± 0.023	2.418AsnPro: 2.418 ± 0.022	1.376AsnGln: 1.376 ± 0.019	1.928AsnArg: 1.928 ± 0.019	2.668AsnSer: 2.668 ± 0.026	2.452AsnThr: 2.452 ± 0.023	2.391AsnVal: 2.391 ± 0.022	0.565AsnTrp: 0.565 ± 0.012	1.096AsnTyr: 1.096 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	5.423ProAla: 5.423 ± 0.054	0.486ProCys: 0.486 ± 0.011	3.084ProAsp: 3.084 ± 0.023	3.788ProGlu: 3.788 ± 0.039	2.0ProPhe: 2.0 ± 0.02	3.675ProGly: 3.675 ± 0.028	1.43ProHis: 1.43 ± 0.02	2.61ProIle: 2.61 ± 0.028	2.995ProLys: 2.995 ± 0.027	4.518ProLeu: 4.518 ± 0.032	1.188ProMet: 1.188 ± 0.018	2.347ProAsn: 2.347 ± 0.023	5.34ProPro: 5.34 ± 0.075	2.666ProGln: 2.666 ± 0.033	3.324ProArg: 3.324 ± 0.033	5.831ProSer: 5.831 ± 0.057	4.459ProThr: 4.459 ± 0.043	3.58ProVal: 3.58 ± 0.03	0.71ProTrp: 0.71 ± 0.012	1.59ProTyr: 1.59 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.643GlnAla: 3.643 ± 0.028	0.449GlnCys: 0.449 ± 0.01	2.223GlnAsp: 2.223 ± 0.022	2.519GlnGlu: 2.519 ± 0.028	1.3GlnPhe: 1.3 ± 0.016	2.487GlnGly: 2.487 ± 0.028	1.23GlnHis: 1.23 ± 0.017	1.897GlnIle: 1.897 ± 0.02	2.159GlnLys: 2.159 ± 0.025	3.428GlnLeu: 3.428 ± 0.033	0.944GlnMet: 0.944 ± 0.016	1.607GlnAsn: 1.607 ± 0.021	2.667GlnPro: 2.667 ± 0.032	2.779GlnGln: 2.779 ± 0.05	2.785GlnArg: 2.785 ± 0.026	3.109GlnSer: 3.109 ± 0.024	2.391GlnThr: 2.391 ± 0.022	2.181GlnVal: 2.181 ± 0.022	0.568GlnTrp: 0.568 ± 0.011	1.296GlnTyr: 1.296 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.644ArgAla: 4.644 ± 0.033	0.674ArgCys: 0.674 ± 0.012	3.233ArgAsp: 3.233 ± 0.029	3.841ArgGlu: 3.841 ± 0.038	2.074ArgPhe: 2.074 ± 0.021	3.701ArgGly: 3.701 ± 0.036	1.495ArgHis: 1.495 ± 0.018	2.901ArgIle: 2.901 ± 0.026	3.645ArgLys: 3.645 ± 0.03	5.167ArgLeu: 5.167 ± 0.038	1.374ArgMet: 1.374 ± 0.018	2.387ArgAsn: 2.387 ± 0.024	3.405ArgPro: 3.405 ± 0.034	2.647ArgGln: 2.647 ± 0.027	4.768ArgArg: 4.768 ± 0.045	4.581ArgSer: 4.581 ± 0.038	3.346ArgThr: 3.346 ± 0.028	3.226ArgVal: 3.226 ± 0.027	0.897ArgTrp: 0.897 ± 0.014	1.692ArgTyr: 1.692 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.462SerAla: 6.462 ± 0.039	0.795SerCys: 0.795 ± 0.013	4.129SerAsp: 4.129 ± 0.032	4.062SerGlu: 4.062 ± 0.03	2.852SerPhe: 2.852 ± 0.028	5.164SerGly: 5.164 ± 0.039	1.883SerHis: 1.883 ± 0.018	3.821SerIle: 3.821 ± 0.024	3.807SerLys: 3.807 ± 0.027	6.508SerLeu: 6.508 ± 0.048	1.8SerMet: 1.8 ± 0.021	2.991SerAsn: 2.991 ± 0.026	5.404SerPro: 5.404 ± 0.056	3.162SerGln: 3.162 ± 0.026	4.657SerArg: 4.657 ± 0.042	8.022SerSer: 8.022 ± 0.076	5.692SerThr: 5.692 ± 0.045	4.405SerVal: 4.405 ± 0.031	1.026SerTrp: 1.026 ± 0.015	2.08SerTyr: 2.08 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.482ThrAla: 5.482 ± 0.033	0.767ThrCys: 0.767 ± 0.013	2.925ThrAsp: 2.925 ± 0.025	3.28ThrGlu: 3.28 ± 0.029	2.282ThrPhe: 2.282 ± 0.021	4.088ThrGly: 4.088 ± 0.035	1.402ThrHis: 1.402 ± 0.017	3.163ThrIle: 3.163 ± 0.024	2.942ThrLys: 2.942 ± 0.025	5.31ThrLeu: 5.31 ± 0.032	1.29ThrMet: 1.29 ± 0.015	2.272ThrAsn: 2.272 ± 0.024	4.779ThrPro: 4.779 ± 0.053	2.327ThrGln: 2.327 ± 0.022	3.201ThrArg: 3.201 ± 0.028	5.431ThrSer: 5.431 ± 0.043	4.706ThrThr: 4.706 ± 0.042	3.76ThrVal: 3.76 ± 0.025	0.869ThrTrp: 0.869 ± 0.014	1.703ThrTyr: 1.703 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.23ValAla: 5.23 ± 0.037	0.785ValCys: 0.785 ± 0.012	3.656ValAsp: 3.656 ± 0.026	4.011ValGlu: 4.011 ± 0.035	2.348ValPhe: 2.348 ± 0.026	4.013ValGly: 4.013 ± 0.037	1.423ValHis: 1.423 ± 0.016	2.851ValIle: 2.851 ± 0.024	3.106ValLys: 3.106 ± 0.027	5.252ValLeu: 5.252 ± 0.039	1.347ValMet: 1.347 ± 0.015	2.262ValAsn: 2.262 ± 0.023	3.613ValPro: 3.613 ± 0.031	2.478ValGln: 2.478 ± 0.022	3.307ValArg: 3.307 ± 0.026	4.304ValSer: 4.304 ± 0.029	3.505ValThr: 3.505 ± 0.027	4.257ValVal: 4.257 ± 0.036	0.851ValTrp: 0.851 ± 0.013	1.723ValTyr: 1.723 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.099TrpAla: 1.099 ± 0.014	0.197TrpCys: 0.197 ± 0.006	0.922TrpAsp: 0.922 ± 0.013	0.849TrpGlu: 0.849 ± 0.013	0.546TrpPhe: 0.546 ± 0.01	0.919TrpGly: 0.919 ± 0.015	0.348TrpHis: 0.348 ± 0.008	0.754TrpIle: 0.754 ± 0.012	0.823TrpLys: 0.823 ± 0.013	1.246TrpLeu: 1.246 ± 0.016	0.381TrpMet: 0.381 ± 0.008	0.634TrpAsn: 0.634 ± 0.012	0.583TrpPro: 0.583 ± 0.011	0.601TrpGln: 0.601 ± 0.011	0.918TrpArg: 0.918 ± 0.014	1.03TrpSer: 1.03 ± 0.014	0.916TrpThr: 0.916 ± 0.014	0.843TrpVal: 0.843 ± 0.013	0.274TrpTrp: 0.274 ± 0.008	0.438TrpTyr: 0.438 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.237TyrAla: 2.237 ± 0.024	0.407TyrCys: 0.407 ± 0.009	1.742TyrAsp: 1.742 ± 0.019	1.647TyrGlu: 1.647 ± 0.019	1.173TyrPhe: 1.173 ± 0.017	2.089TyrGly: 2.089 ± 0.027	0.75TyrHis: 0.75 ± 0.013	1.42TyrIle: 1.42 ± 0.016	1.248TyrLys: 1.248 ± 0.017	2.537TyrLeu: 2.537 ± 0.026	0.71TyrMet: 0.71 ± 0.012	1.217TyrAsn: 1.217 ± 0.017	1.566TyrPro: 1.566 ± 0.018	1.166TyrGln: 1.166 ± 0.016	1.611TyrArg: 1.611 ± 0.016	1.99TyrSer: 1.99 ± 0.019	1.778TyrThr: 1.778 ± 0.02	1.613TyrVal: 1.613 ± 0.02	0.439TyrTrp: 0.439 ± 0.009	0.971TyrTyr: 0.971 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12062 proteins (5414714 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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