Amino acid dipepetide frequency for Flavonifractor sp. An306

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.897AlaAla: 11.897 ± 0.16
1.491AlaCys: 1.491 ± 0.038
5.261AlaAsp: 5.261 ± 0.073
6.498AlaGlu: 6.498 ± 0.085
3.366AlaPhe: 3.366 ± 0.07
7.946AlaGly: 7.946 ± 0.11
1.578AlaHis: 1.578 ± 0.041
4.998AlaIle: 4.998 ± 0.072
3.915AlaLys: 3.915 ± 0.081
10.483AlaLeu: 10.483 ± 0.112
2.719AlaMet: 2.719 ± 0.059
2.444AlaAsn: 2.444 ± 0.044
3.57AlaPro: 3.57 ± 0.063
3.958AlaGln: 3.958 ± 0.067
5.082AlaArg: 5.082 ± 0.082
4.198AlaSer: 4.198 ± 0.065
3.842AlaThr: 3.842 ± 0.063
7.88AlaVal: 7.88 ± 0.096
1.031AlaTrp: 1.031 ± 0.029
2.846AlaTyr: 2.846 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
1.558CysAla: 1.558 ± 0.039
0.357CysCys: 0.357 ± 0.019
0.836CysAsp: 0.836 ± 0.031
0.74CysGlu: 0.74 ± 0.026
0.575CysPhe: 0.575 ± 0.023
1.801CysGly: 1.801 ± 0.041
0.309CysHis: 0.309 ± 0.016
0.769CysIle: 0.769 ± 0.028
0.6CysLys: 0.6 ± 0.024
1.438CysLeu: 1.438 ± 0.034
0.38CysMet: 0.38 ± 0.018
0.4CysAsn: 0.4 ± 0.019
0.864CysPro: 0.864 ± 0.031
0.602CysGln: 0.602 ± 0.022
1.091CysArg: 1.091 ± 0.034
0.924CysSer: 0.924 ± 0.034
0.91CysThr: 0.91 ± 0.03
1.121CysVal: 1.121 ± 0.032
0.186CysTrp: 0.186 ± 0.013
0.518CysTyr: 0.518 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
4.706AspAla: 4.706 ± 0.066
0.92AspCys: 0.92 ± 0.034
2.522AspAsp: 2.522 ± 0.055
3.699AspGlu: 3.699 ± 0.073
2.327AspPhe: 2.327 ± 0.048
5.315AspGly: 5.315 ± 0.077
1.044AspHis: 1.044 ± 0.034
3.144AspIle: 3.144 ± 0.053
2.536AspLys: 2.536 ± 0.048
5.221AspLeu: 5.221 ± 0.07
1.55AspMet: 1.55 ± 0.035
1.656AspAsn: 1.656 ± 0.043
2.723AspPro: 2.723 ± 0.051
2.022AspGln: 2.022 ± 0.046
3.217AspArg: 3.217 ± 0.053
2.69AspSer: 2.69 ± 0.054
3.114AspThr: 3.114 ± 0.06
3.592AspVal: 3.592 ± 0.063
0.788AspTrp: 0.788 ± 0.03
2.365AspTyr: 2.365 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
6.34GluAla: 6.34 ± 0.073
0.743GluCys: 0.743 ± 0.029
3.789GluAsp: 3.789 ± 0.065
6.218GluGlu: 6.218 ± 0.101
2.064GluPhe: 2.064 ± 0.044
4.93GluGly: 4.93 ± 0.076
1.49GluHis: 1.49 ± 0.039
3.725GluIle: 3.725 ± 0.056
3.988GluLys: 3.988 ± 0.075
7.613GluLeu: 7.613 ± 0.091
1.823GluMet: 1.823 ± 0.04
2.613GluAsn: 2.613 ± 0.045
2.459GluPro: 2.459 ± 0.058
3.652GluGln: 3.652 ± 0.07
4.398GluArg: 4.398 ± 0.071
2.921GluSer: 2.921 ± 0.052
3.506GluThr: 3.506 ± 0.059
4.143GluVal: 4.143 ± 0.07
0.74GluTrp: 0.74 ± 0.026
2.266GluTyr: 2.266 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
3.199PheAla: 3.199 ± 0.059
0.814PheCys: 0.814 ± 0.028
2.226PheAsp: 2.226 ± 0.047
1.958PheGlu: 1.958 ± 0.05
1.631PhePhe: 1.631 ± 0.043
2.848PheGly: 2.848 ± 0.053
0.847PheHis: 0.847 ± 0.029
1.743PheIle: 1.743 ± 0.038
1.206PheLys: 1.206 ± 0.038
3.997PheLeu: 3.997 ± 0.072
0.765PheMet: 0.765 ± 0.029
1.168PheAsn: 1.168 ± 0.029
1.559PhePro: 1.559 ± 0.039
1.552PheGln: 1.552 ± 0.041
2.01PheArg: 2.01 ± 0.042
2.615PheSer: 2.615 ± 0.052
2.491PheThr: 2.491 ± 0.048
2.345PheVal: 2.345 ± 0.053
0.466PheTrp: 0.466 ± 0.023
1.392PheTyr: 1.392 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
6.815GlyAla: 6.815 ± 0.09
1.396GlyCys: 1.396 ± 0.04
4.088GlyAsp: 4.088 ± 0.068
5.42GlyGlu: 5.42 ± 0.068
2.943GlyPhe: 2.943 ± 0.052
6.635GlyGly: 6.635 ± 0.1
1.444GlyHis: 1.444 ± 0.037
4.441GlyIle: 4.441 ± 0.077
4.439GlyLys: 4.439 ± 0.056
7.693GlyLeu: 7.693 ± 0.108
2.492GlyMet: 2.492 ± 0.046
2.483GlyAsn: 2.483 ± 0.052
2.198GlyPro: 2.198 ± 0.047
2.987GlyGln: 2.987 ± 0.057
4.453GlyArg: 4.453 ± 0.069
4.323GlySer: 4.323 ± 0.069
4.632GlyThr: 4.632 ± 0.09
6.225GlyVal: 6.225 ± 0.075
1.067GlyTrp: 1.067 ± 0.035
3.152GlyTyr: 3.152 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
1.365HisAla: 1.365 ± 0.035
0.351HisCys: 0.351 ± 0.019
0.916HisAsp: 0.916 ± 0.028
0.988HisGlu: 0.988 ± 0.034
0.82HisPhe: 0.82 ± 0.03
1.566HisGly: 1.566 ± 0.042
0.426HisHis: 0.426 ± 0.023
1.252HisIle: 1.252 ± 0.038
0.776HisLys: 0.776 ± 0.03
1.74HisLeu: 1.74 ± 0.037
0.549HisMet: 0.549 ± 0.021
0.611HisAsn: 0.611 ± 0.021
1.158HisPro: 1.158 ± 0.035
0.67HisGln: 0.67 ± 0.026
1.118HisArg: 1.118 ± 0.034
0.906HisSer: 0.906 ± 0.026
1.195HisThr: 1.195 ± 0.034
1.106HisVal: 1.106 ± 0.035
0.237HisTrp: 0.237 ± 0.016
0.718HisTyr: 0.718 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
4.624IleAla: 4.624 ± 0.065
0.934IleCys: 0.934 ± 0.028
2.985IleAsp: 2.985 ± 0.057
2.776IleGlu: 2.776 ± 0.06
1.968IlePhe: 1.968 ± 0.047
3.876IleGly: 3.876 ± 0.068
1.14IleHis: 1.14 ± 0.039
2.849IleIle: 2.849 ± 0.063
2.012IleLys: 2.012 ± 0.049
5.441IleLeu: 5.441 ± 0.072
1.202IleMet: 1.202 ± 0.036
1.73IleAsn: 1.73 ± 0.042
2.845IlePro: 2.845 ± 0.055
2.193IleGln: 2.193 ± 0.046
3.206IleArg: 3.206 ± 0.053
3.382IleSer: 3.382 ± 0.051
3.345IleThr: 3.345 ± 0.062
3.549IleVal: 3.549 ± 0.066
0.521IleTrp: 0.521 ± 0.021
1.818IleTyr: 1.818 ± 0.036
0.0IleXaa: 0.0 ± 0.0
Lys
4.335LysAla: 4.335 ± 0.075
0.514LysCys: 0.514 ± 0.021
2.49LysAsp: 2.49 ± 0.06
3.686LysGlu: 3.686 ± 0.067
1.243LysPhe: 1.243 ± 0.035
3.331LysGly: 3.331 ± 0.058
0.771LysHis: 0.771 ± 0.029
2.313LysIle: 2.313 ± 0.05
3.129LysLys: 3.129 ± 0.078
4.416LysLeu: 4.416 ± 0.082
1.288LysMet: 1.288 ± 0.034
1.783LysAsn: 1.783 ± 0.052
1.9LysPro: 1.9 ± 0.05
1.822LysGln: 1.822 ± 0.043
2.766LysArg: 2.766 ± 0.058
2.268LysSer: 2.268 ± 0.046
2.611LysThr: 2.611 ± 0.054
3.09LysVal: 3.09 ± 0.052
0.468LysTrp: 0.468 ± 0.02
1.653LysTyr: 1.653 ± 0.041
0.0LysXaa: 0.0 ± 0.0
Leu
10.035LeuAla: 10.035 ± 0.116
1.99LeuCys: 1.99 ± 0.046
5.913LeuAsp: 5.913 ± 0.072
7.395LeuGlu: 7.395 ± 0.075
3.796LeuPhe: 3.796 ± 0.079
7.276LeuGly: 7.276 ± 0.097
1.776LeuHis: 1.776 ± 0.043
4.628LeuIle: 4.628 ± 0.084
4.278LeuLys: 4.278 ± 0.07
11.094LeuLeu: 11.094 ± 0.147
2.634LeuMet: 2.634 ± 0.053
3.215LeuAsn: 3.215 ± 0.053
5.106LeuPro: 5.106 ± 0.082
3.085LeuGln: 3.085 ± 0.054
6.165LeuArg: 6.165 ± 0.081
6.951LeuSer: 6.951 ± 0.08
6.496LeuThr: 6.496 ± 0.092
6.512LeuVal: 6.512 ± 0.092
1.173LeuTrp: 1.173 ± 0.039
3.282LeuTyr: 3.282 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
2.851MetAla: 2.851 ± 0.047
0.33MetCys: 0.33 ± 0.016
1.847MetAsp: 1.847 ± 0.036
2.312MetGlu: 2.312 ± 0.052
0.747MetPhe: 0.747 ± 0.031
2.198MetGly: 2.198 ± 0.047
0.355MetHis: 0.355 ± 0.014
1.147MetIle: 1.147 ± 0.03
1.624MetLys: 1.624 ± 0.036
2.583MetLeu: 2.583 ± 0.055
0.736MetMet: 0.736 ± 0.032
0.999MetAsn: 0.999 ± 0.034
1.123MetPro: 1.123 ± 0.032
0.822MetGln: 0.822 ± 0.03
1.364MetArg: 1.364 ± 0.034
1.581MetSer: 1.581 ± 0.034
1.643MetThr: 1.643 ± 0.04
1.881MetVal: 1.881 ± 0.046
0.181MetTrp: 0.181 ± 0.012
0.628MetTyr: 0.628 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.858AsnAla: 2.858 ± 0.049
0.454AsnCys: 0.454 ± 0.022
1.461AsnAsp: 1.461 ± 0.037
1.67AsnGlu: 1.67 ± 0.04
1.176AsnPhe: 1.176 ± 0.029
2.925AsnGly: 2.925 ± 0.053
0.612AsnHis: 0.612 ± 0.024
1.975AsnIle: 1.975 ± 0.049
1.29AsnLys: 1.29 ± 0.044
3.259AsnLeu: 3.259 ± 0.046
0.898AsnMet: 0.898 ± 0.029
1.051AsnAsn: 1.051 ± 0.033
1.909AsnPro: 1.909 ± 0.042
1.31AsnGln: 1.31 ± 0.036
1.965AsnArg: 1.965 ± 0.045
1.635AsnSer: 1.635 ± 0.037
1.863AsnThr: 1.863 ± 0.05
2.112AsnVal: 2.112 ± 0.046
0.384AsnTrp: 0.384 ± 0.017
1.286AsnTyr: 1.286 ± 0.035
0.0AsnXaa: 0.0 ± 0.0
Pro
4.519ProAla: 4.519 ± 0.075
0.592ProCys: 0.592 ± 0.023
3.006ProAsp: 3.006 ± 0.057
4.163ProGlu: 4.163 ± 0.071
1.627ProPhe: 1.627 ± 0.043
3.409ProGly: 3.409 ± 0.065
0.817ProHis: 0.817 ± 0.028
1.983ProIle: 1.983 ± 0.045
1.759ProLys: 1.759 ± 0.048
3.845ProLeu: 3.845 ± 0.066
1.159ProMet: 1.159 ± 0.035
1.327ProAsn: 1.327 ± 0.038
1.785ProPro: 1.785 ± 0.052
1.668ProGln: 1.668 ± 0.045
1.987ProArg: 1.987 ± 0.047
2.183ProSer: 2.183 ± 0.051
2.242ProThr: 2.242 ± 0.062
3.672ProVal: 3.672 ± 0.055
0.534ProTrp: 0.534 ± 0.023
1.463ProTyr: 1.463 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
4.291GlnAla: 4.291 ± 0.07
0.461GlnCys: 0.461 ± 0.021
1.817GlnAsp: 1.817 ± 0.04
3.0GlnGlu: 3.0 ± 0.059
1.283GlnPhe: 1.283 ± 0.036
2.707GlnGly: 2.707 ± 0.052
0.611GlnHis: 0.611 ± 0.027
2.028GlnIle: 2.028 ± 0.045
2.108GlnLys: 2.108 ± 0.044
3.857GlnLeu: 3.857 ± 0.057
1.153GlnMet: 1.153 ± 0.033
1.402GlnAsn: 1.402 ± 0.036
1.609GlnPro: 1.609 ± 0.04
1.682GlnGln: 1.682 ± 0.047
2.42GlnArg: 2.42 ± 0.054
2.022GlnSer: 2.022 ± 0.043
2.085GlnThr: 2.085 ± 0.049
2.956GlnVal: 2.956 ± 0.058
0.481GlnTrp: 0.481 ± 0.021
1.375GlnTyr: 1.375 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
4.793ArgAla: 4.793 ± 0.08
0.92ArgCys: 0.92 ± 0.034
2.998ArgAsp: 2.998 ± 0.058
4.498ArgGlu: 4.498 ± 0.066
2.304ArgPhe: 2.304 ± 0.052
3.634ArgGly: 3.634 ± 0.06
1.085ArgHis: 1.085 ± 0.033
3.005ArgIle: 3.005 ± 0.05
2.975ArgLys: 2.975 ± 0.057
6.193ArgLeu: 6.193 ± 0.083
1.712ArgMet: 1.712 ± 0.041
1.843ArgAsn: 1.843 ± 0.041
2.474ArgPro: 2.474 ± 0.056
2.789ArgGln: 2.789 ± 0.064
4.316ArgArg: 4.316 ± 0.074
2.9ArgSer: 2.9 ± 0.053
3.03ArgThr: 3.03 ± 0.058
3.659ArgVal: 3.659 ± 0.07
0.812ArgTrp: 0.812 ± 0.028
2.306ArgTyr: 2.306 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
5.131SerAla: 5.131 ± 0.076
0.788SerCys: 0.788 ± 0.027
2.884SerAsp: 2.884 ± 0.058
3.021SerGlu: 3.021 ± 0.056
2.295SerPhe: 2.295 ± 0.046
5.223SerGly: 5.223 ± 0.077
1.071SerHis: 1.071 ± 0.029
3.015SerIle: 3.015 ± 0.064
2.181SerLys: 2.181 ± 0.049
5.271SerLeu: 5.271 ± 0.068
1.538SerMet: 1.538 ± 0.04
1.71SerAsn: 1.71 ± 0.042
2.362SerPro: 2.362 ± 0.048
2.183SerGln: 2.183 ± 0.047
3.201SerArg: 3.201 ± 0.056
2.976SerSer: 2.976 ± 0.065
2.78SerThr: 2.78 ± 0.053
3.832SerVal: 3.832 ± 0.069
0.655SerTrp: 0.655 ± 0.024
1.971SerTyr: 1.971 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
5.832ThrAla: 5.832 ± 0.084
0.769ThrCys: 0.769 ± 0.029
3.084ThrAsp: 3.084 ± 0.054
3.231ThrGlu: 3.231 ± 0.059
2.076ThrPhe: 2.076 ± 0.049
5.199ThrGly: 5.199 ± 0.082
0.992ThrHis: 0.992 ± 0.028
3.237ThrIle: 3.237 ± 0.067
1.98ThrLys: 1.98 ± 0.042
5.819ThrLeu: 5.819 ± 0.091
1.448ThrMet: 1.448 ± 0.035
1.599ThrAsn: 1.599 ± 0.044
3.146ThrPro: 3.146 ± 0.069
2.033ThrGln: 2.033 ± 0.043
2.62ThrArg: 2.62 ± 0.039
2.616ThrSer: 2.616 ± 0.058
2.899ThrThr: 2.899 ± 0.061
4.999ThrVal: 4.999 ± 0.088
0.679ThrTrp: 0.679 ± 0.027
1.874ThrTyr: 1.874 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
5.889ValAla: 5.889 ± 0.082
1.359ValCys: 1.359 ± 0.036
4.082ValAsp: 4.082 ± 0.058
5.043ValGlu: 5.043 ± 0.064
2.752ValPhe: 2.752 ± 0.055
4.897ValGly: 4.897 ± 0.068
1.11ValHis: 1.11 ± 0.035
3.781ValIle: 3.781 ± 0.069
3.222ValLys: 3.222 ± 0.059
7.763ValLeu: 7.763 ± 0.099
1.861ValMet: 1.861 ± 0.044
2.397ValAsn: 2.397 ± 0.047
3.127ValPro: 3.127 ± 0.052
2.221ValGln: 2.221 ± 0.039
3.94ValArg: 3.94 ± 0.064
4.49ValSer: 4.49 ± 0.066
4.591ValThr: 4.591 ± 0.095
5.52ValVal: 5.52 ± 0.083
0.814ValTrp: 0.814 ± 0.027
2.355ValTyr: 2.355 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
1.003TrpAla: 1.003 ± 0.032
0.193TrpCys: 0.193 ± 0.013
0.689TrpAsp: 0.689 ± 0.025
0.837TrpGlu: 0.837 ± 0.033
0.455TrpPhe: 0.455 ± 0.022
0.899TrpGly: 0.899 ± 0.029
0.222TrpHis: 0.222 ± 0.013
0.468TrpIle: 0.468 ± 0.022
0.568TrpLys: 0.568 ± 0.023
1.346TrpLeu: 1.346 ± 0.04
0.332TrpMet: 0.332 ± 0.019
0.455TrpAsn: 0.455 ± 0.022
0.405TrpPro: 0.405 ± 0.017
0.518TrpGln: 0.518 ± 0.021
0.722TrpArg: 0.722 ± 0.025
0.669TrpSer: 0.669 ± 0.024
0.584TrpThr: 0.584 ± 0.026
0.768TrpVal: 0.768 ± 0.027
0.161TrpTrp: 0.161 ± 0.013
0.466TrpTyr: 0.466 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.964TyrAla: 2.964 ± 0.057
0.602TyrCys: 0.602 ± 0.025
2.255TyrAsp: 2.255 ± 0.049
2.272TyrGlu: 2.272 ± 0.046
1.385TyrPhe: 1.385 ± 0.034
2.708TyrGly: 2.708 ± 0.053
0.765TyrHis: 0.765 ± 0.027
1.893TyrIle: 1.893 ± 0.042
1.289TyrLys: 1.289 ± 0.036
3.727TyrLeu: 3.727 ± 0.057
0.713TyrMet: 0.713 ± 0.027
1.208TyrAsn: 1.208 ± 0.032
1.419TyrPro: 1.419 ± 0.041
1.581TyrGln: 1.581 ± 0.041
2.204TyrArg: 2.204 ± 0.053
1.84TyrSer: 1.84 ± 0.043
2.273TyrThr: 2.273 ± 0.058
2.252TyrVal: 2.252 ± 0.041
0.383TyrTrp: 0.383 ± 0.017
1.444TyrTyr: 1.444 ± 0.047
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3799 proteins (1118621 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski