Amino acid dipepetide frequency for Streptococcus phage D1811

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.279AlaAla: 3.279 ± 0.95
0.386AlaCys: 0.386 ± 0.23
4.725AlaAsp: 4.725 ± 1.398
4.436AlaGlu: 4.436 ± 0.67
2.025AlaPhe: 2.025 ± 0.578
4.339AlaGly: 4.339 ± 0.863
0.675AlaHis: 0.675 ± 0.234
4.339AlaIle: 4.339 ± 0.787
6.268AlaLys: 6.268 ± 0.848
6.365AlaLeu: 6.365 ± 0.699
1.736AlaMet: 1.736 ± 0.423
5.207AlaAsn: 5.207 ± 0.809
1.446AlaPro: 1.446 ± 0.395
3.086AlaGln: 3.086 ± 0.552
2.122AlaArg: 2.122 ± 0.463
4.05AlaSer: 4.05 ± 0.581
4.436AlaThr: 4.436 ± 0.802
4.339AlaVal: 4.339 ± 0.663
1.254AlaTrp: 1.254 ± 0.312
2.989AlaTyr: 2.989 ± 0.651
0.0AlaXaa: 0.0 ± 0.0
Cys
0.193CysAla: 0.193 ± 0.126
0.0CysCys: 0.0 ± 0.0
0.482CysAsp: 0.482 ± 0.289
0.193CysGlu: 0.193 ± 0.133
0.482CysPhe: 0.482 ± 0.234
0.193CysGly: 0.193 ± 0.151
0.193CysHis: 0.193 ± 0.126
0.096CysIle: 0.096 ± 0.099
0.675CysLys: 0.675 ± 0.315
0.579CysLeu: 0.579 ± 0.278
0.096CysMet: 0.096 ± 0.086
0.289CysAsn: 0.289 ± 0.188
0.289CysPro: 0.289 ± 0.155
0.096CysGln: 0.096 ± 0.104
0.289CysArg: 0.289 ± 0.225
0.482CysSer: 0.482 ± 0.271
0.289CysThr: 0.289 ± 0.178
0.096CysVal: 0.096 ± 0.07
0.193CysTrp: 0.193 ± 0.131
0.096CysTyr: 0.096 ± 0.107
0.0CysXaa: 0.0 ± 0.0
Asp
3.761AspAla: 3.761 ± 0.654
0.289AspCys: 0.289 ± 0.192
4.147AspAsp: 4.147 ± 0.945
4.629AspGlu: 4.629 ± 0.793
3.568AspPhe: 3.568 ± 0.61
6.75AspGly: 6.75 ± 1.056
1.157AspHis: 1.157 ± 0.278
5.786AspIle: 5.786 ± 0.856
4.629AspLys: 4.629 ± 0.586
3.472AspLeu: 3.472 ± 0.807
2.218AspMet: 2.218 ± 0.421
3.182AspAsn: 3.182 ± 0.552
2.218AspPro: 2.218 ± 0.478
1.736AspGln: 1.736 ± 0.404
2.122AspArg: 2.122 ± 0.542
4.147AspSer: 4.147 ± 1.026
4.436AspThr: 4.436 ± 0.799
3.279AspVal: 3.279 ± 0.591
1.254AspTrp: 1.254 ± 0.298
2.7AspTyr: 2.7 ± 0.4
0.0AspXaa: 0.0 ± 0.0
Glu
3.664GluAla: 3.664 ± 0.494
0.096GluCys: 0.096 ± 0.07
3.857GluAsp: 3.857 ± 0.644
4.05GluGlu: 4.05 ± 0.869
2.604GluPhe: 2.604 ± 0.545
3.182GluGly: 3.182 ± 0.568
1.157GluHis: 1.157 ± 0.313
5.882GluIle: 5.882 ± 0.691
3.954GluLys: 3.954 ± 0.674
6.268GluLeu: 6.268 ± 0.962
1.736GluMet: 1.736 ± 0.297
3.761GluAsn: 3.761 ± 0.715
1.832GluPro: 1.832 ± 0.488
3.279GluGln: 3.279 ± 0.647
3.086GluArg: 3.086 ± 0.587
3.664GluSer: 3.664 ± 0.687
3.182GluThr: 3.182 ± 0.606
4.822GluVal: 4.822 ± 0.693
1.061GluTrp: 1.061 ± 0.343
3.182GluTyr: 3.182 ± 0.482
0.0GluXaa: 0.0 ± 0.0
Phe
3.472PheAla: 3.472 ± 0.535
0.193PheCys: 0.193 ± 0.123
3.086PheAsp: 3.086 ± 0.504
2.411PheGlu: 2.411 ± 0.458
1.736PhePhe: 1.736 ± 0.398
2.989PheGly: 2.989 ± 0.695
0.579PheHis: 0.579 ± 0.145
2.604PheIle: 2.604 ± 0.529
4.05PheLys: 4.05 ± 0.64
2.7PheLeu: 2.7 ± 0.568
0.289PheMet: 0.289 ± 0.144
3.664PheAsn: 3.664 ± 0.72
0.386PhePro: 0.386 ± 0.203
0.964PheGln: 0.964 ± 0.228
1.736PheArg: 1.736 ± 0.331
3.568PheSer: 3.568 ± 0.655
3.182PheThr: 3.182 ± 0.599
2.797PheVal: 2.797 ± 0.429
0.482PheTrp: 0.482 ± 0.204
2.122PheTyr: 2.122 ± 0.558
0.0PheXaa: 0.0 ± 0.0
Gly
3.664GlyAla: 3.664 ± 0.773
0.579GlyCys: 0.579 ± 0.285
3.954GlyAsp: 3.954 ± 0.521
3.664GlyGlu: 3.664 ± 0.657
3.472GlyPhe: 3.472 ± 0.442
4.822GlyGly: 4.822 ± 0.792
0.675GlyHis: 0.675 ± 0.224
5.786GlyIle: 5.786 ± 0.753
6.75GlyLys: 6.75 ± 0.786
5.304GlyLeu: 5.304 ± 0.584
2.314GlyMet: 2.314 ± 0.457
4.532GlyAsn: 4.532 ± 0.892
1.157GlyPro: 1.157 ± 0.707
2.893GlyGln: 2.893 ± 0.68
3.086GlyArg: 3.086 ± 0.572
5.014GlySer: 5.014 ± 0.827
4.822GlyThr: 4.822 ± 0.773
3.472GlyVal: 3.472 ± 0.659
1.254GlyTrp: 1.254 ± 0.337
2.604GlyTyr: 2.604 ± 0.551
0.0GlyXaa: 0.0 ± 0.0
His
0.482HisAla: 0.482 ± 0.326
0.0HisCys: 0.0 ± 0.0
0.868HisAsp: 0.868 ± 0.283
0.675HisGlu: 0.675 ± 0.259
0.675HisPhe: 0.675 ± 0.245
0.579HisGly: 0.579 ± 0.196
0.482HisHis: 0.482 ± 0.134
1.157HisIle: 1.157 ± 0.279
1.254HisLys: 1.254 ± 0.279
1.061HisLeu: 1.061 ± 0.267
0.289HisMet: 0.289 ± 0.142
0.675HisAsn: 0.675 ± 0.294
0.579HisPro: 0.579 ± 0.153
0.482HisGln: 0.482 ± 0.222
0.771HisArg: 0.771 ± 0.222
0.675HisSer: 0.675 ± 0.235
0.868HisThr: 0.868 ± 0.282
1.254HisVal: 1.254 ± 0.314
0.096HisTrp: 0.096 ± 0.096
1.157HisTyr: 1.157 ± 0.328
0.0HisXaa: 0.0 ± 0.0
Ile
5.593IleAla: 5.593 ± 0.821
0.289IleCys: 0.289 ± 0.22
6.075IleAsp: 6.075 ± 0.782
3.857IleGlu: 3.857 ± 0.669
1.736IlePhe: 1.736 ± 0.345
5.111IleGly: 5.111 ± 0.606
0.675IleHis: 0.675 ± 0.29
2.604IleIle: 2.604 ± 0.429
6.943IleLys: 6.943 ± 0.635
4.339IleLeu: 4.339 ± 0.877
2.025IleMet: 2.025 ± 0.525
3.664IleAsn: 3.664 ± 0.565
2.989IlePro: 2.989 ± 0.512
3.279IleGln: 3.279 ± 0.628
2.7IleArg: 2.7 ± 0.463
3.761IleSer: 3.761 ± 0.409
3.472IleThr: 3.472 ± 0.502
3.375IleVal: 3.375 ± 0.626
1.157IleTrp: 1.157 ± 0.299
2.122IleTyr: 2.122 ± 0.486
0.0IleXaa: 0.0 ± 0.0
Lys
6.075LysAla: 6.075 ± 0.746
0.193LysCys: 0.193 ± 0.134
4.147LysAsp: 4.147 ± 0.692
6.847LysGlu: 6.847 ± 0.859
3.664LysPhe: 3.664 ± 0.981
5.786LysGly: 5.786 ± 0.743
1.446LysHis: 1.446 ± 0.569
5.4LysIle: 5.4 ± 0.629
6.268LysLys: 6.268 ± 1.197
5.786LysLeu: 5.786 ± 0.713
1.639LysMet: 1.639 ± 0.456
5.497LysAsn: 5.497 ± 0.818
2.604LysPro: 2.604 ± 0.437
3.954LysGln: 3.954 ± 0.479
3.472LysArg: 3.472 ± 0.565
4.243LysSer: 4.243 ± 0.403
6.365LysThr: 6.365 ± 1.001
4.243LysVal: 4.243 ± 0.589
1.254LysTrp: 1.254 ± 0.274
2.893LysTyr: 2.893 ± 0.415
0.0LysXaa: 0.0 ± 0.0
Leu
6.847LeuAla: 6.847 ± 0.531
0.579LeuCys: 0.579 ± 0.228
5.689LeuAsp: 5.689 ± 0.838
6.268LeuGlu: 6.268 ± 1.339
2.797LeuPhe: 2.797 ± 0.401
5.111LeuGly: 5.111 ± 0.995
0.771LeuHis: 0.771 ± 0.241
3.568LeuIle: 3.568 ± 0.588
6.268LeuLys: 6.268 ± 0.715
5.111LeuLeu: 5.111 ± 0.672
2.7LeuMet: 2.7 ± 0.503
4.725LeuAsn: 4.725 ± 0.624
2.989LeuPro: 2.989 ± 0.501
2.893LeuGln: 2.893 ± 0.531
3.182LeuArg: 3.182 ± 0.706
4.147LeuSer: 4.147 ± 0.802
5.979LeuThr: 5.979 ± 1.017
3.857LeuVal: 3.857 ± 0.512
1.061LeuTrp: 1.061 ± 0.232
1.543LeuTyr: 1.543 ± 0.437
0.0LeuXaa: 0.0 ± 0.0
Met
1.736MetAla: 1.736 ± 0.353
0.0MetCys: 0.0 ± 0.0
0.868MetAsp: 0.868 ± 0.349
1.639MetGlu: 1.639 ± 0.397
1.35MetPhe: 1.35 ± 0.322
0.771MetGly: 0.771 ± 0.247
0.386MetHis: 0.386 ± 0.241
1.832MetIle: 1.832 ± 0.355
2.893MetLys: 2.893 ± 0.569
2.025MetLeu: 2.025 ± 0.363
0.482MetMet: 0.482 ± 0.242
0.868MetAsn: 0.868 ± 0.291
1.157MetPro: 1.157 ± 0.253
0.482MetGln: 0.482 ± 0.154
0.675MetArg: 0.675 ± 0.238
2.122MetSer: 2.122 ± 0.429
1.736MetThr: 1.736 ± 0.444
1.929MetVal: 1.929 ± 0.508
0.096MetTrp: 0.096 ± 0.07
0.579MetTyr: 0.579 ± 0.178
0.0MetXaa: 0.0 ± 0.0
Asn
4.629AsnAla: 4.629 ± 0.984
0.289AsnCys: 0.289 ± 0.157
3.472AsnAsp: 3.472 ± 0.516
3.954AsnGlu: 3.954 ± 0.739
2.989AsnPhe: 2.989 ± 0.382
6.75AsnGly: 6.75 ± 1.226
1.061AsnHis: 1.061 ± 0.268
4.05AsnIle: 4.05 ± 0.56
4.147AsnLys: 4.147 ± 0.456
5.304AsnLeu: 5.304 ± 0.584
0.868AsnMet: 0.868 ± 0.238
4.822AsnAsn: 4.822 ± 0.718
3.182AsnPro: 3.182 ± 0.534
2.893AsnGln: 2.893 ± 0.557
2.507AsnArg: 2.507 ± 0.675
3.568AsnSer: 3.568 ± 0.559
3.086AsnThr: 3.086 ± 0.565
3.182AsnVal: 3.182 ± 0.496
1.157AsnTrp: 1.157 ± 0.319
2.604AsnTyr: 2.604 ± 0.426
0.0AsnXaa: 0.0 ± 0.0
Pro
1.639ProAla: 1.639 ± 0.427
0.0ProCys: 0.0 ± 0.0
1.446ProAsp: 1.446 ± 0.457
2.411ProGlu: 2.411 ± 0.422
1.543ProPhe: 1.543 ± 0.365
1.832ProGly: 1.832 ± 0.74
0.386ProHis: 0.386 ± 0.177
1.832ProIle: 1.832 ± 0.317
3.568ProLys: 3.568 ± 0.717
2.122ProLeu: 2.122 ± 0.347
0.193ProMet: 0.193 ± 0.208
3.086ProAsn: 3.086 ± 0.571
0.579ProPro: 0.579 ± 0.26
1.543ProGln: 1.543 ± 0.384
0.579ProArg: 0.579 ± 0.287
2.507ProSer: 2.507 ± 0.437
2.411ProThr: 2.411 ± 0.418
1.254ProVal: 1.254 ± 0.387
0.579ProTrp: 0.579 ± 0.196
1.061ProTyr: 1.061 ± 0.363
0.0ProXaa: 0.0 ± 0.0
Gln
4.147GlnAla: 4.147 ± 0.681
0.096GlnCys: 0.096 ± 0.099
2.122GlnAsp: 2.122 ± 0.569
2.893GlnGlu: 2.893 ± 0.485
1.639GlnPhe: 1.639 ± 0.403
3.568GlnGly: 3.568 ± 0.82
0.289GlnHis: 0.289 ± 0.153
2.604GlnIle: 2.604 ± 0.623
2.893GlnLys: 2.893 ± 0.567
2.989GlnLeu: 2.989 ± 0.491
1.446GlnMet: 1.446 ± 0.36
2.411GlnAsn: 2.411 ± 0.425
0.868GlnPro: 0.868 ± 0.347
3.182GlnGln: 3.182 ± 0.669
2.122GlnArg: 2.122 ± 0.448
2.893GlnSer: 2.893 ± 0.481
2.797GlnThr: 2.797 ± 0.47
2.122GlnVal: 2.122 ± 0.436
0.579GlnTrp: 0.579 ± 0.203
2.218GlnTyr: 2.218 ± 0.443
0.0GlnXaa: 0.0 ± 0.0
Arg
2.122ArgAla: 2.122 ± 0.467
0.096ArgCys: 0.096 ± 0.104
2.218ArgAsp: 2.218 ± 0.549
2.218ArgGlu: 2.218 ± 0.476
2.604ArgPhe: 2.604 ± 0.535
2.604ArgGly: 2.604 ± 0.537
0.675ArgHis: 0.675 ± 0.233
2.507ArgIle: 2.507 ± 0.497
3.182ArgLys: 3.182 ± 0.588
4.147ArgLeu: 4.147 ± 0.716
0.771ArgMet: 0.771 ± 0.304
2.604ArgAsn: 2.604 ± 0.336
0.868ArgPro: 0.868 ± 0.246
2.218ArgGln: 2.218 ± 0.481
0.964ArgArg: 0.964 ± 0.273
1.639ArgSer: 1.639 ± 0.431
2.604ArgThr: 2.604 ± 0.73
2.989ArgVal: 2.989 ± 0.535
0.868ArgTrp: 0.868 ± 0.188
2.218ArgTyr: 2.218 ± 0.52
0.0ArgXaa: 0.0 ± 0.0
Ser
3.761SerAla: 3.761 ± 0.644
0.579SerCys: 0.579 ± 0.233
4.918SerAsp: 4.918 ± 1.034
4.147SerGlu: 4.147 ± 0.602
2.989SerPhe: 2.989 ± 0.498
5.014SerGly: 5.014 ± 0.611
0.386SerHis: 0.386 ± 0.167
3.857SerIle: 3.857 ± 0.44
4.243SerLys: 4.243 ± 0.822
5.111SerLeu: 5.111 ± 0.557
2.025SerMet: 2.025 ± 0.426
4.147SerAsn: 4.147 ± 0.45
1.736SerPro: 1.736 ± 0.395
2.893SerGln: 2.893 ± 0.465
2.7SerArg: 2.7 ± 0.63
3.857SerSer: 3.857 ± 0.588
3.954SerThr: 3.954 ± 0.491
4.436SerVal: 4.436 ± 0.516
0.964SerTrp: 0.964 ± 0.348
1.929SerTyr: 1.929 ± 0.433
0.0SerXaa: 0.0 ± 0.0
Thr
4.918ThrAla: 4.918 ± 0.645
0.386ThrCys: 0.386 ± 0.176
4.918ThrAsp: 4.918 ± 0.728
3.182ThrGlu: 3.182 ± 0.433
2.507ThrPhe: 2.507 ± 0.597
3.857ThrGly: 3.857 ± 0.514
1.157ThrHis: 1.157 ± 0.255
4.339ThrIle: 4.339 ± 0.793
4.436ThrLys: 4.436 ± 0.717
5.689ThrLeu: 5.689 ± 0.815
0.771ThrMet: 0.771 ± 0.216
4.436ThrAsn: 4.436 ± 0.409
1.929ThrPro: 1.929 ± 0.695
3.086ThrGln: 3.086 ± 0.764
2.314ThrArg: 2.314 ± 0.458
3.761ThrSer: 3.761 ± 0.655
3.664ThrThr: 3.664 ± 0.737
4.339ThrVal: 4.339 ± 0.504
1.446ThrTrp: 1.446 ± 0.395
3.761ThrTyr: 3.761 ± 0.694
0.0ThrXaa: 0.0 ± 0.0
Val
4.436ValAla: 4.436 ± 0.782
0.386ValCys: 0.386 ± 0.191
4.629ValAsp: 4.629 ± 0.447
3.664ValGlu: 3.664 ± 0.597
2.604ValPhe: 2.604 ± 0.44
4.05ValGly: 4.05 ± 0.602
0.579ValHis: 0.579 ± 0.19
3.761ValIle: 3.761 ± 0.665
5.979ValLys: 5.979 ± 0.681
3.086ValLeu: 3.086 ± 0.544
1.061ValMet: 1.061 ± 0.389
3.761ValAsn: 3.761 ± 0.701
1.929ValPro: 1.929 ± 0.428
1.736ValGln: 1.736 ± 0.441
1.832ValArg: 1.832 ± 0.462
5.014ValSer: 5.014 ± 0.777
4.147ValThr: 4.147 ± 0.556
2.893ValVal: 2.893 ± 0.508
1.157ValTrp: 1.157 ± 0.314
1.929ValTyr: 1.929 ± 0.388
0.0ValXaa: 0.0 ± 0.0
Trp
0.675TrpAla: 0.675 ± 0.231
0.096TrpCys: 0.096 ± 0.095
1.35TrpAsp: 1.35 ± 0.445
0.868TrpGlu: 0.868 ± 0.2
0.675TrpPhe: 0.675 ± 0.244
0.386TrpGly: 0.386 ± 0.162
0.482TrpHis: 0.482 ± 0.21
0.675TrpIle: 0.675 ± 0.201
0.964TrpLys: 0.964 ± 0.218
1.832TrpLeu: 1.832 ± 0.367
0.096TrpMet: 0.096 ± 0.094
1.254TrpAsn: 1.254 ± 0.399
0.289TrpPro: 0.289 ± 0.123
0.771TrpGln: 0.771 ± 0.31
1.157TrpArg: 1.157 ± 0.268
1.639TrpSer: 1.639 ± 0.648
1.157TrpThr: 1.157 ± 0.372
1.157TrpVal: 1.157 ± 0.265
0.289TrpTrp: 0.289 ± 0.137
0.386TrpTyr: 0.386 ± 0.223
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.411TyrAla: 2.411 ± 0.389
0.771TyrCys: 0.771 ± 0.33
2.507TyrAsp: 2.507 ± 0.42
2.314TyrGlu: 2.314 ± 0.578
1.35TyrPhe: 1.35 ± 0.294
2.122TyrGly: 2.122 ± 0.566
0.868TyrHis: 0.868 ± 0.361
3.086TyrIle: 3.086 ± 0.556
2.411TyrLys: 2.411 ± 0.479
2.797TyrLeu: 2.797 ± 0.426
0.771TyrMet: 0.771 ± 0.36
1.929TyrAsn: 1.929 ± 0.373
1.543TyrPro: 1.543 ± 0.402
2.411TyrGln: 2.411 ± 0.415
2.7TyrArg: 2.7 ± 0.532
2.893TyrSer: 2.893 ± 0.667
2.314TyrThr: 2.314 ± 0.742
2.797TyrVal: 2.797 ± 0.447
0.0TyrTrp: 0.0 ± 0.0
2.797TyrTyr: 2.797 ± 0.645
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 40 proteins (10371 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski