Amino acid dipepetide frequency for Monosporascus sp. CRB-8-3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.748AlaAla: 10.748 ± 0.068	1.072AlaCys: 1.072 ± 0.015	4.82AlaAsp: 4.82 ± 0.032	5.797AlaGlu: 5.797 ± 0.044	3.166AlaPhe: 3.166 ± 0.025	6.647AlaGly: 6.647 ± 0.043	1.866AlaHis: 1.866 ± 0.021	4.094AlaIle: 4.094 ± 0.03	4.119AlaLys: 4.119 ± 0.034	8.018AlaLeu: 8.018 ± 0.049	2.011AlaMet: 2.011 ± 0.018	3.032AlaAsn: 3.032 ± 0.024	5.135AlaPro: 5.135 ± 0.044	3.414AlaGln: 3.414 ± 0.029	5.689AlaArg: 5.689 ± 0.038	7.311AlaSer: 7.311 ± 0.04	5.518AlaThr: 5.518 ± 0.035	5.909AlaVal: 5.909 ± 0.038	1.204AlaTrp: 1.204 ± 0.017	2.272AlaTyr: 2.272 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	0.966CysAla: 0.966 ± 0.014	0.231CysCys: 0.231 ± 0.007	0.662CysAsp: 0.662 ± 0.012	0.615CysGlu: 0.615 ± 0.012	0.493CysPhe: 0.493 ± 0.009	0.964CysGly: 0.964 ± 0.015	0.304CysHis: 0.304 ± 0.008	0.644CysIle: 0.644 ± 0.011	0.455CysLys: 0.455 ± 0.011	1.162CysLeu: 1.162 ± 0.017	0.245CysMet: 0.245 ± 0.007	0.41CysAsn: 0.41 ± 0.009	0.632CysPro: 0.632 ± 0.011	0.398CysGln: 0.398 ± 0.008	0.781CysArg: 0.781 ± 0.014	0.807CysSer: 0.807 ± 0.012	0.634CysThr: 0.634 ± 0.012	0.788CysVal: 0.788 ± 0.013	0.195CysTrp: 0.195 ± 0.007	0.349CysTyr: 0.349 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.253AspAla: 5.253 ± 0.03	0.601AspCys: 0.601 ± 0.009	4.65AspAsp: 4.65 ± 0.043	4.69AspGlu: 4.69 ± 0.037	2.215AspPhe: 2.215 ± 0.02	4.642AspGly: 4.642 ± 0.036	1.238AspHis: 1.238 ± 0.015	2.979AspIle: 2.979 ± 0.027	2.324AspLys: 2.324 ± 0.025	5.067AspLeu: 5.067 ± 0.033	1.268AspMet: 1.268 ± 0.016	1.917AspAsn: 1.917 ± 0.019	3.619AspPro: 3.619 ± 0.026	1.805AspGln: 1.805 ± 0.017	3.363AspArg: 3.363 ± 0.032	4.033AspSer: 4.033 ± 0.035	2.896AspThr: 2.896 ± 0.023	3.938AspVal: 3.938 ± 0.026	0.938AspTrp: 0.938 ± 0.014	1.667AspTyr: 1.667 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.979GluAla: 5.979 ± 0.049	0.651GluCys: 0.651 ± 0.011	4.437GluAsp: 4.437 ± 0.039	5.52GluGlu: 5.52 ± 0.054	1.989GluPhe: 1.989 ± 0.018	4.113GluGly: 4.113 ± 0.031	1.39GluHis: 1.39 ± 0.017	2.932GluIle: 2.932 ± 0.026	3.539GluLys: 3.539 ± 0.037	5.426GluLeu: 5.426 ± 0.036	1.418GluMet: 1.418 ± 0.017	2.286GluAsn: 2.286 ± 0.02	3.037GluPro: 3.037 ± 0.035	2.461GluGln: 2.461 ± 0.023	4.285GluArg: 4.285 ± 0.034	4.178GluSer: 4.178 ± 0.034	3.499GluThr: 3.499 ± 0.026	3.732GluVal: 3.732 ± 0.03	0.914GluTrp: 0.914 ± 0.014	1.683GluTyr: 1.683 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	3.067PheAla: 3.067 ± 0.025	0.516PheCys: 0.516 ± 0.01	2.245PheAsp: 2.245 ± 0.022	2.17PheGlu: 2.17 ± 0.019	1.485PhePhe: 1.485 ± 0.019	2.883PheGly: 2.883 ± 0.026	0.831PheHis: 0.831 ± 0.012	1.592PheIle: 1.592 ± 0.017	1.438PheLys: 1.438 ± 0.016	3.239PheLeu: 3.239 ± 0.031	0.752PheMet: 0.752 ± 0.011	1.298PheAsn: 1.298 ± 0.014	1.874PhePro: 1.874 ± 0.019	1.272PheGln: 1.272 ± 0.015	2.111PheArg: 2.111 ± 0.019	2.709PheSer: 2.709 ± 0.026	1.979PheThr: 1.979 ± 0.021	2.356PheVal: 2.356 ± 0.022	0.621PheTrp: 0.621 ± 0.011	1.08PheTyr: 1.08 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	6.208GlyAla: 6.208 ± 0.043	0.881GlyCys: 0.881 ± 0.016	4.259GlyAsp: 4.259 ± 0.033	4.0GlyGlu: 4.0 ± 0.026	2.8GlyPhe: 2.8 ± 0.026	6.947GlyGly: 6.947 ± 0.062	1.794GlyHis: 1.794 ± 0.021	3.455GlyIle: 3.455 ± 0.029	3.412GlyLys: 3.412 ± 0.029	6.196GlyLeu: 6.196 ± 0.037	1.58GlyMet: 1.58 ± 0.017	2.675GlyAsn: 2.675 ± 0.024	3.779GlyPro: 3.779 ± 0.034	2.563GlyGln: 2.563 ± 0.024	4.821GlyArg: 4.821 ± 0.032	5.935GlySer: 5.935 ± 0.037	4.166GlyThr: 4.166 ± 0.031	4.642GlyVal: 4.642 ± 0.036	1.211GlyTrp: 1.211 ± 0.015	2.196GlyTyr: 2.196 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.884HisAla: 1.884 ± 0.019	0.319HisCys: 0.319 ± 0.007	1.299HisAsp: 1.299 ± 0.015	1.351HisGlu: 1.351 ± 0.017	0.867HisPhe: 0.867 ± 0.011	1.803HisGly: 1.803 ± 0.021	0.89HisHis: 0.89 ± 0.016	1.132HisIle: 1.132 ± 0.014	0.86HisLys: 0.86 ± 0.013	2.098HisLeu: 2.098 ± 0.02	0.494HisMet: 0.494 ± 0.008	0.807HisAsn: 0.807 ± 0.013	1.646HisPro: 1.646 ± 0.02	0.979HisGln: 0.979 ± 0.015	1.575HisArg: 1.575 ± 0.019	1.663HisSer: 1.663 ± 0.02	1.167HisThr: 1.167 ± 0.015	1.451HisVal: 1.451 ± 0.017	0.344HisTrp: 0.344 ± 0.008	0.701HisTyr: 0.701 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	3.977IleAla: 3.977 ± 0.026	0.674IleCys: 0.674 ± 0.012	2.756IleAsp: 2.756 ± 0.022	2.744IleGlu: 2.744 ± 0.023	1.772IlePhe: 1.772 ± 0.021	3.003IleGly: 3.003 ± 0.028	1.083IleHis: 1.083 ± 0.014	2.222IleIle: 2.222 ± 0.023	1.98IleLys: 1.98 ± 0.022	4.159IleLeu: 4.159 ± 0.032	0.937IleMet: 0.937 ± 0.012	1.624IleAsn: 1.624 ± 0.018	2.853IlePro: 2.853 ± 0.022	1.719IleGln: 1.719 ± 0.018	2.875IleArg: 2.875 ± 0.023	3.374IleSer: 3.374 ± 0.028	2.622IleThr: 2.622 ± 0.022	2.995IleVal: 2.995 ± 0.024	0.692IleTrp: 0.692 ± 0.011	1.29IleTyr: 1.29 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.271LysAla: 4.271 ± 0.035	0.43LysCys: 0.43 ± 0.01	2.683LysAsp: 2.683 ± 0.028	3.242LysGlu: 3.242 ± 0.036	1.354LysPhe: 1.354 ± 0.016	2.983LysGly: 2.983 ± 0.03	1.039LysHis: 1.039 ± 0.015	2.01LysIle: 2.01 ± 0.019	3.082LysLys: 3.082 ± 0.044	3.922LysLeu: 3.922 ± 0.03	0.94LysMet: 0.94 ± 0.014	1.577LysAsn: 1.577 ± 0.019	2.75LysPro: 2.75 ± 0.029	1.758LysGln: 1.758 ± 0.018	3.341LysArg: 3.341 ± 0.03	3.198LysSer: 3.198 ± 0.028	2.65LysThr: 2.65 ± 0.024	2.712LysVal: 2.712 ± 0.024	0.626LysTrp: 0.626 ± 0.011	1.273LysTyr: 1.273 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	8.154LeuAla: 8.154 ± 0.046	1.148LeuCys: 1.148 ± 0.017	5.21LeuAsp: 5.21 ± 0.035	5.631LeuGlu: 5.631 ± 0.041	3.096LeuPhe: 3.096 ± 0.025	6.129LeuGly: 6.129 ± 0.037	2.066LeuHis: 2.066 ± 0.023	3.571LeuIle: 3.571 ± 0.033	4.003LeuLys: 4.003 ± 0.031	8.205LeuLeu: 8.205 ± 0.058	1.752LeuMet: 1.752 ± 0.018	2.938LeuAsn: 2.938 ± 0.025	5.406LeuPro: 5.406 ± 0.035	3.565LeuGln: 3.565 ± 0.028	6.211LeuArg: 6.211 ± 0.038	6.809LeuSer: 6.809 ± 0.045	4.552LeuThr: 4.552 ± 0.029	5.474LeuVal: 5.474 ± 0.038	1.231LeuTrp: 1.231 ± 0.016	2.25LeuTyr: 2.25 ± 0.02	0.0LeuXaa: 0.0 ± 0.0
Met	2.289MetAla: 2.289 ± 0.016	0.233MetCys: 0.233 ± 0.006	1.234MetAsp: 1.234 ± 0.013	1.239MetGlu: 1.239 ± 0.015	0.701MetPhe: 0.701 ± 0.012	1.456MetGly: 1.456 ± 0.018	0.465MetHis: 0.465 ± 0.009	0.895MetIle: 0.895 ± 0.014	0.958MetLys: 0.958 ± 0.014	1.782MetLeu: 1.782 ± 0.02	0.547MetMet: 0.547 ± 0.01	0.743MetAsn: 0.743 ± 0.012	1.302MetPro: 1.302 ± 0.016	0.803MetGln: 0.803 ± 0.015	1.367MetArg: 1.367 ± 0.015	1.704MetSer: 1.704 ± 0.017	1.277MetThr: 1.277 ± 0.016	1.295MetVal: 1.295 ± 0.017	0.266MetTrp: 0.266 ± 0.007	0.507MetTyr: 0.507 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.142AsnAla: 3.142 ± 0.025	0.429AsnCys: 0.429 ± 0.009	1.895AsnAsp: 1.895 ± 0.02	1.959AsnGlu: 1.959 ± 0.021	1.286AsnPhe: 1.286 ± 0.016	3.094AsnGly: 3.094 ± 0.029	0.825AsnHis: 0.825 ± 0.013	1.843AsnIle: 1.843 ± 0.02	1.443AsnLys: 1.443 ± 0.018	3.076AsnLeu: 3.076 ± 0.024	0.792AsnMet: 0.792 ± 0.012	1.468AsnAsn: 1.468 ± 0.021	2.457AsnPro: 2.457 ± 0.024	1.231AsnGln: 1.231 ± 0.016	2.012AsnArg: 2.012 ± 0.022	2.573AsnSer: 2.573 ± 0.024	1.999AsnThr: 1.999 ± 0.021	2.198AsnVal: 2.198 ± 0.02	0.538AsnTrp: 0.538 ± 0.01	1.0AsnTyr: 1.0 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	5.658ProAla: 5.658 ± 0.044	0.514ProCys: 0.514 ± 0.01	3.496ProAsp: 3.496 ± 0.023	4.133ProGlu: 4.133 ± 0.03	1.978ProPhe: 1.978 ± 0.019	4.519ProGly: 4.519 ± 0.038	1.323ProHis: 1.323 ± 0.016	2.317ProIle: 2.317 ± 0.02	2.617ProLys: 2.617 ± 0.025	4.756ProLeu: 4.756 ± 0.033	1.08ProMet: 1.08 ± 0.015	2.182ProAsn: 2.182 ± 0.022	5.598ProPro: 5.598 ± 0.07	2.456ProGln: 2.456 ± 0.027	3.813ProArg: 3.813 ± 0.031	5.805ProSer: 5.805 ± 0.039	3.977ProThr: 3.977 ± 0.034	3.63ProVal: 3.63 ± 0.025	0.78ProTrp: 0.78 ± 0.014	1.537ProTyr: 1.537 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.471GlnAla: 3.471 ± 0.03	0.405GlnCys: 0.405 ± 0.01	2.009GlnAsp: 2.009 ± 0.019	2.343GlnGlu: 2.343 ± 0.021	1.21GlnPhe: 1.21 ± 0.017	2.42GlnGly: 2.42 ± 0.02	1.052GlnHis: 1.052 ± 0.013	1.689GlnIle: 1.689 ± 0.019	1.836GlnLys: 1.836 ± 0.021	3.325GlnLeu: 3.325 ± 0.028	0.811GlnMet: 0.811 ± 0.014	1.378GlnAsn: 1.378 ± 0.017	2.594GlnPro: 2.594 ± 0.032	2.496GlnGln: 2.496 ± 0.046	2.672GlnArg: 2.672 ± 0.022	2.827GlnSer: 2.827 ± 0.025	2.122GlnThr: 2.122 ± 0.019	2.103GlnVal: 2.103 ± 0.02	0.551GlnTrp: 0.551 ± 0.011	1.099GlnTyr: 1.099 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	5.393ArgAla: 5.393 ± 0.035	0.736ArgCys: 0.736 ± 0.014	3.927ArgAsp: 3.927 ± 0.035	4.212ArgGlu: 4.212 ± 0.035	2.221ArgPhe: 2.221 ± 0.023	4.422ArgGly: 4.422 ± 0.035	1.729ArgHis: 1.729 ± 0.017	2.911ArgIle: 2.911 ± 0.025	3.384ArgLys: 3.384 ± 0.029	5.879ArgLeu: 5.879 ± 0.041	1.398ArgMet: 1.398 ± 0.016	2.387ArgAsn: 2.387 ± 0.022	3.906ArgPro: 3.906 ± 0.034	2.718ArgGln: 2.718 ± 0.028	5.868ArgArg: 5.868 ± 0.045	4.811ArgSer: 4.811 ± 0.03	3.428ArgThr: 3.428 ± 0.024	3.686ArgVal: 3.686 ± 0.028	1.018ArgTrp: 1.018 ± 0.015	1.755ArgTyr: 1.755 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.708SerAla: 6.708 ± 0.04	0.798SerCys: 0.798 ± 0.013	4.102SerAsp: 4.102 ± 0.027	4.147SerGlu: 4.147 ± 0.032	2.748SerPhe: 2.748 ± 0.023	5.817SerGly: 5.817 ± 0.037	1.785SerHis: 1.785 ± 0.018	3.469SerIle: 3.469 ± 0.025	3.366SerLys: 3.366 ± 0.031	6.638SerLeu: 6.638 ± 0.038	1.597SerMet: 1.597 ± 0.02	2.751SerAsn: 2.751 ± 0.021	5.428SerPro: 5.428 ± 0.048	3.013SerGln: 3.013 ± 0.028	5.154SerArg: 5.154 ± 0.04	8.169SerSer: 8.169 ± 0.056	5.034SerThr: 5.034 ± 0.036	4.397SerVal: 4.397 ± 0.028	1.106SerTrp: 1.106 ± 0.014	1.982SerTyr: 1.982 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.47ThrAla: 5.47 ± 0.037	0.708ThrCys: 0.708 ± 0.013	2.793ThrAsp: 2.793 ± 0.024	3.146ThrGlu: 3.146 ± 0.028	2.072ThrPhe: 2.072 ± 0.021	4.278ThrGly: 4.278 ± 0.032	1.176ThrHis: 1.176 ± 0.013	2.789ThrIle: 2.789 ± 0.026	2.424ThrLys: 2.424 ± 0.026	4.881ThrLeu: 4.881 ± 0.033	1.167ThrMet: 1.167 ± 0.016	1.941ThrAsn: 1.941 ± 0.021	4.309ThrPro: 4.309 ± 0.035	1.937ThrGln: 1.937 ± 0.019	3.284ThrArg: 3.284 ± 0.023	4.976ThrSer: 4.976 ± 0.04	4.288ThrThr: 4.288 ± 0.045	3.735ThrVal: 3.735 ± 0.033	0.855ThrTrp: 0.855 ± 0.013	1.555ThrTyr: 1.555 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.707ValAla: 5.707 ± 0.037	0.798ValCys: 0.798 ± 0.012	3.903ValAsp: 3.903 ± 0.025	4.048ValGlu: 4.048 ± 0.031	2.386ValPhe: 2.386 ± 0.021	4.223ValGly: 4.223 ± 0.035	1.382ValHis: 1.382 ± 0.016	2.828ValIle: 2.828 ± 0.026	2.808ValLys: 2.808 ± 0.025	5.645ValLeu: 5.645 ± 0.035	1.307ValMet: 1.307 ± 0.015	2.182ValAsn: 2.182 ± 0.021	3.744ValPro: 3.744 ± 0.027	2.28ValGln: 2.28 ± 0.02	3.792ValArg: 3.792 ± 0.024	4.449ValSer: 4.449 ± 0.029	3.548ValThr: 3.548 ± 0.026	4.541ValVal: 4.541 ± 0.037	0.884ValTrp: 0.884 ± 0.013	1.742ValTyr: 1.742 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.238TrpAla: 1.238 ± 0.017	0.193TrpCys: 0.193 ± 0.006	0.979TrpAsp: 0.979 ± 0.014	0.881TrpGlu: 0.881 ± 0.014	0.545TrpPhe: 0.545 ± 0.01	0.99TrpGly: 0.99 ± 0.014	0.357TrpHis: 0.357 ± 0.009	0.734TrpIle: 0.734 ± 0.013	0.761TrpLys: 0.761 ± 0.012	1.357TrpLeu: 1.357 ± 0.02	0.354TrpMet: 0.354 ± 0.007	0.616TrpAsn: 0.616 ± 0.011	0.616TrpPro: 0.616 ± 0.01	0.54TrpGln: 0.54 ± 0.009	1.045TrpArg: 1.045 ± 0.015	0.979TrpSer: 0.979 ± 0.014	0.901TrpThr: 0.901 ± 0.012	0.92TrpVal: 0.92 ± 0.014	0.276TrpTrp: 0.276 ± 0.007	0.422TrpTyr: 0.422 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.259TyrAla: 2.259 ± 0.02	0.398TyrCys: 0.398 ± 0.009	1.743TyrAsp: 1.743 ± 0.019	1.601TyrGlu: 1.601 ± 0.02	1.136TyrPhe: 1.136 ± 0.015	2.187TyrGly: 2.187 ± 0.023	0.736TyrHis: 0.736 ± 0.012	1.244TyrIle: 1.244 ± 0.016	1.034TyrLys: 1.034 ± 0.013	2.568TyrLeu: 2.568 ± 0.023	0.611TyrMet: 0.611 ± 0.012	1.046TyrAsn: 1.046 ± 0.013	1.484TyrPro: 1.484 ± 0.019	1.003TyrGln: 1.003 ± 0.015	1.731TyrArg: 1.731 ± 0.02	1.9TyrSer: 1.9 ± 0.023	1.526TyrThr: 1.526 ± 0.017	1.697TyrVal: 1.697 ± 0.018	0.454TyrTrp: 0.454 ± 0.01	0.949TyrTyr: 0.949 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 11773 proteins (5704079 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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