Amino acid dipepetide frequency for Moraxella phage Mcat11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.228AlaAla: 4.228 ± 0.934
1.057AlaCys: 1.057 ± 0.412
6.077AlaAsp: 6.077 ± 1.157
4.888AlaGlu: 4.888 ± 0.71
4.492AlaPhe: 4.492 ± 0.803
4.36AlaGly: 4.36 ± 0.836
1.85AlaHis: 1.85 ± 0.445
6.738AlaIle: 6.738 ± 0.77
8.191AlaLys: 8.191 ± 1.18
9.38AlaLeu: 9.38 ± 0.926
2.907AlaMet: 2.907 ± 0.641
4.228AlaAsn: 4.228 ± 0.963
1.057AlaPro: 1.057 ± 0.256
3.964AlaGln: 3.964 ± 0.961
3.303AlaArg: 3.303 ± 0.457
6.606AlaSer: 6.606 ± 0.891
7.531AlaThr: 7.531 ± 1.624
5.813AlaVal: 5.813 ± 0.681
1.718AlaTrp: 1.718 ± 0.462
2.246AlaTyr: 2.246 ± 0.387
0.0AlaXaa: 0.0 ± 0.0
Cys
0.264CysAla: 0.264 ± 0.252
0.264CysCys: 0.264 ± 0.174
0.396CysAsp: 0.396 ± 0.221
0.396CysGlu: 0.396 ± 0.22
0.264CysPhe: 0.264 ± 0.176
0.661CysGly: 0.661 ± 0.336
0.528CysHis: 0.528 ± 0.233
0.264CysIle: 0.264 ± 0.212
0.264CysLys: 0.264 ± 0.162
0.661CysLeu: 0.661 ± 0.29
0.132CysMet: 0.132 ± 0.129
0.264CysAsn: 0.264 ± 0.189
0.396CysPro: 0.396 ± 0.218
0.925CysGln: 0.925 ± 0.381
0.925CysArg: 0.925 ± 0.366
0.396CysSer: 0.396 ± 0.226
0.528CysThr: 0.528 ± 0.277
0.396CysVal: 0.396 ± 0.231
0.132CysTrp: 0.132 ± 0.156
0.264CysTyr: 0.264 ± 0.172
0.0CysXaa: 0.0 ± 0.0
Asp
5.153AspAla: 5.153 ± 0.71
0.661AspCys: 0.661 ± 0.289
5.945AspAsp: 5.945 ± 1.002
3.831AspGlu: 3.831 ± 0.473
2.774AspPhe: 2.774 ± 0.509
7.531AspGly: 7.531 ± 0.984
0.925AspHis: 0.925 ± 0.335
3.699AspIle: 3.699 ± 0.682
5.02AspLys: 5.02 ± 0.736
4.756AspLeu: 4.756 ± 0.653
0.925AspMet: 0.925 ± 0.233
5.417AspAsn: 5.417 ± 0.746
1.718AspPro: 1.718 ± 0.617
1.189AspGln: 1.189 ± 0.398
2.642AspArg: 2.642 ± 0.57
3.567AspSer: 3.567 ± 0.513
2.51AspThr: 2.51 ± 0.528
4.888AspVal: 4.888 ± 0.668
0.925AspTrp: 0.925 ± 0.38
2.907AspTyr: 2.907 ± 0.661
0.0AspXaa: 0.0 ± 0.0
Glu
3.699GluAla: 3.699 ± 0.617
0.661GluCys: 0.661 ± 0.3
2.907GluAsp: 2.907 ± 0.733
1.718GluGlu: 1.718 ± 0.426
3.039GluPhe: 3.039 ± 0.708
2.114GluGly: 2.114 ± 0.338
1.585GluHis: 1.585 ± 0.405
4.36GluIle: 4.36 ± 0.752
3.435GluLys: 3.435 ± 0.912
7.134GluLeu: 7.134 ± 0.769
2.51GluMet: 2.51 ± 0.578
3.171GluAsn: 3.171 ± 0.689
2.378GluPro: 2.378 ± 0.578
4.228GluGln: 4.228 ± 0.612
3.171GluArg: 3.171 ± 0.726
2.246GluSer: 2.246 ± 0.461
2.51GluThr: 2.51 ± 0.353
3.171GluVal: 3.171 ± 0.874
0.661GluTrp: 0.661 ± 0.27
2.642GluTyr: 2.642 ± 0.541
0.0GluXaa: 0.0 ± 0.0
Phe
3.039PheAla: 3.039 ± 0.577
0.528PheCys: 0.528 ± 0.232
3.567PheAsp: 3.567 ± 0.57
3.303PheGlu: 3.303 ± 0.789
1.321PhePhe: 1.321 ± 0.467
3.567PheGly: 3.567 ± 0.836
0.925PheHis: 0.925 ± 0.229
2.51PheIle: 2.51 ± 0.576
1.718PheLys: 1.718 ± 0.537
2.378PheLeu: 2.378 ± 0.6
1.453PheMet: 1.453 ± 0.396
1.057PheAsn: 1.057 ± 0.316
0.925PhePro: 0.925 ± 0.325
0.661PheGln: 0.661 ± 0.44
1.453PheArg: 1.453 ± 0.446
1.982PheSer: 1.982 ± 0.485
2.774PheThr: 2.774 ± 0.552
1.85PheVal: 1.85 ± 0.447
0.528PheTrp: 0.528 ± 0.276
1.982PheTyr: 1.982 ± 0.472
0.0PheXaa: 0.0 ± 0.0
Gly
4.624GlyAla: 4.624 ± 0.735
0.396GlyCys: 0.396 ± 0.213
4.492GlyAsp: 4.492 ± 0.959
6.342GlyGlu: 6.342 ± 0.851
3.435GlyPhe: 3.435 ± 0.603
5.285GlyGly: 5.285 ± 0.898
1.057GlyHis: 1.057 ± 0.422
3.567GlyIle: 3.567 ± 0.421
7.002GlyLys: 7.002 ± 0.903
6.738GlyLeu: 6.738 ± 0.955
2.246GlyMet: 2.246 ± 0.531
3.039GlyAsn: 3.039 ± 0.763
0.0GlyPro: 0.0 ± 0.0
2.51GlyGln: 2.51 ± 0.56
4.096GlyArg: 4.096 ± 0.749
2.907GlySer: 2.907 ± 0.468
2.51GlyThr: 2.51 ± 0.64
5.813GlyVal: 5.813 ± 0.816
1.189GlyTrp: 1.189 ± 0.319
2.114GlyTyr: 2.114 ± 0.68
0.0GlyXaa: 0.0 ± 0.0
His
2.378HisAla: 2.378 ± 0.466
0.264HisCys: 0.264 ± 0.167
2.114HisAsp: 2.114 ± 0.458
1.585HisGlu: 1.585 ± 0.364
0.793HisPhe: 0.793 ± 0.285
2.774HisGly: 2.774 ± 0.617
0.925HisHis: 0.925 ± 0.449
1.189HisIle: 1.189 ± 0.335
1.321HisLys: 1.321 ± 0.273
1.453HisLeu: 1.453 ± 0.509
0.264HisMet: 0.264 ± 0.178
1.057HisAsn: 1.057 ± 0.327
0.793HisPro: 0.793 ± 0.457
0.793HisGln: 0.793 ± 0.27
0.925HisArg: 0.925 ± 0.374
0.661HisSer: 0.661 ± 0.448
1.585HisThr: 1.585 ± 0.435
0.661HisVal: 0.661 ± 0.23
0.661HisTrp: 0.661 ± 0.287
0.925HisTyr: 0.925 ± 0.304
0.0HisXaa: 0.0 ± 0.0
Ile
7.266IleAla: 7.266 ± 0.877
0.396IleCys: 0.396 ± 0.175
4.756IleAsp: 4.756 ± 0.56
3.435IleGlu: 3.435 ± 0.63
1.585IlePhe: 1.585 ± 0.349
4.624IleGly: 4.624 ± 0.692
1.057IleHis: 1.057 ± 0.345
5.285IleIle: 5.285 ± 0.657
4.756IleLys: 4.756 ± 0.698
3.964IleLeu: 3.964 ± 0.535
1.453IleMet: 1.453 ± 0.424
3.831IleAsn: 3.831 ± 1.084
2.114IlePro: 2.114 ± 0.423
1.982IleGln: 1.982 ± 0.662
1.982IleArg: 1.982 ± 0.487
3.831IleSer: 3.831 ± 0.712
5.153IleThr: 5.153 ± 0.677
2.774IleVal: 2.774 ± 0.431
0.132IleTrp: 0.132 ± 0.147
2.51IleTyr: 2.51 ± 0.505
0.0IleXaa: 0.0 ± 0.0
Lys
7.927LysAla: 7.927 ± 0.871
0.661LysCys: 0.661 ± 0.236
4.756LysAsp: 4.756 ± 0.755
3.171LysGlu: 3.171 ± 0.694
2.114LysPhe: 2.114 ± 0.717
5.02LysGly: 5.02 ± 0.758
1.453LysHis: 1.453 ± 0.397
3.303LysIle: 3.303 ± 0.829
4.36LysLys: 4.36 ± 0.596
6.87LysLeu: 6.87 ± 0.899
2.246LysMet: 2.246 ± 0.563
3.699LysAsn: 3.699 ± 0.757
1.718LysPro: 1.718 ± 0.429
4.228LysGln: 4.228 ± 0.801
4.36LysArg: 4.36 ± 0.882
3.964LysSer: 3.964 ± 0.964
5.153LysThr: 5.153 ± 0.865
4.096LysVal: 4.096 ± 0.77
0.661LysTrp: 0.661 ± 0.321
1.85LysTyr: 1.85 ± 0.54
0.0LysXaa: 0.0 ± 0.0
Leu
10.834LeuAla: 10.834 ± 1.643
0.661LeuCys: 0.661 ± 0.304
7.399LeuAsp: 7.399 ± 0.939
4.888LeuGlu: 4.888 ± 1.011
1.982LeuPhe: 1.982 ± 0.425
6.21LeuGly: 6.21 ± 1.08
2.378LeuHis: 2.378 ± 0.566
5.285LeuIle: 5.285 ± 0.588
6.342LeuLys: 6.342 ± 0.855
5.681LeuLeu: 5.681 ± 0.733
2.246LeuMet: 2.246 ± 0.422
4.096LeuAsn: 4.096 ± 0.697
3.435LeuPro: 3.435 ± 0.635
3.567LeuGln: 3.567 ± 0.509
3.964LeuArg: 3.964 ± 0.658
6.342LeuSer: 6.342 ± 0.665
4.888LeuThr: 4.888 ± 0.724
4.096LeuVal: 4.096 ± 0.798
1.057LeuTrp: 1.057 ± 0.329
3.171LeuTyr: 3.171 ± 0.388
0.0LeuXaa: 0.0 ± 0.0
Met
2.907MetAla: 2.907 ± 0.514
0.132MetCys: 0.132 ± 0.133
1.585MetAsp: 1.585 ± 0.499
0.925MetGlu: 0.925 ± 0.377
0.925MetPhe: 0.925 ± 0.349
1.982MetGly: 1.982 ± 0.438
0.528MetHis: 0.528 ± 0.216
1.718MetIle: 1.718 ± 0.391
1.585MetLys: 1.585 ± 0.487
2.51MetLeu: 2.51 ± 0.439
0.661MetMet: 0.661 ± 0.265
1.453MetAsn: 1.453 ± 0.461
1.189MetPro: 1.189 ± 0.295
1.718MetGln: 1.718 ± 0.446
1.057MetArg: 1.057 ± 0.418
2.51MetSer: 2.51 ± 0.673
1.982MetThr: 1.982 ± 0.541
2.246MetVal: 2.246 ± 0.731
0.264MetTrp: 0.264 ± 0.157
0.264MetTyr: 0.264 ± 0.188
0.0MetXaa: 0.0 ± 0.0
Asn
5.285AsnAla: 5.285 ± 1.083
0.0AsnCys: 0.0 ± 0.0
2.378AsnAsp: 2.378 ± 0.436
3.039AsnGlu: 3.039 ± 0.627
2.114AsnPhe: 2.114 ± 0.566
3.039AsnGly: 3.039 ± 0.479
1.321AsnHis: 1.321 ± 0.448
3.039AsnIle: 3.039 ± 0.52
2.774AsnLys: 2.774 ± 0.854
3.567AsnLeu: 3.567 ± 0.85
1.85AsnMet: 1.85 ± 0.653
3.039AsnAsn: 3.039 ± 0.568
3.039AsnPro: 3.039 ± 0.822
2.246AsnGln: 2.246 ± 0.614
2.51AsnArg: 2.51 ± 0.588
2.246AsnSer: 2.246 ± 0.814
2.114AsnThr: 2.114 ± 0.447
2.114AsnVal: 2.114 ± 0.717
0.264AsnTrp: 0.264 ± 0.195
1.718AsnTyr: 1.718 ± 0.404
0.0AsnXaa: 0.0 ± 0.0
Pro
2.378ProAla: 2.378 ± 0.577
0.264ProCys: 0.264 ± 0.165
1.85ProAsp: 1.85 ± 0.463
2.114ProGlu: 2.114 ± 0.658
1.321ProPhe: 1.321 ± 0.324
0.661ProGly: 0.661 ± 0.322
0.793ProHis: 0.793 ± 0.278
2.378ProIle: 2.378 ± 0.504
3.171ProLys: 3.171 ± 0.455
2.378ProLeu: 2.378 ± 0.643
0.661ProMet: 0.661 ± 0.304
2.246ProAsn: 2.246 ± 0.671
1.718ProPro: 1.718 ± 0.458
0.925ProGln: 0.925 ± 0.314
0.793ProArg: 0.793 ± 0.297
2.774ProSer: 2.774 ± 0.708
1.718ProThr: 1.718 ± 0.323
1.585ProVal: 1.585 ± 0.427
0.264ProTrp: 0.264 ± 0.181
0.661ProTyr: 0.661 ± 0.269
0.0ProXaa: 0.0 ± 0.0
Gln
5.02GlnAla: 5.02 ± 0.757
0.264GlnCys: 0.264 ± 0.174
2.114GlnAsp: 2.114 ± 0.514
1.189GlnGlu: 1.189 ± 0.338
1.189GlnPhe: 1.189 ± 0.377
2.114GlnGly: 2.114 ± 0.451
0.925GlnHis: 0.925 ± 0.288
4.228GlnIle: 4.228 ± 0.729
5.02GlnLys: 5.02 ± 0.628
5.945GlnLeu: 5.945 ± 0.712
1.321GlnMet: 1.321 ± 0.291
1.585GlnAsn: 1.585 ± 0.296
1.321GlnPro: 1.321 ± 0.386
1.982GlnGln: 1.982 ± 0.483
1.85GlnArg: 1.85 ± 0.458
2.246GlnSer: 2.246 ± 0.518
2.642GlnThr: 2.642 ± 0.564
2.378GlnVal: 2.378 ± 0.479
0.528GlnTrp: 0.528 ± 0.274
1.189GlnTyr: 1.189 ± 0.309
0.0GlnXaa: 0.0 ± 0.0
Arg
3.964ArgAla: 3.964 ± 0.583
0.264ArgCys: 0.264 ± 0.174
3.039ArgAsp: 3.039 ± 0.516
3.171ArgGlu: 3.171 ± 0.477
2.907ArgPhe: 2.907 ± 0.821
2.642ArgGly: 2.642 ± 0.633
1.718ArgHis: 1.718 ± 0.409
2.114ArgIle: 2.114 ± 0.469
2.907ArgLys: 2.907 ± 0.609
6.21ArgLeu: 6.21 ± 1.013
0.528ArgMet: 0.528 ± 0.23
1.189ArgAsn: 1.189 ± 0.349
1.189ArgPro: 1.189 ± 0.386
2.246ArgGln: 2.246 ± 0.414
1.982ArgArg: 1.982 ± 0.564
2.907ArgSer: 2.907 ± 0.617
3.171ArgThr: 3.171 ± 0.546
2.774ArgVal: 2.774 ± 0.545
0.661ArgTrp: 0.661 ± 0.279
2.51ArgTyr: 2.51 ± 0.646
0.0ArgXaa: 0.0 ± 0.0
Ser
5.681SerAla: 5.681 ± 0.887
0.264SerCys: 0.264 ± 0.224
3.567SerAsp: 3.567 ± 0.758
3.964SerGlu: 3.964 ± 0.64
1.982SerPhe: 1.982 ± 0.545
3.039SerGly: 3.039 ± 0.456
2.114SerHis: 2.114 ± 0.485
3.831SerIle: 3.831 ± 1.043
3.171SerLys: 3.171 ± 0.605
5.153SerLeu: 5.153 ± 1.17
1.189SerMet: 1.189 ± 0.372
3.303SerAsn: 3.303 ± 0.861
1.453SerPro: 1.453 ± 0.633
3.699SerGln: 3.699 ± 0.746
3.171SerArg: 3.171 ± 0.558
2.907SerSer: 2.907 ± 0.659
2.774SerThr: 2.774 ± 0.615
5.02SerVal: 5.02 ± 0.777
0.528SerTrp: 0.528 ± 0.213
1.585SerTyr: 1.585 ± 0.358
0.0SerXaa: 0.0 ± 0.0
Thr
6.606ThrAla: 6.606 ± 0.801
0.264ThrCys: 0.264 ± 0.15
3.699ThrAsp: 3.699 ± 0.518
3.699ThrGlu: 3.699 ± 0.606
1.982ThrPhe: 1.982 ± 0.505
5.549ThrGly: 5.549 ± 0.935
1.057ThrHis: 1.057 ± 0.256
3.171ThrIle: 3.171 ± 0.651
5.417ThrLys: 5.417 ± 1.114
5.285ThrLeu: 5.285 ± 0.719
1.718ThrMet: 1.718 ± 0.384
1.718ThrAsn: 1.718 ± 0.366
2.907ThrPro: 2.907 ± 0.661
1.85ThrGln: 1.85 ± 0.425
2.246ThrArg: 2.246 ± 0.537
2.907ThrSer: 2.907 ± 0.505
2.907ThrThr: 2.907 ± 0.499
3.435ThrVal: 3.435 ± 0.596
1.057ThrTrp: 1.057 ± 0.342
0.925ThrTyr: 0.925 ± 0.286
0.0ThrXaa: 0.0 ± 0.0
Val
5.549ValAla: 5.549 ± 0.867
0.528ValCys: 0.528 ± 0.252
2.907ValAsp: 2.907 ± 0.586
3.039ValGlu: 3.039 ± 0.674
1.718ValPhe: 1.718 ± 0.534
4.492ValGly: 4.492 ± 0.775
0.925ValHis: 0.925 ± 0.333
3.699ValIle: 3.699 ± 0.51
3.171ValLys: 3.171 ± 0.698
4.888ValLeu: 4.888 ± 0.578
2.378ValMet: 2.378 ± 0.514
1.718ValAsn: 1.718 ± 0.459
1.585ValPro: 1.585 ± 0.475
3.435ValGln: 3.435 ± 0.495
4.492ValArg: 4.492 ± 0.851
4.756ValSer: 4.756 ± 0.783
3.567ValThr: 3.567 ± 0.629
3.964ValVal: 3.964 ± 0.8
1.453ValTrp: 1.453 ± 0.395
2.246ValTyr: 2.246 ± 0.467
0.0ValXaa: 0.0 ± 0.0
Trp
1.85TrpAla: 1.85 ± 0.373
0.264TrpCys: 0.264 ± 0.184
1.057TrpAsp: 1.057 ± 0.405
0.528TrpGlu: 0.528 ± 0.206
0.396TrpPhe: 0.396 ± 0.216
0.661TrpGly: 0.661 ± 0.347
0.132TrpHis: 0.132 ± 0.122
0.396TrpIle: 0.396 ± 0.207
0.264TrpLys: 0.264 ± 0.198
1.585TrpLeu: 1.585 ± 0.414
0.396TrpMet: 0.396 ± 0.213
0.132TrpAsn: 0.132 ± 0.1
0.132TrpPro: 0.132 ± 0.118
1.453TrpGln: 1.453 ± 0.517
0.661TrpArg: 0.661 ± 0.294
0.925TrpSer: 0.925 ± 0.329
0.661TrpThr: 0.661 ± 0.254
1.189TrpVal: 1.189 ± 0.329
0.264TrpTrp: 0.264 ± 0.195
0.396TrpTyr: 0.396 ± 0.232
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.982TyrAla: 1.982 ± 0.533
0.528TyrCys: 0.528 ± 0.298
2.378TyrAsp: 2.378 ± 0.57
2.114TyrGlu: 2.114 ± 0.527
1.189TyrPhe: 1.189 ± 0.425
3.039TyrGly: 3.039 ± 0.486
0.925TyrHis: 0.925 ± 0.478
2.114TyrIle: 2.114 ± 0.41
1.718TyrLys: 1.718 ± 0.548
1.982TyrLeu: 1.982 ± 0.521
0.925TyrMet: 0.925 ± 0.352
1.585TyrAsn: 1.585 ± 0.593
1.585TyrPro: 1.585 ± 0.447
1.453TyrGln: 1.453 ± 0.467
2.51TyrArg: 2.51 ± 0.618
1.718TyrSer: 1.718 ± 0.431
1.718TyrThr: 1.718 ± 0.412
2.246TyrVal: 2.246 ± 0.527
0.396TyrTrp: 0.396 ± 0.2
1.321TyrTyr: 1.321 ± 0.454
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 33 proteins (7570 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski