Amino acid dipepetide frequency for Halarsenatibacter silvermanii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.771AlaAla: 7.771 ± 0.13	0.71AlaCys: 0.71 ± 0.032	4.922AlaAsp: 4.922 ± 0.075	8.196AlaGlu: 8.196 ± 0.126	2.508AlaPhe: 2.508 ± 0.063	7.81AlaGly: 7.81 ± 0.106	1.141AlaHis: 1.141 ± 0.043	4.169AlaIle: 4.169 ± 0.08	2.264AlaLys: 2.264 ± 0.057	7.016AlaLeu: 7.016 ± 0.1	1.636AlaMet: 1.636 ± 0.053	1.829AlaAsn: 1.829 ± 0.048	2.004AlaPro: 2.004 ± 0.053	1.849AlaGln: 1.849 ± 0.048	4.789AlaArg: 4.789 ± 0.084	3.916AlaSer: 3.916 ± 0.079	2.317AlaThr: 2.317 ± 0.054	5.811AlaVal: 5.811 ± 0.105	0.47AlaTrp: 0.47 ± 0.026	1.674AlaTyr: 1.674 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.46CysAla: 0.46 ± 0.028	0.139CysCys: 0.139 ± 0.018	0.571CysAsp: 0.571 ± 0.03	0.715CysGlu: 0.715 ± 0.032	0.329CysPhe: 0.329 ± 0.018	0.943CysGly: 0.943 ± 0.037	0.221CysHis: 0.221 ± 0.018	0.45CysIle: 0.45 ± 0.026	0.32CysLys: 0.32 ± 0.02	0.718CysLeu: 0.718 ± 0.027	0.17CysMet: 0.17 ± 0.014	0.284CysAsn: 0.284 ± 0.019	0.589CysPro: 0.589 ± 0.032	0.44CysGln: 0.44 ± 0.027	0.735CysArg: 0.735 ± 0.033	0.709CysSer: 0.709 ± 0.031	0.37CysThr: 0.37 ± 0.022	0.428CysVal: 0.428 ± 0.026	0.082CysTrp: 0.082 ± 0.009	0.314CysTyr: 0.314 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	2.932AspAla: 2.932 ± 0.069	0.708AspCys: 0.708 ± 0.029	4.07AspAsp: 4.07 ± 0.093	6.975AspGlu: 6.975 ± 0.115	3.326AspPhe: 3.326 ± 0.067	3.622AspGly: 3.622 ± 0.089	1.173AspHis: 1.173 ± 0.04	5.776AspIle: 5.776 ± 0.097	3.642AspLys: 3.642 ± 0.067	6.634AspLeu: 6.634 ± 0.114	1.773AspMet: 1.773 ± 0.053	2.397AspAsn: 2.397 ± 0.055	2.389AspPro: 2.389 ± 0.064	1.605AspGln: 1.605 ± 0.048	3.971AspArg: 3.971 ± 0.066	3.447AspSer: 3.447 ± 0.074	2.221AspThr: 2.221 ± 0.053	3.815AspVal: 3.815 ± 0.076	0.687AspTrp: 0.687 ± 0.033	2.777AspTyr: 2.777 ± 0.064	0.0AspXaa: 0.0 ± 0.0
Glu	6.832GluAla: 6.832 ± 0.12	0.573GluCys: 0.573 ± 0.031	6.848GluAsp: 6.848 ± 0.123	12.914GluGlu: 12.914 ± 0.187	3.741GluPhe: 3.741 ± 0.072	6.028GluGly: 6.028 ± 0.101	1.53GluHis: 1.53 ± 0.047	8.818GluIle: 8.818 ± 0.12	8.447GluLys: 8.447 ± 0.152	10.188GluLeu: 10.188 ± 0.141	3.02GluMet: 3.02 ± 0.074	5.113GluAsn: 5.113 ± 0.092	2.519GluPro: 2.519 ± 0.067	2.65GluGln: 2.65 ± 0.066	4.974GluArg: 4.974 ± 0.092	4.292GluSer: 4.292 ± 0.077	3.799GluThr: 3.799 ± 0.08	6.804GluVal: 6.804 ± 0.107	0.67GluTrp: 0.67 ± 0.033	2.891GluTyr: 2.891 ± 0.066	0.0GluXaa: 0.0 ± 0.0
Phe	2.98PheAla: 2.98 ± 0.06	0.429PheCys: 0.429 ± 0.023	2.714PheAsp: 2.714 ± 0.061	3.217PheGlu: 3.217 ± 0.069	1.884PhePhe: 1.884 ± 0.068	2.805PheGly: 2.805 ± 0.064	0.651PheHis: 0.651 ± 0.026	2.851PheIle: 2.851 ± 0.071	1.849PheLys: 1.849 ± 0.056	4.208PheLeu: 4.208 ± 0.101	1.126PheMet: 1.126 ± 0.04	1.568PheAsn: 1.568 ± 0.05	1.489PhePro: 1.489 ± 0.038	1.308PheGln: 1.308 ± 0.039	1.777PheArg: 1.777 ± 0.041	3.394PheSer: 3.394 ± 0.074	2.181PheThr: 2.181 ± 0.053	2.411PheVal: 2.411 ± 0.065	0.382PheTrp: 0.382 ± 0.025	1.447PheTyr: 1.447 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	5.288GlyAla: 5.288 ± 0.094	0.859GlyCys: 0.859 ± 0.039	4.251GlyAsp: 4.251 ± 0.087	7.436GlyGlu: 7.436 ± 0.116	3.357GlyPhe: 3.357 ± 0.077	5.876GlyGly: 5.876 ± 0.117	1.329GlyHis: 1.329 ± 0.038	5.612GlyIle: 5.612 ± 0.101	3.548GlyLys: 3.548 ± 0.079	7.334GlyLeu: 7.334 ± 0.103	2.152GlyMet: 2.152 ± 0.054	2.254GlyAsn: 2.254 ± 0.059	2.09GlyPro: 2.09 ± 0.055	2.033GlyGln: 2.033 ± 0.053	4.21GlyArg: 4.21 ± 0.081	4.598GlySer: 4.598 ± 0.082	3.232GlyThr: 3.232 ± 0.073	4.953GlyVal: 4.953 ± 0.092	0.681GlyTrp: 0.681 ± 0.03	2.677GlyTyr: 2.677 ± 0.071	0.0GlyXaa: 0.0 ± 0.0
His	0.912HisAla: 0.912 ± 0.041	0.183HisCys: 0.183 ± 0.015	1.074HisAsp: 1.074 ± 0.04	1.334HisGlu: 1.334 ± 0.04	0.731HisPhe: 0.731 ± 0.032	1.265HisGly: 1.265 ± 0.041	0.458HisHis: 0.458 ± 0.023	1.133HisIle: 1.133 ± 0.04	0.749HisLys: 0.749 ± 0.034	1.718HisLeu: 1.718 ± 0.049	0.353HisMet: 0.353 ± 0.022	0.701HisAsn: 0.701 ± 0.029	1.013HisPro: 1.013 ± 0.041	0.6HisGln: 0.6 ± 0.028	1.047HisArg: 1.047 ± 0.037	0.993HisSer: 0.993 ± 0.04	0.788HisThr: 0.788 ± 0.033	0.842HisVal: 0.842 ± 0.031	0.129HisTrp: 0.129 ± 0.013	0.671HisTyr: 0.671 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.079IleAla: 5.079 ± 0.093	0.695IleCys: 0.695 ± 0.029	5.04IleAsp: 5.04 ± 0.095	7.215IleGlu: 7.215 ± 0.108	3.305IlePhe: 3.305 ± 0.07	4.743IleGly: 4.743 ± 0.092	0.975IleHis: 0.975 ± 0.034	5.902IleIle: 5.902 ± 0.099	4.504IleLys: 4.504 ± 0.08	6.616IleLeu: 6.616 ± 0.122	1.98IleMet: 1.98 ± 0.052	3.26IleAsn: 3.26 ± 0.07	3.078IlePro: 3.078 ± 0.064	1.681IleGln: 1.681 ± 0.05	3.149IleArg: 3.149 ± 0.057	5.391IleSer: 5.391 ± 0.092	3.748IleThr: 3.748 ± 0.067	4.273IleVal: 4.273 ± 0.085	0.56IleTrp: 0.56 ± 0.029	2.405IleTyr: 2.405 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	3.922LysAla: 3.922 ± 0.072	0.419LysCys: 0.419 ± 0.024	3.102LysAsp: 3.102 ± 0.062	5.707LysGlu: 5.707 ± 0.112	2.091LysPhe: 2.091 ± 0.056	3.062LysGly: 3.062 ± 0.063	0.745LysHis: 0.745 ± 0.034	4.82LysIle: 4.82 ± 0.094	5.128LysLys: 5.128 ± 0.11	5.471LysLeu: 5.471 ± 0.093	1.491LysMet: 1.491 ± 0.046	3.4LysAsn: 3.4 ± 0.088	1.835LysPro: 1.835 ± 0.046	1.473LysGln: 1.473 ± 0.046	2.768LysArg: 2.768 ± 0.066	3.27LysSer: 3.27 ± 0.079	2.664LysThr: 2.664 ± 0.059	3.126LysVal: 3.126 ± 0.067	0.339LysTrp: 0.339 ± 0.023	1.83LysTyr: 1.83 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	8.548LeuAla: 8.548 ± 0.127	0.633LeuCys: 0.633 ± 0.029	6.306LeuAsp: 6.306 ± 0.1	9.971LeuGlu: 9.971 ± 0.134	3.459LeuPhe: 3.459 ± 0.085	7.027LeuGly: 7.027 ± 0.11	1.52LeuHis: 1.52 ± 0.042	6.986LeuIle: 6.986 ± 0.119	6.407LeuLys: 6.407 ± 0.108	9.48LeuLeu: 9.48 ± 0.172	2.192LeuMet: 2.192 ± 0.057	4.092LeuAsn: 4.092 ± 0.071	4.119LeuPro: 4.119 ± 0.083	3.326LeuGln: 3.326 ± 0.08	4.443LeuArg: 4.443 ± 0.096	6.495LeuSer: 6.495 ± 0.105	4.91LeuThr: 4.91 ± 0.085	5.791LeuVal: 5.791 ± 0.091	0.618LeuTrp: 0.618 ± 0.029	2.516LeuTyr: 2.516 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.165MetAla: 2.165 ± 0.053	0.14MetCys: 0.14 ± 0.012	1.545MetAsp: 1.545 ± 0.05	2.342MetGlu: 2.342 ± 0.059	0.726MetPhe: 0.726 ± 0.032	1.927MetGly: 1.927 ± 0.052	0.332MetHis: 0.332 ± 0.02	1.907MetIle: 1.907 ± 0.06	1.705MetLys: 1.705 ± 0.048	2.52MetLeu: 2.52 ± 0.061	0.878MetMet: 0.878 ± 0.037	1.076MetAsn: 1.076 ± 0.037	1.023MetPro: 1.023 ± 0.036	0.771MetGln: 0.771 ± 0.034	1.16MetArg: 1.16 ± 0.036	1.61MetSer: 1.61 ± 0.039	1.392MetThr: 1.392 ± 0.046	1.71MetVal: 1.71 ± 0.049	0.134MetTrp: 0.134 ± 0.014	0.473MetTyr: 0.473 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	1.972AsnAla: 1.972 ± 0.053	0.446AsnCys: 0.446 ± 0.023	2.004AsnAsp: 2.004 ± 0.06	2.806AsnGlu: 2.806 ± 0.067	2.126AsnPhe: 2.126 ± 0.054	1.858AsnGly: 1.858 ± 0.059	0.663AsnHis: 0.663 ± 0.028	3.578AsnIle: 3.578 ± 0.08	2.278AsnLys: 2.278 ± 0.069	4.582AsnLeu: 4.582 ± 0.087	1.111AsnMet: 1.111 ± 0.039	1.734AsnAsn: 1.734 ± 0.057	1.975AsnPro: 1.975 ± 0.054	1.256AsnGln: 1.256 ± 0.041	2.231AsnArg: 2.231 ± 0.054	2.542AsnSer: 2.542 ± 0.061	1.554AsnThr: 1.554 ± 0.044	2.152AsnVal: 2.152 ± 0.049	0.407AsnTrp: 0.407 ± 0.024	1.676AsnTyr: 1.676 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	3.12ProAla: 3.12 ± 0.064	0.317ProCys: 0.317 ± 0.021	2.796ProAsp: 2.796 ± 0.067	5.035ProGlu: 5.035 ± 0.103	1.386ProPhe: 1.386 ± 0.045	3.723ProGly: 3.723 ± 0.079	0.781ProHis: 0.781 ± 0.032	1.892ProIle: 1.892 ± 0.051	1.072ProLys: 1.072 ± 0.038	3.324ProLeu: 3.324 ± 0.068	0.692ProMet: 0.692 ± 0.03	0.871ProAsn: 0.871 ± 0.03	1.402ProPro: 1.402 ± 0.045	1.163ProGln: 1.163 ± 0.037	1.774ProArg: 1.774 ± 0.052	1.665ProSer: 1.665 ± 0.045	1.392ProThr: 1.392 ± 0.041	3.087ProVal: 3.087 ± 0.058	0.325ProTrp: 0.325 ± 0.02	1.121ProTyr: 1.121 ± 0.048	0.0ProXaa: 0.0 ± 0.0
Gln	2.438GlnAla: 2.438 ± 0.061	0.168GlnCys: 0.168 ± 0.015	1.93GlnAsp: 1.93 ± 0.05	3.503GlnGlu: 3.503 ± 0.086	0.933GlnPhe: 0.933 ± 0.035	1.962GlnGly: 1.962 ± 0.047	0.506GlnHis: 0.506 ± 0.028	2.075GlnIle: 2.075 ± 0.055	2.384GlnLys: 2.384 ± 0.058	2.74GlnLeu: 2.74 ± 0.063	0.702GlnMet: 0.702 ± 0.031	1.387GlnAsn: 1.387 ± 0.043	1.013GlnPro: 1.013 ± 0.033	1.315GlnGln: 1.315 ± 0.049	1.61GlnArg: 1.61 ± 0.054	1.455GlnSer: 1.455 ± 0.045	1.163GlnThr: 1.163 ± 0.042	1.779GlnVal: 1.779 ± 0.053	0.17GlnTrp: 0.17 ± 0.015	0.757GlnTyr: 0.757 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	3.78ArgAla: 3.78 ± 0.082	0.482ArgCys: 0.482 ± 0.031	3.403ArgAsp: 3.403 ± 0.064	6.342ArgGlu: 6.342 ± 0.116	1.875ArgPhe: 1.875 ± 0.055	3.95ArgGly: 3.95 ± 0.07	0.858ArgHis: 0.858 ± 0.034	3.77ArgIle: 3.77 ± 0.079	3.28ArgLys: 3.28 ± 0.073	5.452ArgLeu: 5.452 ± 0.111	1.332ArgMet: 1.332 ± 0.043	1.778ArgAsn: 1.778 ± 0.044	1.834ArgPro: 1.834 ± 0.048	2.083ArgGln: 2.083 ± 0.06	3.631ArgArg: 3.631 ± 0.092	3.038ArgSer: 3.038 ± 0.069	2.175ArgThr: 2.175 ± 0.055	3.452ArgVal: 3.452 ± 0.067	0.488ArgTrp: 0.488 ± 0.029	1.612ArgTyr: 1.612 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	4.269SerAla: 4.269 ± 0.07	0.71SerCys: 0.71 ± 0.033	3.589SerAsp: 3.589 ± 0.073	5.432SerGlu: 5.432 ± 0.092	2.727SerPhe: 2.727 ± 0.067	5.46SerGly: 5.46 ± 0.087	1.106SerHis: 1.106 ± 0.042	3.65SerIle: 3.65 ± 0.068	2.203SerLys: 2.203 ± 0.058	6.317SerLeu: 6.317 ± 0.098	1.365SerMet: 1.365 ± 0.039	1.643SerAsn: 1.643 ± 0.048	2.619SerPro: 2.619 ± 0.07	2.052SerGln: 2.052 ± 0.05	4.43SerArg: 4.43 ± 0.087	4.449SerSer: 4.449 ± 0.093	2.4SerThr: 2.4 ± 0.054	3.26SerVal: 3.26 ± 0.072	0.724SerTrp: 0.724 ± 0.034	1.964SerTyr: 1.964 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	4.137ThrAla: 4.137 ± 0.07	0.388ThrCys: 0.388 ± 0.02	2.696ThrAsp: 2.696 ± 0.059	3.819ThrGlu: 3.819 ± 0.076	1.665ThrPhe: 1.665 ± 0.043	4.641ThrGly: 4.641 ± 0.075	0.769ThrHis: 0.769 ± 0.033	2.773ThrIle: 2.773 ± 0.068	1.38ThrLys: 1.38 ± 0.045	3.939ThrLeu: 3.939 ± 0.069	0.937ThrMet: 0.937 ± 0.032	1.22ThrAsn: 1.22 ± 0.044	1.967ThrPro: 1.967 ± 0.043	0.928ThrGln: 0.928 ± 0.032	2.226ThrArg: 2.226 ± 0.055	2.699ThrSer: 2.699 ± 0.067	2.005ThrThr: 2.005 ± 0.064	3.14ThrVal: 3.14 ± 0.063	0.314ThrTrp: 0.314 ± 0.02	1.203ThrTyr: 1.203 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	4.055ValAla: 4.055 ± 0.089	0.581ValCys: 0.581 ± 0.028	4.432ValAsp: 4.432 ± 0.079	6.231ValGlu: 6.231 ± 0.101	2.66ValPhe: 2.66 ± 0.058	4.348ValGly: 4.348 ± 0.084	1.004ValHis: 1.004 ± 0.033	4.873ValIle: 4.873 ± 0.094	3.67ValLys: 3.67 ± 0.065	6.252ValLeu: 6.252 ± 0.091	1.786ValMet: 1.786 ± 0.051	2.631ValAsn: 2.631 ± 0.063	2.375ValPro: 2.375 ± 0.057	1.593ValGln: 1.593 ± 0.046	3.073ValArg: 3.073 ± 0.065	3.873ValSer: 3.873 ± 0.076	2.961ValThr: 2.961 ± 0.054	4.162ValVal: 4.162 ± 0.087	0.433ValTrp: 0.433 ± 0.024	1.841ValTyr: 1.841 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.492TrpAla: 0.492 ± 0.023	0.077TrpCys: 0.077 ± 0.011	0.474TrpAsp: 0.474 ± 0.024	0.685TrpGlu: 0.685 ± 0.033	0.315TrpPhe: 0.315 ± 0.024	0.556TrpGly: 0.556 ± 0.028	0.173TrpHis: 0.173 ± 0.016	0.497TrpIle: 0.497 ± 0.027	0.41TrpLys: 0.41 ± 0.021	0.859TrpLeu: 0.859 ± 0.033	0.207TrpMet: 0.207 ± 0.016	0.387TrpAsn: 0.387 ± 0.026	0.343TrpPro: 0.343 ± 0.022	0.595TrpGln: 0.595 ± 0.026	0.467TrpArg: 0.467 ± 0.024	0.477TrpSer: 0.477 ± 0.024	0.285TrpThr: 0.285 ± 0.018	0.366TrpVal: 0.366 ± 0.019	0.107TrpTrp: 0.107 ± 0.011	0.236TrpTyr: 0.236 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.652TyrAla: 1.652 ± 0.049	0.332TyrCys: 0.332 ± 0.019	2.173TyrAsp: 2.173 ± 0.064	2.772TyrGlu: 2.772 ± 0.063	1.525TyrPhe: 1.525 ± 0.049	2.162TyrGly: 2.162 ± 0.051	0.76TyrHis: 0.76 ± 0.032	2.068TyrIle: 2.068 ± 0.051	1.425TyrLys: 1.425 ± 0.042	3.472TyrLeu: 3.472 ± 0.067	0.632TyrMet: 0.632 ± 0.026	1.327TyrAsn: 1.327 ± 0.043	1.264TyrPro: 1.264 ± 0.041	1.27TyrGln: 1.27 ± 0.039	2.148TyrArg: 2.148 ± 0.057	2.056TyrSer: 2.056 ± 0.051	1.29TyrThr: 1.29 ± 0.047	1.47TyrVal: 1.47 ± 0.045	0.286TyrTrp: 0.286 ± 0.021	1.22TyrTyr: 1.22 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2587 proteins (792929 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---