Amino acid dipepetide frequency for Streptococcus satellite phage Javan625

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.338AlaCys: 0.338 ± 0.371
4.051AlaAsp: 4.051 ± 0.581
5.739AlaGlu: 5.739 ± 2.745
2.363AlaPhe: 2.363 ± 0.625
2.701AlaGly: 2.701 ± 0.653
0.338AlaHis: 0.338 ± 0.336
5.402AlaIle: 5.402 ± 1.395
6.415AlaLys: 6.415 ± 2.051
6.752AlaLeu: 6.752 ± 2.562
2.026AlaMet: 2.026 ± 0.678
3.714AlaAsn: 3.714 ± 0.5
0.675AlaPro: 0.675 ± 0.397
1.013AlaGln: 1.013 ± 0.516
3.038AlaArg: 3.038 ± 0.885
3.376AlaSer: 3.376 ± 0.903
3.038AlaThr: 3.038 ± 0.816
2.026AlaVal: 2.026 ± 0.719
1.013AlaTrp: 1.013 ± 0.412
3.376AlaTyr: 3.376 ± 1.015
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.675CysPhe: 0.675 ± 0.363
0.0CysGly: 0.0 ± 0.0
0.338CysHis: 0.338 ± 0.351
0.338CysIle: 0.338 ± 0.364
0.0CysLys: 0.0 ± 0.0
1.013CysLeu: 1.013 ± 0.43
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.675CysArg: 0.675 ± 0.363
0.338CysSer: 0.338 ± 0.299
0.0CysThr: 0.0 ± 0.0
0.338CysVal: 0.338 ± 0.342
0.0CysTrp: 0.0 ± 0.0
0.338CysTyr: 0.338 ± 0.371
0.0CysXaa: 0.0 ± 0.0
Asp
3.376AspAla: 3.376 ± 1.022
0.0AspCys: 0.0 ± 0.0
4.389AspAsp: 4.389 ± 2.255
5.739AspGlu: 5.739 ± 2.065
3.038AspPhe: 3.038 ± 0.787
0.675AspGly: 0.675 ± 0.378
0.0AspHis: 0.0 ± 0.0
5.739AspIle: 5.739 ± 1.456
6.752AspLys: 6.752 ± 2.508
6.752AspLeu: 6.752 ± 1.378
1.688AspMet: 1.688 ± 0.785
4.389AspAsn: 4.389 ± 0.882
0.338AspPro: 0.338 ± 0.297
2.363AspGln: 2.363 ± 0.658
2.363AspArg: 2.363 ± 0.881
3.714AspSer: 3.714 ± 1.411
2.363AspThr: 2.363 ± 1.082
4.051AspVal: 4.051 ± 1.077
1.35AspTrp: 1.35 ± 0.578
4.051AspTyr: 4.051 ± 1.065
0.0AspXaa: 0.0 ± 0.0
Glu
2.701GluAla: 2.701 ± 1.145
0.0GluCys: 0.0 ± 0.0
5.064GluAsp: 5.064 ± 1.553
6.077GluGlu: 6.077 ± 1.236
5.402GluPhe: 5.402 ± 1.9
1.688GluGly: 1.688 ± 0.708
0.338GluHis: 0.338 ± 0.3
7.09GluIle: 7.09 ± 1.283
9.115GluLys: 9.115 ± 2.61
10.466GluLeu: 10.466 ± 1.564
2.701GluMet: 2.701 ± 1.12
5.402GluAsn: 5.402 ± 1.436
1.688GluPro: 1.688 ± 0.654
3.714GluGln: 3.714 ± 1.418
5.064GluArg: 5.064 ± 2.113
2.363GluSer: 2.363 ± 0.897
3.038GluThr: 3.038 ± 0.666
6.752GluVal: 6.752 ± 1.5
1.35GluTrp: 1.35 ± 0.613
2.363GluTyr: 2.363 ± 1.001
0.0GluXaa: 0.0 ± 0.0
Phe
2.701PheAla: 2.701 ± 1.269
0.338PheCys: 0.338 ± 0.297
2.701PheAsp: 2.701 ± 1.113
2.363PheGlu: 2.363 ± 1.111
3.038PhePhe: 3.038 ± 0.766
1.688PheGly: 1.688 ± 0.411
1.013PheHis: 1.013 ± 0.498
3.376PheIle: 3.376 ± 1.188
3.714PheLys: 3.714 ± 1.384
4.727PheLeu: 4.727 ± 1.355
1.013PheMet: 1.013 ± 0.452
1.688PheAsn: 1.688 ± 0.564
1.35PhePro: 1.35 ± 0.504
1.35PheGln: 1.35 ± 0.763
1.688PheArg: 1.688 ± 0.511
2.701PheSer: 2.701 ± 1.024
1.688PheThr: 1.688 ± 0.99
3.714PheVal: 3.714 ± 0.871
0.338PheTrp: 0.338 ± 0.299
2.026PheTyr: 2.026 ± 0.66
0.0PheXaa: 0.0 ± 0.0
Gly
3.714GlyAla: 3.714 ± 0.906
0.675GlyCys: 0.675 ± 0.424
2.026GlyAsp: 2.026 ± 0.908
1.013GlyGlu: 1.013 ± 0.647
1.688GlyPhe: 1.688 ± 0.895
1.013GlyGly: 1.013 ± 0.451
0.338GlyHis: 0.338 ± 0.291
3.714GlyIle: 3.714 ± 0.848
4.389GlyLys: 4.389 ± 1.134
4.389GlyLeu: 4.389 ± 1.131
1.013GlyMet: 1.013 ± 0.669
1.35GlyAsn: 1.35 ± 0.533
0.0GlyPro: 0.0 ± 0.0
0.338GlyGln: 0.338 ± 0.377
1.013GlyArg: 1.013 ± 0.412
2.363GlySer: 2.363 ± 0.861
1.688GlyThr: 1.688 ± 0.854
3.714GlyVal: 3.714 ± 1.319
1.688GlyTrp: 1.688 ± 0.637
3.038GlyTyr: 3.038 ± 1.039
0.0GlyXaa: 0.0 ± 0.0
His
0.675HisAla: 0.675 ± 0.582
0.0HisCys: 0.0 ± 0.0
1.013HisAsp: 1.013 ± 0.541
0.675HisGlu: 0.675 ± 0.409
1.35HisPhe: 1.35 ± 0.819
0.675HisGly: 0.675 ± 0.399
0.0HisHis: 0.0 ± 0.0
1.688HisIle: 1.688 ± 0.677
0.0HisLys: 0.0 ± 0.0
1.688HisLeu: 1.688 ± 0.567
0.0HisMet: 0.0 ± 0.0
0.338HisAsn: 0.338 ± 0.299
0.338HisPro: 0.338 ± 0.297
0.338HisGln: 0.338 ± 0.299
0.675HisArg: 0.675 ± 0.406
1.35HisSer: 1.35 ± 0.731
1.013HisThr: 1.013 ± 0.46
0.675HisVal: 0.675 ± 0.598
0.338HisTrp: 0.338 ± 0.377
0.675HisTyr: 0.675 ± 0.363
0.0HisXaa: 0.0 ± 0.0
Ile
5.402IleAla: 5.402 ± 1.371
0.338IleCys: 0.338 ± 0.342
4.727IleAsp: 4.727 ± 2.005
9.791IleGlu: 9.791 ± 2.753
3.376IlePhe: 3.376 ± 1.394
1.35IleGly: 1.35 ± 0.555
0.675IleHis: 0.675 ± 0.582
4.051IleIle: 4.051 ± 1.019
6.077IleLys: 6.077 ± 0.97
5.064IleLeu: 5.064 ± 1.712
0.338IleMet: 0.338 ± 0.299
6.415IleAsn: 6.415 ± 1.077
2.363IlePro: 2.363 ± 0.616
4.727IleGln: 4.727 ± 1.084
4.051IleArg: 4.051 ± 1.167
5.739IleSer: 5.739 ± 1.305
4.727IleThr: 4.727 ± 1.292
3.714IleVal: 3.714 ± 1.074
0.675IleTrp: 0.675 ± 0.418
1.688IleTyr: 1.688 ± 0.592
0.0IleXaa: 0.0 ± 0.0
Lys
7.427LysAla: 7.427 ± 1.629
0.338LysCys: 0.338 ± 0.297
4.051LysAsp: 4.051 ± 1.254
11.816LysGlu: 11.816 ± 2.602
1.35LysPhe: 1.35 ± 0.768
2.363LysGly: 2.363 ± 0.823
1.35LysHis: 1.35 ± 1.114
5.402LysIle: 5.402 ± 1.249
10.128LysLys: 10.128 ± 1.353
9.791LysLeu: 9.791 ± 1.3
1.688LysMet: 1.688 ± 0.513
7.427LysAsn: 7.427 ± 1.61
2.363LysPro: 2.363 ± 0.744
4.727LysGln: 4.727 ± 1.397
4.051LysArg: 4.051 ± 1.418
5.064LysSer: 5.064 ± 1.276
5.064LysThr: 5.064 ± 1.399
4.727LysVal: 4.727 ± 1.173
1.35LysTrp: 1.35 ± 0.416
3.714LysTyr: 3.714 ± 0.878
0.0LysXaa: 0.0 ± 0.0
Leu
6.752LeuAla: 6.752 ± 1.808
0.675LeuCys: 0.675 ± 0.44
7.765LeuAsp: 7.765 ± 1.486
8.44LeuGlu: 8.44 ± 1.346
4.389LeuPhe: 4.389 ± 1.758
5.064LeuGly: 5.064 ± 1.509
1.013LeuHis: 1.013 ± 0.498
5.064LeuIle: 5.064 ± 1.398
7.765LeuLys: 7.765 ± 1.597
13.167LeuLeu: 13.167 ± 2.588
2.363LeuMet: 2.363 ± 0.778
8.778LeuAsn: 8.778 ± 2.564
2.701LeuPro: 2.701 ± 0.74
7.765LeuGln: 7.765 ± 1.472
2.363LeuArg: 2.363 ± 0.763
5.064LeuSer: 5.064 ± 1.162
6.415LeuThr: 6.415 ± 1.417
4.727LeuVal: 4.727 ± 1.133
0.675LeuTrp: 0.675 ± 0.39
4.051LeuTyr: 4.051 ± 0.805
0.0LeuXaa: 0.0 ± 0.0
Met
0.338MetAla: 0.338 ± 0.342
0.0MetCys: 0.0 ± 0.0
1.688MetAsp: 1.688 ± 0.628
2.363MetGlu: 2.363 ± 0.787
0.338MetPhe: 0.338 ± 0.299
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
1.35MetIle: 1.35 ± 0.713
2.701MetLys: 2.701 ± 1.189
1.013MetLeu: 1.013 ± 0.575
0.338MetMet: 0.338 ± 0.364
1.35MetAsn: 1.35 ± 0.769
0.338MetPro: 0.338 ± 0.299
1.013MetGln: 1.013 ± 0.569
1.688MetArg: 1.688 ± 0.708
0.0MetSer: 0.0 ± 0.0
2.701MetThr: 2.701 ± 0.946
2.701MetVal: 2.701 ± 0.803
0.0MetTrp: 0.0 ± 0.0
0.675MetTyr: 0.675 ± 0.598
0.0MetXaa: 0.0 ± 0.0
Asn
4.727AsnAla: 4.727 ± 1.746
0.0AsnCys: 0.0 ± 0.0
3.038AsnAsp: 3.038 ± 0.975
7.765AsnGlu: 7.765 ± 1.643
3.038AsnPhe: 3.038 ± 0.887
4.727AsnGly: 4.727 ± 1.1
1.35AsnHis: 1.35 ± 0.584
2.363AsnIle: 2.363 ± 0.821
7.765AsnLys: 7.765 ± 2.451
6.415AsnLeu: 6.415 ± 1.51
0.338AsnMet: 0.338 ± 0.334
3.376AsnAsn: 3.376 ± 1.084
2.363AsnPro: 2.363 ± 0.429
4.389AsnGln: 4.389 ± 1.29
3.038AsnArg: 3.038 ± 1.01
2.363AsnSer: 2.363 ± 0.849
3.376AsnThr: 3.376 ± 0.835
3.714AsnVal: 3.714 ± 1.051
0.675AsnTrp: 0.675 ± 0.397
3.376AsnTyr: 3.376 ± 0.494
0.0AsnXaa: 0.0 ± 0.0
Pro
1.35ProAla: 1.35 ± 0.638
0.0ProCys: 0.0 ± 0.0
2.701ProAsp: 2.701 ± 0.73
1.688ProGlu: 1.688 ± 0.878
1.688ProPhe: 1.688 ± 0.57
0.675ProGly: 0.675 ± 0.418
0.338ProHis: 0.338 ± 0.299
2.026ProIle: 2.026 ± 0.764
1.013ProLys: 1.013 ± 0.469
2.026ProLeu: 2.026 ± 0.875
0.0ProMet: 0.0 ± 0.0
3.038ProAsn: 3.038 ± 0.946
1.35ProPro: 1.35 ± 0.632
0.675ProGln: 0.675 ± 0.486
1.35ProArg: 1.35 ± 0.53
1.013ProSer: 1.013 ± 0.683
2.363ProThr: 2.363 ± 0.607
1.013ProVal: 1.013 ± 0.423
0.0ProTrp: 0.0 ± 0.0
1.35ProTyr: 1.35 ± 0.499
0.0ProXaa: 0.0 ± 0.0
Gln
3.038GlnAla: 3.038 ± 1.037
0.0GlnCys: 0.0 ± 0.0
2.701GlnAsp: 2.701 ± 1.135
2.363GlnGlu: 2.363 ± 0.831
0.675GlnPhe: 0.675 ± 0.474
3.038GlnGly: 3.038 ± 0.936
1.013GlnHis: 1.013 ± 0.596
3.376GlnIle: 3.376 ± 1.42
4.051GlnLys: 4.051 ± 1.241
4.051GlnLeu: 4.051 ± 1.157
1.35GlnMet: 1.35 ± 0.629
2.701GlnAsn: 2.701 ± 0.811
0.675GlnPro: 0.675 ± 0.399
1.35GlnGln: 1.35 ± 0.832
2.701GlnArg: 2.701 ± 0.784
1.35GlnSer: 1.35 ± 0.723
1.35GlnThr: 1.35 ± 0.652
3.376GlnVal: 3.376 ± 1.124
0.675GlnTrp: 0.675 ± 0.536
1.013GlnTyr: 1.013 ± 0.632
0.0GlnXaa: 0.0 ± 0.0
Arg
3.714ArgAla: 3.714 ± 1.201
0.338ArgCys: 0.338 ± 0.364
3.038ArgAsp: 3.038 ± 1.152
2.026ArgGlu: 2.026 ± 0.675
2.026ArgPhe: 2.026 ± 0.679
1.013ArgGly: 1.013 ± 0.587
1.013ArgHis: 1.013 ± 0.484
6.077ArgIle: 6.077 ± 1.636
3.714ArgLys: 3.714 ± 1.442
5.739ArgLeu: 5.739 ± 1.256
1.013ArgMet: 1.013 ± 0.833
5.064ArgAsn: 5.064 ± 1.007
0.675ArgPro: 0.675 ± 0.446
1.013ArgGln: 1.013 ± 0.46
2.026ArgArg: 2.026 ± 0.708
1.013ArgSer: 1.013 ± 0.741
2.363ArgThr: 2.363 ± 0.914
2.026ArgVal: 2.026 ± 0.891
1.35ArgTrp: 1.35 ± 0.693
2.026ArgTyr: 2.026 ± 0.932
0.0ArgXaa: 0.0 ± 0.0
Ser
2.701SerAla: 2.701 ± 0.854
0.338SerCys: 0.338 ± 0.291
3.714SerAsp: 3.714 ± 1.537
3.376SerGlu: 3.376 ± 0.854
1.35SerPhe: 1.35 ± 0.611
3.376SerGly: 3.376 ± 0.855
1.013SerHis: 1.013 ± 0.47
6.077SerIle: 6.077 ± 1.726
3.714SerLys: 3.714 ± 1.145
3.714SerLeu: 3.714 ± 0.951
0.338SerMet: 0.338 ± 0.299
3.376SerAsn: 3.376 ± 0.79
1.688SerPro: 1.688 ± 0.836
1.688SerGln: 1.688 ± 0.967
3.038SerArg: 3.038 ± 1.315
1.688SerSer: 1.688 ± 0.641
2.701SerThr: 2.701 ± 1.187
2.026SerVal: 2.026 ± 0.553
0.675SerTrp: 0.675 ± 0.399
3.714SerTyr: 3.714 ± 1.142
0.0SerXaa: 0.0 ± 0.0
Thr
3.376ThrAla: 3.376 ± 0.796
0.0ThrCys: 0.0 ± 0.0
3.714ThrAsp: 3.714 ± 1.309
3.038ThrGlu: 3.038 ± 1.069
3.038ThrPhe: 3.038 ± 0.831
2.026ThrGly: 2.026 ± 0.766
1.35ThrHis: 1.35 ± 0.629
3.038ThrIle: 3.038 ± 1.113
3.038ThrLys: 3.038 ± 1.241
6.077ThrLeu: 6.077 ± 1.439
0.675ThrMet: 0.675 ± 0.383
3.714ThrAsn: 3.714 ± 0.961
2.363ThrPro: 2.363 ± 0.744
1.688ThrGln: 1.688 ± 0.752
3.376ThrArg: 3.376 ± 1.163
2.363ThrSer: 2.363 ± 1.028
1.35ThrThr: 1.35 ± 0.477
4.051ThrVal: 4.051 ± 1.229
0.0ThrTrp: 0.0 ± 0.0
2.363ThrTyr: 2.363 ± 0.665
0.0ThrXaa: 0.0 ± 0.0
Val
3.376ValAla: 3.376 ± 0.687
0.0ValCys: 0.0 ± 0.0
3.038ValAsp: 3.038 ± 1.127
3.714ValGlu: 3.714 ± 1.316
2.701ValPhe: 2.701 ± 0.733
3.714ValGly: 3.714 ± 0.673
1.688ValHis: 1.688 ± 0.668
4.389ValIle: 4.389 ± 1.143
6.752ValLys: 6.752 ± 1.252
7.09ValLeu: 7.09 ± 1.344
1.35ValMet: 1.35 ± 0.935
3.714ValAsn: 3.714 ± 0.943
3.038ValPro: 3.038 ± 1.132
1.013ValGln: 1.013 ± 0.561
1.688ValArg: 1.688 ± 0.943
4.051ValSer: 4.051 ± 0.764
3.038ValThr: 3.038 ± 1.285
3.714ValVal: 3.714 ± 1.09
0.338ValTrp: 0.338 ± 0.299
1.35ValTyr: 1.35 ± 0.609
0.0ValXaa: 0.0 ± 0.0
Trp
0.338TrpAla: 0.338 ± 0.291
0.0TrpCys: 0.0 ± 0.0
0.675TrpAsp: 0.675 ± 0.39
1.688TrpGlu: 1.688 ± 0.736
0.675TrpPhe: 0.675 ± 0.44
0.675TrpGly: 0.675 ± 0.446
0.0TrpHis: 0.0 ± 0.0
1.35TrpIle: 1.35 ± 0.642
0.338TrpLys: 0.338 ± 0.377
1.013TrpLeu: 1.013 ± 0.623
1.013TrpMet: 1.013 ± 0.62
0.675TrpAsn: 0.675 ± 0.425
0.675TrpPro: 0.675 ± 0.421
0.338TrpGln: 0.338 ± 0.336
0.338TrpArg: 0.338 ± 0.299
1.35TrpSer: 1.35 ± 0.6
0.675TrpThr: 0.675 ± 0.406
0.675TrpVal: 0.675 ± 0.594
0.338TrpTrp: 0.338 ± 0.291
0.675TrpTyr: 0.675 ± 0.378
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.688TyrAla: 1.688 ± 0.666
0.675TyrCys: 0.675 ± 0.363
3.038TyrAsp: 3.038 ± 1.124
3.038TyrGlu: 3.038 ± 1.045
1.013TyrPhe: 1.013 ± 0.423
2.701TyrGly: 2.701 ± 0.654
0.338TyrHis: 0.338 ± 0.299
3.376TyrIle: 3.376 ± 1.032
6.752TyrLys: 6.752 ± 1.742
4.051TyrLeu: 4.051 ± 1.095
1.013TyrMet: 1.013 ± 0.784
1.688TyrAsn: 1.688 ± 0.607
0.675TyrPro: 0.675 ± 0.399
1.35TyrGln: 1.35 ± 0.723
3.038TyrArg: 3.038 ± 1.038
3.038TyrSer: 3.038 ± 0.919
1.688TyrThr: 1.688 ± 0.555
2.026TyrVal: 2.026 ± 0.773
0.675TyrTrp: 0.675 ± 0.425
4.051TyrTyr: 4.051 ± 1.983
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 15 proteins (2963 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski