Amino acid dipepetide frequency for Laccaria amethystina LaAM-08-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.993AlaAla: 6.993 ± 0.042	1.09AlaCys: 1.09 ± 0.015	3.576AlaAsp: 3.576 ± 0.028	4.357AlaGlu: 4.357 ± 0.031	3.118AlaPhe: 3.118 ± 0.026	4.693AlaGly: 4.693 ± 0.034	1.94AlaHis: 1.94 ± 0.017	3.976AlaIle: 3.976 ± 0.028	3.644AlaLys: 3.644 ± 0.028	7.623AlaLeu: 7.623 ± 0.041	1.754AlaMet: 1.754 ± 0.019	2.722AlaAsn: 2.722 ± 0.023	4.495AlaPro: 4.495 ± 0.039	3.0AlaGln: 3.0 ± 0.023	4.469AlaArg: 4.469 ± 0.027	7.001AlaSer: 7.001 ± 0.04	4.821AlaThr: 4.821 ± 0.028	4.79AlaVal: 4.79 ± 0.032	1.06AlaTrp: 1.06 ± 0.013	1.949AlaTyr: 1.949 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	0.958CysAla: 0.958 ± 0.015	0.321CysCys: 0.321 ± 0.008	0.693CysAsp: 0.693 ± 0.011	0.669CysGlu: 0.669 ± 0.011	0.637CysPhe: 0.637 ± 0.01	0.969CysGly: 0.969 ± 0.013	0.428CysHis: 0.428 ± 0.009	0.779CysIle: 0.779 ± 0.011	0.612CysLys: 0.612 ± 0.011	1.534CysLeu: 1.534 ± 0.02	0.305CysMet: 0.305 ± 0.007	0.508CysAsn: 0.508 ± 0.009	0.872CysPro: 0.872 ± 0.014	0.539CysGln: 0.539 ± 0.009	0.885CysArg: 0.885 ± 0.013	1.198CysSer: 1.198 ± 0.015	0.843CysThr: 0.843 ± 0.013	0.858CysVal: 0.858 ± 0.013	0.24CysTrp: 0.24 ± 0.006	0.358CysTyr: 0.358 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.249AspAla: 4.249 ± 0.026	0.639AspCys: 0.639 ± 0.01	4.099AspAsp: 4.099 ± 0.038	4.086AspGlu: 4.086 ± 0.031	2.153AspPhe: 2.153 ± 0.021	3.778AspGly: 3.778 ± 0.028	1.326AspHis: 1.326 ± 0.016	3.029AspIle: 3.029 ± 0.021	2.192AspLys: 2.192 ± 0.019	5.012AspLeu: 5.012 ± 0.031	1.11AspMet: 1.11 ± 0.014	1.885AspAsn: 1.885 ± 0.016	3.182AspPro: 3.182 ± 0.025	1.688AspGln: 1.688 ± 0.015	2.664AspArg: 2.664 ± 0.026	4.021AspSer: 4.021 ± 0.027	2.843AspThr: 2.843 ± 0.022	3.784AspVal: 3.784 ± 0.023	0.831AspTrp: 0.831 ± 0.011	1.36AspTyr: 1.36 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	4.618GluAla: 4.618 ± 0.036	0.699GluCys: 0.699 ± 0.01	3.839GluAsp: 3.839 ± 0.032	5.255GluGlu: 5.255 ± 0.055	1.848GluPhe: 1.848 ± 0.018	3.743GluGly: 3.743 ± 0.024	1.48GluHis: 1.48 ± 0.02	2.899GluIle: 2.899 ± 0.024	3.321GluLys: 3.321 ± 0.029	5.113GluLeu: 5.113 ± 0.03	1.346GluMet: 1.346 ± 0.013	2.088GluAsn: 2.088 ± 0.017	2.504GluPro: 2.504 ± 0.024	2.075GluGln: 2.075 ± 0.02	3.839GluArg: 3.839 ± 0.036	3.941GluSer: 3.941 ± 0.025	2.944GluThr: 2.944 ± 0.02	3.563GluVal: 3.563 ± 0.022	0.914GluTrp: 0.914 ± 0.011	1.463GluTyr: 1.463 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	2.8PheAla: 2.8 ± 0.022	0.67PheCys: 0.67 ± 0.011	2.224PheAsp: 2.224 ± 0.021	2.048PheGlu: 2.048 ± 0.02	1.817PhePhe: 1.817 ± 0.022	2.585PheGly: 2.585 ± 0.025	1.048PheHis: 1.048 ± 0.014	2.003PheIle: 2.003 ± 0.02	1.626PheLys: 1.626 ± 0.016	3.935PheLeu: 3.935 ± 0.029	0.792PheMet: 0.792 ± 0.01	1.485PheAsn: 1.485 ± 0.014	2.242PhePro: 2.242 ± 0.021	1.433PheGln: 1.433 ± 0.019	2.075PheArg: 2.075 ± 0.019	3.606PheSer: 3.606 ± 0.026	2.252PheThr: 2.252 ± 0.019	2.509PheVal: 2.509 ± 0.022	0.595PheTrp: 0.595 ± 0.01	1.077PheTyr: 1.077 ± 0.011	0.0PheXaa: 0.0 ± 0.0
Gly	4.285GlyAla: 4.285 ± 0.033	0.931GlyCys: 0.931 ± 0.013	3.263GlyAsp: 3.263 ± 0.025	3.428GlyGlu: 3.428 ± 0.027	2.449GlyPhe: 2.449 ± 0.023	5.215GlyGly: 5.215 ± 0.046	1.71GlyHis: 1.71 ± 0.02	3.181GlyIle: 3.181 ± 0.022	3.52GlyLys: 3.52 ± 0.029	5.429GlyLeu: 5.429 ± 0.029	1.467GlyMet: 1.467 ± 0.017	2.383GlyAsn: 2.383 ± 0.021	3.155GlyPro: 3.155 ± 0.031	2.119GlyGln: 2.119 ± 0.019	3.98GlyArg: 3.98 ± 0.026	5.412GlySer: 5.412 ± 0.038	3.659GlyThr: 3.659 ± 0.029	4.164GlyVal: 4.164 ± 0.031	1.073GlyTrp: 1.073 ± 0.014	1.738GlyTyr: 1.738 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	1.934HisAla: 1.934 ± 0.016	0.433HisCys: 0.433 ± 0.008	1.369HisAsp: 1.369 ± 0.016	1.293HisGlu: 1.293 ± 0.015	1.145HisPhe: 1.145 ± 0.014	1.593HisGly: 1.593 ± 0.017	1.152HisHis: 1.152 ± 0.016	1.486HisIle: 1.486 ± 0.016	1.019HisLys: 1.019 ± 0.013	2.882HisLeu: 2.882 ± 0.024	0.49HisMet: 0.49 ± 0.009	0.942HisAsn: 0.942 ± 0.013	2.259HisPro: 2.259 ± 0.026	1.117HisGln: 1.117 ± 0.015	1.733HisArg: 1.733 ± 0.018	2.259HisSer: 2.259 ± 0.022	1.622HisThr: 1.622 ± 0.017	1.607HisVal: 1.607 ± 0.017	0.382HisTrp: 0.382 ± 0.008	0.736HisTyr: 0.736 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	3.865IleAla: 3.865 ± 0.024	0.874IleCys: 0.874 ± 0.013	2.726IleAsp: 2.726 ± 0.025	2.611IleGlu: 2.611 ± 0.02	2.135IlePhe: 2.135 ± 0.022	2.851IleGly: 2.851 ± 0.025	1.457IleHis: 1.457 ± 0.015	2.653IleIle: 2.653 ± 0.024	2.252IleLys: 2.252 ± 0.02	5.035IleLeu: 5.035 ± 0.037	1.005IleMet: 1.005 ± 0.014	1.864IleAsn: 1.864 ± 0.02	3.526IlePro: 3.526 ± 0.024	2.025IleGln: 2.025 ± 0.018	2.902IleArg: 2.902 ± 0.022	4.376IleSer: 4.376 ± 0.026	3.017IleThr: 3.017 ± 0.022	3.213IleVal: 3.213 ± 0.026	0.778IleTrp: 0.778 ± 0.013	1.38IleTyr: 1.38 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	3.955LysAla: 3.955 ± 0.028	0.606LysCys: 0.606 ± 0.012	2.561LysAsp: 2.561 ± 0.021	3.228LysGlu: 3.228 ± 0.029	1.609LysPhe: 1.609 ± 0.016	3.035LysGly: 3.035 ± 0.027	1.218LysHis: 1.218 ± 0.015	2.312LysIle: 2.312 ± 0.021	3.348LysLys: 3.348 ± 0.039	4.229LysLeu: 4.229 ± 0.03	0.965LysMet: 0.965 ± 0.012	1.686LysAsn: 1.686 ± 0.018	2.617LysPro: 2.617 ± 0.021	1.729LysGln: 1.729 ± 0.018	3.546LysArg: 3.546 ± 0.03	3.545LysSer: 3.545 ± 0.024	2.854LysThr: 2.854 ± 0.022	2.903LysVal: 2.903 ± 0.019	0.685LysTrp: 0.685 ± 0.01	1.368LysTyr: 1.368 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	7.536LeuAla: 7.536 ± 0.039	1.442LeuCys: 1.442 ± 0.016	5.255LeuAsp: 5.255 ± 0.031	5.509LeuGlu: 5.509 ± 0.035	3.635LeuPhe: 3.635 ± 0.032	5.631LeuGly: 5.631 ± 0.037	2.687LeuHis: 2.687 ± 0.021	4.199LeuIle: 4.199 ± 0.03	4.689LeuLys: 4.689 ± 0.032	9.035LeuLeu: 9.035 ± 0.053	1.791LeuMet: 1.791 ± 0.016	3.413LeuAsn: 3.413 ± 0.024	6.54LeuPro: 6.54 ± 0.038	3.931LeuGln: 3.931 ± 0.028	5.99LeuArg: 5.99 ± 0.034	8.498LeuSer: 8.498 ± 0.043	5.452LeuThr: 5.452 ± 0.032	5.603LeuVal: 5.603 ± 0.035	1.242LeuTrp: 1.242 ± 0.014	2.327LeuTyr: 2.327 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	1.826MetAla: 1.826 ± 0.018	0.274MetCys: 0.274 ± 0.007	1.185MetAsp: 1.185 ± 0.014	1.222MetGlu: 1.222 ± 0.015	0.724MetPhe: 0.724 ± 0.01	1.336MetGly: 1.336 ± 0.017	0.513MetHis: 0.513 ± 0.008	0.911MetIle: 0.911 ± 0.014	1.037MetLys: 1.037 ± 0.012	1.766MetLeu: 1.766 ± 0.017	0.524MetMet: 0.524 ± 0.01	0.815MetAsn: 0.815 ± 0.012	1.27MetPro: 1.27 ± 0.015	0.781MetGln: 0.781 ± 0.011	1.213MetArg: 1.213 ± 0.014	1.943MetSer: 1.943 ± 0.017	1.284MetThr: 1.284 ± 0.013	1.206MetVal: 1.206 ± 0.014	0.271MetTrp: 0.271 ± 0.006	0.499MetTyr: 0.499 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.947AsnAla: 2.947 ± 0.024	0.464AsnCys: 0.464 ± 0.009	2.045AsnAsp: 2.045 ± 0.02	1.927AsnGlu: 1.927 ± 0.017	1.479AsnPhe: 1.479 ± 0.016	2.556AsnGly: 2.556 ± 0.024	1.024AsnHis: 1.024 ± 0.013	2.13AsnIle: 2.13 ± 0.017	1.526AsnLys: 1.526 ± 0.015	3.581AsnLeu: 3.581 ± 0.027	0.737AsnMet: 0.737 ± 0.012	1.525AsnAsn: 1.525 ± 0.017	2.58AsnPro: 2.58 ± 0.02	1.292AsnGln: 1.292 ± 0.014	1.957AsnArg: 1.957 ± 0.019	2.969AsnSer: 2.969 ± 0.022	2.223AsnThr: 2.223 ± 0.022	2.51AsnVal: 2.51 ± 0.019	0.518AsnTrp: 0.518 ± 0.01	0.972AsnTyr: 0.972 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	4.803ProAla: 4.803 ± 0.035	0.713ProCys: 0.713 ± 0.012	3.114ProAsp: 3.114 ± 0.025	3.284ProGlu: 3.284 ± 0.025	2.36ProPhe: 2.36 ± 0.021	3.486ProGly: 3.486 ± 0.027	1.835ProHis: 1.835 ± 0.018	3.022ProIle: 3.022 ± 0.023	2.598ProLys: 2.598 ± 0.025	5.782ProLeu: 5.782 ± 0.032	1.096ProMet: 1.096 ± 0.011	2.455ProAsn: 2.455 ± 0.019	6.74ProPro: 6.74 ± 0.079	2.502ProGln: 2.502 ± 0.026	3.572ProArg: 3.572 ± 0.032	7.53ProSer: 7.53 ± 0.051	4.781ProThr: 4.781 ± 0.032	3.602ProVal: 3.602 ± 0.029	0.712ProTrp: 0.712 ± 0.01	1.51ProTyr: 1.51 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	3.047GlnAla: 3.047 ± 0.025	0.537GlnCys: 0.537 ± 0.009	1.87GlnAsp: 1.87 ± 0.015	2.127GlnGlu: 2.127 ± 0.022	1.251GlnPhe: 1.251 ± 0.014	2.216GlnGly: 2.216 ± 0.021	1.174GlnHis: 1.174 ± 0.015	1.889GlnIle: 1.889 ± 0.019	1.847GlnLys: 1.847 ± 0.019	3.493GlnLeu: 3.493 ± 0.025	0.797GlnMet: 0.797 ± 0.011	1.425GlnAsn: 1.425 ± 0.014	2.534GlnPro: 2.534 ± 0.027	2.113GlnGln: 2.113 ± 0.045	2.608GlnArg: 2.608 ± 0.025	3.059GlnSer: 3.059 ± 0.027	2.275GlnThr: 2.275 ± 0.019	2.313GlnVal: 2.313 ± 0.019	0.533GlnTrp: 0.533 ± 0.009	0.996GlnTyr: 0.996 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	4.35ArgAla: 4.35 ± 0.03	0.909ArgCys: 0.909 ± 0.013	3.015ArgAsp: 3.015 ± 0.026	3.593ArgGlu: 3.593 ± 0.037	2.244ArgPhe: 2.244 ± 0.018	3.606ArgGly: 3.606 ± 0.026	1.692ArgHis: 1.692 ± 0.018	3.07ArgIle: 3.07 ± 0.025	3.488ArgLys: 3.488 ± 0.028	5.707ArgLeu: 5.707 ± 0.03	1.349ArgMet: 1.349 ± 0.013	2.298ArgAsn: 2.298 ± 0.02	3.624ArgPro: 3.624 ± 0.028	2.364ArgGln: 2.364 ± 0.022	5.213ArgArg: 5.213 ± 0.039	5.18ArgSer: 5.18 ± 0.039	3.519ArgThr: 3.519 ± 0.025	3.568ArgVal: 3.568 ± 0.023	0.923ArgTrp: 0.923 ± 0.012	1.558ArgTyr: 1.558 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	6.449SerAla: 6.449 ± 0.036	1.143SerCys: 1.143 ± 0.014	4.318SerAsp: 4.318 ± 0.032	4.033SerGlu: 4.033 ± 0.026	3.513SerPhe: 3.513 ± 0.026	5.36SerGly: 5.36 ± 0.038	2.334SerHis: 2.334 ± 0.018	4.346SerIle: 4.346 ± 0.03	3.79SerLys: 3.79 ± 0.028	8.471SerLeu: 8.471 ± 0.042	1.723SerMet: 1.723 ± 0.017	3.248SerAsn: 3.248 ± 0.022	6.658SerPro: 6.658 ± 0.055	3.369SerGln: 3.369 ± 0.027	5.268SerArg: 5.268 ± 0.036	10.594SerSer: 10.594 ± 0.071	6.357SerThr: 6.357 ± 0.044	5.091SerVal: 5.091 ± 0.037	1.145SerTrp: 1.145 ± 0.013	2.08SerTyr: 2.08 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	4.63ThrAla: 4.63 ± 0.03	0.881ThrCys: 0.881 ± 0.011	2.665ThrAsp: 2.665 ± 0.02	2.756ThrGlu: 2.756 ± 0.023	2.508ThrPhe: 2.508 ± 0.021	3.598ThrGly: 3.598 ± 0.029	1.655ThrHis: 1.655 ± 0.016	3.373ThrIle: 3.373 ± 0.028	2.591ThrLys: 2.591 ± 0.025	5.975ThrLeu: 5.975 ± 0.032	1.195ThrMet: 1.195 ± 0.014	2.254ThrAsn: 2.254 ± 0.021	4.803ThrPro: 4.803 ± 0.035	2.173ThrGln: 2.173 ± 0.018	3.37ThrArg: 3.37 ± 0.024	6.169ThrSer: 6.169 ± 0.039	4.8ThrThr: 4.8 ± 0.037	3.622ThrVal: 3.622 ± 0.028	0.839ThrTrp: 0.839 ± 0.011	1.697ThrTyr: 1.697 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	4.861ValAla: 4.861 ± 0.033	0.916ValCys: 0.916 ± 0.014	3.686ValAsp: 3.686 ± 0.025	3.89ValGlu: 3.89 ± 0.024	2.492ValPhe: 2.492 ± 0.022	3.78ValGly: 3.78 ± 0.032	1.592ValHis: 1.592 ± 0.016	3.134ValIle: 3.134 ± 0.025	2.987ValLys: 2.987 ± 0.026	5.945ValLeu: 5.945 ± 0.035	1.292ValMet: 1.292 ± 0.015	2.244ValAsn: 2.244 ± 0.019	3.676ValPro: 3.676 ± 0.024	2.35ValGln: 2.35 ± 0.019	3.477ValArg: 3.477 ± 0.026	4.816ValSer: 4.816 ± 0.031	3.54ValThr: 3.54 ± 0.027	4.528ValVal: 4.528 ± 0.033	0.979ValTrp: 0.979 ± 0.015	1.696ValTyr: 1.696 ± 0.015	0.0ValXaa: 0.0 ± 0.0
Trp	1.011TrpAla: 1.011 ± 0.013	0.238TrpCys: 0.238 ± 0.005	0.906TrpAsp: 0.906 ± 0.015	0.828TrpGlu: 0.828 ± 0.011	0.573TrpPhe: 0.573 ± 0.01	0.86TrpGly: 0.86 ± 0.013	0.362TrpHis: 0.362 ± 0.008	0.759TrpIle: 0.759 ± 0.01	0.841TrpLys: 0.841 ± 0.012	1.318TrpLeu: 1.318 ± 0.016	0.359TrpMet: 0.359 ± 0.007	0.664TrpAsn: 0.664 ± 0.011	0.627TrpPro: 0.627 ± 0.01	0.492TrpGln: 0.492 ± 0.01	0.963TrpArg: 0.963 ± 0.013	1.12TrpSer: 1.12 ± 0.014	0.891TrpThr: 0.891 ± 0.014	0.897TrpVal: 0.897 ± 0.01	0.292TrpTrp: 0.292 ± 0.007	0.383TrpTyr: 0.383 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.952TyrAla: 1.952 ± 0.018	0.428TyrCys: 0.428 ± 0.01	1.522TyrAsp: 1.522 ± 0.017	1.348TyrGlu: 1.348 ± 0.015	1.133TyrPhe: 1.133 ± 0.015	1.672TyrGly: 1.672 ± 0.016	0.824TyrHis: 0.824 ± 0.012	1.394TyrIle: 1.394 ± 0.014	1.07TyrLys: 1.07 ± 0.013	2.54TyrLeu: 2.54 ± 0.021	0.503TyrMet: 0.503 ± 0.009	1.056TyrAsn: 1.056 ± 0.013	1.591TyrPro: 1.591 ± 0.019	1.014TyrGln: 1.014 ± 0.013	1.543TyrArg: 1.543 ± 0.016	2.055TyrSer: 2.055 ± 0.022	1.577TyrThr: 1.577 ± 0.017	1.551TyrVal: 1.551 ± 0.015	0.373TyrTrp: 0.373 ± 0.007	0.832TyrTyr: 0.832 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 20893 proteins (6674714 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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