Amino acid dipepetide frequency for Candidatus Hoaglandella endobia

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.513AlaAla: 7.513 ± 0.263
1.059AlaCys: 1.059 ± 0.074
4.001AlaAsp: 4.001 ± 0.146
4.866AlaGlu: 4.866 ± 0.214
2.636AlaPhe: 2.636 ± 0.103
5.931AlaGly: 5.931 ± 0.196
1.694AlaHis: 1.694 ± 0.093
6.148AlaIle: 6.148 ± 0.223
4.319AlaLys: 4.319 ± 0.164
10.149AlaLeu: 10.149 ± 0.283
2.324AlaMet: 2.324 ± 0.114
3.312AlaAsn: 3.312 ± 0.157
2.654AlaPro: 2.654 ± 0.121
3.913AlaGln: 3.913 ± 0.148
4.86AlaArg: 4.86 ± 0.189
4.636AlaSer: 4.636 ± 0.157
4.113AlaThr: 4.113 ± 0.168
5.625AlaVal: 5.625 ± 0.167
0.841AlaTrp: 0.841 ± 0.067
2.406AlaTyr: 2.406 ± 0.095
0.0AlaXaa: 0.0 ± 0.0
Cys
0.865CysAla: 0.865 ± 0.066
0.235CysCys: 0.235 ± 0.038
0.647CysAsp: 0.647 ± 0.067
0.535CysGlu: 0.535 ± 0.061
0.53CysPhe: 0.53 ± 0.053
1.053CysGly: 1.053 ± 0.077
0.424CysHis: 0.424 ± 0.052
0.788CysIle: 0.788 ± 0.073
0.453CysLys: 0.453 ± 0.053
1.171CysLeu: 1.171 ± 0.085
0.3CysMet: 0.3 ± 0.043
0.506CysAsn: 0.506 ± 0.052
0.424CysPro: 0.424 ± 0.051
0.582CysGln: 0.582 ± 0.058
0.683CysArg: 0.683 ± 0.063
0.9CysSer: 0.9 ± 0.071
0.659CysThr: 0.659 ± 0.059
0.565CysVal: 0.565 ± 0.062
0.206CysTrp: 0.206 ± 0.039
0.488CysTyr: 0.488 ± 0.052
0.0CysXaa: 0.0 ± 0.0
Asp
4.148AspAla: 4.148 ± 0.166
0.63AspCys: 0.63 ± 0.061
2.336AspAsp: 2.336 ± 0.132
2.824AspGlu: 2.824 ± 0.135
2.077AspPhe: 2.077 ± 0.114
3.26AspGly: 3.26 ± 0.146
1.018AspHis: 1.018 ± 0.082
4.13AspIle: 4.13 ± 0.17
3.036AspLys: 3.036 ± 0.136
4.907AspLeu: 4.907 ± 0.182
1.389AspMet: 1.389 ± 0.086
2.442AspAsn: 2.442 ± 0.135
1.836AspPro: 1.836 ± 0.11
1.642AspGln: 1.642 ± 0.09
2.854AspArg: 2.854 ± 0.136
2.801AspSer: 2.801 ± 0.137
2.448AspThr: 2.448 ± 0.116
3.477AspVal: 3.477 ± 0.129
0.624AspTrp: 0.624 ± 0.062
2.118AspTyr: 2.118 ± 0.108
0.0AspXaa: 0.0 ± 0.0
Glu
5.072GluAla: 5.072 ± 0.19
0.524GluCys: 0.524 ± 0.051
2.401GluAsp: 2.401 ± 0.131
3.265GluGlu: 3.265 ± 0.168
1.806GluPhe: 1.806 ± 0.095
3.301GluGly: 3.301 ± 0.165
1.318GluHis: 1.318 ± 0.088
4.277GluIle: 4.277 ± 0.149
3.371GluLys: 3.371 ± 0.159
6.09GluLeu: 6.09 ± 0.187
1.524GluMet: 1.524 ± 0.088
2.306GluAsn: 2.306 ± 0.149
1.706GluPro: 1.706 ± 0.117
3.318GluGln: 3.318 ± 0.144
4.083GluArg: 4.083 ± 0.165
2.548GluSer: 2.548 ± 0.123
2.595GluThr: 2.595 ± 0.128
4.207GluVal: 4.207 ± 0.166
0.435GluTrp: 0.435 ± 0.051
1.389GluTyr: 1.389 ± 0.086
0.0GluXaa: 0.0 ± 0.0
Phe
2.595PheAla: 2.595 ± 0.123
0.618PheCys: 0.618 ± 0.065
2.142PheAsp: 2.142 ± 0.124
1.883PheGlu: 1.883 ± 0.114
1.577PhePhe: 1.577 ± 0.115
2.748PheGly: 2.748 ± 0.137
0.835PheHis: 0.835 ± 0.066
3.024PheIle: 3.024 ± 0.169
1.547PheLys: 1.547 ± 0.106
3.289PheLeu: 3.289 ± 0.139
0.959PheMet: 0.959 ± 0.081
2.065PheAsn: 2.065 ± 0.106
1.206PhePro: 1.206 ± 0.092
1.188PheGln: 1.188 ± 0.085
1.747PheArg: 1.747 ± 0.104
2.901PheSer: 2.901 ± 0.133
2.124PheThr: 2.124 ± 0.114
2.095PheVal: 2.095 ± 0.126
0.406PheTrp: 0.406 ± 0.052
1.436PheTyr: 1.436 ± 0.087
0.0PheXaa: 0.0 ± 0.0
Gly
4.695GlyAla: 4.695 ± 0.173
0.865GlyCys: 0.865 ± 0.075
3.307GlyAsp: 3.307 ± 0.142
3.924GlyGlu: 3.924 ± 0.154
2.789GlyPhe: 2.789 ± 0.127
4.772GlyGly: 4.772 ± 0.216
1.7GlyHis: 1.7 ± 0.112
5.525GlyIle: 5.525 ± 0.186
4.719GlyLys: 4.719 ± 0.17
6.654GlyLeu: 6.654 ± 0.189
2.042GlyMet: 2.042 ± 0.117
2.83GlyAsn: 2.83 ± 0.158
1.912GlyPro: 1.912 ± 0.113
2.865GlyGln: 2.865 ± 0.121
4.101GlyArg: 4.101 ± 0.17
4.024GlySer: 4.024 ± 0.165
3.666GlyThr: 3.666 ± 0.131
4.919GlyVal: 4.919 ± 0.19
0.853GlyTrp: 0.853 ± 0.082
2.271GlyTyr: 2.271 ± 0.116
0.0GlyXaa: 0.0 ± 0.0
His
1.73HisAla: 1.73 ± 0.091
0.4HisCys: 0.4 ± 0.047
1.006HisAsp: 1.006 ± 0.083
0.988HisGlu: 0.988 ± 0.068
1.0HisPhe: 1.0 ± 0.078
1.718HisGly: 1.718 ± 0.113
0.759HisHis: 0.759 ± 0.083
1.789HisIle: 1.789 ± 0.102
1.065HisLys: 1.065 ± 0.078
2.242HisLeu: 2.242 ± 0.114
0.559HisMet: 0.559 ± 0.043
1.183HisAsn: 1.183 ± 0.076
1.2HisPro: 1.2 ± 0.093
1.194HisGln: 1.194 ± 0.098
1.247HisArg: 1.247 ± 0.076
1.112HisSer: 1.112 ± 0.086
1.359HisThr: 1.359 ± 0.093
1.312HisVal: 1.312 ± 0.099
0.335HisTrp: 0.335 ± 0.054
0.93HisTyr: 0.93 ± 0.089
0.0HisXaa: 0.0 ± 0.0
Ile
6.649IleAla: 6.649 ± 0.202
0.924IleCys: 0.924 ± 0.081
4.53IleAsp: 4.53 ± 0.171
4.66IleGlu: 4.66 ± 0.184
2.548IlePhe: 2.548 ± 0.152
5.507IleGly: 5.507 ± 0.156
1.306IleHis: 1.306 ± 0.092
6.019IleIle: 6.019 ± 0.241
4.572IleLys: 4.572 ± 0.175
6.207IleLeu: 6.207 ± 0.21
1.747IleMet: 1.747 ± 0.107
3.948IleAsn: 3.948 ± 0.164
2.636IlePro: 2.636 ± 0.126
2.418IleGln: 2.418 ± 0.126
3.813IleArg: 3.813 ± 0.156
4.901IleSer: 4.901 ± 0.161
4.589IleThr: 4.589 ± 0.184
4.477IleVal: 4.477 ± 0.139
0.618IleTrp: 0.618 ± 0.071
1.983IleTyr: 1.983 ± 0.125
0.0IleXaa: 0.0 ± 0.0
Lys
4.313LysAla: 4.313 ± 0.181
0.488LysCys: 0.488 ± 0.061
2.501LysAsp: 2.501 ± 0.12
3.018LysGlu: 3.018 ± 0.143
1.724LysPhe: 1.724 ± 0.098
3.195LysGly: 3.195 ± 0.153
1.247LysHis: 1.247 ± 0.09
4.242LysIle: 4.242 ± 0.162
3.601LysLys: 3.601 ± 0.162
6.137LysLeu: 6.137 ± 0.166
1.547LysMet: 1.547 ± 0.095
2.695LysAsn: 2.695 ± 0.125
2.006LysPro: 2.006 ± 0.113
2.571LysGln: 2.571 ± 0.13
3.112LysArg: 3.112 ± 0.14
2.806LysSer: 2.806 ± 0.102
2.736LysThr: 2.736 ± 0.125
3.813LysVal: 3.813 ± 0.158
0.4LysTrp: 0.4 ± 0.052
1.347LysTyr: 1.347 ± 0.091
0.0LysXaa: 0.0 ± 0.0
Leu
9.967LeuAla: 9.967 ± 0.251
1.241LeuCys: 1.241 ± 0.09
5.648LeuAsp: 5.648 ± 0.201
5.89LeuGlu: 5.89 ± 0.215
3.748LeuPhe: 3.748 ± 0.161
6.654LeuGly: 6.654 ± 0.208
2.654LeuHis: 2.654 ± 0.124
7.231LeuIle: 7.231 ± 0.255
5.425LeuLys: 5.425 ± 0.173
11.732LeuLeu: 11.732 ± 0.379
3.018LeuMet: 3.018 ± 0.141
4.677LeuAsn: 4.677 ± 0.156
5.484LeuPro: 5.484 ± 0.183
4.324LeuGln: 4.324 ± 0.139
6.319LeuArg: 6.319 ± 0.193
6.919LeuSer: 6.919 ± 0.218
6.143LeuThr: 6.143 ± 0.19
7.731LeuVal: 7.731 ± 0.226
1.147LeuTrp: 1.147 ± 0.091
2.836LeuTyr: 2.836 ± 0.138
0.0LeuXaa: 0.0 ± 0.0
Met
2.401MetAla: 2.401 ± 0.105
0.194MetCys: 0.194 ± 0.033
1.118MetAsp: 1.118 ± 0.078
1.294MetGlu: 1.294 ± 0.097
0.835MetPhe: 0.835 ± 0.078
1.83MetGly: 1.83 ± 0.106
0.565MetHis: 0.565 ± 0.061
1.736MetIle: 1.736 ± 0.106
1.494MetLys: 1.494 ± 0.091
3.383MetLeu: 3.383 ± 0.138
0.83MetMet: 0.83 ± 0.068
1.124MetAsn: 1.124 ± 0.076
1.312MetPro: 1.312 ± 0.087
1.188MetGln: 1.188 ± 0.081
1.765MetArg: 1.765 ± 0.098
1.665MetSer: 1.665 ± 0.109
1.624MetThr: 1.624 ± 0.092
2.071MetVal: 2.071 ± 0.111
0.159MetTrp: 0.159 ± 0.026
0.553MetTyr: 0.553 ± 0.054
0.0MetXaa: 0.0 ± 0.0
Asn
3.107AsnAla: 3.107 ± 0.116
0.541AsnCys: 0.541 ± 0.053
2.242AsnAsp: 2.242 ± 0.116
2.33AsnGlu: 2.33 ± 0.123
1.912AsnPhe: 1.912 ± 0.105
2.971AsnGly: 2.971 ± 0.153
1.083AsnHis: 1.083 ± 0.089
3.613AsnIle: 3.613 ± 0.156
2.848AsnLys: 2.848 ± 0.155
4.472AsnLeu: 4.472 ± 0.169
1.224AsnMet: 1.224 ± 0.075
2.412AsnAsn: 2.412 ± 0.135
1.847AsnPro: 1.847 ± 0.103
2.018AsnGln: 2.018 ± 0.099
2.483AsnArg: 2.483 ± 0.119
2.542AsnSer: 2.542 ± 0.137
2.2AsnThr: 2.2 ± 0.128
2.677AsnVal: 2.677 ± 0.131
0.6AsnTrp: 0.6 ± 0.06
1.565AsnTyr: 1.565 ± 0.099
0.0AsnXaa: 0.0 ± 0.0
Pro
3.071ProAla: 3.071 ± 0.135
0.377ProCys: 0.377 ± 0.048
2.048ProAsp: 2.048 ± 0.11
2.648ProGlu: 2.648 ± 0.104
1.371ProPhe: 1.371 ± 0.08
2.577ProGly: 2.577 ± 0.132
0.847ProHis: 0.847 ± 0.079
2.489ProIle: 2.489 ± 0.12
1.712ProLys: 1.712 ± 0.094
4.56ProLeu: 4.56 ± 0.181
1.03ProMet: 1.03 ± 0.079
1.618ProAsn: 1.618 ± 0.109
1.318ProPro: 1.318 ± 0.101
1.559ProGln: 1.559 ± 0.076
1.712ProArg: 1.712 ± 0.106
2.289ProSer: 2.289 ± 0.121
2.106ProThr: 2.106 ± 0.102
3.101ProVal: 3.101 ± 0.115
0.518ProTrp: 0.518 ± 0.056
1.289ProTyr: 1.289 ± 0.088
0.0ProXaa: 0.0 ± 0.0
Gln
4.16GlnAla: 4.16 ± 0.158
0.441GlnCys: 0.441 ± 0.048
1.783GlnAsp: 1.783 ± 0.098
2.395GlnGlu: 2.395 ± 0.13
1.459GlnPhe: 1.459 ± 0.103
2.895GlnGly: 2.895 ± 0.138
1.177GlnHis: 1.177 ± 0.092
2.871GlnIle: 2.871 ± 0.118
1.953GlnLys: 1.953 ± 0.115
5.501GlnLeu: 5.501 ± 0.197
1.0GlnMet: 1.0 ± 0.085
1.43GlnAsn: 1.43 ± 0.099
1.859GlnPro: 1.859 ± 0.117
3.018GlnGln: 3.018 ± 0.163
2.777GlnArg: 2.777 ± 0.132
2.289GlnSer: 2.289 ± 0.128
1.989GlnThr: 1.989 ± 0.096
3.489GlnVal: 3.489 ± 0.156
0.506GlnTrp: 0.506 ± 0.055
1.371GlnTyr: 1.371 ± 0.089
0.0GlnXaa: 0.0 ± 0.0
Arg
4.754ArgAla: 4.754 ± 0.172
0.747ArgCys: 0.747 ± 0.071
2.801ArgAsp: 2.801 ± 0.117
3.43ArgGlu: 3.43 ± 0.152
2.489ArgPhe: 2.489 ± 0.122
3.607ArgGly: 3.607 ± 0.137
1.312ArgHis: 1.312 ± 0.096
4.272ArgIle: 4.272 ± 0.146
2.854ArgLys: 2.854 ± 0.128
6.666ArgLeu: 6.666 ± 0.205
1.642ArgMet: 1.642 ± 0.099
2.501ArgAsn: 2.501 ± 0.119
2.071ArgPro: 2.071 ± 0.134
3.242ArgGln: 3.242 ± 0.152
3.707ArgArg: 3.707 ± 0.169
3.077ArgSer: 3.077 ± 0.148
2.754ArgThr: 2.754 ± 0.11
3.683ArgVal: 3.683 ± 0.155
0.753ArgTrp: 0.753 ± 0.067
2.195ArgTyr: 2.195 ± 0.091
0.0ArgXaa: 0.0 ± 0.0
Ser
4.754SerAla: 4.754 ± 0.146
0.794SerCys: 0.794 ± 0.072
2.924SerAsp: 2.924 ± 0.123
2.907SerGlu: 2.907 ± 0.144
2.406SerPhe: 2.406 ± 0.117
4.783SerGly: 4.783 ± 0.184
1.424SerHis: 1.424 ± 0.083
4.301SerIle: 4.301 ± 0.159
2.806SerLys: 2.806 ± 0.133
6.578SerLeu: 6.578 ± 0.225
1.712SerMet: 1.712 ± 0.109
2.589SerAsn: 2.589 ± 0.142
1.912SerPro: 1.912 ± 0.1
2.371SerGln: 2.371 ± 0.127
3.495SerArg: 3.495 ± 0.139
4.048SerSer: 4.048 ± 0.165
3.065SerThr: 3.065 ± 0.135
3.76SerVal: 3.76 ± 0.146
0.747SerTrp: 0.747 ± 0.066
1.936SerTyr: 1.936 ± 0.122
0.0SerXaa: 0.0 ± 0.0
Thr
4.595ThrAla: 4.595 ± 0.18
0.524ThrCys: 0.524 ± 0.06
2.595ThrAsp: 2.595 ± 0.138
2.877ThrGlu: 2.877 ± 0.147
1.706ThrPhe: 1.706 ± 0.096
4.277ThrGly: 4.277 ± 0.148
1.124ThrHis: 1.124 ± 0.086
3.654ThrIle: 3.654 ± 0.145
2.512ThrLys: 2.512 ± 0.126
6.519ThrLeu: 6.519 ± 0.194
1.277ThrMet: 1.277 ± 0.087
2.095ThrAsn: 2.095 ± 0.112
2.448ThrPro: 2.448 ± 0.131
1.895ThrGln: 1.895 ± 0.104
2.795ThrArg: 2.795 ± 0.132
3.112ThrSer: 3.112 ± 0.142
3.107ThrThr: 3.107 ± 0.138
3.96ThrVal: 3.96 ± 0.142
0.506ThrTrp: 0.506 ± 0.053
1.389ThrTyr: 1.389 ± 0.09
0.0ThrXaa: 0.0 ± 0.0
Val
5.801ValAla: 5.801 ± 0.201
0.753ValCys: 0.753 ± 0.069
3.977ValAsp: 3.977 ± 0.164
3.948ValGlu: 3.948 ± 0.171
2.065ValPhe: 2.065 ± 0.115
4.542ValGly: 4.542 ± 0.151
1.518ValHis: 1.518 ± 0.085
5.231ValIle: 5.231 ± 0.176
3.542ValLys: 3.542 ± 0.167
7.225ValLeu: 7.225 ± 0.246
1.871ValMet: 1.871 ± 0.119
3.118ValAsn: 3.118 ± 0.136
2.818ValPro: 2.818 ± 0.11
2.401ValGln: 2.401 ± 0.139
3.989ValArg: 3.989 ± 0.14
4.254ValSer: 4.254 ± 0.168
3.918ValThr: 3.918 ± 0.169
5.266ValVal: 5.266 ± 0.226
0.677ValTrp: 0.677 ± 0.063
1.547ValTyr: 1.547 ± 0.092
0.0ValXaa: 0.0 ± 0.0
Trp
0.641TrpAla: 0.641 ± 0.058
0.165TrpCys: 0.165 ± 0.033
0.418TrpAsp: 0.418 ± 0.051
0.435TrpGlu: 0.435 ± 0.052
0.494TrpPhe: 0.494 ± 0.059
0.518TrpGly: 0.518 ± 0.057
0.282TrpHis: 0.282 ± 0.038
0.777TrpIle: 0.777 ± 0.059
0.418TrpLys: 0.418 ± 0.054
1.642TrpLeu: 1.642 ± 0.121
0.324TrpMet: 0.324 ± 0.042
0.406TrpAsn: 0.406 ± 0.05
0.471TrpPro: 0.471 ± 0.067
0.894TrpGln: 0.894 ± 0.089
0.9TrpArg: 0.9 ± 0.073
0.541TrpSer: 0.541 ± 0.06
0.365TrpThr: 0.365 ± 0.043
0.618TrpVal: 0.618 ± 0.058
0.106TrpTrp: 0.106 ± 0.025
0.382TrpTyr: 0.382 ± 0.049
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.177TyrAla: 2.177 ± 0.12
0.494TyrCys: 0.494 ± 0.055
1.571TyrAsp: 1.571 ± 0.104
1.418TyrGlu: 1.418 ± 0.093
1.212TyrPhe: 1.212 ± 0.085
2.295TyrGly: 2.295 ± 0.113
0.841TyrHis: 0.841 ± 0.066
1.936TyrIle: 1.936 ± 0.114
1.253TyrLys: 1.253 ± 0.08
3.666TyrLeu: 3.666 ± 0.162
0.818TyrMet: 0.818 ± 0.07
1.43TyrAsn: 1.43 ± 0.082
1.118TyrPro: 1.118 ± 0.082
1.759TyrGln: 1.759 ± 0.101
2.112TyrArg: 2.112 ± 0.122
1.947TyrSer: 1.947 ± 0.122
1.406TyrThr: 1.406 ± 0.088
1.618TyrVal: 1.618 ± 0.093
0.359TyrTrp: 0.359 ± 0.046
1.224TyrTyr: 1.224 ± 0.097
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 517 proteins (169964 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski